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    Method for purifying proteins
    72.
    发明申请
    Method for purifying proteins 有权
    蛋白质纯化方法

    公开(公告)号：US20060216751A1

    公开(公告)日：2006-09-28

    申请号：US11388181

    申请日：2006-03-22

    Applicant: Egisto Boschetti ,  Lee Lomas

    Inventor： Egisto Boschetti ,  Lee Lomas

    IPC: C40B40/04 ,  C40B40/08 ,  C40B40/10

    CPC classification number: C07K1/047 ,  C07K1/22

    Abstract: The present invention provides methods and kits for purifying a target protein group. The method comprises the steps of contacting a sample comprising at least 95% of the target protein group and at most 5% of contaminating proteins with a library of binding moieties having different binding moieties, binding the contaminating proteins and a minority of the target protein group to the library of binding moieties, separating the unbound target protein group from the proteins bound to the library of binding moieties and collecting the unbound target protein. The collected target protein is more pure than the target protein group in the sample.

    Abstract translation: 本发明提供了用于纯化靶蛋白质组的方法和试剂盒。 该方法包括以下步骤：将包含至少95％的目标蛋白质组和至多5％的污染蛋白质的样品与具有不同结合部分的结合部分的文库结合，结合污染蛋白质和少数靶蛋白质组 到结合部分的文库，将未结合的靶蛋白基团与结合到结合部分文库的蛋白质分离并收集未结合的靶蛋白质。 收集的目标蛋白质比样品中的目标蛋白质组更为纯净。

    Method of embolization using polyvinyl alcohol microspheres
    73.
    发明授权
    Method of embolization using polyvinyl alcohol microspheres 有权
    使用聚乙烯醇微球栓塞的方法

    公开(公告)号：US06680046B1

    公开(公告)日：2004-01-20

    申请号：US09419114

    申请日：1999-10-15

    Applicant: Egisto Boschetti

    Inventor： Egisto Boschetti

    IPC: A61K4900

    CPC classification number: A61K9/1635 ,  A61K47/6927

    Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present, invention relates to a process for producing the polyvinylalcbhol microspheres.

    Abstract translation: 本发明涉及包含聚乙烯醇的栓塞用微球。 本发明还涉及适用于栓塞的可注射悬浮液，其包含聚乙烯醇微球和合适的液体载体。 本发明还涉及一种用于预防或治疗性栓塞的方法，其包括向哺乳动物施用含有聚乙烯醇微球和适合的液体载体的可注射悬浮液。 最后，本发明涉及一种生产聚乙烯基苯乙醇微球的方法。

    Dried rehydratable film containing agarose or gelose and process for preparing same
    75.
    发明授权
    Dried rehydratable film containing agarose or gelose and process for preparing same 失效
    含有琼脂糖或果胶的干燥可再水化膜及其制备方法

    公开(公告)号：US4048377A

    公开(公告)日：1977-09-13

    申请号：US648084

    申请日：1976-01-12

    Applicant: Egisto Boschetti ,  Yvette Paule Nicole Moroux ,  Rene Tixier

    Inventor： Egisto Boschetti ,  Yvette Paule Nicole Moroux ,  Rene Tixier

    IPC: C08L5/12 ,  G01N27/447 ,  B32B27/08 ,  C08L5/00

    CPC classification number: G01N27/44747 ,  C08L5/12 ,  Y10T428/31725 ,  Y10T428/31736 ,  Y10T428/31797

    Abstract: Dried agarose or gelose-containing films which are rehydratable into aqueous gel films are disclosed. The dried films are prepared by first forming, on a support, an aqueous gel film containing at most 5% by weight of agarose or gelose and a water-soluble linear polymer or copolymer of acrylamide or methacrylamide. The viscosity of such polymer and copolymer in a 5% aqueous solution at 22.degree. C is about 17000 centipoises or less and preferably about 6000 centipoises or less. The aqueous gel film is then dried according to known techniques, with the linear polymer or copolymer of acrylamide or methacrylamide being included in the dried film.

