公开(公告)号：US20180362614A1

公开(公告)日：2018-12-20

申请号：US16116644

申请日：2018-08-29

申请人： China Synthetic Rubber Corporation

发明人： Kuo-Jang Kao ,  Yun-Hsin Wang

IPC分类号： C07K14/745

摘要： The invention provides, inter alia, conjugates comprising a coagulating agent conjugated to an antibody, where the antibody specifically binds an extracellular domain epitope of a mammalian PLVAP protein. These agents specifically target HCC tumors and treat the HCC. The invention also provides methods of using these conjugates, such as methods of treating HCC by administering the conjugates provided by the invention or compositions provided by the invention, such as pharmaceutical compositions.

公开(公告)号：US10144921B2

公开(公告)日：2018-12-04

申请号：US15159641

申请日：2016-05-19

申请人： OPKO Biologics Ltd.

发明人： Udi Eyal Fima ,  Gili Hart

IPC分类号： C07K14/00 ,  C07K16/00 ,  A61K38/00 ,  C12N9/50 ,  C07K14/505 ,  C07K14/59 ,  C07K14/745 ,  C12N9/64 ,  A61K47/64

摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

公开(公告)号：US20180327471A1

公开(公告)日：2018-11-15

申请号：US15907123

申请日：2018-02-27

申请人： Arcturus Therapeutics, Inc.

发明人： Pattraranee Limphong ,  Kiyoshi Tachikawa ,  Padmanabh Chivukula ,  Daiki Matsuda ,  Arisa Cale

IPC分类号： C07K14/505 ,  C07K14/745 ,  C07K14/81 ,  C07K14/575

CPC分类号： C07K14/505 ,  A61K31/7088 ,  A61K31/7105 ,  A61K35/545 ,  A61K38/00 ,  A61K38/17 ,  C07K14/575 ,  C07K14/745 ,  C07K14/81

摘要： A range of therapeutic mRNA molecules expressible to provide a target polypeptide or protein. The RNA molecules can contain one or more 5-methoxyuridines and 5-methylcytidines. Further provided are DNA templates, which can be transcribed to provide a target mRNA, and can have altered nucleotides, such as reduced deoxyadenosines. This invention also provides processes for making the therapeutic mRNA molecules. The RNA molecules can be translated in vitro or in vivo to provide an active polypeptide or protein.

公开(公告)号：US10119132B2

公开(公告)日：2018-11-06

申请号：US14948890

申请日：2015-11-23

申请人： OPKO Biologics Ltd.

发明人： Udi Eyal Fima ,  Gili Hart

IPC分类号： A61K38/36 ,  C07K14/745 ,  C12N9/64 ,  C12N9/96 ,  C07K14/505 ,  C07K14/59 ,  A61K38/00 ,  A61K38/48

摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

公开(公告)号：US20180311381A1

公开(公告)日：2018-11-01

申请号：US15790246

申请日：2017-10-23

申请人： ModernaTX, Inc.

发明人： Stephane BANCEL ,  Tirtha CHAKRABORTY ,  Antonin DE FOUGEROLLES ,  Sayda M. ELBASHIR ,  Matthias JOHN ,  Atanu ROY ,  Susan WHORISKEY ,  Kristy M. WOOD ,  Paul HATALA ,  Jason P. SCHRUM ,  Kenechi EJEBE ,  Jeff Lynn ELLSWORTH ,  Justin GUILD

IPC分类号： A61K48/00 ,  C12P21/00 ,  C12P13/04 ,  C12N15/87 ,  C12N15/85 ,  C12N15/52 ,  C12N15/11 ,  C12N9/00 ,  C12N9/88 ,  C12N9/64 ,  C12N9/68 ,  C12N9/42 ,  C12N9/24 ,  C12N9/16 ,  C12N9/12 ,  C12N9/10 ,  C12N9/02 ,  C07K16/40 ,  C07K16/28 ,  C07K16/00 ,  C07K14/745 ,  C07K14/705 ,  C07K14/62 ,  C07K14/61 ,  C07K14/56 ,  C07K14/54 ,  C07K14/535 ,  C07K14/525 ,  C07K14/515 ,  C07K14/505 ,  C07K14/495 ,  C07K14/485 ,  C07K14/475 ,  C07K14/47 ,  C07K14/435 ,  C07K14/005 ,  C07H21/02 ,  A61K38/48 ,  A61K38/45 ,  A61K38/21 ,  A61K38/19 ,  A61K38/18 ,  A61K38/17 ,  A61K31/7115 ,  A61K9/51 ,  A61K9/14 ,  A61K9/127 ,  A61K47/54 ,  A61K38/00

摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US20180305437A1

公开(公告)日：2018-10-25

申请号：US15767801

申请日：2016-10-28

申请人： AFFIBODY AB

发明人： Elisabet Wahlberg

IPC分类号： C07K14/705 ,  C07K14/745

CPC分类号： C07K14/70532 ,  A61K38/1774 ,  A61P31/18 ,  A61P31/20 ,  A61P35/02 ,  C07K14/745 ,  C07K2319/00

摘要： The present disclosure relates to a class of engineered polypeptides having a binding affinity for programmed death-ligand 1 (PD-L1), and provides a PD-L1 binding polypeptide comprising the sequence ERTX4AX6WEIX10X11LPNLX16X17X18QX20GAFIX25X26LHD. The present disclosure also relates to the use of such a PD-L1 binding polypeptide a prognostic and/or diagnostic agent as well as a therapeutic agent.

