公开(公告)号：US09871948B2

公开(公告)日：2018-01-16

申请号：US14389275

申请日：2013-03-28

Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

Inventor： Ioannis Papadopoulos ,  Salma Farahi ,  Christophe Moser ,  Demetri Psaltis

IPC: H04N1/40 ,  G02B6/028 ,  G02F1/313 ,  G02F1/01 ,  G01J3/44 ,  G01J3/02 ,  G02B23/26 ,  G02B26/06 ,  G03H1/00 ,  G02B27/58 ,  H04B10/2581 ,  G03H1/22 ,  G03H1/04

CPC classification number: H04N1/40 ,  G01J3/0218 ,  G01J3/44 ,  G02B6/0288 ,  G02B23/26 ,  G02B26/06 ,  G02B27/58 ,  G02F1/011 ,  G02F1/0136 ,  G02F1/313 ,  G03H1/0005 ,  G03H1/2286 ,  G03H1/2294 ,  G03H2001/0434 ,  G03H2001/0447 ,  H04B10/2581

Abstract: A multimode waveguide illuminator and imager relies on a wave front shaping system that acts to compensate for modal scrambling and light dispersion by the multimode waveguide. A first step consists of calibrating the multimode waveguide and a second step consists in projecting a specific pattern on the wave guide proximal end in order to produce the desire light pattern at its distal end. The illumination pattern can be scanned or changed dynamically only by changing the phase pattern projected at the proximal end of the waveguide. The third and last step consists in collecting the optical information, generated by the sample, through the same waveguide in order to form an image. Known free space microscopy technique can be adapted to endoscopy with multimode waveguide, such as, but not limited to, fluorescence imaging or Raman spectros copy or imaging, 3D linear scattering imaging or two-photon imaging. Super-resolution, i.e., resolution below the diffraction limit, is achieved for example but not limited to, using the STimulated Emission Depletion microscopy (STED) technique or the Structured Illumination Microscopy (SIM) technique or a stochastic illumination based method (PALM, STORM) in combination with the multimode waveguide imaging method.

公开(公告)号：US09869591B2

公开(公告)日：2018-01-16

申请号：US14784366

申请日：2013-08-22

Applicant: Hitachi, Ltd.

Inventor： Shigeharu Kimura

IPC: G01J3/44 ,  G02F1/365 ,  G02F1/35 ,  G01J3/02 ,  G01N21/65 ,  G02B21/00

CPC classification number: G01J3/44 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/36 ,  G01J3/453 ,  G01N21/65 ,  G01N2021/653 ,  G02B21/002 ,  G02B21/0056 ,  G02F1/353 ,  G02F1/365 ,  G02F2001/3528

Abstract: To measure homodyne interference with a CARS microscope, a supercontinuum beam is used as a light source. A supercontinuum beam is generated using a nonlinear optical fiber that has normal dispersion in which the coherence between pulses is maintained. As the phases of the interference components of detected beams are the same between pulses, it is possible to integrate the interference components and thus improve the signal-noise ratio.

公开(公告)号：US20170370774A1

公开(公告)日：2017-12-28

申请号：US15527055

申请日：2015-10-28

Applicant: KONICA MINOLTA, INC.

Inventor： Mikio UEMATSU

IPC: G01J3/46 ,  G09G5/02 ,  G01J3/51 ,  H04N1/60 ,  G01J1/04

CPC classification number: G01J3/465 ,  G01J1/04 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/505 ,  G01J3/51 ,  G01J3/513 ,  G01J3/524 ,  G01M11/0285 ,  G09G5/02 ,  G09G2320/0693 ,  H04N1/603 ,  H04N1/6033 ,  H04N1/6052

Abstract: In a direct stimulus value reading type colorimetric photometer, first, second, and third colorimetric optical systems have spectral responsivities approximate to first, second, and third parts of the color matching function, respectively. A deriving unit derives a colorimetric value corresponding to a case in which the color matching function is selected as an evaluation function for colorimetry and a photometric value corresponding to a case in which the spectral luminous efficiency is selected as an evaluation function for photometry (i.e. “CASE”) from three signals. The spectral luminous efficiency is not consistent with any one of the first, second, and third parts. A fourth colorimetric optical system may have spectral responsivity approximate to the spectral luminous efficiency, and the deriving unit may derive the colorimetric value corresponding to the CASE from a fourth signal.

