公开(公告)号：US11151674B2

公开(公告)日：2021-10-19

申请号：US15570730

申请日：2016-04-30

Applicant: IntegenX Inc.

Inventor： Robert A. Schueren ,  David King ,  Stevan B. Jovanovich

IPC: G01N33/48 ,  G01N33/50 ,  G06Q50/26 ,  G06F16/11 ,  G06Q50/00 ,  G06Q50/18 ,  G06Q10/06 ,  G06Q30/06 ,  H04W4/12

Abstract: Provided herein is a system and method for review of forensic report computer files. The method can involve notifying a plurality of service providers of a job to be performed, accepting a bid from a service provider to perform the job, providing the computer file to the service provider, receiving from the service provider a forensic result such as a reviewed file.

公开(公告)号：US10690627B2

公开(公告)日：2020-06-23

申请号：US14919620

申请日：2015-10-21

Applicant: IntegenX Inc.

Inventor： Alexander Kindwall ,  Chungsoo Charles Park ,  Fedor Ilkov ,  Stevan Jovanovich ,  David King ,  Tristan Robert Littlehale ,  David Grant Nilson ,  Rick Pittaro ,  Robert A. Schueren ,  Mattias Vangbo ,  Philip Justus Wunderle

IPC: G01N27/447 ,  G01N27/453 ,  B01L3/00 ,  B01L7/00

Abstract: The present disclosure provides systems and methods for sample preparation, processing and analysis. Also provided in the present disclosure is a fully-integrated electrophoresis cartridge which has a small footprint and configured to removably engage with the system.

公开(公告)号：USD848880S1

公开(公告)日：2019-05-21

申请号：US29616150

申请日：2017-09-01

Applicant: IntegenX, Inc.

Designer： Corey M. Smith ,  Tracy Lee Dahlmann ,  Daniel M. Parker ,  Robert A. Schueren ,  David King

公开(公告)号：US10233491B2

公开(公告)日：2019-03-19

申请号：US15173894

申请日：2016-06-06

Applicant: IntegenX Inc.

Inventor： Philip Justus Wunderle ,  Chungsoo Charles Park ,  David King ,  Dennis Lehto

IPC: C12Q1/6874 ,  C12Q1/686 ,  B01L3/00 ,  F16K99/00 ,  B01L7/00 ,  B01F13/00 ,  B01F13/02

Abstract: This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface, wherein (II) the cartridge interface comprises: (A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and (B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve.

公开(公告)号：USD819470S1

公开(公告)日：2018-06-05

申请号：US29581062

申请日：2016-10-14

Applicant: IntegenX, Inc.

Designer： Robert A. Schueren ,  Alexander Kindwall ,  David King ,  Chungsoo Charles Park ,  James Klevenberg

公开(公告)号：USD772086S1

公开(公告)日：2016-11-22

申请号：US29525151

申请日：2015-04-27

Applicant: IntegenX Inc.

Designer： Robert A. Schueren ,  Alexander Kindwall ,  David King ,  Chungsoo Charles Park ,  James Klevenberg

公开(公告)号：US20160053314A1

公开(公告)日：2016-02-25

申请号：US14824333

申请日：2015-08-12

Applicant: Stevan Bogdan Jovanovich ,  Iuliu Ioan Blaga ,  Allen Boronkay

Inventor： Stevan Bogdan Jovanovich ,  Iuliu Ioan Blaga ,  Allen Boronkay

IPC: C12Q1/68 ,  B01L3/00 ,  C12N15/10

CPC classification number: C12Q1/6869 ,  B01F11/0071 ,  B01F13/0059 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502753 ,  B01L3/502761 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1844 ,  B01L2400/0415 ,  B01L2400/0421 ,  B01L2400/0481 ,  B01L2400/0655 ,  C12N15/1003 ,  C12N15/1013 ,  C12Q1/24 ,  C12Q1/6806 ,  C12Q1/6844 ,  C12Q1/686 ,  C12Q1/70 ,  G01N2035/00514 ,  Y10T436/163333 ,  Y10T436/25875

Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.

