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704 条记录 (耗时 0.046 秒)

    Methods of forming ciclopirox or derivatives thereof in a subject by administration of prodrug
    63.
    发明授权
    Methods of forming ciclopirox or derivatives thereof in a subject by administration of prodrug 有权
    通过给药前药在受试者中形成环吡酮或其衍生物的方法

    公开(公告)号：US09545413B2

    公开(公告)日：2017-01-17

    申请号：US14966323

    申请日：2015-12-11

    申请人： The University of Kansas

    发明人： Mehmet Tanol ,  Scott Weir

    IPC分类号： A01N57/00 ,  A61K31/675 ,  C07F9/58 ,  C07F9/59 ,  C07F9/09 ,  C07F9/11

    CPC分类号： A61K31/675 ,  C07F9/091 ,  C07F9/094 ,  C07F9/11 ,  C07F9/58 ,  C07F9/59 ,  C07F9/6596

    摘要： A method of forming a compound in a subject can include: providing a composition having a prodrug compound represented by a structure of Formula 1 or stereoisomer thereof or pharmaceutically acceptable salt thereof; and administering the composition to a subject such that the prodrug compound has a phosphoryloxyalkyl prodrug moiety removed therefrom to form the compound in the subject and to form the separate phosphoryloxyalkyl compound. The prodrug can be included in a pharmaceutical composition for use in treatment of fungus, various cancers (e.g., bladder, breast, etc.), dermatitis, superficial mycoses; inflammation, tinea pedis, tinea cruris, and tinea corporis, Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis, candidiasis (moniliasis), Candida albicans, tinea (pityriasis) vesicolor, Malassezia furfur, acute myeloid leukemia, acute lymphoid leukemia, chronic myelogenous leukemia, lymphoma or multiple myeloma.

    摘要翻译： 在受试者中形成化合物的方法可以包括：提供具有由式1的结构或其立体异构体或其药学上可接受的盐表示的前药化合物的组合物; 以及将所述组合物施用于受试者，使得所述前药化合物具有从其中除去的磷酰氧基烷基前药部分以在受试者中形成化合物并形成分离的磷酰氧基烷基化合物。 前药可以包括在药物组合物中，用于治疗真菌，各种癌症（例如膀胱，乳房等），皮炎，浅表性真菌病; 癣菌，癣菌，癣菌，癣菌，癣菌和癣菌，红色毛癣菌，癣菌和小孢子癣菌，念珠菌病（moniliasis），白色念珠菌，癣（糠疹），糠疹马拉色菌，急性淋巴细胞性白血病， 慢性骨髓性白血病，淋巴瘤或多发性骨髓瘤。

    HEATED LENS LIGHTING ARRANGEMENT
    66.
    发明申请
    HEATED LENS LIGHTING ARRANGEMENT 有权
    加热镜头照明安装

    公开(公告)号：US20160209022A1

    公开(公告)日：2016-07-21

    申请号：US14915468

    申请日：2014-08-29

    申请人： UNIVERSITY OF KANSAS

    发明人： Hongyi CAI ,  Steven D. SCHROCK ,  Eric FITZSIMMONS

    IPC分类号： F21V29/89 ,  G02B6/04 ,  F21V8/00 ,  F21V29/70

    CPC分类号： F21V29/70 ,  F21S8/08 ,  F21V29/90 ,  F21V2200/10 ,  F21V2200/17 ,  F21W2111/02 ,  F21W2131/10 ,  F21Y2115/10 ,  G02B6/0008 ,  G02B6/04 ,  G08G1/095

    摘要： According to aspects of the embodiments, a lighting fixture is designed to help prevent the accumulation of snow or ice on the light emitting face {e.g., lens) of the lighting fixture. The lighting fixture harvests both the light and heat generated by at least one light source, such as but not limited to at least one LED light source. The lighting fixture adopts a flip-mount light source mounting design in which one side of a passive heat exchanger is mounted or secured closely adjacent or proximate to the lens, and the light source is mounted or secured to another side of the passive heat exchanger. The heat generated by the light source is conducted by the passive heat exchanger to heat the lens. Additionally, the light emitted from the light source is redirected back through the passive heat exchanger and to the lens using a bundle of light fiber cables.

