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    METHOD AND APPARATUS FOR DETECTING AND COUNTING PLATELETS INDIVIDUALLY AND IN AGGREGATE CLUMPS
    84.
    发明申请
    METHOD AND APPARATUS FOR DETECTING AND COUNTING PLATELETS INDIVIDUALLY AND IN AGGREGATE CLUMPS 有权
    用于检测和计数平板电脑的方法和装置

    公开(公告)号：US20090238439A1

    公开(公告)日：2009-09-24

    申请号：US12408500

    申请日：2009-03-20

    申请人： Stephen C. Wardlaw ,  Robert A. Levine ,  Niten V. Lalpuria

    发明人： Stephen C. Wardlaw ,  Robert A. Levine ,  Niten V. Lalpuria

    IPC分类号： G06K9/00

    CPC分类号： G01N33/49 ,  G01N15/147 ,  G01N15/1475 ,  G01N2015/0076 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/0092 ,  G01N2015/1486

    摘要： A method for enumerating platelets within a blood sample is provided. The method includes the steps of: 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by a first panel and a second panel, both of which panels are transparent; 2) admixing a colorant with the sample, which colorant is operative to cause the platelets to fluoresce upon exposure to one or more predetermined first wavelengths of light; 3) illuminating at least a portion of the sample containing the platelets at the first wavelengths; 4) imaging the sample, including producing image signals indicative of fluorescent emissions from the platelets, which fluorescent emissions have an intensity; 5) identifying the platelets by their fluorescent emissions, using the image signals; 6) determining an average fluorescent emission intensity value for the individual platelets identified within the sample; 7) identifying clumps of platelets within the sample using one or more of their fluorescent emissions, area, shape, and granularity; and 8) enumerating platelets within each platelet clump using the average fluorescent emission intensity value determined for the individual platelets within the sample.

    摘要翻译： 提供了一种用于列举血液样品中的血小板的方法。 该方法包括以下步骤：1）将样品沉积到适于静态保持样品进行分析的分析室中，所述室由第一面板和第二面板限定，两个面板都是透明的; 2）将着色剂与所述样品混合，所述着色剂在暴露于一个或多个预定的第一波长的光时会使血小板发荧光; 3）以第一波长照射含有血小板的样品的至少一部分; 4）对样品进行成像，包括产生指示来自血小板的荧光发射的图像信号，该荧光发射具有强度; 5）使用图像信号通过荧光发射识别血小板; 6）确定样品内识别的各个血小板的平均荧光发射强度值; 7）使用其荧光发射，面积，形状和粒度中的一种或多种来鉴定样品中的血小板团块; 和8）使用为样品中的各个血小板确定的平均荧光发射强度值来列举每个血小板聚集体内的血小板。

    Method and apparatus for performing chemical, qualitative, quantitative, and semi-quantitative analyses of a urine sample
    86.
    发明授权
    Method and apparatus for performing chemical, qualitative, quantitative, and semi-quantitative analyses of a urine sample 有权
    用于对尿样进行化学，定性，定量和半定量分析的方法和装置

    公开(公告)号：US6004821A

    公开(公告)日：1999-12-21

    申请号：US236168

    申请日：1999-01-25

    申请人： Robert A. Levine ,  Stephen C. Wardlaw

    发明人： Robert A. Levine ,  Stephen C. Wardlaw

    IPC分类号： G01N33/48 ,  B01L3/00 ,  G01N33/493 ,  G01N33/50 ,  G01N33/52

    CPC分类号： G01N33/523 ,  B01L3/5027 ,  G01N33/493 ,  G01N33/5002 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2400/0481 ,  B01L2400/0611 ,  B01L3/50273 ,  Y10S436/808 ,  Y10S436/809 ,  Y10T436/25125 ,  Y10T436/25375

    摘要： A urine sample is analyzed for urine chemistry, formed bodies, and rare event evidence, all in a single sample container and under low power magnification. The sample container includes a urine sample receiving chamber which is connected to a urine chemistry chamber, to a formed body isolation chamber, and to a rare events detection chamber, so that the urine can flow from the receiving chamber to the other three chambers. The container may also include a sterile chamber for receiving an auxiliary portion of the urine which may be used for further analysis by the clinician if necessary. The chemistry chamber contains a miniaturized urine dip stick which is scanned by an optical scanning instrument for color emissions. The formed body isolation chamber can be precoated with one or more stains, and is formed with a plurality of different through plane thicknesses whereby smaller formed bodies will be isolated in the smaller thickness regions of the chamber which the larger formed bodies cannot enter. The scanning instrument will scan the isolation chamber and can identify formed bodies by their characteristic light wave emission properties which result from the formed bodies exposure to the stains. The formed bodies can also be morphologically examined in the isolation chamber. The rare event detection chamber will include a component which will absorb essentially all of the water in the urine thus concentrating formed bodies on a surface in the chamber. This chamber can also be provided with one or more stains which will differentially highlight any rare events noted in the chamber by the scanning instrument. Rare events such as casts can be detected in this chamber.

