公开(公告)号：US20160169799A1

公开(公告)日：2016-06-16

申请号：US15049594

申请日：2016-02-22

申请人： NXGEN PARTNERS IP, LLC

发明人： SOLYMAN ASHRAFI ,  ROGER LINQUIST ,  NIMA ASHRAFI

IPC分类号： G01N21/59 ,  G01N33/483

CPC分类号： G01N21/59 ,  G01N21/17 ,  G01N21/21 ,  G01N21/453 ,  G01N24/00 ,  G01N33/483 ,  G01N33/50

摘要： An apparatus that measures a concentration of a material within a sample includes signal generation circuitry that generates a first signal having at least one orthogonal function applied thereto and applies the first signal to the sample. A detector receives the first signal after the first signal passes through the sample and determines the concentration of the material within the sample based on a detected orthogonal function within the first signal received from the sample.

摘要翻译： 测量样品中材料浓度的装置包括信号产生电路，其生成具有施加到其上的至少一个正交函数的第一信号，并将第一信号施加到样本。 检测器在第一信号通过样本之后接收第一信号，并且基于从样本接收到的第一信号内检测到的正交函数确定样本内的材料的浓度。

公开(公告)号：US09360468B2

公开(公告)日：2016-06-07

申请号：US13816855

申请日：2011-08-16

申请人： Nicolas Pavillon ,  Jonas Kühn ,  Pascal Jourdain ,  Christian Depeursinge ,  Pierre Julius Magistretti ,  Pierre Marquet

发明人： Nicolas Pavillon ,  Jonas Kühn ,  Pascal Jourdain ,  Christian Depeursinge ,  Pierre Julius Magistretti ,  Pierre Marquet

IPC分类号： G01N33/483 ,  G01N21/45 ,  G03H1/00 ,  G03H1/08 ,  G01N21/17

CPC分类号： G01N33/4833 ,  G01N21/453 ,  G01N2021/1789 ,  G01N2510/00 ,  G03H1/0005 ,  G03H1/0866 ,  G03H2001/005

摘要： A method for measuring through optical means temporally resolved, optical properties, and/or phenotypes that are linked to cellular homeostasis. Those temporal measurements enable the detection of cell regulation through various channels linked to homeostasis, in order to monitor cell viability.

摘要翻译： 用于通过光学手段测量与细胞稳态相关的时间分辨的光学性质和/或表型的方法。 这些时间测量使得能够通过与体内平衡相关的各种通道检测细胞调节，以便监测细胞活力。

公开(公告)号：US09176152B2

公开(公告)日：2015-11-03

申请号：US13699519

申请日：2011-05-25

申请人： Christopher Knutson ,  Osman Akcakir ,  Haojun Fu

发明人： Christopher Knutson ,  Osman Akcakir ,  Haojun Fu

IPC分类号： G01N33/80 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  C40B30/04 ,  G01N15/02 ,  G01N15/14 ,  G06F19/10 ,  G01N21/45

CPC分类号： G01N33/80 ,  C40B30/04 ,  G01N15/0211 ,  G01N15/1463 ,  G01N21/453 ,  G01N33/5029 ,  G01N33/53 ,  G01N33/54313 ,  G01N2015/0216 ,  G01N2015/1497 ,  G06F19/10

摘要： The present invention relates to methods and apparatuses for the detection of positional freedom of particles used in biological, biochemical, physical, biophysical, and chemical analyses. In particular, the present invention relates to methods and apparatuses which can detect and characterize a population of particles/cells based upon their detected mobility. In one embodiment consistent with the invention, detection of certain cells is based on differences detected in populations of cells that bind to a substrate and those that exhibit weaker binding forces. Initially, cells are settled on the substrate, and in the presence of gravitational, natural thermodynamic pressure fluctuations, and other random or applied forces, some of the particles may exhibit translational movement. Particle movement is detected, and measurements are computed, according to the methods and apparatuses of the present invention, to determine the binding of specific analytes.

