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211 条记录 (耗时 0.03 秒)

    Azo dyes
    61.
    发明授权
    Azo dyes 失效
    偶氮染料

    公开(公告)号：US5550217A

    公开(公告)日：1996-08-27

    申请号：US328943

    申请日：1994-10-25

    申请人： Martin Trottmann

    发明人： Martin Trottmann

    IPC分类号： C09B29/085 ,  C07C229/16 ,  C07C229/40 ,  C07C233/43 ,  C07C233/54 ,  C07C233/80 ,  C07C235/10 ,  C07C235/16 ,  C07C253/30 ,  C07C255/61 ,  C07C271/28 ,  C07C275/40 ,  C07C311/05 ,  C07C311/08 ,  C07C317/42 ,  C09B29/08 ,  C09B31/043 ,  D06P1/18 ,  D06P3/54 ,  C09B29/00

    CPC分类号： C09B31/043 ,  C07C229/16 ,  C07C233/43 ,  C07C235/16 ,  C07C271/28 ,  C07C275/40 ,  C07C311/05 ,  C07C311/08 ,  C09B29/0816 ,  C09B29/0817

    摘要： Disperse dyes of formula ##STR1## wherein D is the radical of a diazo component of formula ##STR2## Z.sub.1 is a radical of formula ##STR3## Z.sub.2 is hydrogen or a radical of formula (4), X is hydrogen, halogen, CF.sub.3, R.sub.3, OR.sub.3, NH--CO--R.sub.7, NH--CO--OR.sub.8, NH--SO.sub.2 --R.sub.7 or ##STR4## wherein R.sub.3 is C.sub.1 -C.sub.6 alkyl; R.sub.4 and R.sub.5 are each independently of the other hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy-C.sub.2 -C.sub.4 alkyl; R.sub.7 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 alkoxy-C.sub.1 -C.sub.4 alkyl or phenyl; and R.sub.8 is C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.4 alkoxy-C.sub.2 -C.sub.4 alkyl; A.sub.1 is hydrogen, halogen, SO.sub.2 R.sub.3, CF.sub.3, NO.sub.2 or CN; A.sub.2 is hydrogen, halogen or CN; A.sub.3 is hydrogen or halogen, with the proviso that at least one of the substituents X, A.sub.1, A.sub.2 and A.sub.3 may not be hydrogen, and A.sub.4 is hydrogen, halogen, nitro, R.sub.3, NHCOR.sub.3 or OR.sub.3.

    摘要翻译： （1）的分散染料其中D是式（2）或（IMAGE）（3）的重氮组分的基团，Z1是下式的基团：（4）Z2是氢或 式（4）的基团，X是氢，卤素，CF 3，R 3，OR 3，NH-CO-R 7，NH-CO-OR 8，NH-SO 2 -R 7或者其中R 3是C 1 -C 6烷基; R 4和R 5各自独立地为另一个氢，C 1 -C 4烷基或C 1 -C 4烷氧基-C 2 -C 4烷基; R 7是氢，C 1 -C 6烷基，C 1 -C 4烷氧基-C 1 -C 4烷基或苯基; 并且R 8是C 1 -C 6烷基或C 1 -C 4烷氧基-C 2 -C 4烷基; A1是氢，卤素，SO2R3，CF3，NO2或CN; A2是氢，卤素或CN; A3是氢或卤素，条件是至少一个取代基X，A1，A2和A3可以不是氢，A4是氢，卤素，硝基，R3，NHCOR3或OR3。

    Process for preparing poly (glucaramides)
    63.
    发明授权
    Process for preparing poly (glucaramides) 失效
    制备聚（葡糖酰胺）的方法

    公开(公告)号：US5473035A

    公开(公告)日：1995-12-05

    申请号：US225696

    申请日：1994-04-11

    申请人： Donald E. Kiely ,  Liang Chen

    发明人： Donald E. Kiely ,  Liang Chen

    IPC分类号： C07C235/10 ,  C08G69/10 ,  C08G73/00

    CPC分类号： C07C235/10 ,  C08G69/10

    摘要： Novel monomers are described which contain a glucaric acid unit linked through an amide bond formed between a carbonyl carbon of a D-glucaric acid and one of the amino nitrogens of a primary diamine as well as their alkali metal salts. These N-aminohydrocarbylene (or N-aminoheterohydrocarbylene)-D-glucaramidates may then be polymerized to form polyhydroxypolyamides and in particular stereoregular polyhydroxypolyamides.

