利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

98 条记录 (耗时 0.043 秒)

    Ceramic implants affording controlled release of active materials
    61.
    发明授权
    Ceramic implants affording controlled release of active materials 有权

    公开(公告)号：US10010500B2

    公开(公告)日：2018-07-03

    申请号：US12195789

    申请日：2008-08-21

    申请人： Mukesh Kumar

    发明人： Mukesh Kumar

    IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K38/18 ,  A61K9/50

    CPC分类号： A61K9/0024 ,  A61K9/5031

    摘要： Implantable compositions providing release of bioactive agents according to a predetermined release profile and methods for their use. Such compositions include at least one ceramic substrate; a bioactive substance loaded on a surface of the ceramic substrate forming a loaded surface zone operable to release said bioactive substance according to a release profile under physiological conditions; and a biodegradable polymer having an in vivo degradation period, forming a continuous or discontinuous coating on an area of the ceramic substrate.

    VALVE EXTENSION HANDLE
    62.
    发明申请
    VALVE EXTENSION HANDLE 审中-公开
    阀门伸缩手柄

    公开(公告)号：US20140027659A1

    公开(公告)日：2014-01-30

    申请号：US13558629

    申请日：2012-07-26

    申请人： Mukesh Kumar

    发明人： Mukesh Kumar

    IPC分类号： F16K31/44

    CPC分类号： F16K31/465 ,  A47J37/0713 ,  F16K31/46 ,  G05G1/08

    摘要： A valve extension handle is disclosed in the present invention. Said valve extension handle is comprised of a extension member with opposed first and second ends, a clamping member connected to the first end of the extension member, and a control member connected to the second end of the extension member. Said clamping member can be attached to the gas tank valve. When the control member connected to the second end of the extension member is turned, the clamping member attached to gas tank valve moves gas tank valve to turn on or shut off the gas flow from said tank.

    摘要翻译： 在本发明中公开了一种阀延伸手柄。 所述阀延伸手柄包括具有相对的第一和第二端的延伸构件，连接到延伸构件的第一端的夹紧构件和连接到延伸构件的第二端的控制构件。 所述夹紧构件可以附接到气罐阀。 当连接到延伸构件的第二端的控制构件转动时，附接到气罐阀的夹紧构件移动气罐阀，以打开或关闭来自所述罐的气体流。

    Genetic adjuvants for immunotherapy
    64.
    发明授权
    Genetic adjuvants for immunotherapy 失效

    公开(公告)号：US08603458B2

    公开(公告)日：2013-12-10

    申请号：US12476896

    申请日：2009-06-02

    申请人： Shyam S. Mohapatra ,  Mukesh Kumar

    发明人： Shyam S. Mohapatra ,  Mukesh Kumar

    IPC分类号： A61K48/00 ,  A61K39/385

    CPC分类号： A61K38/217 ,  A61K38/208 ,  A61K39/35 ,  A61K39/36 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55522 ,  A61K2039/55538

    摘要： The present invention pertains to methods and pharmaceutical compositions for modulating an immune response. The method of the present invention involves administration of an effective amount of nucleic acid molecules encoding interleukin-12 (IL-12), interferon-gamma (IFN-γ), or a combination thereof, to a patient in need of such treatment. The pharmaceutical compositions of the invention contain nucleic acid molecules encoding IL-12 and/or IFN-γ and an operably-linked promoter sequence. In another aspect, the present invention concerns expression vectors containing a nucleotide sequence encoding IL-12 and IFN-γ, and an operably-linked promoter sequence. In another aspect, the present invention concerns cells genetically modified with a nucleotide sequence encoding IL-12 and IFN-γ.

    Drug delivery and diagnostic system for orthopedic implants
    66.
    发明授权
    Drug delivery and diagnostic system for orthopedic implants 有权
    骨科植入物的药物输送和诊断系统

    公开(公告)号：US08500819B2

    公开(公告)日：2013-08-06

    申请号：US13039362

    申请日：2011-03-03

    申请人： Jason Meridew ,  Mukesh Kumar ,  Tayler E. Kreider

    发明人： Jason Meridew ,  Mukesh Kumar ,  Tayler E. Kreider

    IPC分类号： A61N1/30

    CPC分类号： A61M5/14 ,  A61F2/34 ,  A61F2/3662 ,  A61F2/389 ,  A61F2002/3068 ,  A61F2002/368 ,  A61F2002/3694 ,  A61M5/14276 ,  A61M39/0208 ,  A61M2205/3523 ,  A61M2210/086

    摘要： A drug delivery and diagnostic system can include an orthopedic implant having an outer attachment surface. A conduit can be coupled to the outer attachment surface. The conduit can have an inlet and a plurality of perforations formed along a length thereof. The conduit can be adapted to pass fluid between the inlet and the perforations. A subcutaneous port can be fluidly coupled to the inlet and be adapted to communicate fluid through the inlet, along the conduit and out of the perforations around and along the outer attachment surface of the orthopedic implant.