    摘要翻译： 根据实施例的方面，照明器具被设计成有助于防止雪或冰积聚在照明器材的发光面（例如，透镜）上。 照明装置收集由至少一个光源产生的光和热，例如但不限于至少一个LED光源。 照明器具采用倒装式光源安装设计，其中被动热交换器的一侧安装或紧固在透镜附近或靠近透镜，并且光源被安装或固定到被动热交换器的另一侧。 由光源产生的热量由被动热交换器进行，以加热透镜。 此外，从光源发射的光被重新引导回通过被动热交换器并且使用一束光纤电缆到达透镜。

    Apparatus for providing coolant fluid
    67.
    发明授权
    Apparatus for providing coolant fluid 有权
    用于提供冷却剂流体的装置

    公开(公告)号：US09289760B2

    公开(公告)日：2016-03-22

    申请号：US12393362

    申请日：2009-02-26

    申请人： Gerald G. Williams ,  Andrew D. Hager ,  George S. Wilson ,  William Scott Jeffress ,  Frank J. Schoenen

    发明人： Gerald G. Williams ,  Andrew D. Hager ,  George S. Wilson ,  William Scott Jeffress ,  Frank J. Schoenen

    IPC分类号： B01L1/00

    CPC分类号： B01L1/50 ,  B01L2300/185

    摘要： An apparatus for providing coolant fluid to a device, the apparatus includes a heat exchanger having a hot side and a cold side. The cold side is in fluid communication with a chilled fluid supply and adapted to receive a first fluid from the chilled fluid supply in a first inlet and return the first fluid from the cold side to the chilled fluid supply. The cold side and the chilled fluid supply form a first fluid circuit. The apparatus further includes a second fluid circuit in fluid communication with the hot side, means for introducing a second fluid within the second fluid circuit and integral thereto, a pump integral to the second fluid circuit and adapted to transmit a second fluid within the second fluid circuit and means for controlling a rate of flow of the second fluid within the second fluid circuit. The device is within the second fluid circuit and the means for controlling the rate of flow operates in the absence of internal recirculation.

    摘要翻译： 一种用于向装置提供冷却剂流体的装置，该装置包括具有热侧和冷侧的热交换器。 冷侧与冷却液供应流体连通并且适于在第一入口中从冷冻流体供应源接收第一流体并将第一流体从冷侧返回到冷却液供应。 冷侧和冷却液供应形成第一流体回路。 该装置还包括与热侧流体连通的第二流体回路，用于在第二流体回路内引入第二流体并与其成一体的装置，与第二流体回路成一体的泵，适于在第二流体内传输第二流体 电路和用于控制第二流体回路内的第二流体的流量的装置。 该装置在第二流体回路内，用于控制流量的装置在没有内部再循环的情况下运行。

    REPROGRAMMING OF HUMAN WHARTONS JELLY CELLS TO PRODUCE HAIR CELLS
    69.
    发明申请
    REPROGRAMMING OF HUMAN WHARTONS JELLY CELLS TO PRODUCE HAIR CELLS 有权
    人乳头瘤细胞生成头发细胞

    公开(公告)号：US20150307837A1

    公开(公告)日：2015-10-29

    申请号：US14698157

    申请日：2015-04-28

    申请人： Adam J. Mellott ,  Michael Detamore ,  Hinrich Staecker

    发明人： Adam J. Mellott ,  Michael Detamore ,  Hinrich Staecker

    IPC分类号： C12N5/0793 ,  C12N15/113 ,  A61K35/30 ,  C07K14/47

    CPC分类号： C12N5/062 ,  A61K35/30 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/51 ,  C12N2506/025 ,  C12N2510/00 ,  C12N2533/90

    摘要： A method of transforming human cells into mechanosensory hair cells (MHCs), such as inner hear hair cells in the cochlea and vestibular organs, can include: causing human Wharton's jelly cells (hWJCs) to increase expression of or biological function of HATH1 so as to transform the hWJCs into MHCs. The method can include; administering a nucleic acid that encodes HATH1 to the hWJCs; causing inhibited expression of or biological function of HES1 and/or HES5 in the hWJCs; administering a nucleic acid that inhibits HES1 and/or a nucleic acid that inhibits HES5 to the hWJCs; causing inhibited expression of or biological function of HES1 and/or HES5 in the WJCs by administering a nucleic acid that inhibits HES1 and/or a nucleic acid that inhibits HES5; nucleic acids are administered includes a sequence of SEQ ID NO: 2, SEQ ID NO: 3, and/or SEQ ID NO: 4.

