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公开(公告)号：US20170152554A1
公开(公告)日：2017-06-01
申请号：US15425791
申请日：2017-02-06
Applicant: Complete Genomics, Inc
Inventor： RADOJE DRMANAC , Matthew Callow , Snezana Drmanac , Brian K. Hauser , George Yeung
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C07H21/04 , C07K1/047 , C12Q1/6806 , C12Q1/682 , C12Q1/6837 , C12Q1/6869 , C12Q2525/151 , C12Q2525/313 , C12Q2531/125 , C12Q2565/513 , G01N15/1404 , G01N15/1434 , Y10S977/778 , Y10S977/789 , Y10S977/792 , Y10S977/88 , Y10S977/882 , C12Q2521/307 , C12Q2525/161 , C12Q2535/122 , C12Q2563/179 , C12Q2565/514
Abstract: A high density DNA array comprising a patterned surface, said surface comprising a pattern of small DNA binding regions separated by a non-DNA binding surface, wherein the DNA binding regions comprise DNA capture chemistry and the non-DNA binding surface does not have the DNA capture chemistry wherein more than 50% of the DNA binding regions in the array have single informative DNA species.
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82.发明申请公开(公告)号：US20170120213A1
公开(公告)日：2017-05-04
申请号：US15289407
申请日：2016-10-10
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev , Peter Hong
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2219/00722 , C12P19/34 , C12Q1/6869 , C12Q1/6874 , C12Q2525/101 , C12Q2521/101
Abstract: The present invention is directed to methods and compositions for long fragment read sequencing. The present invention encompasses methods and compositions for preparing long fragments of genomic DNA, for processing genomic DNA for long fragment read sequencing methods, as well as software and algorithms for processing and analyzing sequence data.
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公开(公告)号：US09523125B2
公开(公告)日：2016-12-20
申请号：US14094630
申请日：2013-12-02
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac
CPC classification number: C12Q1/6874 , C12Q1/68 , C12Q1/686 , C12Q1/6869 , C12Q1/6876 , C12Q2565/102 , C12Q2565/1025 , C12Q2565/518
Abstract: The present invention is directed to methods and compositions for acquiring nucleotide sequence information of target sequences. In particular, the present invention provides methods and compositions for improving the efficiency of sequencing reactions by using fewer labels to distinguish between nucleotides and by detecting nucleotides at multiple detection positions in a target sequence.
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公开(公告)号：US09499863B2
公开(公告)日：2016-11-22
申请号：US14028319
申请日：2013-09-16
Applicant: Complete Genomics, Inc.
Inventor： Radoje Drmanac , Brock A. Peters , Andrei Alexeev , Peter Hong
CPC classification number: B01J19/0046 , B01J2219/00722 , C12P19/34 , C12Q1/6869 , C12Q1/6874 , C12Q2525/101 , C12Q2521/101
Abstract: The present invention is directed to methods and compositions for long fragment read sequencing. The present invention encompasses methods and compositions for preparing long fragments of genomic DNA, for processing genomic DNA for long fragment read sequencing methods, as well as software and algorithms for processing and analyzing sequence data.
Abstract translation: 本发明涉及用于长片段读取测序的方法和组合物。 本发明包括用于制备基因组DNA长片段的方法和组合物，用于处理长片段读取测序方法的基因组DNA，以及用于处理和分析序列数据的软件和算法。
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公开(公告)号：US09488823B2
公开(公告)日：2016-11-08
申请号：US13908964
申请日：2013-06-03
Applicant: Complete Genomics, Inc.
Inventor： Bryan P. Staker , Craig E. Uhrich
CPC classification number: H04N5/3742 , G01N21/6452 , G01N21/6456 , G02B21/361 , G02B21/365 , G06T1/0007 , G06T2207/10056 , G06T2207/10064 , G06T2207/10152 , G06T2207/30004 , G06T2207/30072 , H04N3/08 , H04N5/2256 , H04N5/3452 , H04N5/3532 , H04N5/378 , H04N7/18
Abstract: Imaging systems are provided for high speed, high resolution imaging of biochemical materials. In an example embodiment, an imaging system comprises an objective lens component, a line generator, a digital camera, a positioning stage, and a scan mirror. The line generator generates a line of light that is scanned across a portion of a substrate that is mounted on the positioning stage. The positioning stage moves the substrate in a particular direction that is substantially normal to an optical axis of the objective lens component. The camera collects an image of the portion of the substrate through the objective lens component. The scan mirror moves in coordination with the positioning stage, while the line of light is being scanned across the portion of the substrate and the substrate is being moved in the particular direction, in order to keep the image still with respect to the camera while the image is being collected by the camera.
Abstract translation: 提供成像系统用于生化材料的高速，高分辨率成像。 在示例性实施例中，成像系统包括物镜组件，线生成器，数字照相机，定位台和扫描镜。 线发生器产生沿安装在定位台上的衬底的一部分扫描的光线。 定位台沿着基本上垂直于物镜部件的光轴的特定方向移动基板。 相机通过物镜组件收集基板部分的图像。 扫描镜与定位台配合移动，同时沿着基板的一部分扫描光线，并且基板沿着特定方向移动，以便使图像相对于照相机保持不动，同时 相机正在收集图像。
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Patent Agency Ranking
公开(公告)号：US20160237488A1
公开(公告)日：2016-08-18
申请号：US15040906
申请日：2016-02-10
Applicant: Complete Genomics, Inc.
