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    Multi-compartment filter and method of filtering using same
    71.
    发明授权
    Multi-compartment filter and method of filtering using same 有权
    多室过滤器和使用其的过滤方法

    公开(公告)号：US07815783B2

    公开(公告)日：2010-10-19

    申请号：US11073999

    申请日：2005-03-08

    Applicant: Egisto Boschetti ,  Lee O. Lomas ,  Pierre Girot

    Inventor： Egisto Boschetti ,  Lee O. Lomas ,  Pierre Girot

    IPC: G01N27/453 ,  B01D57/02

    CPC classification number: G01N27/44704 ,  B01D57/02 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3274 ,  B01J2220/54 ,  C07K1/24 ,  C07K1/34 ,  G01N27/44795

    Abstract: Each embodiment includes a central sample reservoir and a plurality of satellite reservoirs. In a first embodiment, a first electrode in electrical contact with the central reservoir is charged and second electrodes in electrical contact with the satellite reservoirs are sequentially charged, thereby pI filtering molecules in the central reservoir into the satellite reservoirs. In a second embodiment, the central reservoir is configured to rotate so that molecules in a sample in the central reservoir are centrifugally pI-filtered into the satellite reservoirs. In a third embodiment, first and second electrodes proximate opposite first and second satellite reservoirs, respectively, are charged. Some molecules in a sample are pI filtered into the first and second satellite reservoirs. Third and fourth electrodes proximate opposite third and fourth satellite reservoirs, respectively, are then charged. Some molecules in a sample are pI filtered into the third and fourth satellite reservoirs.

    Abstract translation: 每个实施例包括中央样品储存器和多个卫星储存器。 在第一实施例中，与中央储存器电接触的第一电极被充电，并且与卫星储存器电接触的第二电极被顺序地充电，从而将中央储存器中的分子过滤到卫星储存器中。 在第二实施例中，中央储存器被配置为旋转，使得中央储存器中的样品中的分子被离心地pI过滤到卫星储存器中。 在第三实施例中，分别与第一和第二卫星储存器相邻的第一和第二电极被充电。 样品中的一些分子被pI过滤到第一和第二卫星储层中。 然后分别靠近相对的第三和第四卫星储存器的第三和第四电极被充电。 样品中的一些分子被pI过滤到第三和第四卫星储层中。

    POROUS COMPOSITE PARTICULATE MATERIALS, METHODS OF MAKING AND USING SAME, AND RELATED APPARATUSES
    74.
    发明申请
    POROUS COMPOSITE PARTICULATE MATERIALS, METHODS OF MAKING AND USING SAME, AND RELATED APPARATUSES 有权
    多孔复合颗粒材料，制备和使用它们的方法和相关装置

    公开(公告)号：US20100213131A1

    公开(公告)日：2010-08-26

    申请号：US12774777

    申请日：2010-05-06

    Applicant: Matthew R. Linford ,  Andrew E. Dadson

    Inventor： Matthew R. Linford ,  Andrew E. Dadson

    IPC: B01D15/08 ,  B32B37/12 ,  B01J20/26

    CPC classification number: B01J20/285 ,  B01D15/10 ,  B01J13/02 ,  B01J13/14 ,  B01J13/22 ,  B01J20/20 ,  B01J20/262 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28057 ,  B01J20/282 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3223 ,  B01J20/3236 ,  B01J20/324 ,  B01J20/3268 ,  B01J20/3272 ,  B01J20/3282 ,  B01J20/3289 ,  B01J20/3293 ,  B01J20/3295 ,  B01J2220/52 ,  B01J2220/58

    Abstract: In an embodiment, a porous composite particulate material includes a plurality of composite particles. Each composite particle includes an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles. The shell particles are adhered to the core particle by a polymeric layer. The shell particles and/or core particles may be made from an acid-base-resistant material that is stable in harsh chemical conditions. For example, the shell particles and/or core particles may be made from diamond, graphitic carbon, silicon carbide, boron nitride, tungsten carbide, niobium carbide, zirconia, noble metals, acid-base stable highly cross-linked polymers, acid-base stable at least partially cross-linked polymers, titania, alumina, thoria combinations of the foregoing, or other acid-base-resistant materials. The porous composite particulate materials disclosed herein and related methods and devices may be used in separation technologies, including, but not limited to, chromatography and solid phase extraction.