公开(公告)号：US20130203634A1

公开(公告)日：2013-08-08

申请号：US13202884

申请日：2011-08-20

Applicant: Stevan B. Jovanovich ,  Seth Stern ,  Ezra Van Gelder ,  Mattias Vangbo

Inventor： Stevan B. Jovanovich ,  Seth Stern ,  Ezra Van Gelder ,  Mattias Vangbo

IPC: C12Q1/68

CPC classification number: B01J19/0046 ,  B01J2219/00389 ,  B01J2219/00599 ,  B01J2219/00716 ,  B01J2219/00722 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/043 ,  B01L2400/0481 ,  B01L2400/0655 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q1/6874 ,  F16K99/0015 ,  F16K99/0059 ,  F16K2099/0084

Abstract: The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.

Abstract translation: 本发明提供用于执行综合分析的系统，设备，方法和套件。 综合分析可以包括样品处理，库构建，扩增和测序。 集成分析可以在一个或多个流体连接的模块中进行。 一个或多个模块可以由计算机控制和/或自动化。 可以对组织样品，临床样品或环境样品进行综合分析。 集成分析系统可以具有紧凑的格式，并在指定的时间段内返回结果。

公开(公告)号：US20130115607A1

公开(公告)日：2013-05-09

申请号：US13656503

申请日：2012-10-19

Applicant: IntegenX Inc.

Inventor： William D. Nielsen ,  Richard J. Belcinski ,  Gregory Bogdan ,  David Eberhart ,  Omar El-Sissi ,  Stevan B. Jovanovich ,  Michael Recknor ,  Ezra Van Gelder ,  David W. Wyrick

IPC: C12Q1/68

CPC classification number: C12Q1/68 ,  B01L3/502715 ,  B01L3/5029 ,  B01L3/527 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2200/0647 ,  B01L2200/143 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/0672 ,  B01L2300/123 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0616 ,  G01N27/44704 ,  G01N2035/00158

Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.

Abstract translation: 本公开提供了一种综合和自动化的样本回答系统，其从包含生物材料的样品开始，在少于两小时内产生遗传图谱。 在某些实施方案中，生物材料是DNA，并且遗传图谱涉及确定受试者的一个或多个位点（例如，遗传基因座）等位基因，例如STR（短串联重复）分布，例如如 CODIS系统。 该系统可以执行若干操作，包括（a）提取和分离核酸; （b）在选择的位点（例如遗传基因座）扩增核苷酸序列; 和（c）扩增产物的检测和分析。 这些操作可以在包括多个集成模块的系统中进行，包括分析物准备模块; 检测和分析模块和控制模块。

公开(公告)号：US08431340B2

公开(公告)日：2013-04-30

申请号：US12605217

申请日：2009-10-23

Applicant: Stevan Bogdan Jovanovich ,  Iuliu Ioan Blaga

Inventor： Stevan Bogdan Jovanovich ,  Iuliu Ioan Blaga

IPC: C12Q1/68 ,  C12P19/34 ,  C12N13/00 ,  C12M1/34 ,  C12M1/02 ,  C07H21/00

CPC classification number: B01L3/50273 ,  B01F11/0071 ,  B01F13/0059 ,  B01J2219/005 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502761 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0654 ,  B01L2300/0803 ,  B01L2300/0806 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/1822 ,  B01L2300/1844 ,  B01L2400/0409 ,  B01L2400/0421 ,  B01L2400/043 ,  B01L2400/0487 ,  B01L2400/0638 ,  B01L2400/0655 ,  B01L2400/086 ,  C12Q2565/629 ,  G01N1/34 ,  G01N27/44721 ,  G01N27/44743 ,  G01N27/44791 ,  G01N35/0098

Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.

Abstract translation: 公开了用于将微芯片连接到各种类型的模块的方法和装置。 所公开的技术可用作各种应用的样品制备和分析系统，如DNA测序和基因分型，蛋白质组学，病原体检测，诊断和生物防治。