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    FLUID CONNECTION DEVICE FOR BIOLOGICAL ANALYSIS APPARATUSES, SUITABLE FLUIDIC COMPONENT AND BIOLOGICAL ANALYSIS DEVICE EQUIPPED WITH SAME
    71.
    发明申请
    FLUID CONNECTION DEVICE FOR BIOLOGICAL ANALYSIS APPARATUSES, SUITABLE FLUIDIC COMPONENT AND BIOLOGICAL ANALYSIS DEVICE EQUIPPED WITH SAME 有权
    用于生物分析装置的流体连接装置，适用的流体组件和配备有其的生物分析装置

    公开(公告)号：US20150165437A1

    公开(公告)日：2015-06-18

    申请号：US14402055

    申请日：2013-05-17

    Applicant: C2 Diagnostics

    Inventor： Henri Champseix

    IPC: B01L3/00

    CPC classification number: B01L3/563 ,  B01L3/565 ,  G01N35/00029 ,  G01N35/085 ,  G01N35/1002 ,  G01N35/1095

    Abstract: A fluid connection device is provided for biological analysis apparatuses, intended to simultaneously connect a plurality of fluid conduits and at least one fluidic component including a connecting surface with a plurality of fluid ports, the device having: (i) a holding plate, (ii) removable attachment structure capable of pressing the holding plate against the connecting surface, (iii) connectors suitable for being fixed to the ends of the fluid conduits and provided with a seal suitable for allowing a sealed connection to be made between the connectors and the fluid ports, holding plate including through-openings opposite the fluid ports and being shaped in such a way as to be able to receive the connectors in through-openings and to hold them pressed against the connecting surface. A biological analysis apparatus implementing the device is also provided.

    Abstract translation: 为生物分析装置提供一种流体连接装置，用于同时连接多个流体导管和包括连接表面的至少一个流体部件与多个流体端口，该装置具有：（i）保持板，（ii） ）可移除的连接结构，其能够将保持板压靠在连接表面上，（iii）适于固定到流体导管的端部并具有适于允许在连接器和流体之间进行密封连接的密封件的连接器 端口，保持板包括与流体端口相对的通孔，并且形成为能够将连接器接纳在通孔中并将其压靠在连接表面上。 还提供了实现该装置的生物分析装置。

    Ion-selective electrode
    72.
    发明授权
    Ion-selective electrode 有权
    离子选择电极

    公开(公告)号：US08961758B2

    公开(公告)日：2015-02-24

    申请号：US13141367

    申请日：2009-11-27

    Applicant: Stefan Wilke

    Inventor： Stefan Wilke

    IPC: G01N27/333 ,  G01N27/403 ,  G01N27/28

    CPC classification number: G01N27/28 ,  G01N27/333 ,  G01N27/403 ,  G01N35/085

    Abstract: An ion-selective electrode comprising: a housing, which surrounds a housing interior; an ion-selective membrane; especially a polymer membrane; and a sensing system, which is in contact with the ion-selective membrane, for sensing a potential of the ion-selective membrane, wherein the ion-selective membrane at least partially fills the housing interior, and is in contact with a medium surrounding the housing via at least one traversing bore through a housing wall of the housing.

    Abstract translation: 一种离子选择性电极，包括：壳体，其围绕壳体内部; 离子选择膜; 特别是聚合物膜; 以及与所述离子选择性膜接触的感测系统，用于感测所述离子选择性膜的电位，其中所述离子选择性膜至少部分地填充所述壳体内部，并且与围绕所述离子选择性膜的介质接触 通过至少一个穿过所述壳体的壳体壁的穿过孔来容纳壳体。

    Control over hydrogen fluoride levels in oxide etchant
    73.
    发明授权
    Control over hydrogen fluoride levels in oxide etchant 有权
    控制氧化物腐蚀剂中的氟化氢水平

    公开(公告)号：US08945939B2

    公开(公告)日：2015-02-03

    申请号：US14082448

    申请日：2013-11-18

    Applicant: Nalco Company

    Inventor： Amy M. Tseng ,  Brian V. Jenkins ,  Robert Mack

    IPC: G01N21/75

    CPC classification number: G01N31/221 ,  B81C1/00531 ,  B81C2201/0132 ,  B81C2201/0142 ,  C09K13/00 ,  G01N21/272 ,  G01N21/80 ,  G01N35/085 ,  G01N2021/8411 ,  G01N2021/8557 ,  H01L21/67063 ,  H01L22/12 ,  Y10T436/153333

    Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.

