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公开(公告)号：US08842208B2
公开(公告)日：2014-09-23
申请号：US13127242
申请日：2009-11-09
CPC分类号： G02B23/2423 , A61B1/00096 , A61B1/00172 , A61B1/07 , G02B23/2469 , G02B26/103
摘要： Optical probes are provided for miniature applications, e.g. medical inspections and procedures or in industrial inspections. The probe comprises an optical guide, a first lens system mounted on a distal end portion of the optical guide for focusing light from the optical guide, an actuator for displacing the distal end portion and the first lens system to enable optical scanning, and a second lens system fixed inside the probe to receive radiation from the first lens system. The second lens system is selected to enable a deflection of radiation from the first lens system in a direction corresponding to a direction of displacement of the first lens system by the actuator. The second lens system can be a cheap negative lens, and the invention is thereby particularly useful for increasing the field of view (FOV) of cheap, disposable optical probes.
摘要翻译： 提供光学探针用于微型应用，例如 医疗检查和程序或工业检查。 探针包括光导，安装在光导的远端部分上的第一透镜系统，用于聚焦来自光导的光;用于移位远端部分和第一透镜系统以使光学扫描的致动器，以及第二透镜系统 透镜系统固定在探头内部以接收来自第一透镜系统的辐射。 选择第二透镜系统以使得能够在与致动器的第一透镜系统的位移方向相对应的方向上偏转来自第一透镜系统的辐射。 第二透镜系统可以是便宜的负透镜，因此本发明特别有助于增加便宜的一次性光学探针的视野（FOV）。
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公开(公告)号：US20140200459A1
公开(公告)日：2014-07-17
申请号：US13995967
申请日：2011-12-22
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Rami Nachabe , Gerhardus Wilhelmus Lucassen , Adrien Emmanuel Desjardins , Theodoor Jacques Marie Ruers
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Rami Nachabe , Gerhardus Wilhelmus Lucassen , Adrien Emmanuel Desjardins , Theodoor Jacques Marie Ruers
CPC分类号： A61B5/0075 , A61B1/00 , A61B5/0084 , A61B5/4836 , A61B18/18 , G01N21/25
摘要： The present invention relates to an apparatus 100 and, a method and a computer program for determining a parameter indicative of a tissue type of an associated tissue 116. In particular, the invention relates to an apparatus 100 comprising a spectrometer 102, which spectrometer comprises a light source 104 and a detector 106, 108 arranged to measure an optical spectrum. This enables determination of a first parameter being indicative of a bile concentration. As the inventors of the present invention have made the insight that bile concentration may serve as a discriminative feature for different tissue types, the apparatus is arranged to determine a second parameter indicative of a tissue type based on a concentration of bile. According to a specific embodiment, the apparatus further comprises an interventional device 112.
摘要翻译： 本发明涉及一种用于确定指示相关组织116的组织类型的参数的装置100和方法和计算机程序。特别地，本发明涉及一种包括分光计102的装置100，该分光计包括： 光源104和被布置成测量光谱的检测器106,108。 这使得能够确定指示胆汁浓度的第一参数。 本发明的发明人已经认识到胆汁浓度可以用作不同组织类型的鉴别特征，该装置被设置为基于胆汁的浓度来确定指示组织类型的第二参数。 根据具体实施例，该装置还包括介入装置112。
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公开(公告)号：US08717654B2
公开(公告)日：2014-05-06
申请号：US13320601
申请日：2010-05-10
申请人： Cornelius Antonius Hezemans , Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Augustinus Laurentius Braun , Nenad Mihajlovic
发明人： Cornelius Antonius Hezemans , Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Augustinus Laurentius Braun , Nenad Mihajlovic
CPC分类号： A61B5/6848 , A61B5/0068 , A61B5/0084 , G02B21/0012 , G02B21/0036 , G02B23/2423 , G02B23/26 , G02B26/103
摘要： The present invention relates to an optical probe (1) suitable for miniature applications. An example application is a fiber-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system (9, 10) comprising drive coils (9) capable of displacing the distal end (3) of an optical guide (2) housed (4) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set-point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.
摘要翻译： 本发明涉及适合于微型应用的光学探头（1）。 一个示例应用是基于光纤的共聚焦微型显微镜。 光探头包括基于线圈的致动系统（9,10），其包括驱动线圈（9），该驱动线圈能够移动由光学探头容纳（4）的光导（2）的远端（3）。 探头利用反馈回路，通过驱动通过驱动线圈的电流驱动光导的位移和切断通过驱动线圈的电流之间的交替，并且当驱动电流被切断时，测量速度 光导的远端。 将测量的速度与设定点速度进行比较，并且如果检测到差异，则调节驱动电流以消除或至少降低该差异。
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公开(公告)号：US20130026367A1
公开(公告)日：2013-01-31
申请号：US13641229
申请日：2011-04-18
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Jeroen Jan Lambertus Horikx , Gerhardus Wilhelmus Lucassen , Rami Nachabe , Marjolein Van Der Voort
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Jeroen Jan Lambertus Horikx , Gerhardus Wilhelmus Lucassen , Rami Nachabe , Marjolein Van Der Voort
CPC分类号： A61B5/0059 , A61B5/4869 , G01N21/359
摘要： The present invention relates to an apparatus, a method and a computer program for determining a lipid-water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water-lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid-water ratio and scattering during an intervention.