摘要翻译： 本发明涉及用于检测生物，生化，物理，生物物理和化学分析中使用的颗粒的位置自由度的方法和装置。 特别地，本发明涉及可以基于其检测到的移动性来检测和表征粒子/细胞群体的方法和装置。 在与本发明一致的一个实施方案中，某些细胞的检测基于在与底物结合的细胞群体中检测到的差异以及显示较弱结合力的细胞的差异。 最初，细胞沉积在基底上，并且在重力，天然热力学压力波动和其它随机或施加的力的存在下，一些颗粒可能表现出平移运动。 检测到颗粒运动，并且根据本发明的方法和装置计算测量值，以确定特定分析物的结合。

公开(公告)号：US20140375792A1

公开(公告)日：2014-12-25

申请号：US14363686

申请日：2012-12-10

申请人： Massachusetts Institute of Technology

发明人： Zahid Yaqoob ,  Niyom Lue ,  Timothy Robert Hillman

IPC分类号： G02B21/00

CPC分类号： G02B21/0056 ,  G01J9/02 ,  G01N21/453 ,  G02B21/14 ,  G02B21/365

摘要： Systems and methods of self-referenced quantitative phase microscopy (SrQPM). The SrQPM systems and methods provide single-shot, full-field imaging capability for increased imaging speed, and near-common-path geometry for increased phase stability, allowing the study of internal structures of biological cells, live cell dynamics, and the like.

摘要翻译： 自参考定量相位显微镜（SrQPM）的系统和方法。 SrQPM系统和方法提供单次，全场成像能力，以提高成像速度，并提供近常规路径几何，增加相位稳定性，允许研究生物细胞的内部结构，活细胞动力学等。

公开(公告)号：US20140320865A1

公开(公告)日：2014-10-30

申请号：US14259942

申请日：2014-04-23

申请人： Voco GmbH

发明人： Alexander Knüttel

IPC分类号： G01B11/24 ,  G01B9/02

CPC分类号： G01B11/2441 ,  A61B6/145 ,  G01B9/02001 ,  G01B9/02007 ,  G01B9/02027 ,  G01B9/02032 ,  G01B9/02047 ,  G01B9/02067 ,  G01N21/211 ,  G01N21/453 ,  G01N2021/213 ,  G01S7/4815 ,  G01S17/36 ,  G02B5/32 ,  G02B21/367 ,  G03H1/0005 ,  G03H1/0443 ,  G03H1/0465 ,  G03H1/0486 ,  G03H1/2645 ,  G03H1/265 ,  G03H1/32 ,  G03H2001/0033 ,  G03H2001/0212 ,  G03H2001/0445 ,  G03H2001/046 ,  G03H2001/0491 ,  G03H2001/266 ,  G03H2210/63 ,  G03H2222/13 ,  G03H2222/16 ,  G03H2222/17 ,  G03H2222/31 ,  G03H2222/34 ,  G03H2222/35 ,  G03H2222/44 ,  G03H2223/19 ,  G03H2223/22 ,  G03H2223/23

摘要： An apparatus for detecting a 3D structure of an object. The apparatus has first and second laser emitters which generate laser radiation having first and second wavelengths, respectively, the first wavelength being different from the second wavelength. Optical devices are disclosed, including a beam splitter, which splits the laser radiation of the laser emitters in each case into a reference radiation and an illuminating radiation. The illuminating radiation impinges upon the object to be measured, is reflected by the object as object radiation and interferes with the reference radiation. A detector receives the interference patterns. The laser emitters are located such that the illuminating radiation of the first and second laser emitters impinge upon the object at different angles of incidence. Also discussed is a measuring device which measures the two wavelengths of the laser radiation of the laser emitters and influences the recording of the interference patterns.

