公开(公告)号：US20110293555A1

公开(公告)日：2011-12-01

申请号：US13205053

申请日：2011-08-08

申请人： TADANORI MAYUMI ,  YASUO TSUTSUMI ,  SHINSAKU NAKAGAWA ,  TSUNETAKA OHTA

发明人： TADANORI MAYUMI ,  YASUO TSUTSUMI ,  SHINSAKU NAKAGAWA ,  TSUNETAKA OHTA

IPC分类号： A61K38/19 ,  A61P31/00 ,  C07K14/525

CPC分类号： A61K38/191 ,  C07K14/525 ,  Y02A50/411

摘要： The present invention has an object to provide a tumor necrosis factor mutant protein, particularly, a tumor necrosis factor mutant protein specific to TNF-R1 or TNF-R2; tumor necrosis factor inhibitor; or tumor necrosis factor preparation containing it as an effective ingredient, and the object is solved by providing a tumor necrosis factor mutant protein where one or more amino acid residues selected from the group consisting of 29th, 31st, 32nd, 145th, 146th and 147th, or the group consisting of 84th to 89th from the N-terminal of the amino acid sequence of SEQ ID NO:1 is/are replaced with other amino acid residue(s); a tumor necrosis factor inhibitor; and a tumor necrosis factor preparation containing it as an effective ingredient.

摘要翻译： 本发明的目的是提供肿瘤坏死因子突变蛋白，特别是TNF-R1或TNF-R2特异的肿瘤坏死因子突变体蛋白; 肿瘤坏死因子抑制剂; 或含有其作为有效成分的肿瘤坏死因子制剂，其目的是通过提供一种或多种选自第29,31,32,35,146和147位的氨基酸残基的肿瘤坏死因子突变蛋白来解决， 或由SEQ ID NO：1的氨基酸序列的N末端第84位至第89位的基团被其它氨基酸残基取代; 肿瘤坏死因子抑制剂; 和含有它作为有效成分的肿瘤坏死因子制剂。

公开(公告)号：US08008058B2

公开(公告)日：2011-08-30

申请号：US12093902

申请日：2006-11-06

申请人： Kazuhiko Maruta ,  Kozo Yamamoto ,  Tomoyuki Nishimoto ,  Hiroto Chaen ,  Tetsuya Nakada

发明人： Kazuhiko Maruta ,  Kozo Yamamoto ,  Tomoyuki Nishimoto ,  Hiroto Chaen ,  Tetsuya Nakada

IPC分类号： C12N9/90 ,  C07K14/00 ,  C12P19/24 ,  C12P21/00

CPC分类号： C12N9/90 ,  C12P19/02

摘要： An object of the present invention is to provide a novel ketose 3-epimerase, a process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, and a process for producing a ketose by using the enzyme. The present invention solves the above objects by providing a ketose 3-epimerase which is obtainable from a microorganism of the genus Rhizobium, a process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, and a process for converting D- or L-ketohexose into corresponding D- or L-ketohexose by epimerizing the hydroxyl group at the C-3 position of the D- or L-ketohexose; and D- or L-ketopentose into corresponding D- or L-ketopentose by epimerizing the hydroxyl group at the C-3 position of the D- or L-ketopentose; by using the enzyme.

摘要翻译： 本发明的目的是提供一种新的酮糖3-差向异构酶，其制备方法，编码该酶的DNA，重组DNA和包含该DNA的转化体，以及使用该酶制备酮糖酮的方法。 本发明通过提供可从根瘤菌属微生物获得的酮糖3-差向异构酶，其制备方法，编码该酶的DNA，重组DNA和包含该DNA的转化体，解决上述目的，以及方法 通过使D-或L-酮基己糖的C-3位的羟基差向异构化将D-或L-酮己糖转化为相应的D-或L-己酮; 和D-或L-酮戊糖转化成相应的D-或L-酮戊糖，通过差异化D-或L-酮戊糖的C-3位的羟基; 通过使用酶。