公开(公告)号：US20170356847A1

公开(公告)日：2017-12-14

申请号：US15651695

申请日：2017-07-17

Applicant: IFE Innovative Forschungs- und Entwicklungs GmbH & Co. KG

Inventor： Thomas Willuweit ,  Ralf Griesbach

IPC: G01N21/64 ,  G01J3/02 ,  G01N21/25 ,  G01J3/32 ,  G01J3/10 ,  G01J3/28 ,  G01J3/44

CPC classification number: G01N21/64 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/28 ,  G01J3/32 ,  G01J3/4406 ,  G01N21/251 ,  G01N21/645 ,  G01N2201/024 ,  G01N2201/08

Abstract: The invention provides a measuring device for analyzing a luminescent sample and, in particular, for measuring the concentration of at least one analyte in a luminescent sample, comprising: a housing with a sample receptacle space for accommodating a sample container; a sample container for accommodating the luminescent sample; a radiation receiver apparatus for receiving radiation emitted by the luminescent sample; and an evaluation apparatus for evaluating the radiation from the luminescent sample received by the radiation receiver apparatus. The invention moreover provides a measuring device comprising a base part and a measuring head arranged at the base part in an interchangeable manner, wherein the measuring head is embodied to analyze the luminescent sample or it is embodied as a spectrometer measuring head.

公开(公告)号：US09823127B2

公开(公告)日：2017-11-21

申请号：US14683066

申请日：2015-04-09

Applicant: Duke University

Inventor： Adam Wax ,  Howard Levinson ,  William J. Brown ,  Thomas Matthews ,  Manuel Medina

IPC: G01J3/28 ,  G01B9/02 ,  G01J3/453 ,  G01N21/45 ,  G01J3/02 ,  A61B5/00 ,  G01N21/47

CPC classification number: G01J3/2823 ,  A61B5/445 ,  G01B9/02044 ,  G01B9/02091 ,  G01J3/0218 ,  G01J3/453 ,  G01J3/4531 ,  G01N21/45 ,  G01N21/4795

Abstract: Disclosed herein are systems and methods for deep spectroscopic imaging of a biological sample. In an aspect, a system includes a broad bandwidth light source configured to generate an illumination beam, an interferometer, and a spectrometer. The interferometer includes a first beam splitter configured to split the illumination beam into an incident beam and a reference beam; an optical lens directs the incident beam onto a biological sample at a predefined offset from corresponding optical axis, and receive a beam scattered from the biological sample. The beams are configured to intersect with each other within a focal zone of the optical lens. Photons of the incident beam undergo multiple forward scattering within the biological sample. A second beam splitter configured to receive and superimpose the scattered and reference beams, to generate an interference beam. The spectrometer uses a spectral domain detection technique to assess tissue properties of the biological sample.

公开(公告)号：US20170328770A1

公开(公告)日：2017-11-16

申请号：US15592274

申请日：2017-05-11

Applicant: OCEAN OPTICS, INC.

Inventor： THOMAS HOPKINS ,  DIETER BINGEMANN ,  DAVID CREASEY

IPC: G01J3/02 ,  G01N33/02

CPC classification number: G01J3/0218 ,  G01N21/49 ,  G01N21/55 ,  G01N21/8806 ,  G01N33/02 ,  G01N2201/0846

Abstract: A food integrity probe design comprising two illumination fiber rings, allowing for two different simultaneous measurements wherein the inner illumination ring generates a surface reflectance signal on the central detection fibers and the outer illumination ring allows for an additional interactance measurement, probing deeper into the sample than the surface reflectance alone while partially eliminating specular reflection, which reduces the signal quality, through the addition of a ring-shaped diffusor onto the inner illumination ring is disclosed.

公开(公告)号：US09797876B2

公开(公告)日：2017-10-24

申请号：US15357225

申请日：2016-11-21

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  G01N33/15 ,  A61B5/1455 ,  A61B5/00 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/359 ,  A61B5/145 ,  G01N33/49 ,  G01N21/3563 ,  G01N21/39 ,  G01N33/02 ,  G01N33/44 ,  G01N21/88 ,  H01S3/30 ,  G01J3/14 ,  G01J3/18 ,  G01M3/38

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A measurement system includes semiconductor light sources generating an input beam, optical amplifiers receiving the input beam and delivering an intermediate beam, and fused silica fibers with core diameters less than 400 microns receiving and delivering the intermediate beam to the fibers forming a first optical beam. A nonlinear element receives the first optical beam and broadens the spectrum to at least 10 nm through a nonlinear effect to form the output optical beam which includes a near-infrared wavelength of 700-2500 nm. A measurement apparatus is configured to receive the output optical beam and deliver it to a sample to generate a spectroscopy output beam. A receiver receives the spectroscopy output beam having a bandwidth of at least 10 nm and processes the beam to generate an output signal, wherein the light source and the receiver are remote from the sample, and wherein the sample comprises plastics or food industry goods.