    Abstract translation: 在一个实施方案中，多孔复合颗粒材料包括多个复合颗粒。 每个复合颗粒包括至少部分地被一层或多层耐酸碱性壳颗粒包围的耐酸碱性芯颗粒。 壳颗粒通过聚合物层粘附到芯颗粒。 壳颗粒和/或芯颗粒可以由在苛刻的化学条件下稳定的耐酸碱材料制成。 例如，壳颗粒和/或芯颗粒可以由金刚石，石墨碳，碳化硅，氮化硼，碳化钨，碳化铌，氧化锆，贵金属，酸碱稳定的高度交联的聚合物，酸碱 稳定的至少部分交联的聚合物，二氧化钛，氧化铝，氧化钍组合，或其它耐酸碱材料。 本文公开的多孔复合颗粒材料和相关方法和装置可以用于分离技术，包括但不限于色谱和固相萃取。

    Method and apparatus for making porous agarose beads
    79.
    发明授权
    Method and apparatus for making porous agarose beads 有权
    制备多孔琼脂糖珠的方法和设备

    公开(公告)号：US07678302B2

    公开(公告)日：2010-03-16

    申请号：US11520775

    申请日：2006-09-13

    Applicant: Kwok-Shun Cheng ,  Senthilkumar Ramaswamy ,  Nanying Bian ,  Brian Gagnon ,  Joaquin Umana ,  Neil P. Soice

    Inventor： Kwok-Shun Cheng ,  Senthilkumar Ramaswamy ,  Nanying Bian ,  Brian Gagnon ,  Joaquin Umana ,  Neil P. Soice

    IPC: B29B9/00

    CPC classification number: B01J20/24 ,  B01J13/04 ,  B01J20/28009 ,  B01J20/285 ,  B01J20/286 ,  B01J20/291 ,  B01J20/3204 ,  B01J20/3242 ,  B01J20/3244 ,  B01J20/3272 ,  B01J20/328 ,  B01J20/3282 ,  B01J20/3289 ,  B01J20/3293 ,  B01J2220/4825

    Abstract: The present invention relates to a method and apparatus for forming agarose or cored agarose beads. The process involves dissolving/gelation the agarose in a suitable liquid, mixing it with a hydrophobic liquid to form an emulsion and maintaining that emulsion at a temperature equal to or greater than the gelation point of the agarose, passing it through a static mixer to create agarose droplets and solidifying the agarose droplets in a second bath of hydrophobic liquid. The beads can then be washed and used or further processed to crosslink the agarose and/or add various functionalities on to the agarose. Another method for solidifying the agarose droplets is by using a heat exchanger to cool the stream continuously after it exits the static mixer. A similar process is used for the “cored” beads except cores, preferably in bead form, are introduced to the agarose before it enters the first hydrophobic liquid so that the agarose forms a coating on the cores. A similar process with either agarose beads (made by this or another process) or cored agarose (made by this or another process) can be used to add multiple layers of agarose on to the existing beads. An apparatus for running the process is also disclosed.

    Abstract translation: 本发明涉及用于形成琼脂糖或核心琼脂糖珠的方法和装置。 该方法包括将琼脂糖溶解/凝胶化在合适的液体中，将其与疏水性液体混合以形成乳液，并将该乳液保持在等于或大于琼脂糖凝胶点的温度，将其通过静态混合器以产生 琼脂糖滴并在第二浴疏水性液体中固化琼脂糖滴。 然后可以将珠子洗涤并使用或进一步加工以使琼脂糖交联和/或在琼脂糖上添加各种功能。 用于固化琼脂糖滴的另一种方法是通过使用热交换器在离开静态混合器之后连续冷却流。 对于“核心”珠粒，使用类似的方法，除了核心，优选以珠粒形式，在其进入第一疏水性液体之前将其引入琼脂糖，使得琼脂糖在芯上形成涂层。 可以使用与琼脂糖珠（由该方法或另一方法制备）或核心琼脂糖（由该方法或另一方法制备）相似的方法将多层琼脂糖添加到现有珠粒上。 还公开了一种用于运行该过程的装置。

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