公开(公告)号：US20110166089A1

公开(公告)日：2011-07-07

申请号：US13047551

申请日：2011-03-14

申请人： Shigeki SUZUKI ,  Yoshikatsu MIWA ,  Nobuo SASAKI ,  Yuiichi TEI

发明人： Shigeki SUZUKI ,  Yoshikatsu MIWA ,  Nobuo SASAKI ,  Yuiichi TEI

IPC分类号： A61K31/7016 ,  A61P41/00 ,  A61K31/7048 ,  A61P39/06

CPC分类号： A61K31/7016 ,  A61L31/042

摘要： The objective of the invention is to provide a solution for tissue adhesion prevention and a method for tissue adhesion prevention that are applicable to general surgery and in which covering condition during surgery is stable and convenient. The invention is the solution for tissue adhesion prevention of which the active ingredient is trehalose. Also, it contains at least one or more among antioxidants, chelates, antiseptics, hemostatics, anti-inflammatory agents, and polysaccharides, mucopolysaccharides, salts of polysaccharides and salts of mucopolysaccharides having lubricating properties. This solution for tissue adhesion prevention is provided as any form of perfusion fluid, spray fluid, solution for spray or vaporization administration, foam-like aerosol preparation, injection solution for intravenous fluids, intravenous fluid.

摘要翻译： 本发明的目的是提供一种适用于一般手术的组织粘连防止方法和组织粘连防止方法，其中手术中的覆盖状态是稳定和方便的。 本发明是用于组织粘附预防的方法，其中活性成分是海藻糖。 此外，它还含有至少一种或多种抗氧化剂，螯合物，防腐剂，止血剂，抗炎剂和多糖，粘多糖，多糖的盐和具有润滑性质的粘多糖的盐中的至少一种或多种。 用于组织粘附防止的这种解决方案提供为任何形式的灌注液，喷雾液，用于喷雾或蒸发给药的溶液，泡沫状气溶胶制剂，静脉注射液注射液，静脉注射液。

公开(公告)号：US07973021B2

公开(公告)日：2011-07-05

申请号：US12067577

申请日：2006-09-15

申请人： Keiko Hino ,  Mayumi Kurose ,  Takeo Sakurai ,  Shinichiro Inoue ,  Tohru Ogawa ,  Kazuyuki Oku ,  Hiroto Chaen ,  Shigeharu Fukuda

发明人： Keiko Hino ,  Mayumi Kurose ,  Takeo Sakurai ,  Shinichiro Inoue ,  Tohru Ogawa ,  Kazuyuki Oku ,  Hiroto Chaen ,  Shigeharu Fukuda

IPC分类号： A01N43/04 ,  A61K31/715

CPC分类号： A61K31/702 ,  A23L33/10 ,  A23V2002/00 ,  Y02A50/411 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/471 ,  Y02A50/475 ,  Y02A50/483 ,  A23V2200/324 ,  A23V2250/60

摘要： An object of the present invention is to provide an immunomodulating agent in gut that can be ingested continuously in daily diet without adverse side effect. The object is attained by providing an immunomodulating agent in gut comprising a cyclic tetrasaccharide as an effective ingredient.

摘要翻译： 本发明的目的在于提供一种可以在日常饮食中连续摄取而不会产生副作用的肠道免疫调节剂。 该目的是通过在肠中提供包含环状四糖作为有效成分的免疫调节剂来实现的。

公开(公告)号：US07951530B2

公开(公告)日：2011-05-31

申请号：US11941862

申请日：2007-11-16

申请人： Kazuhisa Mukai ,  Hikaru Watanabe ,  Tomoyuki Nishimoto ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

发明人： Kazuhisa Mukai ,  Hikaru Watanabe ,  Tomoyuki Nishimoto ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

