公开(公告)号：US20190254535A1

公开(公告)日：2019-08-22

申请号：US16334037

申请日：2017-09-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon HARMELIN ,  Vyacheslav KALCHENKO ,  Guillaume MOLODIJ

IPC: A61B5/02 ,  G06T7/593 ,  G06T7/246 ,  G06T5/00 ,  G06T5/20 ,  A61B5/00

Abstract: There is provided a computer implemented method for generating a three dimensional (3D) image based of fluorescent illumination, comprising: receiving in parallel by each of at least three imaging sensors positioned at a respective parallax towards an object having a plurality of regions with fluorescent illumination therein, a respective sequence of a plurality of images including fluorescent illumination of the plurality of regions, each of the plurality of images separated by an interval of time; analyzing the respective sequences, to create a volume-dataset indicative of the depth of each respective region of the plurality of regions; and generating a 3D image according to the volume-dataset.

公开(公告)号：US20190240378A1

公开(公告)日：2019-08-08

申请号：US16387591

申请日：2019-04-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob KLEIN ,  Ronit GOLDBERG ,  Noa IUSTER ,  Raya SORKIN

IPC: A61L27/52 ,  A61K9/00 ,  C09D133/06 ,  C08F2/10 ,  A61L27/44 ,  C08F2/44 ,  A61L27/34

CPC classification number: A61L27/52 ,  A61K9/0019 ,  A61K9/0024 ,  A61L27/34 ,  A61L27/44 ,  A61L2300/626 ,  A61L2400/10 ,  A61L2430/06 ,  A61L2430/10 ,  A61L2430/24 ,  A61L2430/38 ,  C08F2/10 ,  C08F2/44 ,  C09D133/066

Abstract: Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.

公开(公告)号：US20190211342A1

公开(公告)日：2019-07-11

申请号：US16362897

申请日：2019-03-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ron MILO ,  Niv ANTONOVSKY ,  Elad NOOR ,  Arren BAR-EVEN ,  Yehudit ZOHAR ,  Lior ZELCBUCH ,  Shmuel GLEIZER ,  Shira AMRAM

IPC: C12N15/70 ,  C07K14/195 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N9/90 ,  C07K14/245 ,  C12N1/20

CPC classification number: C12N15/70 ,  C07K14/195 ,  C07K14/245 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1025 ,  C12N9/1205 ,  C12N9/88 ,  C12N9/90 ,  C12Y101/01049 ,  C12Y203/03009 ,  C12Y207/01011 ,  C12Y207/01019 ,  C12Y401/01039 ,  C12Y402/01011 ,  C12Y504/02

Abstract: A microorganism which is genetically modified so that it produces a first essential biomass precursor by metabolizing CO2 using a recombinant carbon fixation enzyme is disclosed. The microorganism produces a second biomass precursor by metabolizing an organic carbon source and not by metabolizing CO2. The microorganism does not use the organic carbon source for producing the first essential biomass precursor.

公开(公告)号：US20190194653A1

公开(公告)日：2019-06-27

申请号：US16330774

申请日：2017-09-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Diego JAITIN ,  David LARA-ASTIASO ,  Assaf WEINER ,  Ido YOFE

IPC: C12N15/11 ,  C12N15/10 ,  C12N9/22 ,  C12Q1/6883

CPC classification number: C12N15/11 ,  C12N9/22 ,  C12N15/102 ,  C12N15/1093 ,  C12N15/63 ,  C12N2310/20 ,  C12N2800/80 ,  C12Q1/6883

Abstract: An expression construct is disclosed which comprises: (i) a DNA sequence which encodes at least one guide RNA (gRNA) operatively linked to a transcriptional regulatory sequence so as to allow expression of the gRNA in a target cell; (ii) a barcode sequence for identification of the at least one gRNA operatively linked to a transcriptional regulatory sequence so as to allow expression of the barcode sequence in the target cell.