    Abstract translation: 公开了可再水化成水性凝胶膜的干琼脂糖或含有糖的胶囊。 干燥的膜通过首先在载体上形成含有至多5重量％的琼脂糖或谷蛋白的水凝胶膜和丙烯酰胺或甲基丙烯酰胺的水溶性线性聚合物或共聚物来制备。 这种聚合物和共聚物在22℃的5％水溶液中的粘度为约17000厘泊或更低，优选约6000厘泊或更小。 然后根据已知技术干燥水性凝胶膜，其中包括丙烯酰胺或甲基丙烯酰胺的直链聚合物或共聚物。

    Fluidics device
    78.
    发明授权
    Fluidics device 有权
    流体装置

    公开(公告)号：US08491791B2

    公开(公告)日：2013-07-23

    申请号：US13552356

    申请日：2012-07-18

    Applicant: Lee O. Lomas ,  Jian Ding ,  Egisto Boschetti

    Inventor： Lee O. Lomas ,  Jian Ding ,  Egisto Boschetti

    IPC: B01D63/00 ,  B01D61/00 ,  B01D15/08 ,  G01N1/00

    CPC classification number: G01N30/461 ,  B01D15/325 ,  B01D15/362 ,  B01D15/363 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/563 ,  B01L2200/026 ,  B01L2200/028 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/087 ,  B01L2400/0487 ,  C07K1/34 ,  G01N27/44704 ,  G01N27/44795 ,  G01N30/466 ,  G01N30/468 ,  Y10T137/2224 ,  Y10T137/794 ,  Y10T137/86187 ,  Y10T436/255

    Abstract: The present invention contemplates various devices that are configured to separate a sample, which contains more than one unique species, into any desired number of sub-samples by passing the sample across a like number of separation media configured for a first separation protocol. Each of the sub-samples may be further separated by an additional separation protocol, thereby creating a plurality of mini-samples, each of which may be further separated and/or analyzed. The invention also contemplates using a simple method of using conduits to form a fluid path that passes through a plurality of separation media, each of which media is configured to isolate a particular sub-sample. After various sub-samples of the sample are isolated by the various separation media, the conduits may be removed, thereby enabling each of the isolated sub-samples to be further separated and/or analyzed independent of any other sub-sample.

    Abstract translation: 本发明考虑了通过将样品穿过配置用于第一分离方案的相似数量的分离介质，将被配置成将含有多于一种独特物种的样品分离成任何所需数量的子样品的各种装置。 每个子样品可以通过另外的分离方案进一步分离，从而产生多个微型样品，每个小样品可进一步分离和/或分析。 本发明还考虑使用简单的方法来使用导管来形成通过多个分离介质的流体路径，其中每个介质被配置为隔离特定的子样品。 在通过各种分离介质分离样品的各种亚样品之后，可以去除导管，从而使每个分离的子样品能够独立于任何其它亚样品进一步分离和/或分析。

    Fluidics device
    79.
    发明授权
    Fluidics device 有权
    流体装置

    公开(公告)号：US08246832B2

    公开(公告)日：2012-08-21

    申请号：US11915151

    申请日：2006-01-19

    Applicant: Lee O. Lomas ,  Jian Ding ,  Egisto Boschetti

    Inventor： Lee O. Lomas ,  Jian Ding ,  Egisto Boschetti

    IPC: B01D63/00

    CPC classification number: G01N30/461 ,  B01D15/325 ,  B01D15/362 ,  B01D15/363 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/563 ,  B01L2200/026 ,  B01L2200/028 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/087 ,  B01L2400/0487 ,  C07K1/34 ,  G01N27/44704 ,  G01N27/44795 ,  G01N30/466 ,  G01N30/468 ,  Y10T137/2224 ,  Y10T137/794 ,  Y10T137/86187 ,  Y10T436/255

    Abstract: The present invention contemplates various devices that are configured to separate a sample, which contains more than one unique species, into any desired number of sub-samples by passing the sample across a like number of separation media configured for a first separation protocol. Each of the sub-samples may be further separated by an additional separation protocol, thereby creating a plurality of mini-samples, each of which may be further separated and/or analyzed. The invention also contemplates using a simple method of using conduits to form a fluid path that passes through a plurality of separation media, each of which media is configured to isolate a particular sub-sample. After various sub-samples of the sample are isolated by the various separation media, the conduits may be removed, thereby enabling each of the isolated sub-samples to be further separated and/or analyzed independent of any other sub-sample.

    Abstract translation: 本发明考虑了通过将样品穿过配置用于第一分离方案的相似数量的分离介质，将被配置成将含有多于一种独特物种的样品分离成任何所需数量的子样品的各种装置。 每个子样品可以通过另外的分离方案进一步分离，从而产生多个微型样品，每个小样品可进一步分离和/或分析。 本发明还考虑使用简单的方法来使用导管来形成通过多个分离介质的流体路径，其中每个介质被配置为隔离特定的子样品。 在通过各种分离介质分离样品的各种亚样品之后，可以去除导管，从而使每个分离的子样品能够独立于任何其它亚样品进一步分离和/或分析。

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