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公开(公告)号：US20050106710A1
公开(公告)日：2005-05-19
申请号：US10878649
申请日：2004-06-28
Applicant: Marc Friedman , Stephen Evans , Paul Zalesky , Jon Dahm , Philip Levin
Inventor： Marc Friedman , Stephen Evans , Paul Zalesky , Jon Dahm , Philip Levin
IPC: A61B18/18 , A61B18/24 , A61B19/00 , A61F2/958 , A61M29/00 , A61N1/06 , A61N5/00 , A61N5/06 , A61N5/067 , A61N5/10 , H01L33/62 , G01N33/554 , A61N1/00 , C12M1/34 , G01N33/569 , G02B6/44
CPC classification number: A61N5/0603 , A61B2090/036 , A61M25/1011 , A61N5/0601 , A61N5/062 , A61N2005/005 , A61N2005/0602 , A61N2005/0609 , A61N2005/0652 , A61N2005/0661 , A61N2005/0662 , F21S4/20 , F21Y2115/10 , H01L33/62 , H01L2224/32245 , H01L2224/48091 , H01L2224/48247 , H01L2224/73265 , H01L2924/12044 , H01L2924/3025 , H01L2924/00014 , H01L2924/00
Abstract: Physically flexible radiation-emitting probes and associated illumination methods and systems for delivering radiation or light to the interior of a lumen or cavity. Light-emitting devices are immersed in a flowing liquid coolant within a probe to provide high light output power, and convoluted electrical power buss structures provide physical flexibility of a probe about a longitudinal axis. The probes can be configured for delivering light to the interior of any lumen including for performing therapeutic medical procedures at locations in body lumens including the interior of the human gastrointestinal tract.
Abstract translation: 物理灵活的辐射发射探针和相关的照明方法和系统，用于将辐射或光传递到内腔或空腔的内部。 发光器件浸入到探针内的流动的液体冷却剂中以提供高的光输出功率，并且卷积的电力总线结构提供探针围绕纵向轴线的物理灵活性。 探针可以被配置为将光传送到任何内腔的内部，包括用于在包括人胃肠道内部的体腔内的位置执行治疗性医疗程序。
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公开(公告)号：US20050104059A1
公开(公告)日：2005-05-19
申请号：US10878648
申请日：2004-06-28
Applicant: Marc Friedman , Stephen Evans , Paul Zalesky , Jon Dahm , Philip Levin
Inventor： Marc Friedman , Stephen Evans , Paul Zalesky , Jon Dahm , Philip Levin
IPC: A61B18/18 , A61B18/24 , A61B19/00 , A61F2/958 , A61M29/00 , A61N1/06 , A61N5/00 , A61N5/06 , A61N5/067 , A61N5/10 , H01L33/62 , H01L21/00 , C12M1/34 , H01L29/08 , H01L35/24
CPC classification number: A61N5/0603 , A61B2090/036 , A61M25/1011 , A61N5/0601 , A61N5/062 , A61N2005/005 , A61N2005/0602 , A61N2005/0609 , A61N2005/0652 , A61N2005/0661 , A61N2005/0662 , F21S4/20 , F21Y2115/10 , H01L33/62 , H01L2224/32245 , H01L2224/48091 , H01L2224/48247 , H01L2224/73265 , H01L2924/12044 , H01L2924/3025 , H01L2924/00014 , H01L2924/00
Abstract: Physically flexible radiation-emitting probes and associated illumination methods and systems for delivering radiation or light to the interior of a lumen or cavity. Light-emitting devices are immersed in a flowing liquid coolant within a probe to provide high light output power, and convoluted electrical power buss structures provide physical flexibility of a probe about a longitudinal axis. The probes can be configured for delivering light to the interior of any lumen including for performing therapeutic medical procedures at locations in body lumens including the interior of the human gastrointestinal tract.
Abstract translation: 物理灵活的辐射发射探针和相关的照明方法和系统，用于将辐射或光传递到内腔或空腔的内部。 发光器件浸入到探针内的流动的液体冷却剂中以提供高的光输出功率，并且卷积的电力总线结构提供探针围绕纵向轴线的物理灵活性。 探针可以被配置为将光传送到任何内腔的内部，包括用于在包括人胃肠道内部的体腔内的位置执行治疗性医疗程序。
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公开(公告)号：US11998757B2
公开(公告)日：2024-06-04
申请号：US17701099
申请日：2022-03-22
Applicant: The Medical College of Wisconsin, Inc.