摘要翻译： 一种用于检测物体的3D结构的装置。 该装置具有分别产生具有第一和第二波长的激光辐射的第一和第二激光发射器，第一波长分别与第二波长不同。 公开了包括分束器的光学装置，其将激光发射器的激光辐射在每种情况下分裂成参考辐射和照射辐射。 照射的辐射照射在待测物体上，被物体作为物体辐射反射，并干扰参考辐射。 检测器接收干扰图案。 激光发射器被定位成使得第一和第二激光发射器的照射辐射以不同的入射角撞击在物体上。 还讨论了测量激光发射器的激光辐射的两个波长并影响干涉图案的记录的测量装置。

公开(公告)号：US20130310270A1

公开(公告)日：2013-11-21

申请号：US13899479

申请日：2013-05-21

申请人： IMEC

发明人： Frederik Colle ,  Liesbet Lagae ,  Dries Vercruysse

IPC分类号： G01N33/543

CPC分类号： G01N33/54373 ,  G01N15/1463 ,  G01N21/453 ,  G01N33/54326 ,  G01N2015/1445 ,  G01N2015/1454 ,  G03H1/0443 ,  G03H2001/0447

摘要： The present disclosure provides a device for analyzing target molecules. The device comprises a substrate retention device for holding a substrate having a functionalized surface provided thereon. This functionalized surface is adapted for capturing a plurality of target molecules. The device also comprises a light source for illuminating the functionalized surface and an image sensor for recording interference patterns of magnetic particles present on the functionalized surface. The device further comprises a first magnetic field generator configured to generate a magnetic field to attract magnetic particles linked to the target molecules to the functionalized surface. The disclosure further relates to a method for analyzing target molecules.

摘要翻译： 本公开提供了用于分析靶分子的装置。 该装置包括用于保持其上设置有官能化表面的基板的基板保持装置。 该功能化表面适于捕获多个靶分子。 该装置还包括用于照亮功能化表面的光源和用于记录存在于功能化表面上的磁性颗粒的干涉图案的图像传感器。 该装置还包括第一磁场发生器，其被配置为产生磁场以吸引与目标分子连接的功能化表面的磁性颗粒。 本公开还涉及分析靶分子的方法。

公开(公告)号：US20130286403A1

公开(公告)日：2013-10-31

申请号：US13455931

申请日：2012-04-25

申请人： Isao Matsubara ,  Chung-Chieh Yu ,  Yasuyuki Unno ,  William Dallas

发明人： Isao Matsubara ,  Chung-Chieh Yu ,  Yasuyuki Unno ,  William Dallas

IPC分类号： G01B9/02 ,  G01B9/023 ,  G01B11/24

CPC分类号： G01N21/453 ,  G02B21/0052 ,  G03H1/0443 ,  G03H2001/005 ,  G03H2001/0456 ,  G03H2001/046 ,  G03H2222/36 ,  G03H2222/44

摘要： An interferometric method for detecting information about a sample includes emitting a laser beam; splitting the laser beam into a reference beam and an object beam; transmitting the object beam through the sample in an incident angle; combining the reference beam with the object beam passed through the sample to form an interference pattern; detecting the interference pattern, and non-linearly scanning the object beam in order to detect a plurality of interference patterns.

摘要翻译： 用于检测关于样本的信息的干涉测量方法包括发射激光束; 将激光束分成参考光束和物体光束; 以入射角透射物体通过样品; 将参考光束与通过样本的物体光束组合以形成干涉图案; 检测干涉图案，以及非线性扫描物体光束，以便检测多个干涉图案。

公开(公告)号：US20130278743A1

公开(公告)日：2013-10-24

申请号：US13883260

申请日：2011-11-04

申请人： Fook Chiong Cheong ,  Ke Xiao ,  David Pine ,  David G. Grier

发明人： Fook Chiong Cheong ,  Ke Xiao ,  David Pine ,  David G. Grier

IPC分类号： G02B21/36

CPC分类号： G01N15/088 ,  G01N15/08 ,  G01N15/1463 ,  G01N21/4133 ,  G01N21/453 ,  G01N21/47 ,  G01N2015/0846 ,  G02B21/367

摘要： A method for analyzing porosity of a particle and a medium disposed in the porosity of the particle. A video-holographic microscope is provided to analyze interference patterns produced by providing a laser source to output a collimated beam, scattering the collimated beam off a particle and interacting with an unscattered beam to generate the interference pattern for analyzation to determine the refractive index of the particle and a medium disposed in the porosity of the particle to measure porosity and the medium.