    摘要翻译： 分析尿液样品的尿液化学成分，成形体和罕见的事件证据，全部在单个样品容器中，在低功率放大下。 样品容器包括尿液接收室，尿液接收室连接到尿化学室，形成体隔离室，并且与稀有事件检测室相连，使得尿液可以从接收室流到另外的三个室。 容器还可以包括用于接收尿的辅助部分的无菌室，如果需要，其可以用于临床医生的进一步分析。 化学室包含一个小型化的尿液浸渍棒，由一个光学扫描仪扫描，用于颜色排放。 成型体隔离室可以预涂一个或多个污渍，并且形成有多个不同的通过平面厚度，从而较小的成形体将在较大的成形体不能进入的室的较小厚度区域中被隔离。 扫描仪器将扫描隔离室，并且可以通过其形成的物体暴露于污渍产生的特征性光波发射特性来识别成形体。 成型体也可以在隔离室中进行形态学检查。 罕见事件检测室将包括将吸收尿液中基本上所有的水的成分，从而将成形体集中在腔室的表面上。 该室还可以具有一个或多个污渍，其将通过扫描仪器差异地突出腔室中注明的罕见事件。 在这个房间里可以检测到诸如铸件的罕见事件。

    Method for differentiating the source of occult gastrointestinal bleeding
    87.
    发明授权
    Method for differentiating the source of occult gastrointestinal bleeding 失效
    用于区分隐匿性胃肠道出血的来源的方法

    公开(公告)号：US5064766A

    公开(公告)日：1991-11-12

    申请号：US423181

    申请日：1989-10-18

    申请人： Stephen C. Wardlaw ,  Robert A. Levine

    发明人： Stephen C. Wardlaw ,  Robert A. Levine

    IPC分类号： G01N33/72

    CPC分类号： G01N33/726 ,  G01N33/725 ,  Y10S435/805 ,  Y10T436/25125 ,  Y10T436/255

    摘要： The specification discloses a fecal occult blood test device capable of determining whether the blood found during the test originated in the upper or lower gastrointestinal track. A fecal sample is applied to a test medium charged to be differentially attractive to blood components originating in the upper and lower gastrointestinal track respectively. A solvent is applied to the test specimen to cause differential migration of the blood components and an indicator is then applied to indicate the presence of the blood components, if any.

    摘要翻译： 本说明书公开了一种能够确定测试期间发现的血液是否起源于上胃肠道或下胃肠道的粪便潜血检测装置。 将粪便样品应用于分别对源自上胃肠道和下胃肠道的血液成分具有差异吸引力的测试介质。 将溶剂施加到测试样品上以引起血液成分的差异迁移，然后施加指示剂以指示血液成分的存在（如果有的话）。

    Correction of material layer volume measurements
    88.
    发明授权
    Correction of material layer volume measurements 失效
    材料层体积测量的校正

    公开(公告)号：US4953975A

    公开(公告)日：1990-09-04

    申请号：US303125

    申请日：1989-01-30

    申请人： Robert A. Levine ,  Stephen C. Wardlaw

    发明人： Robert A. Levine ,  Stephen C. Wardlaw

    IPC分类号： B01L3/14

    CPC分类号： B01L3/50215

    摘要： Centrifuged material layer volume measurements are made in a transparent capillary tube containing an elongated float which expands the layers being measured. The extent of layer expansion will vary depending on the tube bore diameter and the float diameter. The tube bore diameter and float diameter for each tube/float pair are measured, and an indication of the difference between the two is marked on the tube. When the volume determinations are made, the measured difference between the tube bore diameter and the float diameter is taken into account before calculating actual layer volume malues.

    摘要翻译： 离心材料层体积测量是在含有细长浮子的透明毛细管中进行的，该细长的浮子膨胀所测量的层。 层膨胀的程度将根据管孔直径和浮子直径而变化。 测量每个管/浮子对的管孔直径和浮子直径，并在管上标出两者之间的差异指示。 当进行体积确定时，在计算实际层体积误差之前，考虑管孔直径和浮子直径之间的测量差。