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公开(公告)号：US10076567B2
公开(公告)日：2018-09-18
申请号：US15024600
申请日：2014-09-29
发明人： Barton F. Haynes , Bette T. Korber , S. Munir Alam
IPC分类号： A61K39/21 , A61K38/16 , A61K38/21 , A61K9/127 , A61K9/00 , A61K39/12 , A61K47/48 , C07K14/005 , A61K39/39 , C12N7/00 , A61K39/00
CPC分类号： A61K39/21 , A61K9/0019 , A61K9/127 , A61K38/162 , A61K38/212 , A61K39/12 , A61K39/39 , A61K47/6911 , A61K2039/545 , A61K2039/55555 , A61K2039/55572 , A61K2039/575 , C07K14/005 , C12N7/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , A61K2300/00
摘要： The present invention relates to peptides and compositions suitable for use in inducing anti-HIV-1 antibodies. The compositions comprise HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such compositions.
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公开(公告)号：US10052373B2
公开(公告)日：2018-08-21
申请号：US15022708
申请日：2014-09-18
发明人： Dominea Rathwell , Sharavathi Guddehalli Parameswarappa , Subramanian Govindan , Chakkumkal Anish , Claney Lebev Pereira , Peter H. Seeberger , Felix Bröcker
CPC分类号： A61K39/092 , A61K47/54 , A61K47/543 , A61K47/545 , A61K47/549 , A61K47/55 , A61K47/61 , A61K2039/55555 , A61K2039/575 , A61K2039/6012 , A61K2039/6087
摘要： The present invention provides a protein- and peptide-free conjugate comprising a synthetic carbohydrate and a carrier molecule, wherein the synthetic carbohydrate is a Streptococcus pneumoniae type 3 capsular polysaccharide related carbohydrate and the carrier molecule is a glycosphingolipid. Said conjugate and pharmaceutical composition thereof are useful for immunization against diseases associated with Streptococcus pneumoniae, and more specifically against diseases associated with Streptococcus pneumoniae type 3.
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公开(公告)号：US10047116B2
公开(公告)日：2018-08-14
申请号：US14349142
申请日：2012-10-01
申请人： MX Adjuvac AB
发明人： Bror Morein , Saideh Berenjian , Kafei Hu
IPC分类号： A61K39/00 , C07J9/00 , A61K31/255 , A61K31/337 , A61K31/52 , A61K31/593 , A61K31/704 , A61K31/7068 , A61K39/145 , A61K39/39 , A61K36/73 , C12Q1/48 , G01N33/50 , A61K9/51 , A61K39/12
CPC分类号： C07J9/00 , A61K9/5123 , A61K31/255 , A61K31/337 , A61K31/52 , A61K31/593 , A61K31/704 , A61K31/7068 , A61K36/73 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5252 , A61K2039/55555 , A61K2039/55577 , A61K2300/00 , C12N2760/16134 , C12N2760/16234 , C12Q1/485 , G01N33/5011 , G01N2800/52 , Y10T428/2982
摘要： The present invention regards nanoparticles comprising a sterol and a component derived from Quillaja saponaria Molina selected from quillaja acid and quillaja saponin, which nanoparticles do not comprise a phospholipid. It also relates to a composition comprising the nanoparticles, and the use thereof as adjuvant, especially in vaccines, as carriers for amphipathic or hydrophobic molecules and as agents for treatment of cancer. Further, it regards a method for producing the phospholipid-free nanoparticles, a method for the treatment of cancer and a method for assessing the applicability of the cancer treating method.
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公开(公告)号：US20180207256A1
公开(公告)日：2018-07-26
申请号：US15896711
申请日：2018-02-14
发明人： Simon Urwyler , Markus Haake , Michael Rudolf
IPC分类号： A61K39/104 , C07K16/12 , C07K14/22 , C07K14/21 , A61K39/00
CPC分类号： A61K39/1045 , A61K39/104 , A61K2039/55555 , C07K14/212 , C07K14/22 , C07K16/1217
摘要： The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising these polypeptides. The invention further provides compositions for use in treating, preventing or detecting a bacterial infection, in particular vaccine compositions using the antigenic polypeptides. The invention further provides antibodies directed to said antigenic polypeptides.
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公开(公告)号：US20180193448A1
公开(公告)日：2018-07-12
申请号：US15674929
申请日：2017-08-11
发明人： Kejian YANG , Dennis L. GUBERSKI
IPC分类号： A61K39/245 , A61K31/7088 , A61K39/00 , A61K39/12 , A61K9/127
CPC分类号： A61K39/245 , A61K9/127 , A61K31/7088 , A61K39/00 , A61K39/12 , A61K2039/505 , A61K2039/5158 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/545 , A61K2039/55555 , A61K2039/57 , C12N2710/16634
摘要： Methods and kits for immunizing animals (e.g. mammals) against viral antigens, including herpes-simplex virus type 2 are provided. The protective immune response elicited by the methods and kits is characterized by robust humoral, cellular, and mucosal immunity. In particular, a heterologous immunization method comprising a priming DNA vaccine encoding an antigen and a boosting protein vaccine, in which the protein form of the antigen is encapsulated in liposomes is provided. Methods of preventing primary acute, latent and recurrent viral infections, such as that caused by HSV-2 virus, and methods of providing passive protective immunity against a viral pathogen such as HSV-2 virus to a mammal are also disclosed.