IPC分类号： G01N33/573 ,  C12Q1/48 ,  C12P1/00 ,  C13K7/00 ,  C07H1/00

CPC分类号： A61K9/2018 ,  A21D2/181 ,  A23L2/52 ,  A23L2/60 ,  A23L13/428 ,  A23L27/33 ,  A23L33/10 ,  A61K8/60 ,  A61Q11/00 ,  C07H3/06 ,  C12N9/1048 ,  C12P19/18

摘要： An object of the present invention is to provide an option of non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents and to provide a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof. The present invention solves the above object by providing a novel cyclic saccharide having a structure of cyclo{>6)-α-D-glucopyranosyl-(1>4)-α-D-glucopyranosyl-(1>6)-α-D-glucopyranosyl-(1>4)-α-D-glucopyranosyl-(1>}, cyclic maltosylmaltose, novel cyclic maltosylmaltose-forming enzyme, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the cyclic maltosylmaltose or a saccharide composition comprising the same, and uses thereof.

摘要翻译： 本发明的目的是通过提供一种由葡萄糖组成的新型非还原性糖组成并提供形成非还原性糖的新型酶，提供一种非还原性糖的方法及其制备方法 ，编码该酶的DNA，重组DNA和包含该DNA的转化体，包含非还原性糖的组合物及其用途。 本发明通过提供具有环{（6）-α-D-吡喃葡萄糖基 - （1,4）-α-D-吡喃葡萄糖基 - （1,6）-α-D结构的新型环状糖来解决上述目的 - 吡喃葡萄糖基 - （1> 4）-α-D-吡喃葡萄糖基 - （1>），环状麦芽糖基麦芽糖，新型环状麦芽糖基麦芽糖酶形成酶，其制备方法和方法，编码该酶的DNA，重组DNA和转化体 包含该DNA，包含环状麦芽糖麦芽糖的组合物或包含其的糖组合物及其用途。

公开(公告)号：US20110091726A1

公开(公告)日：2011-04-21

申请号：US12875786

申请日：2010-09-03

申请人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

IPC分类号： B32B5/00 ,  C07H19/01 ,  C12P19/60

CPC分类号： C12P19/60 ,  A23L33/10 ,  A23L33/15 ,  A61K8/0241 ,  A61K8/676 ,  A61K8/732 ,  A61K31/7048 ,  A61K2800/57 ,  A61K2800/654 ,  A61Q19/02 ,  C07H17/04 ,  Y10T428/2982

摘要： The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid, when calculated based on a profile of powder X-ray diffraction analysis of the particulate composition, and a dynamic vapor sorption level of 0.01% by weight or lower, when kept at 25° C. under a relative humidity of 35% by weight for 12 hours after removal water in the particulate composition under nitrogen gas stream; and by providing a process for producing the same and uses thereof.

摘要翻译： 本发明的目的在于提供一种含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其与用于准药物的级别相比，具有显着难以固化的性能; 其制造方法; 及其用途。 本发明通过提供含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物来解决上述目的，其含量超过98.0重量％但小于99.9重量％，基于干固体 ; 或无水结晶2-O-α-D-葡糖基-L-抗坏血酸的结晶度为90％以上时，基于颗粒组合物的粉末X射线衍射分析曲线和动态蒸气 当在氮气流下除去颗粒组合物中的水后，在25℃相对湿度35重量％下保持12小时，吸附水平为0.01重量％以下; 并提供其制造方法及其用途。