    摘要翻译： 将人类细胞转化为机械感染毛细胞（MHC）的方法，例如耳蜗和前庭器官内部听到的毛细胞，可以包括：引起人类沃顿的果冻细胞（hWJCs）增加HATH1的表达或生物学功能，以便 将hWJCs转化为MHC。 该方法可以包括 向hWJCs施用编码HATH1的核酸; 导致hWJCs中HES1和/或HES5的表达或生物学功能受到抑制; 施用抑制HES1的核酸和/或对hWJC抑制HES5的核酸; 通过施用抑制HES1的核酸和/或抑制HES5的核酸来抑制WJCs中HES1和/或HES5的表达或生物学功能; 核酸被给予包括SEQ ID NO：2，SEQ ID NO：3和/或SEQ ID NO：4的序列。

    BIOMATERIAL BASED ON ALIGNED FIBERS, ARRANGED IN A GRADIENT INTERFACE, WITH MECHANICAL REINFORCEMENT FOR TRACHEAL REGENERATION AND REPAIR
    70.
    发明申请
    BIOMATERIAL BASED ON ALIGNED FIBERS, ARRANGED IN A GRADIENT INTERFACE, WITH MECHANICAL REINFORCEMENT FOR TRACHEAL REGENERATION AND REPAIR 审中-公开
    基于对准纤维的生物材料，安装在梯度界面，机械加固用​​于河道再生和修复

    公开(公告)号：US20150230918A1

    公开(公告)日：2015-08-20

    申请号：US14239049

    申请日：2012-08-15

    申请人： Michael Detamore ,  Lindsey Ott ,  Robert Weatherly

    发明人： Michael Detamore ,  Lindsey Ott ,  Robert Weatherly

    IPC分类号： A61F2/20 ,  A61L27/10 ,  A61L27/14

    CPC分类号： A61F2/20 ,  A61F2/04 ,  A61F2002/046 ,  A61F2210/0076 ,  A61F2250/0018 ,  A61F2250/0028 ,  A61L27/10 ,  A61L27/14 ,  A61L27/18 ,  A61L27/34 ,  A61L2300/414 ,  A61L2420/04 ,  A61L2420/08 ,  A61L2430/22 ,  C08L67/04

    摘要： An implant can include a plurality of polymeric fibers associated together into a fibrous body. The fibrous body is capable of being shaped to fit a tracheal defect and capable of being secured in place by suture or by bioadhesive. The fibrous body can have aligned fibers (e.g., circumferentially aligned) or unaligned fibers. The fibrous body can be electrospun. The fibrous body can have a first characteristic in a first gradient distribution across at least a portion of the fibrous body. The fibrous body can include one or more structural reinforcing members, such as ribbon structural reinforcing members, which can be embedded in the plurality of fibers. The fibrous body can include one or more structural reinforcing members bonded to the fibers with liquid polymer as an adhesive, the liquid polymer having a substantially similar composition of the fibers.

    摘要翻译： 植入物可以包括与纤维体相关联的多个聚合物纤维。 纤维体能够成形为适合气管缺损并且能够通过缝线或通过生物粘附固定在适当位置。 纤维体可以具有对准的纤维（例如，周向排列）或未对准的纤维。 纤维体可以电纺丝。 纤维体可以具有穿过纤维体的至少一部分的第一梯度分布的第一特征。 纤维体可以包括一个或多个可以嵌入多根纤维中的结构加强构件，例如带状结构增强构件。 纤维体可以包括一个或多个结合的增强部件，其结合到具有液体聚合物作为粘合剂的纤维上，该液体聚合物具有基本相似的纤维组成。