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    ELECTROCHEMICAL ACTUATOR
    72.
    发明申请
    ELECTROCHEMICAL ACTUATOR 有权
    电化学执行器

    公开(公告)号：US20090014320A1

    公开(公告)日：2009-01-15

    申请号：US12035406

    申请日：2008-02-21

    申请人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

    发明人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

    IPC分类号： F03G7/00

    CPC分类号： F03G7/005 ,  H01M10/052

    摘要： The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example.

    摘要翻译： 本发明提供涉及电化学致动的系统，装置和相关方法。 在一些情况下，将电压或电流施加到本发明的系统或装置可能产生容积或尺寸变化，这可能产生机械作业。 例如，系统的至少一部分可以被构造和布置成从第一取向向第二取向移位。 诸如这些的系统可用于各种应用，例如泵（例如输注泵）和药物输送装置。

    Manipulating micron scale items
    74.
    发明授权
    Manipulating micron scale items 失效
    操作微米级物品

    公开(公告)号：US07338636B2

    公开(公告)日：2008-03-04

    申请号：US10770347

    申请日：2004-02-02

    申请人： Malinda M. Tupper ,  Michael J. Cima ,  Marjorie E. Chopinaud

    发明人： Malinda M. Tupper ,  Michael J. Cima ,  Marjorie E. Chopinaud

    IPC分类号： B01L3/02 ,  G01N1/00

    CPC分类号： G01N35/10 ,  B01D17/04 ,  B01D17/06 ,  B01D21/0009 ,  B01J2219/00274 ,  B01J2219/00315 ,  B01J2219/00387 ,  B01J2219/00596 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00756 ,  B01L3/5085 ,  B03C5/026 ,  B03C5/028 ,  C40B30/08 ,  C40B40/10 ,  C40B40/14 ,  C40B40/18 ,  C40B60/14 ,  G01N2035/00188 ,  G01N2035/00237 ,  Y10T436/25 ,  Y10T436/25375

    摘要： Micron scale dielectric items are manipulated by methods and apparatus taking advantage of spatially non-uniform field. Such fields give rise to a force on dielectric items, directing them generally toward regions of more concentrated field. The electrode may be elongated, either unitary, with a generally planar counter electrode, or dual, such as parallel pins, loops or plates. If dual, particles are generally attracted to regions of high field concentration, including tips, edges and spaces between electrode conductors. Items can be granular, threadlike, or sheets, and microelectronic parts and other shapes. Items can also be collected directly into a recess of a pharmaceutical material delivery microchip, with a conductive membrane of the microchip acting as a manipulating electrode. Items are attracted without regard to their surface charge, or the polarity of the field, which can be AC or DC. Charging, or knowing the charge of items to be manipulated is not necessary. The amount of material collected can be precisely controlled by varying parameters of collection, such as distance between the electrode and the items, distance between dual conductors, size (diameter, length) of the conductors, any dielectric sheathing thereof, and voltage. Elongated electrodes can be used to manipulate items into and from recesses, such as wells of microtitre trays, microchips, and semiconductor chips.

    摘要翻译： 通过利用空间不均匀场的方法和装置来操纵微米级介电材料。 这样的场引起介电物质的力，将其引导到更集中的场的区域。 电极可以是单一的，具有大致平面的对电极或双重的，例如平行的针，环或板。 如果是双重的，颗粒通常被吸引到高场浓度的区域，包括电极导体之间​​的尖端，边缘和间隔。 物品可以是颗粒状，线状或片状，以及微电子部件等形状。 物品也可以直接收集在药物输送微芯片的凹部中，微芯片的导电膜用作操纵电极。 物品被吸引，不考虑它们的表面电荷或场的极性，其可以是AC或DC。 不需要充电或知道要操作的物品的费用。 收集的材料的量可以通过变化的收集参数（例如电极和物品之间的距离，双导体之间的距离，导体的尺寸（直径，长度），其任何电介质外壳和电压）进行精确控制。 细长的电极可用于将物品从凹槽中进行操作，例如微量托盘，微芯片和半导体芯片的孔。

    Microchip reservoir devices using wireless transmission of power and data
    75.
    发明授权
    Microchip reservoir devices using wireless transmission of power and data 有权
    Microchip库设备使用无线传输电源和数据

    公开(公告)号：US07226442B2

    公开(公告)日：2007-06-05

    申请号：US09975672

    申请日：2001-10-10

    申请人： Norman F. Sheppard, Jr. ,  John T. Santini, Jr. ,  Stephen J. Herman ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello

    发明人： Norman F. Sheppard, Jr. ,  John T. Santini, Jr. ,  Stephen J. Herman ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello

    IPC分类号： A61K9/22

    CPC分类号： A61B1/041 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/14539 ,  A61K9/0009 ,  A61K9/0051 ,  A61K9/0097 ,  A61M5/14 ,  A61M5/14276 ,  A61M2205/0244 ,  A61M2205/3523 ,  A61M2210/0612 ,  A61M2210/1042 ,  G06F19/00

    摘要： Devices, systems, and methods are provided for wirelessly powering and/or communicating with microchip devices used for the controlled exposure and release of reservoir contents, such as drugs, reagents, and sensors. In one embodiment, the system includes (1) a microchip device comprising a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate said release or exposure of the reservoir contents. In another embodiment, the system comprises (1) a microchip device comprising a substrate a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a telemetry system for the wireless transfer of data between the microchip device and a remote controller.