    摘要翻译： 描述了含有通过D-葡糖二酸的羰基碳与一级胺的一种氨基氮之间形成的酰胺键连接的葡糖二酸单元及其碱金属盐的新型单体。 然后可以将这些N-氨基亚烃基（或N-氨基杂烃基）-D-葡糖酰氨基聚合物聚合形成多羟基聚酰胺，特别是立体规则的聚羟基聚酰胺。

    Methods and compounds
    67.
    发明授权
    Methods and compounds 失效
    方法和化合物

    公开(公告)号：US5190946A

    公开(公告)日：1993-03-02

    申请号：US654154

    申请日：1991-02-12

    申请人： Avner Ramu ,  Karel Valter

    发明人： Avner Ramu ,  Karel Valter

    IPC分类号： A61K31/13 ,  A61K31/135 ,  A61K31/165 ,  A61K31/22 ,  A61K31/235 ,  A61K31/475 ,  A61K31/495 ,  A61K31/675 ,  A61P23/02 ,  A61P25/02 ,  A61P35/00 ,  C07C217/06 ,  C07C219/10 ,  C07C219/14 ,  C07C229/04 ,  C07C229/34 ,  C07C233/36 ,  C07C233/78 ,  C07C235/10 ,  C07C235/50 ,  C07C237/10 ,  C07C237/20 ,  C07C237/34 ,  C07D295/088 ,  C07D295/108 ,  C07D295/13 ,  C07D295/14 ,  C07D295/15 ,  C07D295/18 ,  C07D295/185

    CPC分类号： C07D295/185 ,  A61K31/13 ,  A61K31/135 ,  A61K31/22 ,  A61K31/475 ,  A61K31/495 ,  A61K31/675 ,  A61K31/70 ,  C07C219/10 ,  C07D295/088 ,  C07D295/108 ,  C07D295/13 ,  C07D295/15 ,  C07C2101/14

    摘要： Compounds of formula ##STR1## wherein R and R.sup.3, which may be the same or different, each is hydrogen, an alkyl group containing 1 to 5 carbon atoms, or an optionally substituted aryl or aralkyl group, substituents being selected from the group consisting of halogen, alkoxy and alkyl groups containing 1 to 5 carbon atoms, said alkyl groups in turn being optionally halo-substituted; R.sup.1 and R.sup.2, which may be the same or different, each is hydrogen, an alkyl group containing 1 to 5 carbon atoms, or an optionally substituted aryl or aralkyl group, substituents being as indicated above or R.sup.1 and R.sup.2 taken together are an alkylene group containing 2 or 3 carbon atoms; m and p, which may be the same or different each is a number from 0 to 3; n is the number 2 or 3; and X is a group of the formula R.sub.x.sup.4 --CO--, R.sub.x.sup.4 --COO--, R.sub.x.sup.4 --CONH--, R.sub.x.sup.4 --NHCO--, or R.sub.x.sup.4 --O-- and Y is a group of formula R.sub.y.sup.4 --CO--, R.sub.y.sup.4 --COO--, R.sub.y.sup.4 --CONH--, R.sub.y.sup.4 --NHCO--, or R.sub.y.sup.4 --O-- which R.sub.y.sup.4 and R.sub.x.sup.4, which may be the same of different, each is an optionally substituted aryl, aralkyl or aryloxyalkyl group, substitutents being as indicated above, and the alkyl moiety in the aralkyl and aryloxyalkyl groups containing 1 to 5 carbon atoms and can be optionally substituted by a cyloalkyl group containing 3 to 8 carbon atoms; and physiologically acceptable acid addition salts thereof, have been found to be active in restoring drug-sensitivity to cancer cells that have become multidrug-resistant. They can, therefore, be used as adjuvants in oncology, and they can be administered simultaneously, separately or at intervals in combination with one or more conventional anti-cancer agents for treating malignant tumors and corresponding metastases.Compounds and salts which have not been previously described in British Patent Specification No. 883013 as well as their preparation and pharmaceutical compositions containing them are also disclosed.