Inventor： Nicole Lohr , Michael Salinger
CPC classification number: A61N5/0601 , A61B18/24 , A61N5/0613 , A61B2017/0019 , A61B2018/00351 , A61B2018/00577 , A61B2090/049 , A61N2005/0602 , A61N2005/063 , A61N2005/0651 , A61N2005/0663
Abstract: Reperfusion injury is limited during endovascular therapies (e.g., revascularization and/or reperfusion of end organ tissues) by conditioning the tissues against reperfusion injury using an optical fiber catheter to deliver far red and near infrared (R/NIR) light to the tissues. The light may be multiple wavelength or single wavelength light, and may have one or more wavelengths selected from the range of 510 to 830 nm. The R/NIR light may be delivered concurrently with the endovascular therapy, or in other instances may be delivered before or after a particular therapy.
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公开(公告)号：US20240157168A1
公开(公告)日：2024-05-16
申请号：US18404041
申请日：2024-01-04
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Shuai XU , Chenkai XU , Hao ZHANG , Hangbo ZHAO , John A. ROGERS
CPC classification number: A61N5/0601 , A61M37/0015 , A61N5/062 , A61M2037/003 , A61M2037/0061 , A61N2005/0602 , A61N2005/063 , A61N2005/0652 , A61N2005/0661
Abstract: Provided is a light delivery device for delivering light to a tissue of a patient comprising a microarray of tissue penetrating members, each tissue penetrating member having a distal end and a proximal end and configured to be inserted into the tissue, wherein the tissue penetrating members are at least partially optically transparent to provide optical transmission through a surface that extends between the distal and proximal ends of each tissue penetrating member; a transparent substrate having a top surface and a bottom surface, wherein the bottom surface supports the tissue penetrating members; a plurality of optical sources supported by the top surface of the substrate and in optical communication with the microarray of tissue penetrating members; the plurality of optical sources is configured to operably emit light; and an encapsulation layer disposed over the microarray of tissue penetrating members.
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公开(公告)号：US20230390576A1
公开(公告)日：2023-12-07
申请号：US18033172
申请日：2021-10-21
Applicant: KANEKA CORPORATION
Inventor： Hironori TAKATA , Toshihiko UTO
IPC: A61N5/06
CPC classification number: A61N5/062 , A61N5/0603 , A61N2005/0602 , A61N2005/0665
Abstract: A light irradiation medical device comprising: a shaft having a lumen extending in the longitudinal direction; and a light guiding device that is disposed in the lumen of the shaft and is movable in the longitudinal direction. The light guiding device extends in the longitudinal direction and has a light diffusion part at a distal part of the light guiding device. The shaft has: a first window in a peripheral wall of a distal part of the shaft; and a second window at a distal end face of the shaft. The shaft has a reflection surface inside the shaft and at a distal side with respect to the first window, and reflects light emitted from the light guiding device.
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Patent Agency Ranking
公开(公告)号：US11690737B2
公开(公告)日：2023-07-04
申请号：US16328094
申请日：2016-09-05
Inventor： Myung-Gyu Choi , Seok-Hyun Yun , Bo-In Lee , Jae Myung Park , Ehsan Kamrani , Ali Kemal Yetisen
IPC: A61F2/82 , A61F7/12 , A61B5/07 , A61B18/00 , A61F2/48 , A61F7/00 , A61B18/10 , A61B18/08 , A61N5/06 , A61B5/00 , A61N1/372 , A61N1/378 , A61B5/1473
CPC classification number: A61F2/82 , A61B5/076 , A61B5/6862 , A61B18/082 , A61B18/10 , A61F7/12 , A61N1/3787 , A61N1/37223 , A61N5/0601 , A61N5/062 , A61N5/0603 , A61B5/1473 , A61B2018/00577 , A61F2/482 , A61F2007/0094 , A61F2007/126 , A61F2250/0001 , A61N2005/0602 , A61N2005/0651
Abstract: A stent device including a stent coated with a photosensitizer, the stent including a pair of electrodes; and a circuit fixed to the stent, the circuit including a light emitting diode, a power receiving means for wirelessly receiving power from the outside, and converting the power to electric power; a second communicating means for receiving a control command from the outside; and a second control means for applying, based on the control command, the electric power to the electrodes causing an electric current to flow through the stent between the electrodes, the flow causing heating of the stent, and for controlling a temperature of the stent to provide hyperthermia therapy to a tumor, the second control means further for applying, based on the control command, the electric power to the light emitting diode to emit a predetermined wavelength of light to the photosensitizer to provide photodynamic therapy to the tumor.
