公开(公告)号：US09291579B2

公开(公告)日：2016-03-22

申请号：US14111772

申请日：2012-04-16

Applicant: Bin Hu ,  Christopher John Lawrence

Inventor： Bin Hu ,  Christopher John Lawrence

IPC: G01N23/04 ,  G01N23/12

CPC classification number: G01N23/046 ,  G01N23/12 ,  G01N2223/419 ,  G01N2223/601 ,  G01N2223/635

Abstract: A method of estimating chordal holdup values of gas, oil, and water (εG, εO, εW) for tomographic imaging of a three-phase flow through a volume, including: providing an X-ray source for irradiating through said volume and X-ray sensors for discriminating between a first and a second radiation bands, conducting first calibration measurements (IGS, IOS, IWS) of said first radiation band, conducting second calibration measurements (IGH, IOH, IWH) of said second radiation band, arranging a mixture of two or more fluids, irradiating said volume and conducting X-ray measurements (IS, IH) in said radiation bands, establishing a relationship between a function of holdup values f(εG, εW) of at least gas and water and said X-ray measurements (IS, IH), searching holdup values (εG, εW) that minimize said function of holdup values f(εG, εW) under the constraints of the sum of said holdup values is more than or equal to zero and less than or equal to one, i.e. that 0≦εG+εW≦1.

Abstract translation: 一种估计气体，油和水（＆Egr; G，＆egr; O，＆egr; W）的弦状滞留值用于通过体积的三相流的断层成像的方法，包括：提供用于照射的X射线源 通过所述体积和X射线传感器来区分第一和第二辐射带，进行所述第一辐射带的第一校准测量（IGS，IOS，IWS），进行所述第二辐射带的第二校准测量（IGH，IOH，IWH） 辐射带，布置两种或更多种流体的混合物，照射所述体积并在所述辐射带中进行X射线测量（IS，IH），建立保持值f（＆egr; G，＆egr; W）的函数之间的关系， 至少气体和水以及所述X射线测量（IS，IH），搜索在约束条件下使滞留值f（＆egr; G，＆egr; W）的所述功能最小化的保持值（＆egr; G，＆egr; W） 所述保持值的总和大于或等于零且小于或等于1，即tha t 0＆nlE;＆egr; G +＆egr; W＆nlE; 1。

公开(公告)号：US09122169B2

公开(公告)日：2015-09-01

申请号：US13977638

申请日：2011-12-29

Applicant: Bin Hu ,  Vivek K. Singh ,  Sungwon Kim ,  Chulwoo Oh ,  Mehmet E. Yavuz

Inventor： Bin Hu ,  Vivek K. Singh ,  Sungwon Kim ,  Chulwoo Oh ,  Mehmet E. Yavuz

IPC: G06F17/50 ,  G03F1/68 ,  G03F1/26 ,  G03F1/70

CPC classification number: G03F1/68 ,  G03F1/26 ,  G03F1/70

Abstract: Improved mask layout patterns are described for closely spaced primitives in phase shift photolithography masks. In one example, at least a portion of a photolithography mask layout is decomposed into primitives. Jogs are identified from among the primitives, the jogs being characterized by three adjacent corners. E-fields are determined for the identified jogs and are applied to synthesize an electric field at a substrate. The mask layout is corrected using the synthesized electric field and a printed wafer pattern is calculated.

Abstract translation: 在相移光刻掩模中描述了用于紧密间隔的基元的改进的掩模布局图案。 在一个示例中，光刻掩模布局的至少一部分被分解为基元。 从原始图像中识别出慢跑，其特征在于三个相邻角落。 为识别的点动确定电场，并且被应用于在衬底处合成电场。 使用合成电场校正掩模布局，并计算印刷晶片图案。

公开(公告)号：US20150057322A1

公开(公告)日：2015-02-26

申请号：US14311788

申请日：2014-06-23

Applicant: Li Feng ,  Sven Erik Godtfredsen ,  Paul Allen Sutton ,  Mahavir Prashad ,  Michael J. Girgis ,  Bin Hu ,  Yugang Liu ,  Thomas J. Blacklock ,  Piotr Henryk Karpinski