公开(公告)号：US10304535B2

公开(公告)日：2019-05-28

申请号：US15562422

申请日：2016-03-30

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Barak Dayan ,  Itay Shomroni ,  Serge Rosenblum

IPC: G11C13/04 ,  G02F1/01 ,  G02F1/35 ,  G02B6/35 ,  G11C7/00 ,  B82Y20/00 ,  G02B6/27

Abstract: A switch activated by a single control photon for routing a single target photon from either of two switch inputs to either of two switch outputs. The device is based on a single quantum emitter, such as an atom, coupled to a fiber-coupled, chip-based optical micro-resonator. A single reflected control photon toggles the switch from high reflection to high transmission mode, with no additional control fields required. The control and target photons are both in-fiber and practically identical, for compatibility with scalable architectures for quantum information processing.

公开(公告)号：US20190151424A1

公开(公告)日：2019-05-23

申请号：US16192241

申请日：2018-11-15

Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE

Inventor： Edward H. Schuchman ,  Erich Gulbins ,  Anthony Futerman ,  Yael Pewzner-Jung

IPC: A61K38/50 ,  A61K9/00 ,  A61K9/12 ,  A61K45/06

Abstract: The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.

公开(公告)号：US20190142875A1

公开(公告)日：2019-05-16

申请号：US16077751

申请日：2017-02-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Eran ELINAV ,  Eran SEGAL

IPC: A61K35/741 ,  A23L33/135 ,  A23L33/105 ,  A23L33/00 ,  A61K31/352 ,  C12Q1/689 ,  A61P3/04

Abstract: A method of analyzing the likelihood of weight regain in a subject who has reached a target weight by practicing a weight loss program is disclosed. The method comprises determining an amount or presence of at least one microbe and/or product thereof in the gut microbiome of the subject, wherein the amount of the at least one microbe is altered during a prior weight gain period of the subject to reach a level representative of an obese subject and further wherein the amount of the at least one microbe is retained at the level following the weight loss program, wherein the amount or presence of the at least one microbe or product thereof is predictive of weight regain.

公开(公告)号：US20190127392A1

公开(公告)日：2019-05-02

申请号：US16168863

申请日：2018-10-24

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Barak DAYAN ,  Abraham SHANZER ,  Ori Ezrah MOR MARKOVSKY

IPC: C07F5/00 ,  G06N99/00

Abstract: A quantum device for interfacing Lanthanide ions with optical fields or microwave fields or both. The device includes waveguides or resonators or both for optical fields or microwave fields or for both. The device includes at least one surface to which a single customized Lanthanide molecular complex, or an ensemble, layer, multilayer or crystal of such, are attached or bonded. This places the Lanthanide ions within the optical or microwave fields or both. The ability to customize the molecular structure around each Lanthanide ion, and to control their orientation and position and nano-environment in general, enables minimizing the host lattice effects and non-radiative loss channels for each ion, and increasing their homogeneity. Accordingly, the advantages of the present invention include reduced inhomogeneities, narrower linewidths, extended fluorescence and coherence times, and higher operation temperatures. Devices which benefit from the present invention include lasers, amplifiers, sensors, quantum memories, repeaters and quantum information processing devices at optical fields, microwave fields, or both, including bi-directional optical-microwave convertors.

公开(公告)号：US20190119696A1

公开(公告)日：2019-04-25

申请号：US15753024

申请日：2016-08-16

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Avihai DANON ,  Erez ELIYAHU ,  Vivekanand TIWARI

IPC: C12N15/82 ,  C07K14/415

Abstract: The present invention provides compositions for attenuating the function of atypical CYS HIS rich thioredoxin 4 (ACHT4), a light-regulated protein expressed in plants and algae that controls starch storage in chloroplast, and methods for increasing plant and algae growth and yield.

公开(公告)号：US20190091300A1

公开(公告)日：2019-03-28

申请号：US16197435

申请日：2018-11-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Vivian I. TEICHBERG ,  Angela RUBAN

IPC: A61K38/45 ,  A61K31/194 ,  A61K31/495 ,  A61K38/44 ,  A61K38/51 ,  A61K38/53 ,  A61K31/198 ,  A61K31/19 ,  A61K38/52

Abstract: A method of treating a cancer of the central nervous system in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an agent which reduces blood glutamate levels and enhances brain to blood glutamate efflux to thereby treat the cancer of the central nervous system in the subject.