    摘要翻译： 提供了设备，系统和方法，用于与用于受控地暴露和释放储存器内容物（例如药物，试剂和传感器）的微芯片装置的无线供电和/或通信。 在一个实施例中，系统包括（1）微芯片装置，其包括具有多个储存器的基板，所述储存器包含用于释放或曝光的储存器内容物; 和（2）可充电或点播电源，其包括本地组件，其可以从远程发射器无线地接收电力，其中可以直接或继续使用所接收的功率来激活所述储存器内容物的释放或暴露。 在另一个实施例中，系统包括（1）微芯片装置，其包括基板，多个储存器包含用于释放或曝光的储存器内容物; 和（2）用于在微芯片设备和遥控器之间无线传输数据的遥测系统。

    Medical device with array of electrode-containing reservoirs
    76.
    发明授权
    Medical device with array of electrode-containing reservoirs 有权
    带有电极储存器阵列的医疗器械

    公开(公告)号：US07070592B2

    公开(公告)日：2006-07-04

    申请号：US10886405

    申请日：2004-07-07

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer

    IPC分类号： A61K9/22 ,  A61N1/30

    CPC分类号： A61K9/0097 ,  A61K9/0009 ,  A61K9/0024 ,  Y10T436/25

    摘要： Devices are provided for medical diagnostics comprising a substrate; an array of reservoirs; one or more electrodes located at least partially inside the reservoirs; a plurality of discrete reservoir caps covering openings in the plurality reservoirs; control circuitry for selectively disintegrating or permeabilizing the reservoir cap over a reservoir opening; and, optionally, a diagnostic reagent in the reservoirs. Devices also are provided for the controlled delivery of molecules comprising a substrate; an array of reservoirs; a release system in the reservoirs comprising molecules for release; one or more electrodes attached to the substrate inside the reservoirs or to a surface outside of the reservoirs, wherein the electrodes are not reservoir caps; and means for applying an electric current or potential across the electrodes effective to activate release of the molecules from the reservoirs. The devices can be adapted for implantation for in vivo diagnostics or drug delivery.

    摘要翻译： 提供用于医疗诊断的装置，包括基底; 一系列水库; 一个或多个电极至少部分地位于储存器内部; 多个分立储存器盖，覆盖多个储存器中的开口; 用于选择性地将储存器盖分解或渗透在储存器开口上的控制电路; 和任选地，在储存器中的诊断试剂。 还提供了用于受控输送包含基底的分子的装置; 一系列水库; 储存器中的释放系统包括用于释放的分子; 一个或多个电极附着到储存器内的基底或储存器外部的表面，其中电极不是储​​存器盖; 以及用于施加跨过电极的电流或电位的装置，有效地激活分子从储存器的释放。 该装置可适于植入用于体内诊断或药物递送。

    Selective substrate metallization
    79.
    发明授权
    Selective substrate metallization 失效
    选择性基板金属化

    公开(公告)号：US06194032B1

    公开(公告)日：2001-02-27

    申请号：US09165366

    申请日：1998-10-02

    申请人： Lynne M. Svedberg ,  Kenneth C. Arndt ,  Michael J. Cima

    发明人： Lynne M. Svedberg ,  Kenneth C. Arndt ,  Michael J. Cima

    IPC分类号： B05D128

    CPC分类号： C23C18/1651 ,  C23C18/161 ,  C23C18/1617 ,  C23C18/1653 ,  C23C18/34 ,  C23C18/40 ,  C23C18/44

    摘要： A process for selective electroless plating onto a substrate, including providing a substrate having at least a catalytic surface; providing a plating gel comprising a carrier vehicle, an electroless platable metal compound capable of providing metal ions to the carrier vehicle at a specific pH, a reducing agent, and a polymeric thickening agent; applying said plating gel to the substrate surface in a selected pattern, and inducing plating of said metal on the substrate surface in said selected pattern. A stabilizer, and/or buffering and/or organic chelating agent, and/or surfactant and/or a humectant may be included in the plating gel. Preferably the metal compound is a gold complex, and the substrate is aluminum nitride.

    摘要翻译： 一种用于在衬底上进行选择性化学镀的方法，包括提供至少具有催化表面的衬底; 提供包含载体载体的电镀凝胶，能够以特定pH提供载体载体的金属离子的化学镀金属化合物，还原剂和聚合物增稠剂; 以所选择的图案将所述电镀凝胶施加到所述基材表面，并且以所述选择的图案在所述基材表面上诱导所述金属的电镀。 稳定剂和/或缓冲和/或有机螯合剂，和/或表面活性剂和/或湿润剂可以包括在电镀凝胶中。 优选地，金属化合物是金络合物，并且衬底是氮化铝。