公开(公告)号：US20180237762A1

公开(公告)日：2018-08-23

申请号：US15866203

申请日：2018-01-09

申请人： Bioverativ Therapeutics Inc.

发明人： Daniel S. Rivera ,  Robert T. Peters ,  Alan J. Bitonti

IPC分类号： C12N9/64 ,  C07K16/18 ,  A61K38/48 ,  A61K45/06 ,  A61K38/36 ,  C07K14/745 ,  A61K47/68 ,  A61K39/00

摘要： The invention relates to a chimeric protein comprising at least one clotting factor and at least a portion of an immunoglobulin constant region. The invention relates to a method of treating a hemostatic disorder comprising administering a therapeutically effective amount of a chimeric protein wherein the chimeric protein comprises at least one clotting factor and at least a portion of an immunoglobulin constant region.

公开(公告)号：US10053515B2

公开(公告)日：2018-08-21

申请号：US15409607

申请日：2017-01-19

申请人： Merck Sharp & Dohme Corp. ,  Adimab, LLC

发明人： Zhu Chen ,  Kenneth P. Ellsworth ,  James A. Milligan ,  Elizabeth Oldham ,  Dietmar Seiffert ,  Vaishnavi Ganti ,  Mohammad Tabrizifard ,  Bianka Prinz

IPC分类号： C07K16/36 ,  A61K39/395 ,  A61P7/02 ,  C07K16/30 ,  C07K14/745 ,  A61K39/00

CPC分类号： C07K16/36 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/545 ,  A61P7/02 ,  C07K14/745 ,  C07K16/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： Antibodies that bind the apple 2 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa are described.

公开(公告)号：US20180201917A1

公开(公告)日：2018-07-19

申请号：US15922301

申请日：2018-03-15

申请人： Omrix Biopharmaceticals Ltd.

发明人： Tamar AUERBACH-NEVO ,  Nadav ORR ,  Israel NUR

IPC分类号： C12N9/74 ,  C07K14/745 ,  C12Q1/56 ,  G01N33/49 ,  A61K38/00

CPC分类号： C12N9/6429 ,  A61K38/00 ,  C07K14/745 ,  C12Q1/56 ,  C12Y304/21005 ,  G01N33/491 ,  G01N2333/96463

摘要： Provided is a method for purifying α-thrombin and for quantifying α-thrombin and its degradation polypeptides in a liquid proteinatious solution. The method employs a one-step anion exchange chromatography method. The method allows purification and/or quantification of a homogenous post-translationally modified α-thrombin. The method can also be used for purification and/or quantification of β-thrombin.

公开(公告)号：US20180170990A1

公开(公告)日：2018-06-21

申请号：US15662090

申请日：2017-07-27

申请人： ModernaTX, Inc.

发明人： Stephane BANCEL ,  Tirtha CHAKRABORTY ,  Antonin DE FOUGEROLLES ,  Sayda M. ELBASHIR ,  Matthias JOHN ,  Atanu ROY ,  Susan WHORISKEY ,  Paul HATALA ,  Jason P. SCHRUM ,  Kenechi EJEBE ,  Jeff Lynn ELLSWORTH ,  Justin GUILD ,  Ron WEISS ,  Kristy M. WOOD

IPC分类号： C07K14/535 ,  A61K48/00 ,  C07K14/745 ,  C07K16/28 ,  C07K16/32 ,  C12N9/02 ,  C12N9/64 ,  A61K38/19 ,  A61K38/21 ,  A61K38/36 ,  A61K38/44 ,  A61K38/48 ,  A61K39/395 ,  C07K14/475 ,  C07K14/505 ,  C07K14/525 ,  C07K14/56 ,  C07K14/565 ,  C07K14/75 ,  A61K47/10 ,  A61K38/18 ,  A61K38/17 ,  A61K9/14 ,  C07K14/47 ,  C12N15/85 ,  A61K9/50 ,  A61K9/127

CPC分类号： C07K14/535 ,  A61K9/0019 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/1277 ,  A61K9/14 ,  A61K9/5031 ,  A61K31/7088 ,  A61K38/1767 ,  A61K38/1816 ,  A61K38/1866 ,  A61K38/191 ,  A61K38/193 ,  A61K38/212 ,  A61K38/215 ,  A61K38/36 ,  A61K38/363 ,  A61K38/44 ,  A61K38/4833 ,  A61K38/4846 ,  A61K39/3955 ,  A61K47/10 ,  A61K47/54 ,  A61K47/542 ,  A61K48/00 ,  A61K48/0033 ,  A61K48/0066 ,  A61K48/0075 ,  C07K14/47 ,  C07K14/475 ,  C07K14/505 ,  C07K14/525 ,  C07K14/56 ,  C07K14/565 ,  C07K14/745 ,  C07K14/75 ,  C07K16/2887 ,  C07K16/32 ,  C07K19/00 ,  C12N9/0069 ,  C12N9/644 ,  C12N15/85 ,  C12N15/88 ,  C12N2840/00 ,  C12Y113/12007 ,  C12Y304/21005 ,  C12Y304/21022

摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.