公开(公告)号：US07799765B2

公开(公告)日：2010-09-21

申请号：US10486328

申请日：2002-08-08

申请人： Kazuyuki Oku ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

发明人： Kazuyuki Oku ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

IPC分类号： A61K31/715

CPC分类号： A61K8/345 ,  A23C11/103 ,  A23C20/025 ,  A23K20/163 ,  A23K20/24 ,  A23K20/30 ,  A23L2/52 ,  A23L5/00 ,  A23L5/19 ,  A23L5/27 ,  A23L11/09 ,  A23L11/34 ,  A23L23/00 ,  A23L27/40 ,  A23L27/50 ,  A23L27/86 ,  A23L29/274 ,  A23L29/30 ,  A23L29/37 ,  A23L33/16 ,  A23P20/20 ,  A23V2002/00 ,  A61K8/19 ,  A61K8/60 ,  A61K31/7012 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/10 ,  C07H3/04 ,  C07H15/04 ,  C07H23/00 ,  A23V2250/636 ,  A23V2250/6416 ,  A23V2250/1578 ,  A23V2250/7056 ,  A23V2250/708 ,  A23V2250/161 ,  A23V2250/1612

摘要： The object of the present invention is to provide a composition of metal ion compound whose inherent and unsatisfactory properties for its industrial application such as deliquescence, reducing power, oxidizing power, low solubility in water, etc., are improved; and their preparation and uses. The present invention solves the above object by providing an associate of trehalose or maltitol and a metal ion compound or bittern component, and their preparation and uses.

摘要翻译： 本发明的目的是提供一种金属离子化合物的组合物，它的工业应用的固有和不令人满意的性质如潮解，还原能力，氧化能力，在水中的低溶解度等都得到改善; 及其准备和使用。 本发明通过提供海藻糖或麦芽糖醇和金属离子化合物或卤水组分的缔合物及其制备和用途来解决上述目的。

公开(公告)号：US07718404B2

公开(公告)日：2010-05-18

申请号：US11797932

申请日：2007-05-09

申请人： Michio Kubota ,  Keiji Tsusaki ,  Takanobu Higashiyama ,  Shigeharu Fukuda ,  Toshio Miyake

发明人： Michio Kubota ,  Keiji Tsusaki ,  Takanobu Higashiyama ,  Shigeharu Fukuda ,  Toshio Miyake

IPC分类号： C12P19/18 ,  C12P19/04 ,  C12N9/10 ,  C12N1/00 ,  C12N1/20 ,  C07H21/04 ,  C07H1/00

CPC分类号： A23G1/40 ,  A21D2/181 ,  A23C9/005 ,  A23C9/1307 ,  A23C9/1544 ,  A23C9/156 ,  A23G3/42 ,  A23G4/10 ,  A23G9/34 ,  A23L2/60 ,  A23L15/00 ,  A23L15/20 ,  A23L27/30 ,  A23L33/10 ,  A23L33/21 ,  A61K8/60 ,  A61K8/66 ,  A61K9/0014 ,  A61K47/26 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/10 ,  C07H3/04 ,  C07H3/06 ,  C12N9/1051 ,  C12N9/2425 ,  C12N9/2428 ,  C12P19/04 ,  C12Y302/01001 ,  C12Y302/01002 ,  C12Y302/01003 ,  C12Y302/0102

摘要： The object of the present invention is to provide an α-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an α-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the α-1,6 glucosidic linkage as a linkage at the non-reducing end and the α-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the α-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the α-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; α-isomaltosyl-transferring method using the enzyme; method for forming α-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{66)-α-D-glucopyranosyl-(163)-α-D-glucopyranosyl-(166)-α-D-glucopyranosyl-(163)-α-D-glucopyranosyl-(16} using both the α-isomaltosylglucosaccharide-forming enzyme and the α-isomaltosyl-transferring enzyme; and the uses of the saccharides obtainable therewith.

