公开(公告)号：US12133866B2

公开(公告)日：2024-11-05

申请号：US17735146

申请日：2022-05-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair Reisner ,  Yaki Eidelstein ,  Eran Ophir ,  Assaf Lask ,  Ran Afik ,  Noga Or-Geva ,  Esther Bachar-Lustig

IPC: A61K35/17 ,  A61K35/12 ,  A61K35/22 ,  A61K35/26 ,  A61K35/28 ,  A61K35/34 ,  A61K35/36 ,  A61K35/38 ,  A61K35/39 ,  A61K35/407 ,  A61K35/42 ,  A61K39/00 ,  C12N5/0783

Abstract: A method of generating an isolated population of cells comprising anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) contacting peripheral blood mononuclear cells (PBMC) with a third party antigen or antigens in the presence of IL-21 so as to allow enrichment of antigen reactive cells; and (b) culturing the cells resulting from step (a) in the presence of IL-21, IL-15 and IL-7 in an antigen free environment so as to allow proliferation of cells comprising the central memory T-lymphocyte (Tcm) phenotype.

公开(公告)号：US12116428B2

公开(公告)日：2024-10-15

申请号：US17872050

申请日：2022-07-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Weifeng Lin ,  Ronit Goldberg

IPC: C07F9/10 ,  A61K9/00 ,  A61K9/08 ,  A61K9/127 ,  A61P19/02 ,  C08F130/02 ,  A61K47/69

CPC classification number: C08F130/02 ,  A61K9/0051 ,  A61K9/08 ,  A61K9/1273 ,  A61P19/02 ,  C07F9/106 ,  A61K9/0019 ,  A61K47/6909 ,  C08F2438/01

Abstract: A polymeric compound is disclosed herein, having the general formula I:




wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.

公开(公告)号：US20240338585A1

公开(公告)日：2024-10-10

申请号：US18299815

申请日：2023-04-13

Applicant: QUANTUM SOURCE LABS LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Gil SEMO ,  Ziv AQUA ,  Oded MELAMED ,  Dan CHARASH ,  Serge ROSENBLUM ,  Barak DAYAN

IPC: G06N10/40

CPC classification number: G06N10/40

Abstract: Systems and methods for generating photonic graph states for quantum computing include coupling a quantum emitter to a cavity, generating a first dirty photon having a first temporal profile, using the first dirty photon to form a first photonic qubit, generating a second dirty photon having a second temporal profile, using the second dirty photon to form a second photonic qubit, using the quantum emitter coupled to the cavity to entangle the first photonic qubit with the second photonic qubit to form a pair of entangled photonic qubits, and using the pair of entangled photonic qubits for quantum computation.

公开(公告)号：US20240318144A1

公开(公告)日：2024-09-26

申请号：US18433553

申请日：2024-02-06

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yaqub HANNA ,  Noa NOVERSHTERN ,  Yoach RAIS

IPC: C12N5/074 ,  C12N5/00 ,  C12N5/0735

CPC classification number: C12N5/0696 ,  C12N5/0037 ,  C12N5/0606 ,  C12N2500/38 ,  C12N2500/90 ,  C12N2501/01 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/235 ,  C12N2501/415 ,  C12N2501/50 ,  C12N2501/60 ,  C12N2501/71 ,  C12N2501/72 ,  C12N2501/727 ,  C12N2501/73 ,  C12N2501/999 ,  C12N2506/00

Abstract: A culture medium is disclosed which comprises STAT3 activator, an ERK1/2 inhibitor and an Axin stabilizer, and optionally also a PKC inhibitor. Cell cultures comprising same and uses thereof are also disclosed.

公开(公告)号：US20240287693A1

公开(公告)日：2024-08-29

申请号：US18560386

申请日：2022-05-25

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Ronny NEUMANN ,  Dima DABBAH-AZAIZA ,  Ariel ROSENMAN ,  Avra TZAGUY

IPC: C25B11/085 ,  C01B33/20 ,  C07F19/00 ,  C25B1/23 ,  C25B3/26 ,  C25B11/077

CPC classification number: C25B11/085 ,  C01B33/20 ,  C07F19/005 ,  C25B1/23 ,  C25B11/077 ,  C01P2002/50 ,  C01P2002/77 ,  C25B3/26

Abstract: Provided herein a polyoxometalate compound represented by formula (I): (Q)n[XMaMbMc(La)(Lb)(Lc)W9O37] (I) or a solvate thereof; and a method of electrocatalytic reduction of carbon dioxide (CO2) using the polyoxometalate compound.