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公开(公告)号：US11690673B2
公开(公告)日：2023-07-04
申请号：US16976539
申请日：2019-09-19
Applicant: SIA LIGHT GUIDE OPTICS INTERNATIONAL
Inventor： Oskars Dzerins , Daumants Pfafrods
CPC classification number: A61B18/24 , A61L29/02 , A61L29/106 , A61N5/062 , A61N5/0625 , A61B17/12031 , A61B2018/00404 , A61B2018/2261 , A61N5/067 , A61N2005/0602 , A61N2005/0631
Abstract: The invention relates to a device (17) for treatment of body tissue, in particular for the permanent occlusion of varicose veins, preferably in the lower limbs, of varicocele and/or of vascular malformations and/or for the use in aesthetic surgeries, preferably laser assisted lipolysis, and/or for tumor treatment by means of laser induced thermotherapy and/or photodynamic therapy, by means of a light diffuser (13) circumferentially and endoluminally irradiating said tissue by laser light energy, said diffuser (13) being connected at its proximal end to a source (10) of laser light energy via a flexible wave guide (12) comprising a fiber optic core (1) covered by an optical cladding (2) having a refractive index smaller than that of the core (1), wherein in the cladding (2) and/or in the core (1) imperfections (18) are provided, designed as recesses and adapted to direct the light, preferably to refract and/or reflect the light propagating within the core (1) and/or its optical cladding (2) in generally radial directions, wherein a cap (7) transparent to the laser light enclosing the distal end of the core (1) and its optical cladding (2) in a fluid tight and/or liquid tight manner is provided. According to the invention the device (17) is characterized in that the outer surface (19) of said optical cladding (2) is fused in the region (A) between said imperfections (18) to the inner surface (21), preferably the inner diameter, of the cap (7) and/or in that the outer surface (19) of said optical cladding (2) extending over a distance in front and/or behind the region (A) provided with the imperfections (18) is fused to the inner surface (21), preferably the inner diameter, of the cap (7).
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68.发明申请公开(公告)号：US20180333588A1
公开(公告)日：2018-11-22
申请号：US15976199
申请日：2018-05-10
Applicant: Illumnation Corp.
Inventor： Baruch B. LIEBER , John A. ROSE
CPC classification number: A61N5/0601 , A61B1/00045 , A61B1/00087 , A61B1/05 , A61B1/3137 , A61B17/00234 , A61B17/0057 , A61B17/12113 , A61B17/12136 , A61B17/12168 , A61B18/24 , A61B2017/00292 , A61B2017/00778 , A61B2017/22067 , A61B2018/00029 , A61B2018/00404 , A61B2018/00416 , A61B2018/00589 , A61B2018/00982 , A61B2018/2238 , A61B2018/2261 , A61B2217/007 , A61M25/00 , A61N5/062 , A61N2005/0602 , A61N2005/0659 , A61N2005/0662
Abstract: In some embodiments, an apparatus includes a catheter having a catheter body, a light emitter disposed at a distal end of the catheter body, and a fluid conduit coupleable to a source of fluid. The fluid conduit configured to discharge fluid from the source via the conduit and out a distal end of the catheter body. A spacing member is disposed at the distal end of the catheter body and can be moved between a collapsed configuration and an expanded configuration. In the expanded configuration, the spacing member is disposed about the light emitter. The spacing member is at least partially transmissive and/or transflective of light emitted from the light emitter. The apparatus configured to be inserted at least partially into a body lumen, to discharge fluid into the body lumen, and to emit light from the light emitter to illuminate an interior wall of the body lumen.
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公开(公告)号：US09827438B2
公开(公告)日：2017-11-28
申请号：US14323217
申请日：2014-07-03
Applicant: UVL Blood Labs, Inc.
Inventor： Scot Johnson , Michael Harter , Victor Josef Scheeren
CPC classification number: A61N5/0601 , A61N2005/0602 , A61N2005/063 , A61N2005/0661 , G02B6/3816 , G02B6/3825 , G02B6/3851
Abstract: A system for irradiation of a vascular space and its contents is presented. An adapter device having a vascular access end and an optical interface end can include a waveguide affixed within a waveguide lumen and extending outwardly through the vascular access end. The optical interface end includes a tapered terminus configured to engage with a cavity of an optical connector adapter, creating an optical interface between the waveguide of the adapter device and a waveguide of a light or radiation source. The adapter device enables the simultaneous administration of radiation and exogenous fluids to a patient while maintaining the optical interface isolated from any fluids.
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公开(公告)号：US09822189B2
公开(公告)日：2017-11-21
申请号：US14843586
申请日：2015-09-02
Applicant: Alumend, LLC
Inventor： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
IPC: C07D221/00 , C08B37/08 , A61L24/08 , A61B17/00 , A61K41/00 , A61K47/48 , A61K8/73 , A61K31/722 , A61Q17/04 , A61B17/08 , A61N5/06 , A61Q19/00
CPC classification number: C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
Abstract: Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.
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