摘要翻译： 本发明的目的是提供一种α-异麦芽糖基葡萄糖形成酶，其工艺，环四糖和包含可通过使用酶获得的糖的糖组合物; 通过建立形成糖类的α-异麦芽糖基葡萄糖形成酶，其葡萄糖聚合度为至少3，并且在非还原末端具有作为键的α-1,6糖苷键和α- 通过催化葡萄糖聚合度至少为2的糖并且具有α-1,4糖苷键作为连接的α-葡糖基转移而在非还原性末端的连接以外的1,4-葡糖苷键 所述非还原端基本上不增加所述还原能力; 使用该酶的α-异麦角硫基转移法; 形成α-异麦芽糖基糖的方法; 制备具有环{66）-α-D-吡喃葡萄糖基 - （163）-α-D-吡喃葡萄糖基 - （166）-α-D-吡喃葡萄糖基 - （163）-α-D-吡喃葡萄糖基 - （163）-α-D-吡喃葡萄糖基 - （16）同时使用α-异麦芽糖基葡萄糖形成酶和α-异麦芽糖基转移酶;以及可得到的糖的用途。

公开(公告)号：US20100105885A1

公开(公告)日：2010-04-29

申请号：US12515605

申请日：2007-11-20

申请人： Ken Izumori ,  Masaaki Tokuda ,  George Fleet ,  Yoshio Tsujisaka ,  Kei Takeshita ,  Keiji Tsusaki ,  Kazuhiro Okuma

发明人： Ken Izumori ,  Masaaki Tokuda ,  George Fleet ,  Yoshio Tsujisaka ,  Kei Takeshita ,  Keiji Tsusaki ,  Kazuhiro Okuma

IPC分类号： C07H3/02 ,  C12N9/90 ,  C12P19/24

CPC分类号： C07H3/02 ,  C12N9/92 ,  C12P19/24

摘要： Providing 1- or 6-deoxy products corresponding to all of aldohexoses, ketohexoses and sugar alcohols, as based on Deoxy-Izumoring, as well as a method for systematically producing those products. A method for producing deoxyketohexose and a derivative thereof using a deoxyketohexose isomerase derived from Pseudomonas cichorii ST-24 (FERM BP-2736), comprising epimerizing 1-deoxy D-ketohexose or 6-deoxy D-ketohexose or 1-deoxy L-ketohexose or 6-deoxy L-ketohexose at position 3 to produce the individually corresponding 1-deoxy D-ketohexose or 6-deoxy D-ketohexose or 1-deoxy L-ketohexose or 6-deoxy L-ketohexose as an intended product.

摘要翻译： 提供对应于所有醛脱水己酮糖，酮己立糖和糖醇的1-脱氧产物或6-脱氧产物，以脱氧消肿为基础，以及一种系统地生产这些产品的方法。 使用衍生自奇异假单胞菌ST-24（FERM BP-2736）的脱氧己糖异构酶生产脱氧己糖及其衍生物的方法，其包括将1-脱氧D-酮己糖或6-脱氧D-酮己糖或1-脱氧L-酮己糖或 6-脱氧L-酮基己糖，以产生单独相应的1-脱氧D-酮己糖或6-脱氧D-酮己糖或1-脱氧L-酮己糖或6-脱氧L-酮己糖作为目标产物。

公开(公告)号：US07575900B2

公开(公告)日：2009-08-18

申请号：US11564493

申请日：2006-11-29

申请人： Takuo Yamamoto ,  Kazuhiko Maruta ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

发明人： Takuo Yamamoto ,  Kazuhiko Maruta ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

IPC分类号： C12P19/00 ,  C12N9/00 ,  C12N9/10 ,  C12N1/00 ,  C07K14/00 ,  C07H21/04

CPC分类号： C12P19/04 ,  C12N9/2402 ,  C12N9/90 ,  C12P19/14 ,  C12P19/18 ,  C12Y302/01001 ,  C12Y302/01002 ,  C12Y302/01003 ,  C12Y302/0102

摘要： A non-reducing saccharide-forming enzyme and a trehalose-releasing enzyme, which have an optimum temperature in a medium temperature range, i.e., a temperature of over 40 or 45° C. but below 60° C.; and an optimum pH in an acid pH range, i.e., a pH of less than 7. The two-types of enzymes can be obtained in a desired amount, for example, by culturing in a nutrient culture medium microorganisms capable of producing the enzymes or by recombinant DNA technology.