Inventor： Li Feng ,  Sven Erik Godtfredsen ,  Paul Allen Sutton ,  Mahavir Prashad ,  Michael J. Girgis ,  Bin Hu ,  Yugang Liu ,  Thomas J. Blacklock ,  Piotr Henryk Karpinski

IPC: C07D207/50

CPC classification number: A61K31/216 ,  A61K31/41 ,  A61K31/4422 ,  A61K31/5415 ,  A61K45/06 ,  A61K2300/00 ,  C07C233/47 ,  C07D207/50 ,  C07D257/04

Abstract: A method for treatment of a cardiovascular or renal condition or disease with a specific combination, linked pro-drug or a compound of an angiotensin receptor antagonist and a NEPi.

Abstract translation: 用于特异性组合，连接的前药或血管紧张素受体拮抗剂和NEPi的化合物治疗心血管或肾脏疾病或疾病的方法。

公开(公告)号：US08877938B2

公开(公告)日：2014-11-04

申请号：US11722360

申请日：2006-11-08

Applicant: Lili Feng ,  Sven Erik Godtfredsen ,  Bin Hu ,  Yugang Liu ,  Piotr Karpinski ,  Paul Allen Sutton ,  Mahavir Prashad ,  Michael J. Girgis ,  Thomas J. Blacklock

Inventor： Lili Feng ,  Sven Erik Godtfredsen ,  Bin Hu ,  Yugang Liu ,  Piotr Karpinski ,  Paul Allen Sutton ,  Mahavir Prashad ,  Michael J. Girgis ,  Thomas J. Blacklock

IPC: C07D257/04 ,  C07C233/47 ,  A61K31/41 ,  A61K31/4422 ,  A61K31/5415

CPC classification number: A61K31/216 ,  A61K31/41 ,  A61K31/4422 ,  A61K31/5415 ,  A61K45/06 ,  A61K2300/00 ,  C07C233/47 ,  C07D207/50 ,  C07D257/04

Abstract: A compound of an angiotensin receptor antagonist (ARB), a neutral endopeptidase inhibitor (NEPi) and one or more monovalent cations are useful for the treatment of hypertension and/or heart failure. ARB includes S—N-valeryl-N-{[2′-(1H-tetrazole-5-yl)-biphenyl-4-yl]-methyl}-valine in the anion form, NEPi includes (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester in the anion form and cation includes monovalent cations such as Na+. The compound includes trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3′-methyl-2′-(pentanoyl{2″-(tetrazol-5-ylate)biphenyl-4′-ylmethyl}amino)butyrate] hemipentahydrate.

Abstract translation: 血管紧张素受体拮抗剂（ARB），中性内肽酶抑制剂（NEPi）和一种或多种一价阳离子的化合物可用于治疗高血压和/或心力衰竭。 ARB包括阴离子形式的S-N-戊酰基-N - {[2' - （1H-四唑-5-基） - 联苯-4-基] - 甲基} - 缬氨酸，NEPi包括（2R，4S）-5 - 联苯-4-基-4-（3-羧基 - 丙酰基氨基）-2-甲基 - 戊酸乙酯，包括一价阳离子如Na +。 该化合物包括[3 - （（1S，3R）-1-联苯-4-基甲基-3-乙氧基羰基-1-丁基氨基甲酰基）丙酸乙酯 - （S）-3'-甲基-2' - （戊酰基{2“ （四唑-5-基）联苯-4-基甲基}氨基）丁酸乙酯]半水合物。

公开(公告)号：US08868658B2

公开(公告)日：2014-10-21

申请号：US13459002

申请日：2012-04-27

Applicant: Yanghua Liu ,  Bin Hu ,  Erzhen Liang

Inventor： Yanghua Liu ,  Bin Hu ,  Erzhen Liang

IPC: G06F15/16

CPC classification number: H04N21/6405 ,  H04L12/1854

Abstract: A method, a system and computer readable storage media facilitate receiving a data stream from a host media server that is outside of a network, designating a multicasting source within the network to receive the data stream from the host media server, and multicasting the data stream from the multicasting source to a plurality of client devices within the network.