摘要翻译： 用于分析颗粒的孔隙率的方法和设置在颗粒的孔隙中的介质。 提供视频全息显微镜以分析通过提供激光源来输出准直光束产生的干涉图案，将准直光束从粒子散射并与未散射光束相互作用以产生用于分析的干涉图案，以确定折射率 颗粒和设置在颗粒孔隙中的介质以测量孔隙度和介质。

公开(公告)号：US20130274119A1

公开(公告)日：2013-10-17

申请号：US13699519

申请日：2011-05-25

申请人： Christopher Knutson ,  Osman Akcakir ,  Haojun Fu

发明人： Christopher Knutson ,  Osman Akcakir ,  Haojun Fu

IPC分类号： G01N33/80

CPC分类号： G01N33/80 ,  C40B30/04 ,  G01N15/0211 ,  G01N15/1463 ,  G01N21/453 ,  G01N33/5029 ,  G01N33/53 ,  G01N33/54313 ,  G01N2015/0216 ,  G01N2015/1497 ,  G06F19/10

摘要： The present invention relates to methods and apparatuses for the detection of positional freedom of particles used in biological, biochemical, physical, biophysical, and chemical analyses. In particular, the present invention relates to methods and apparatuses which can detect and characterize a population of particles/cells based upon their detected mobility. In one embodiment consistent with the invention, detection of certain cells is based on differences detected in populations of cells that bind to a substrate and those that exhibit weaker binding forces. Initially, cells are settled on the substrate, and in the presence of gravitational, natural thermodynamic pressure fluctuations, and other random or applied forces, some of the particles may exhibit translational movement. Particle movement is detected, and measurements are computed, according to the methods and apparatuses of the present invention, to determine the binding of specific analytes.

摘要翻译： 本发明涉及用于检测生物，生化，物理，生物物理和化学分析中使用的颗粒的位置自由度的方法和装置。 特别地，本发明涉及可以基于其检测到的移动性来检测和表征粒子/细胞群体的方法和装置。 在与本发明一致的一个实施方案中，某些细胞的检测基于在与底物结合的细胞群体中检测到的差异以及显示较弱结合力的细胞的差异。 最初，细胞沉积在基底上，并且在重力，天然热力学压力波动和其它随机或施加的力的存在下，一些颗粒可能表现出平移运动。 检测到颗粒运动，并且根据本发明的方法和装置计算测量值，以确定特定分析物的结合。

公开(公告)号：US20120182558A1

公开(公告)日：2012-07-19

申请号：US13327627

申请日：2011-12-15

申请人： Takahiro Masumura

发明人： Takahiro Masumura

IPC分类号： G01B9/02 ,  G01N21/55

CPC分类号： G01N21/453 ,  A61B5/0068 ,  A61B5/0073 ,  G01N21/4795 ,  G01N21/6458 ,  G01N21/65 ,  G01N2021/1785 ,  G01N2201/0675 ,  G02B21/0032 ,  G02B21/0072 ,  G02B21/0076 ,  G02B26/06 ,  G03H1/2294 ,  G03H2001/0467

摘要： An apparatus includes a light source configured to emit an electromagnetic wave; a spatial light modulator configured to modulate a wavefront of the electromagnetic wave to irradiate a sample; a plate with an aperture; a lens unit configured to set a focal point in the sample; a detector configured to detect light coming from the focal point of the sample through the aperture; and a controller configured to control the spatial light modulator based on the detected light by the detector.

摘要翻译： 一种装置，包括配置为发射电磁波的光源; 空间光调制器，被配置为调制电磁波的波前照射样本; 具有孔径的板; 配置为设置所述样本中的焦点的透镜单元; 检测器，被配置为通过所述孔检测来自所述样品的焦点的光; 以及控制器，被配置为基于检测器检测到的光来控制空间光调制器。