    摘要翻译： 药物递送和诊断系统可以包括具有外部附接表面的矫形植入物。 管道可以联接到外部附接表面。 导管可以具有沿其长度形成的入口和多个穿孔。 导管可适于在入口和穿孔之间传递流体。 皮下端口可以流体地联接到入口，并且适于沿着导管和通过整形外科植入物的外部附接表面的穿孔穿过入口传送流体。

    System and method for providing interactive troubleshooting
    67.
    发明授权
    System and method for providing interactive troubleshooting 有权
    提供交互式故障排除的系统和方法

    公开(公告)号：US08407158B2

    公开(公告)日：2013-03-26

    申请号：US12233637

    申请日：2008-09-19

    申请人： Syam S. Suri ,  Mukesh Kumar ,  Ravi S. Guduru

    发明人： Syam S. Suri ,  Mukesh Kumar ,  Ravi S. Guduru

    IPC分类号： G06F17/00 ,  G06N5/00

    CPC分类号： H04L41/5061 ,  G06Q10/10 ,  H04L41/5074

    摘要： An approach provides interactive troubleshooting. A robotic chat application receives a service inquiry over a chat session from a chat-enabled device, wherein the service inquiry is associated with a service provider network. A troubleshooting engine collects information from a user of the chat-enabled device regarding the service inquiry. The robotic chat application retrieves a flow definition and an associated query corresponding to the service inquiry based upon the collected information. The troubleshooting engine generates a command, based on the query, for resolving the service inquiry.

    摘要翻译： 一种方法提供交互式故障排除。 机器人聊天应用程序通过来自启用聊天的设备的聊天会话接收服务查询，其中服务询问与服务提供商网络相关联。 故障排除引擎从具有聊天功能的设备的用户收集有关服务查询的信息。 机器人聊天应用程序基于所收集的信息检索对应于服务询问的流定义和相关联的查询。 故障排除引擎根据查询生成一个用于解析服务查询的命令。

    METHODS FOR COATING IMPLANTS
    70.
    发明申请
    METHODS FOR COATING IMPLANTS 审中-公开
    涂层的方法

    公开(公告)号：US20110143127A1

    公开(公告)日：2011-06-16

    申请号：US12636379

    申请日：2009-12-11

    申请人： Gautam Gupta ,  Mukesh Kumar ,  Robert M. Ronk

    发明人： Gautam Gupta ,  Mukesh Kumar ,  Robert M. Ronk

    IPC分类号： B32B15/04 ,  C23C28/00 ,  B05D1/08 ,  C23C4/08 ,  C23C16/00

    CPC分类号： A61L27/32 ,  A61L27/30 ,  A61L27/306 ,  A61L27/3604 ,  A61L27/365 ,  A61L27/54 ,  A61L2420/02 ,  A61L2420/08 ,  Y10T428/265

    摘要： An implant and method for applying an osteoconductive coating on a non-conductive surface of an implant. The method includes depositing an electroconductive interlayer on at least a portion of a non-conductive implant surface. A secondary process is applied to the interlayer and an osteoconductive coating is thereby formed on the implant. In various embodiments, the electroconductive interlayer is deposited as a non-structural film and comprises a dense, non-porous metal such as titanium, titanium alloys, cobalt, cobalt alloys, chromium, chromium alloys, tantalum, tantalum alloys, iron alloys, stainless steel, and mixtures thereof. The osteoconductive coating may include a metal, a porous metal, or calcium phosphate. The osteoconductive coating may include additional agents, such as bone product, growth factor, bioactive agent, antibiotic, or combinations thereof.

    摘要翻译： 用于在植入物的非导电表面上施加骨传导性涂层的植入物和方法。 该方法包括在非导电植入物表面的至少一部分上沉积导电中间层。 将二次方法应用于中间层，由此在植入物上形成骨传导性涂层。 在各种实施方案中，导电中间层作为非结构膜沉积并且包含致密的非多孔金属如钛，钛合金，钴，钴合金，铬，铬合金，钽，钽合金，铁合金，不锈钢 钢及其混合物。 骨传导性涂层可以包括金属，多孔金属或磷酸钙。 骨传导性涂层可以包括另外的试剂，例如骨产品，生长因子，生物活性剂，抗生素或其组合。