公开(公告)号：US20240272514A1

公开(公告)日：2024-08-15

申请号：US18300644

申请日：2023-04-14

Applicant: QUANTUM SOURCE LABS LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Gil SEMO ,  Ziv AQUA ,  Oded MELAMED ,  Dan CHARASH ,  Serge ROSENBLUM ,  Barak DAYAN

IPC: G02F1/313 ,  G06N10/40 ,  G21K1/00

CPC classification number: G02F1/3131 ,  G06N10/40 ,  G21K1/006

Abstract: A quantum computing system, method and computer readable medium involve a vacuum enclosure for sustaining a vacuum below 10−3 millibar, optical resonators tuned to a resonance of an alkali atom, and a trapping laser for maintaining the alkali atom within a mode of the optical resonators. An atom excitation laser induces photon emissions, a plurality of waveguides couple photons to and from the optical resonators, and a plurality of detectors detect a presence or absence of an atom-resonator coupling. A processor receives output signals from the detectors and controls optical switches for switching between two or more of the plurality of waveguides.

公开(公告)号：US12038436B2

公开(公告)日：2024-07-16

申请号：US17936729

申请日：2022-09-29

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Rachel Sorek ,  Keren Jakobi-Brook ,  Pennina Safer ,  Irun R Cohen

IPC: G01N33/564 ,  G01N33/577

CPC classification number: G01N33/564 ,  G01N33/577 ,  G01N2800/102 ,  G01N2800/104 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/7095

Abstract: Assays and methods for diagnosing and treating autoimmune diseases. Particularly, the invention provides methods for differential diagnosis of specific autoimmune diseases, including autoimmune rheumatic disorders.

公开(公告)号：US20240182873A1

公开(公告)日：2024-06-06

申请号：US18281536

申请日：2022-03-10

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Asaph AHARONI ,  Prashant SONAWANE ,  Adam JOZWIAK ,  Paula BERMAN ,  Luis DE-HARO

IPC: C12N9/10 ,  C12P7/42

CPC classification number: C12N9/1085 ,  C12P7/42

Abstract: The present invention provides polynucleotide sequences derived from Helichrysum umbraculigerum and encoding a protein or a plurality thereof belonging to the prenyltransferase (PT) family. Further provided are an artificial nucleic acid molecule including the polynucleotide, a transgenic cell, tissue, or plant including same.

公开(公告)号：US20240182566A1

公开(公告)日：2024-06-06

申请号：US18535960

申请日：2023-12-11

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal Eisenbach-Schwartz ,  Kuti Baruch ,  Neta Rosenzweig

IPC: C07K16/28 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/7068 ,  A61K33/36 ,  A61K38/00 ,  A61K38/02 ,  A61K38/14 ,  A61K38/16 ,  A61K38/18 ,  A61K38/20 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/2803 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/7068 ,  A61K33/36 ,  A61K38/00 ,  A61K38/005 ,  A61K38/02 ,  A61K38/14 ,  A61K38/168 ,  A61K38/18 ,  A61K38/208 ,  A61K39/395 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/505

Abstract: A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS that does not include the autoimmune neuroinflammatory disease, relapsing-remitting multiple sclerosis (RRMS), is provided. The pharmaceutical composition is for administration by a dosage regimen comprising at least two courses of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session of non-treatment.

公开(公告)号：US20240167176A1

公开(公告)日：2024-05-23

申请号：US18489882

申请日：2023-10-19

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Sergey N. SEMENOV ,  Evgenil BORTNIKOV

IPC: C25B11/031 ,  C25B3/05 ,  C25B3/07 ,  C25B3/09 ,  C25B3/11 ,  C25B3/23 ,  C25B3/25 ,  C25B9/15 ,  C25B9/19 ,  C25B11/043 ,  C25B13/05

CPC classification number: C25B11/031 ,  C25B3/05 ,  C25B3/07 ,  C25B3/09 ,  C25B3/11 ,  C25B3/23 ,  C25B3/25 ,  C25B9/15 ,  C25B9/19 ,  C25B11/043 ,  C25B13/05

Abstract: The present invention provides a stirring-free scalable electrochemical reactor enabled by alternating current and uses thereof in a method of performing electrosynthesis of organic reaction.