    Abstract translation: 本发明涉及用于鉴定缓冲氧化物蚀刻组合物中氢氟酸的量的方法和组合物。 在缓冲氧化物蚀刻组合物中，非常难以测量氢氟酸的量，因为其具有不同的平衡，并且它是有毒的，因此难以处理和取样。 然而，当用于制造微芯片时，不正确量的氢氟酸会破坏这些芯片。 当与添加的显色剂接触时，本发明利用光谱测量氢氟酸的独特方法，以获得准确，立即和安全的精确测量。

    CONTROL OVER HYDROGEN FLUORIDE LEVELS IN OXIDE ETCHANT
    74.
    发明申请
    CONTROL OVER HYDROGEN FLUORIDE LEVELS IN OXIDE ETCHANT 有权
    控制氧化物中氢氟化物的含量

    公开(公告)号：US20140315320A1

    公开(公告)日：2014-10-23

    申请号：US14322009

    申请日：2014-07-02

    Applicant: Nalco Company

    Inventor： Amy M. Tseng ,  Brian V. Jenkins ,  Robert M. Mack

    IPC: G01N31/22

    CPC classification number: G01N31/221 ,  B81C1/00531 ,  B81C2201/0132 ,  B81C2201/0142 ,  C09K13/00 ,  G01N21/272 ,  G01N21/80 ,  G01N35/085 ,  G01N2021/8411 ,  G01N2021/8557 ,  H01L21/67063 ,  H01L22/12 ,  Y10T436/153333

    Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.

    Abstract translation: 本发明涉及用于鉴定缓冲氧化物蚀刻组合物中氢氟酸的量的方法和组合物。 在缓冲氧化物蚀刻组合物中，非常难以测量氢氟酸的量，因为其具有不同的平衡，并且它是有毒的，因此难以处理和取样。 然而，当用于制造微芯片时，不正确量的氢氟酸会破坏这些芯片。 当与添加的显色剂接触时，本发明利用光谱测量氢氟酸的独特方法，以获得准确，立即和安全的精确测量。

    SIGNAL LOCKING LABEL FREE BIOSENSING
    77.
    发明申请
    SIGNAL LOCKING LABEL FREE BIOSENSING 审中-公开
    信号锁定标签免费生物传感

    公开(公告)号：US20130196343A1

    公开(公告)日：2013-08-01

    申请号：US13636638

    申请日：2011-03-31

    Applicant: Carlos H. Mastrangelo ,  Layne Daryl Williams

    Inventor： Carlos H. Mastrangelo ,  Layne Daryl Williams

    IPC: G01N33/557 ,  G01N33/573

    CPC classification number: G01N33/557 ,  B01L3/5027 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0883 ,  G01N21/1717 ,  G01N21/553 ,  G01N33/573 ,  G01N35/085

    Abstract: A biosensor can include a fluid flow channel (12), a pulsing mechanism (14), and a binding response measurement mechanism (16). The fluid flow channel (12) can include an inlet (18) to accept a fluid into the fluid flow channel and an outlet (20). At least one binding sensor surface (22) can be oriented within the fluid flow channel. The binding sensor surface (22) can include a fixed binding moiety on the binding sensor surface selected to bind with a complimentary target agent within the fluid to form a complimentary bound duplex. The pulsing and flow switching mechanism (14) can be configured to drive the fluid into the fluid flow channel (12) in a pulsed analyte flow.