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公开(公告)号：US20180193445A1
公开(公告)日：2018-07-12
申请号：US15896761
申请日：2018-02-14
发明人： Simon Urwyler , Markus Haake , Michael Rudolf
IPC分类号： A61K39/104 , C07K16/12 , C07K14/22 , C07K14/21 , A61K39/00
CPC分类号： A61K39/1045 , A61K39/104 , A61K2039/55555 , C07K14/212 , C07K14/22 , C07K16/1217
摘要： The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising these polypeptides. The invention further provides compositions for use in treating, preventing or detecting a bacterial infection, in particular vaccine compositions using the antigenic polypeptides. The invention further provides antibodies directed to said antigenic polypeptides.
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公开(公告)号：US10004689B2
公开(公告)日：2018-06-26
申请号：US13261883
申请日：2012-11-14
发明人： Barbara Freund , Jörg Heeren , Peter Nielsen , Antonella Carambia , Johannes Herkel , Oliver Bruns , Ansgar Lohse , Stefan Lüth , Horst Weller , Sunhild Salmen
IPC分类号： A61K9/14 , A61K9/107 , A61K49/00 , A61K49/18 , A61K51/12 , A61K39/00 , A61K39/39 , C12N5/0783 , A61K47/69 , A61K9/00
CPC分类号： A61K9/146 , A61K9/0019 , A61K9/1075 , A61K39/0008 , A61K39/39 , A61K47/6907 , A61K49/0067 , A61K49/1809 , A61K49/1857 , A61K51/1227 , A61K2039/55555 , C12N5/0637 , C12N2502/14
摘要： The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.
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公开(公告)号：US20180169204A1
公开(公告)日：2018-06-21
申请号：US15887203
申请日：2018-02-02
IPC分类号： A61K39/00 , A61K39/12 , A61K39/102 , A61K31/4375 , A61K31/66 , A61K33/06 , A61K39/39 , A61K39/116 , A61K39/295
CPC分类号： A61K39/0018 , A61K31/4375 , A61K31/66 , A61K33/06 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/295 , A61K39/39 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/70 , C12N2730/10134 , C12N2770/32634 , Y02A50/466 , A61K2300/00
摘要： Combination vaccine compositions as well as methods for their manufacture have a relatively low amount of antigen and/or a relatively low amount of aluminium, but they can nevertheless have immunogenicity which is comparable to combination vaccines with a relatively high amount of antigen and/or a relatively high amount of aluminium. Aluminium-free combination vaccine compositions are also provided e.g. compositions which are adjuvanted with an oil-in-water emulsion adjuvant.
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公开(公告)号：US09999600B2
公开(公告)日：2018-06-19
申请号：US15362476
申请日：2016-11-28
申请人： N-Fold LLC
发明人： Howard B. Sosin , Michael J. Caplan
IPC分类号： A61K9/51 , A61K39/35 , A61K9/50 , A61K39/02 , A61K39/145 , A61K39/39 , C12N7/00 , A61K39/108 , A61K39/00
CPC分类号： A61K9/5153 , A61K9/5031 , A61K9/5176 , A61K39/025 , A61K39/0258 , A61K39/145 , A61K39/35 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/542 , A61K2039/545 , A61K2039/55511 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55594 , A61K2039/57 , C12N7/00 , C12N2760/16034 , Y02A50/386 , Y02A50/388 , Y02A50/394 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/416
摘要： The present invention provides, among other things, nanoparticle compositions including a plurality of nanoparticles, each of which is comprised of a biodegradable or biocompatible polymer arranged in a nanoparticle structure defining an internal lumen and an external surface and one or more of a preparation of hydrophilic cellular components and a preparation of hydrophobic cellular components. In some embodiments, the preparation of hydrophilic cellular components is encapsulated within the internal lumen and the preparation of hydrophobic cellular components is associated with the external surface. Various methods of making and using disclosed nanoparticle compositions are also provided.
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公开(公告)号：US20180161416A1
公开(公告)日：2018-06-14
申请号：US15579153
申请日：2016-06-03
申请人： INNOVEX THERAPEUTICS, S.L. , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS , FUNDACIÓ PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA (ISGLOBAL) , FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL , UNIVERSITAT DE LLEIDA
发明人： Hernando Antonio DEL PORTILLO OBANDO , Francisco Enrique BORRÁS SERRES , Lorenzo José FRAILE SAUCE , Sergio Roberto MONTANER TARBES , Maria MONTOYA GONZÁLEZ
CPC分类号： A61K39/12 , A61K9/127 , A61K38/1709 , A61K39/00 , A61K2039/55555 , A61K2039/64 , C12N2770/10034 , C12N2770/10051 , C12N2770/10071 , C12N2770/36034 , C12N2770/36051 , C12N2770/36071 , G16C20/20
摘要： The present invention provides exosomes isolated from an animal, wherein the animal (a) has overcome a disease caused by a pathogen, and (b) it is free from the pathogen that causes the diseases. The invention also provides process for obtaining these exosomes and the use thereof in therapy.
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