Inventor： Rongqin Ke , Snezana Drmanac , Radoje Drmanac , Guangyang Cai , Matthew Callow
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C12Q1/6806 , C12Q2525/191 , C12Q2531/119
Abstract: This application discloses methods of producing a DNA strand for sequencing, as well as genetic constructs, libraries, and arrays using DNA strands produced according to these methods. The application also discloses methods of sequencing using the DNA strands, genetic constructs, libraries, and arrays produced. In certain aspects, DNA being sequenced includes a target sequence and at least one adaptor sequence.
Abstract translation: 本申请公开了用于测序的DNA链的制备方法，以及使用根据这些方法制备的DNA链的遗传构建体，文库和阵列。 本申请还公开了使用DNA链，遗传构建体，文库和产生的阵列进行测序的方法。 在某些方面，被测序的DNA包括靶序列和至少一个衔接子序列。
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公开(公告)号：US20160194686A1
公开(公告)日：2016-07-07
申请号：US14961753
申请日：2015-12-07
Applicant: Complete Genomics, Inc.
Inventor： Radoje T. Drmanac , Matthew J. Callow
IPC: C12Q1/68
CPC classification number: C12Q1/686 , C12Q1/6809 , C12Q1/6874 , C12Q2565/501 , C12Q2539/103 , C12Q2531/119
Abstract: The present invention is related generally to analysis of polynucleotides, particularly polynucleotides derived from genomic DNA. The invention provides methods, compositions and systems for such analysis. Encompassed by the invention are arrays of polynucleotides in which the polynucleotides have undergone multiple rounds of amplification in order to increase the strength of signals associated with single polynucleotide molecules.
Abstract translation: 本发明一般涉及多核苷酸的分析，特别是衍生自基因组DNA的多核苷酸。 本发明提供了用于这种分析的方法，组合物和系统。 本发明所涵盖的是多核苷酸阵列，其中多核苷酸经历了多轮扩增，以增加与单个多核苷酸分子相关的信号强度。
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88.发明申请公开(公告)号：US20160117444A1
公开(公告)日：2016-04-28
申请号：US14960996
申请日：2015-12-07
Applicant: Complete Genomics, Inc.
Inventor： Aaron Halpern , Krishna Pant
CPC classification number: G16B30/00 , C12Q1/6827 , G16B20/00 , G16B35/00 , G16B40/00 , G16B45/00 , G16B50/00 , G16C20/60 , C12Q2537/16 , C12Q2537/165
Abstract: Methods for interpreting absolute copy number of complex tumors and for determining the copy number of a genomic region at a detection position of a target sequence in a sample are disclosed. In certain aspects, genomic regions of a target sequence in a sample are sequenced and measurement data for sequence coverage is obtained. Sequence coverage bias is corrected and may be normalized against a baseline sample. Hidden Markov Model (HMM) segmentation, scoring, and output are performed, and in some embodiments population-based no-calling and identification of low-confidence regions may also be performed. A total copy number value and region-specific copy number value for a plurality of regions are then estimated.
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89.发明授权公开(公告)号：US09285578B2
公开(公告)日：2016-03-15
申请号：US14594979
申请日：2015-01-12
Applicant: Complete Genomics, Inc.
Inventor： Bryan P. Staker , Craig E. Uhrich
CPC classification number: G02B21/365 , G01B11/272 , G02B21/002 , G02B21/025 , G02B21/361 , H04N5/37206 , H04N7/18
Abstract: A method and associated system for imaging high density biochemical arrays comprises one or more imaging channels that share a common objective lens and a corresponding one or more time delay integration-type imaging cameras with optical alignment mechanisms that permit independent inter-channel and intra-channel adjustment of each of four degrees: X, Y, rotation and scale. The imaging channels are configured to independently examine different spectra of the image of the biochemical arrays.
Abstract translation: 用于高密度生物化学阵列成像的方法和相关系统包括共享共同物镜的一个或多个成像通道和具有光学对准机构的相应的一个或多个时间延迟积分型成像相机，其允许独立的通道间和通道内 四度调整：X，Y，旋转和刻度。 成像通道被配置为独立地检查生物化学阵列的图像的不同光谱。
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公开(公告)号：US20130096841A1
公开(公告)日：2013-04-18
申请号：US13649966
申请日：2012-10-11
Applicant: Complete Genomics, Inc.
Inventor： Bahram Ghaffarzadeh Kermani , Radoje Drmanac , Oleg Alferov
IPC: G06F17/18
CPC classification number: G06F19/22
Abstract: Various short reads can be grouped and identified as coming from a same long DNA fragment (e.g., by using wells with a relatively low-concentration of DNA). A histogram of the genomic coverage of a group of short reads can provide the edges of the corresponding long fragment (pulse). The knowledge of these pulses can provide an ability to determine the haploid genome and to identify structural variations.
Abstract translation: 可以将各种短读数分组并鉴定为来自相同的长DNA片段（例如，通过使用具有相对低浓度的DNA的孔）。 一组短读取的基因组覆盖的直方图可以提供对应的长片段（脉冲）的边缘。 这些脉冲的知识可以提供确定单倍体基因组并鉴定结构变化的能力。
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