    Abstract translation: 生物传感器可以包括流体流动通道（12），脉冲机构（14）和结合响应测量机构（16）。 流体流动通道（12）可以包括用于将流体接纳到流体流动通道中的入口（18）和出口（20）。 至少一个装订传感器表面（22）可以在流体流动通道内取向。 结合传感器表面（22）可以包括结合传感器表面上的固定结合部分，其被选择为与流体内的互补目标试剂结合以形成互补结合的双链体。 脉冲和流动切换机构（14）可以被配置成以脉冲的分析物流驱动流体进入流体流动通道（12）。

    CONTROL OVER HYDROGEN FLUORIDE LEVELS IN OXIDE ETCHANT
    78.
    发明申请
    CONTROL OVER HYDROGEN FLUORIDE LEVELS IN OXIDE ETCHANT 有权
    控制氧化物中氢氟化物的含量

    公开(公告)号：US20130183773A1

    公开(公告)日：2013-07-18

    申请号：US13731296

    申请日：2012-12-31

    Applicant: Amy M. Tseng ,  Brian V. Jenkins ,  Robert Mack

    Inventor： Amy M. Tseng ,  Brian V. Jenkins ,  Robert Mack

    IPC: G01N31/22

    CPC classification number: G01N31/221 ,  B81C1/00531 ,  B81C2201/0132 ,  B81C2201/0142 ,  C09K13/00 ,  G01N21/272 ,  G01N21/80 ,  G01N35/085 ,  G01N2021/8411 ,  G01N2021/8557 ,  H01L21/67063 ,  H01L22/12 ,  Y10T436/153333

    Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.

    Abstract translation: 本发明涉及用于鉴定缓冲氧化物蚀刻组合物中氢氟酸的量的方法和组合物。 在缓冲氧化物蚀刻组合物中，非常难以测量氢氟酸的量，因为其具有不同的平衡，并且它是有毒的，因此难以处理和取样。 然而，当用于制造微芯片时，不正确量的氢氟酸会破坏这些芯片。 当与添加的显色剂接触时，本发明利用光谱测量氢氟酸的独特方法，以获得准确，立即和安全的精确测量。

    GRADIENT INJECTION FOR BIOSENSING
    80.
    发明申请
    GRADIENT INJECTION FOR BIOSENSING 有权
    梯度注射用于生物传感

    公开(公告)号：US20110295512A1

    公开(公告)日：2011-12-01

    申请号：US12674290

    申请日：2008-01-16

    Applicant: John Gerard Quinn

    Inventor： John Gerard Quinn

    IPC: G06F19/10

    CPC classification number: G01N35/1097 ,  B01L2300/0636 ,  G01N21/55 ,  G01N21/553 ,  G01N33/53 ,  G01N35/08 ,  G01N35/085 ,  G01N2021/058 ,  Y10S435/808 ,  Y10S436/805 ,  Y10T436/117497

    Abstract: A single injection gradient with a biosensor, both structural and methodological, achieves the binding of analyte to immobilized ligand over a wide concentration range without the necessity of regeneration of the sensing area. A gradient of concentrations adjacent to or within a flow cell facilitates kinetic analysis of interactions without requiring multiple discrete volumes or injections to achieve a range of concentrations. A continuous gradient fluid is preferably formed directly adjacent to the flow cell inlet or a region of sample/buffer dispersion at an injection point into a flow channel of a flow cell. The analyte gradient may be flowed through the flow cell from a low analyte concentration. Multiple component gradients are also provided.

    Abstract translation: 具有结构和方法学的生物传感器的单次注射梯度实现了在宽浓度范围内分析物与固定化配体的结合，而不需要再生感测区域。 与流动池相邻或相邻的浓度梯度促进了相互作用的动力学分析，而不需要多个离散的体积或注射来达到一定范围的浓度。 连续梯度流体优选直接邻近流动池入口或在注入点处的流动池的流动通道中的样品/缓冲液分散区域形成。 分析物梯度可以从低分析物浓度流过流动池。 还提供了多组分梯度。

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