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公开(公告)号：US08975074B2
公开(公告)日：2015-03-10
申请号：US11974798
申请日：2007-10-15
IPC分类号： C12N5/00 , C12N5/02 , C12N11/00 , C12N11/16 , A61K47/46 , A61K9/00 , A61K47/48 , A61L27/36 , A61L27/38 , C12N5/077 , A61K35/12
CPC分类号： A61K47/46 , A61K9/0024 , A61K47/48776 , A61K47/6901 , A61K2035/126 , A61L27/3608 , A61L27/3808 , B33Y80/00 , C12N5/0654 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
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82.发明授权Device for actively removing a target component from blood or lymph of a vertebrate subject 有权用于从脊椎动物受试者的血液或淋巴中主动去除靶组分的装置公开(公告)号：US08317737B2
公开(公告)日：2012-11-27
申请号：US12803449
申请日：2010-06-25
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
CPC分类号： A61M5/14276 , A61M5/1723
摘要： Devices, systems, and methods are disclosed herein for modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject for treatment of a disease or condition in the vertebrate subject. An implantable device is provided which includes a body defining at least one lumen configured for fluid flow; at least one first reservoir in communication with at least one lumen; one or more energy sources configured to provide energy to elicit one or more signal responses associated with one or more labels that bind to one or more target components in one or more of blood fluid or lymph fluid of the vertebrate subject; one or more sensors configured to detect the one or more signal responses associated with one or more labeled target components; and one or more reactive components in communication with the at least one lumen for release responsive to the one or more sensors.
摘要翻译： 本文公开的装置，系统和方法用于调节脊椎动物受试者的血液和/或淋巴中的一种或多种靶组分的水平以治疗脊椎动物受试者中的疾病或病症。 提供了一种可植入装置，其包括限定为流体流动配置的至少一个内腔的主体; 与至少一个内腔连通的至少一个第一储存器; 一个或多个能量源被配置为提供能量以引发与一个或多个与所述脊椎动物对象的一个或多个血液流体或淋巴液中的一个或多个目标成分结合的一个或多个标签相关联的一个或多个信号响应; 一个或多个传感器被配置为检测与一个或多个标记的目标分量相关联的一个或多个信号响应; 以及响应于所述一个或多个传感器而与所述至少一个内腔连通的一个或多个反应性部件用于释放。
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公开(公告)号：US08278094B2
公开(公告)日：2012-10-02
申请号：US11304499
申请日：2005-12-14
CPC分类号： A61K47/46 , A61K9/0024 , A61K47/48776 , A61K47/6901 , A61K2035/126 , A61L27/3608 , A61L27/3808 , B33Y80/00 , C12N5/0654 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
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公开(公告)号：US08198080B2
公开(公告)日：2012-06-12
申请号：US11304486
申请日：2005-12-14
CPC分类号： A61F2/00 , A61K9/0024 , A61K47/6901 , A61K2035/126 , A61L27/3608 , A61L27/3808 , B33Y80/00 , C12N5/0654 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
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公开(公告)号：US08053220B2
公开(公告)日：2011-11-08
申请号：US11451986
申请日：2006-06-12
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
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公开(公告)号：US08900865B2
公开(公告)日：2014-12-02
申请号：US11389268
申请日：2006-03-24
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
IPC分类号： C12N5/00 , C12N5/02 , C12N11/00 , C12N11/16 , A61F2/00 , A61L27/36 , C12N5/077 , A61K47/48 , C12N5/079 , A61L27/38 , A61K9/00 , A61K35/12
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
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87.发明授权公开(公告)号：US08551750B2
公开(公告)日：2013-10-08
申请号：US12462114
申请日：2009-07-28
申请人： Ed Harlow , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
发明人： Ed Harlow , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
IPC分类号： C12N11/00
CPC分类号： A61K39/00 , A61K39/0011 , A61K2039/5156 , A61K2039/555 , A61K2039/55533 , A61K2039/60 , A61K2039/6006 , A61L27/12 , A61L27/34 , A61L27/36 , A61L27/38 , B33Y80/00 , C12N11/00
摘要： Devices, methods, and systems are described for controlling pathogenic condition or disease in a subject. Devices are described that include one or more bone cages. The device including one or more bone cages can be configured to include one or more immunogens and one or more adjuvants. The device including one or more bone cages can be configured to, and/or structured to at least partially or completely surround one or more cells or tissues that produce one or more immunogens and/or one or more adjuvants. The device is useful in a method for treating a pathogenic condition or disease in the subject.
摘要翻译： 描述了用于控制受试者中的病原性病症或疾病的装置，方法和系统。 描述了包括一个或多个骨笼的装置。 包括一个或多个骨笼的装置可以被配置成包括一种或多种免疫原和一种或多种佐剂。 包括一个或多个骨笼的装置可被配置为和/或构造成至少部分地或完全地围绕产生一种或多种免疫原和/或一种或多种佐剂的一种或多种细胞或组织。 该装置可用于治疗受试者中的病原性病症或疾病的方法。
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公开(公告)号：US08304220B2
公开(公告)日：2012-11-06
申请号：US11974750
申请日：2007-10-15
CPC分类号： A61K47/46 , A61K9/0024 , A61K47/48776 , A61K47/6901 , A61K2035/126 , A61L27/3608 , A61L27/3808 , B33Y80/00 , C12N5/0654 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
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89.发明授权公开(公告)号：US08246565B2
公开(公告)日：2012-08-21
申请号：US12660926
申请日：2010-03-05
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
CPC分类号： A61B5/14503 , A61B18/18 , A61F2/82 , A61M1/00 , A61M1/362 , A61M1/3679 , A61M1/3681 , A61M1/3683 , A61M5/00 , A61M5/007 , A61M5/14276 , A61M2202/0405 , A61M2205/04 , A61N5/02 , A61N5/0601 , A61N5/062 , A61N7/00
摘要： Devices, systems, and methods are described herein for controlling or modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject. Devices and systems are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to fluid flow into the at least one lumen; at least one first reservoir disposed within the body and configured to include one or more bifunctional tags, wherein the one or more bifunctional tags are configured to selectively bind to one or more target components in one or more of blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; and at least one second reservoir disposed in the at least one treatment region and configured to include one or more reactive components, wherein the one or more reactive components are configured to sequester the one or more bifunctional tags when bound to the one or more target components.
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90.发明授权Device, system, and method for controllably reducing inflammatory mediators in a subject 有权用于可控地减少受试者中的炎性介质的装置，系统和方法公开(公告)号：US08192385B2
公开(公告)日：2012-06-05
申请号：US12455258
申请日：2009-05-28
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
CPC分类号： A61M1/30 , A61B18/042 , A61B18/1815 , A61B2018/1861 , A61M1/3679 , A61M1/3681 , A61M1/3683 , A61M1/3687 , A61M1/3689 , A61M5/14276 , A61M5/1723 , A61N5/02 , A61N5/062 , A61N7/02 , A61N2007/0039
摘要： Devices, systems, and methods are provided for controlling an inflammatory response in a subject. Devices, systems, and methods are provided that alter the functional structure of one or more inflammatory mediators in the peripheral blood of the subject. The device or system is useful in a method for treating an inflammatory disease or condition in the subject.
摘要翻译： 提供了用于控制受试者的炎症反应的装置，系统和方法。 提供了改变受试者外周血中一种或多种炎症介质的功能结构的装置，系统和方法。 该装置或系统可用于治疗受试者的炎性疾病或病症的方法。
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