Abstract translation: 方法，系统和计算机可读存储介质便于从网络外部的主机媒体服务器接收数据流，指定网络内的多播源以从主机媒体服务器接收数据流，并且多播数据流 从组播源到网络内的多个客户端设备。

公开(公告)号：US08224850B2

公开(公告)日：2012-07-17

申请号：US12191055

申请日：2008-08-13

Applicant: Sean Kelley ,  Bin Hu

Inventor： Sean Kelley ,  Bin Hu

IPC: G06F7/00

CPC classification number: H04L67/24 ,  H04L67/18 ,  H04L67/306 ,  H04W4/02

Abstract: A method and system are disclosed allowing for determining those users of multiple users who satisfy desired condition(s), where characteristics of the users in at least some embodiments vary dynamically. In at least one embodiment, the method includes receiving at a server device a request for a determination regarding which of a plurality of users satisfies a plurality of conditions respectively relating to a plurality of user characteristics, and obtaining at the server device a conditions specification. Additionally, the method includes accessing at least one repository in which is stored information regarding the users to obtain at least some of the information, the information concerning the user characteristics. The method also includes making a determination regarding which of the users satisfies the plurality of conditions, obtaining at the first server device updated information from the at least one repository, re-evaluating the determination, and sending output information regarding the re-evaluated determination.

Abstract translation: 公开了一种方法和系统，其允许确定满足期望条件的多个用户的那些用户，其中至少一些实施例中的用户的特征动态变化。 在至少一个实施例中，该方法包括在服务器设备处接收关于多个用户中的哪一个满足多个用户特征的多个条件的确定请求，以及在服务器设备处获取条件规范。 此外，该方法包括访问至少一个存储库，其中存储关于用户的信息以获得关于用户特征的信息中的至少一些信息。 该方法还包括确定哪个用户满足多个条件，从第一服务器设备获取来自至少一个存储库的更新信息，重新评估该确定，以及发送关于重新评估的确定的输出信息。

公开(公告)号：US08211193B2

公开(公告)日：2012-07-03

申请号：US11526132

申请日：2006-09-22

Applicant: Deepak Mahulikar ,  Yuhu Wang ,  Ken A. Delbridge ,  Gert R. M. Moyaerts ,  Saeed H. Mohseni ,  Nichole R. Koontz ,  Bin Hu ,  Liqing Wen

Inventor： Deepak Mahulikar ,  Yuhu Wang ,  Ken A. Delbridge ,  Gert R. M. Moyaerts ,  Saeed H. Mohseni ,  Nichole R. Koontz ,  Bin Hu ,  Liqing Wen

IPC: B24D3/02 ,  C09C1/68 ,  C09K3/14 ,  C09K13/00 ,  C09K13/02 ,  B24B1/00 ,  C01B33/12 ,  C03C15/00 ,  C03C25/68

CPC classification number: C23F3/04 ,  C01B33/1435 ,  C01B33/1485 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/80 ,  C09G1/02 ,  C09K3/1463 ,  C09K3/1472 ,  H01L21/31053 ,  H01L21/3212

Abstract: A method of chemical mechanical polishing a surface of a substrate including the step of: contacting the substrate and a composition including a plurality of colloidal silica particles having less than 200 ppb of each trace metal impurity, excluding potassium and sodium, have less than 2 ppm residual alcohol and wherein the cumulative concentration of the trace metal, excluding potassium and sodium, is in the range from about 0.5 to about 5 ppm; and a medium for suspending the particles; wherein the composition is an ultrapure colloidal silica dispersion; and wherein the contacting is carried out at a temperature and for a period of time sufficient to planarize the substrate.