公开(公告)号：US09791317B2

公开(公告)日：2017-10-17

申请号：US15376144

申请日：2016-12-12

Applicant: The General Hospital Corporation

Inventor： Milen Shishkov ,  Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Nicusor Iftimia

IPC: G01J3/18 ,  G02B6/24 ,  G02B6/26 ,  B24B9/14 ,  G01J3/02 ,  A61B1/002 ,  G02B23/24 ,  G02B23/26

CPC classification number: G02B23/2453 ,  A61B1/00167 ,  A61B1/00188 ,  A61B1/002 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0084 ,  A61B5/0086 ,  B24B9/14 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/18 ,  G02B5/18 ,  G02B23/2469 ,  G02B23/26

Abstract: Exemplary apparatus for method for forming at least one spectral encoding endoscopy configuration. For example, it is possible to modify a spacer configuration and an lens optics configuration to have respective predetermined lengths, and also to modify a dispersive optics configuration to have a further predetermined length. Further, the modified spacer and modified lens optics configurations can be attached to one another to form a combined spacer-lens optics configuration. The modified dispersive optics configuration can be attached to a substrate to form to form a grating substrate configuration. Additionally, the combined spacer-lens optics configuration can be connected to an optical fiber, and the modified attached dispersed optics configuration can be connected to the modified attached lens optics configuration to form the spectral encoding endoscopy configuration(s) which can extends along a particular axis. The dispersive optics configuration can be modified to be at a predetermined angle with respect to the particular axis.

公开(公告)号：US09778107B2

公开(公告)日：2017-10-03

申请号：US15075187

申请日：2016-03-20

Applicant: Zhilin Hu

Inventor： Zhilin Hu

IPC: G01J3/28 ,  G01J3/18 ,  G02B5/18 ,  G02B1/14 ,  G02B5/04 ,  G01J3/14 ,  G01J3/02 ,  G01J3/12

CPC classification number: G01J3/18 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/14 ,  G01J3/28 ,  G01J2003/1208 ,  G02B1/14 ,  G02B5/04 ,  G02B5/1814

Abstract: A linear frequency domain grating and a multiband spectrometer having the same. The linear frequency domain grating includes a dispersive optical element and a diffractive optical element being substantially in contact with the dispersive optical element or being substantially integrated with the dispersive optical element, configured to receive a beam of incident light along an incident optical path, and diffract and disperse it into its constituent spectrum of frequencies of the light that is output from the dispersive optical element along an output optical path, such that the output light has a spatial distribution on a focal plane in the output optical path that is a linear function of the frequency. The linear frequency domain grating is a transmissive-type grating or a reflective-type grating, depending on whether the incident optical path and the output optical path are in different sides or the same side of the diffractive optical element.

公开(公告)号：US09772226B2

公开(公告)日：2017-09-26

申请号：US13180508

申请日：2011-07-11

Applicant: John Douglas Corless ,  Andrew Weeks Kueny ,  Mark Anthony Meloni

Inventor： John Douglas Corless ,  Andrew Weeks Kueny ,  Mark Anthony Meloni

IPC: G01J1/34 ,  G01J1/00 ,  G01J3/00 ,  G01J3/02 ,  G01J3/10 ,  G01J3/42 ,  G01N21/95

CPC classification number: G01J3/0218 ,  G01J3/10 ,  G01J3/42 ,  G01N21/9501

Abstract: A referenced and stabilized optical measurement system includes a light source, a plurality of optical elements and optical fiber assemblies and a detector arranged to compensate for the effects of system variation which may affect measurement performance. A non-continuous light source provides a common source light on a common source path. A reference light and a measurement light are derived from the common source light and propagated across separate paths of optically matching optical components in order to produce a common signal variation on both the reference light signal and the measurement light signal. Light paths exposed to air are contained indiscrete volumes for purging gasses from the volumes. Ratios of the reference signal and measurement signal are acquired under various conditions for compensating the measurement signal for system variations.