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    Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
    61.
    发明授权
    Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation 有权
    通过寡核苷酸连接或延伸产生官能化微粒文库

    公开(公告)号：US08486629B2

    公开(公告)日：2013-07-16

    申请号：US11411510

    申请日：2006-04-26

    Applicant: Sukanta Banerjee ,  Jiacheng Yang ,  Michael Seul

    Inventor： Sukanta Banerjee ,  Jiacheng Yang ,  Michael Seul

    IPC: C12Q1/68 ,  C40B50/00

    CPC classification number: B01J19/0046 ,  B01J2219/005 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00648 ,  B01J2219/00722 ,  B01J2219/00725 ,  C12N15/1093 ,  C40B20/04 ,  C40B50/14

    Abstract: Disclosed are methods of for constructing a bead-displayed library of oligonucleotide probes (or sequence-modified capture moieties such as protein-nucleic acid conjugates) by ligation of a capture probe, having an analyte-specific sequence, to an anchor probe that is attached, at its 5′-end, (or possibly at the 3′ end) to an encoded carrier such as a color-coded microparticle (“bead”). Such a library can also be constructed by elongation of an anchor probe, using a second probe as the elongation template, wherein the second probe has an anchor-specific subsequence and an analyte-specific subsequence.

    Abstract translation: 公开了通过将具有分析物特异性序列的捕获探针连接到所连接的锚定探针上来构建寡核苷酸探针（或序列修饰的捕获部分，例如蛋白质 - 核酸缀合物）的珠显示文库的方法 （或可能在3'端）的编码载体，例如着色微粒（“珠粒”）。 也可以使用第二探针作为延伸模板，通过锚定探针的伸长来构建这种文库，其中第二探针具有锚特异性亚序列和分析物特异性亚序列。

    AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TARGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION
    62.
    发明申请
    AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TARGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION 有权
    多重探测目标相互作用模式的自动分析：模式匹配与识别

    公开(公告)号：US20120065099A1

    公开(公告)日：2012-03-15

    申请号：US13297487

    申请日：2011-11-16

    Applicant: Xiongwu Xia ,  Michael Seul

    Inventor： Xiongwu Xia ,  Michael Seul

    IPC: C40B30/04

    CPC classification number: C12Q1/6827 ,  G06F19/18 ,  G06F19/22

    Abstract: Methods and algorithms for automated allele assignments within an integrated software environment are provided. These methods and algorithms offer a multiplicity of functionalities including: data management; system configuration including user authorization, training set analysis and probe masking; pattern analysis including string matching and probe flipping; and interactive redaction of data. The methods and algorithms further include methods of setting thresholds, refining thresholds, and probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.

    Abstract translation: 提供了集成软件环境中自动等位基因分配的方法和算法。 这些方法和算法提供了多种功能，包括：数据管理; 系统配置包括用户授权，训练集分析和探测屏蔽; 模式分析包括字符串匹配和探针翻转; 和数据的交互式修改。 所述方法和算法还包括设置阈值，精确阈值和由探针产生的信号的探针掩蔽的方法，这些信号对于等位基因之间的区分不起重要作用。

    Number coding for identification of subtypes of coded types of solid phase carriers
    65.
    发明授权
    Number coding for identification of subtypes of coded types of solid phase carriers 有权
    用于识别编码类型的固相载体亚型的编号

    公开(公告)号：US07927796B2

    公开(公告)日：2011-04-19

    申请号：US10943760

    申请日：2004-09-17

    Applicant: Michael Seul ,  Enqing Tan ,  Chiu Chau

    Inventor： Michael Seul ,  Enqing Tan ,  Chiu Chau

    IPC: C12Q1/68 ,  C12P19/34 ,  C07H21/04 ,  G01N33/543 ,  G01N15/06 ,  G01N33/48

    CPC classification number: G01N33/6845 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/564

    Abstract: Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers which provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the basis of a different code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, to determine whether a sample is homozygous or heterozygous at a number of different sites for one of two different alleles, where the same color code is applied for each of the two alleles, and the alleles with the same color code are distinguished by knowing how many carriers are associated with molecules which detect each different allele.

    Abstract translation: 披露了提供给定类型的这种载体的可区分子类型的固相载体的对（“双”）或小集（“多重”）的数字编码，其中每种载体类型基于不同的代码可区分。 这种数字编码对于增加诸如颜色代码的编码系统是有用的，从而有效地乘以“颜色”的数量（可区分的子类型）。 例如，它可以应用于确定样品在两个不同等位基因之一的多个不同位点是纯合的还是杂合的，其中针对两个等位基因中的每一个应用相同的颜色代码，并且具有相同的等位基因 通过知道多少载体与检测每​​个不同等位基因的分子相关联来区分颜色代码。

    Primers for exons of variants of RHCE and RHD genes
    69.
    发明授权
    Primers for exons of variants of RHCE and RHD genes 有权
    RHCE和RHD基因变体外显子的引物

    公开(公告)号：US07612193B2

    公开(公告)日：2009-11-03

    申请号：US12206859

    申请日：2008-09-09

    Applicant: Ghazala Hashmi ,  Michael Seul ,  Marion E. Reid ,  Michael Pierce

    Inventor： Ghazala Hashmi ,  Michael Seul ,  Marion E. Reid ,  Michael Pierce

    IPC: C07H21/04 ,  C12N15/12

    CPC classification number: C12Q1/6881 ,  C12Q2600/156 ,  C12Q2600/16

    Abstract: Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.

    Abstract translation: 公开了基于接受者和供体基因型的比较以及等位基因和单体型的潜在组合的遗传交叉匹配的方法和算法。 本发明的方法而不是侧重于表型预测，而是依赖于在接受者和可用供体中鉴定的遗传变异体的比较，其信息优选地将在广泛可用的供体登记册中编译，以最大化分子相容性。 可以基于供体和受体之间的基因型差异的加权临床意义来匹配基因型，使得某些错配比其他错配更可接受。

    Analysis, secure access to, and transmission of array images
    70.
    发明授权
    Analysis, secure access to, and transmission of array images 有权
    分析，安全访问和传输阵列图像

    公开(公告)号：US07526114B2

    公开(公告)日：2009-04-28

    申请号：US10714203

    申请日：2003-11-14

    Applicant: Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    Inventor： Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    IPC: G06K9/00

    CPC classification number: G06T7/0012 ,  G01N33/566 ,  G06K9/00 ,  G06K9/00147 ,  G06K2209/07 ,  G06T7/11 ,  G06T7/155 ,  G06T7/33 ,  G06T2207/10064 ,  G06T2207/20152 ,  G06T2207/30072

    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

    Abstract translation: 系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中 许多受体与微粒或微珠相关。 编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。 从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。 访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

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