Abstract translation: 一种对基材表面进行化学机械抛光的方法，包括以下步骤：使除了钾和钠之外的每种微量金属杂质含有少于200ppb的多种胶体二氧化硅颗粒的组合物接触，其含量小于2ppm 残余醇，其中不包括钾和钠的痕量金属的累积浓度在约0.5至约5ppm的范围内; 和用于悬浮颗粒的介质; 其中所述组合物是超纯胶体二氧化硅分散体; 并且其中所述接触在足以平坦化基底的温度和时间段内进行。

公开(公告)号：US08192644B2

公开(公告)日：2012-06-05

申请号：US12580868

申请日：2009-10-16

Applicant: Hyungjun Kim ,  Richard Wen ,  Bin Hu ,  Minae Tanaka ,  Deepak Mahulikar

Inventor： Hyungjun Kim ,  Richard Wen ,  Bin Hu ,  Minae Tanaka ,  Deepak Mahulikar

IPC: C09K13/00

CPC classification number: H01L21/30625 ,  C09G1/02 ,  H01L21/3212 ,  H01L21/7684

Abstract: The present disclosure provides a concentrate for use in chemical mechanical polishing slurries, and a method of diluting that concentrate to a point of use slurry. The concentrate comprises abrasive, complexing agent, and corrosion inhibitor, and the concentrate is diluted with water and oxidizer. These components are present in amounts such that the concentrate can be diluted at very high dilution ratios, without affecting the polishing performance.

Abstract translation: 本公开提供了用于化学机械抛光浆料的浓缩物，以及将该浓缩物稀释到使用点浆料的方法。 浓缩物包括研磨剂，络合剂和缓蚀剂，浓缩物用水和氧化剂稀释。 这些组分的存在量使得浓缩物可以以非常高的稀释比稀释，而不影响抛光性能。

公开(公告)号：US20120083483A1

公开(公告)日：2012-04-05

申请号：US13260684

申请日：2010-03-25

Applicant: Craig A. Coburn ,  John A. McCauley ,  Steven W. Ludmerer ,  Kun Liu ,  Joseph P. Vacca ,  Hao Wu ,  Bin Hu ,  Richard Soll ,  Fei Sun ,  Xinghai Wang ,  Man Yan ,  Chengren Zhang ,  Mingwei Zheng ,  Bin Zhong ,  Jian Zhu

Inventor： Craig A. Coburn ,  John A. McCauley ,  Steven W. Ludmerer ,  Kun Liu ,  Joseph P. Vacca ,  Hao Wu ,  Bin Hu ,  Richard Soll ,  Fei Sun ,  Xinghai Wang ,  Man Yan ,  Chengren Zhang ,  Mingwei Zheng ,  Bin Zhong ,  Jian Zhu

IPC: A61K31/553

CPC classification number: C07D498/04 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/5365 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/553 ,  A61K38/05 ,  A61K38/06 ,  A61K45/06 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/10 ,  C07K5/06 ,  C07K5/08

Abstract: The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Abstract translation: 本发明涉及可用作丙型肝炎病毒（HCV）NS5A抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5A活性用于治疗或预防HCV感染的用途的式（I）化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。

公开(公告)号：US20120077810A1

公开(公告)日：2012-03-29

申请号：US13262096

申请日：2010-03-29

Applicant: Qi Chen ,  Mingxiang Cui ,  Bin Hu ,  Shuangxi Hu ,  Zhifa Pu ,  Philip E. Sanderson ,  Richard Soll ,  Xue Tang ,  Jiabing Wang ,  Yongjin Yan ,  Jinfeng Yao ,  Hongjie Zhang

Inventor： Qi Chen ,  Mingxiang Cui ,  Bin Hu ,  Shuangxi Hu ,  Zhifa Pu ,  Philip E. Sanderson ,  Richard Soll ,  Xue Tang ,  Jiabing Wang ,  Yongjin Yan ,  Jinfeng Yao ,  Hongjie Zhang

IPC: A61K31/5377 ,  A61K31/519 ,  A61P35/00 ,  C07D487/04

CPC classification number: A61K31/44 ,  C07D487/04

Abstract: The instant invention provides for substituted fused pyrimidine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

Abstract translation: 本发明提供抑制Akt活性的取代的稠合嘧啶化合物。 特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。