摘要翻译： 本发明涉及一种用于确定样品的脂质 - 水比和散射参数的装置，方法和计算机程序。 具体地，本发明涉及一种包括光源和检测器的设备，其被布置成测量各种波长的光学参数，其中选择波长使得在两个波长处，水和脂质的吸收系数基本相同。 这使得能够确定散射参数。 在第三波长处的进一步测量使得能够测定水 - 油比。 根据具体实施例，光源和检测器相对于介入装置布置，以便能够在干预期间根据脂质 - 水比和散射来检查组织。
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85.发明申请RE-CALIBRATION OF PRE-RECORDED IMAGES DURING INTERVENTIONS USING A NEEDLE DEVICE 有权使用针头装置进行干预时预先记录的图像重新校准公开(公告)号：US20120059251A1
公开(公告)日：2012-03-08
申请号：US13321189
申请日：2010-05-07
CPC分类号： A61B8/0841 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6848 , A61B6/12 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61B17/34 , A61B17/3403 , A61B17/3417 , A61B2090/3614 , A61B2090/374 , A61B2090/376 , A61B2090/378 , A61B2090/3784
摘要： Re-calibration of pre-recorded images during interventions is proposed, utilizing an interventional system comprising an imaging device providing images of an object, a needle device, and a processing device. The needle device comprises a sensor for providing data corresponding to tissue properties. The processing device is adapted to perform an overlay registration of pre-recorded images and live images provided by the imaging device, utilizing the data from the sensor. Thus, the accuracy of an overlay of images is increased.
摘要翻译： 提出了在干预期间重新校准预先记录的图像，利用包括提供物体，针装置和处理装置的图像的成像装置的介入系统。 针装置包括用于提供对应于组织性质的数据的传感器。 处理装置适用于利用来自传感器的数据来执行由成像装置提供的预先记录的图像和实况图像的重叠登记。 因此，图像的重叠的精度增加。
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公开(公告)号：US20110211104A1
公开(公告)日：2011-09-01
申请号：US13127242
申请日：2009-11-09
CPC分类号： G02B23/2423 , A61B1/00096 , A61B1/00172 , A61B1/07 , G02B23/2469 , G02B26/103
摘要： The invention relates to optical probes for miniature applications, e.g. medical inspections and procedures or in industrial inspections, in particular a probe applying a confocal scanning-scanning endoscope. The probe comprises an optical guide (2), a first lens system mounted (4) on a distal end portion (2A) of the optical guide for focusing light from the optical guide, actuation means (6,7) for displacing the distal end portion and the first lens system to enable optical scanning, and a second lens system (9) fixed inside the probe to receive radiation from the first lens system. The second lens system is selected to enable a deflection of radiation from the first lens system in a direction corresponding to a direction of displacement of the first lens system by the actuation means. The second lens system can be a cheap negative lens, and the invention is thereby particularly useful for increasing the field of view (FOV) cheap, disposable optical probes.
摘要翻译： 本发明涉及用于微型应用的光学探针，例如， 医疗检查和程序或工业检查，特别是应用共焦扫描内窥镜的探头。 探针包括光导（2），第一透镜系统（4），其安装在光导的远端部分（2A）上，用于聚焦来自光导的光，致动装置（6,7）用于使远端 部分和第一透镜系统以实现光学扫描，以及第二透镜系统（9），其固定在探针内部以接收来自第一透镜系统的辐射。 第二透镜系统被选择为能够使第一透镜系统的辐射沿着与致动装置的第一透镜系统的位移方向相对应的方向偏转。 第二透镜系统可以是便宜的负透镜，因此本发明特别适用于增加视场（FOV）便宜的一次性光学探针。
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公开(公告)号：US20100214430A1
公开(公告)日：2010-08-26
申请号：US12678781
申请日：2008-07-23
CPC分类号： G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G02B21/16 , G02B21/244
摘要： The invention provides a method for imaging samples, at least comprising:—staining of a sample with a first marker material and with a second marker material;—utilizing the first marker material in a focusing step for focusing an imaging device with respect to the sample; and—utilizing the second marker material and the imaging device, which has been focused in the focusing step, in an imaging step to acquire an image of the sample. The invention also relates to a system for imaging samples.
摘要翻译： 本发明提供了一种用于成像样品的方法，至少包括： - 用第一标记材料和第二标记材料染色样品; - 在聚焦步骤中利用第一标记材料，用于相对于样品聚焦成像装置 ; 并且利用已经聚焦在聚焦步骤中的第二标记材料和成像装置在获取样本的图像的成像步骤中。 本发明还涉及用于成像样本的系统。
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公开(公告)号：US20100207015A1
公开(公告)日：2010-08-19
申请号：US12668905
申请日：2008-07-14
申请人： Waltherus Cornelis Jozef Bierhoff , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Nanad Mihajlovic
发明人： Waltherus Cornelis Jozef Bierhoff , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Nanad Mihajlovic
IPC分类号： G02B26/10
CPC分类号： G02B26/101 , A61B5/0062 , A61B5/0084
摘要： A fiber scanning system is provided comprising a housing (102) with a fiber (13), the fiber (13) comprising a fixed part and a free end, the fixed part being attached to a bottom of the housing (102) and the fiber (13) extending parallel to the wall of the housing (102). At least one electrical coil (12) is attached to the wall at a position in between the fixed part and the free end of the fiber (13), a winding of the electrical coil (12) being in a plane parallel to the fiber (13). A magnet (11) is attached to the fiber (13), such that the electrical coil (12) may induce a force on the magnet (11). The magnet (11) is attached to the fiber (13) at a position just before or after the electrical coil (12), a width of the magnet (11) being such that the magnet (11) extends over the electrical coil (12).
摘要翻译： 提供一种纤维扫描系统，其包括具有纤维（13）的壳体（102），所述纤维（13）包括固定部分和自由端，所述固定部分附接到所述壳体（102）的底部，并且所述纤维 （13）平行于壳体（102）的壁延伸。 至少一个电线圈（12）在所述固定部分和所述光纤（13）的所述自由端之间的位置处附接到所述壁，所述电线圈（12）的绕组处于与所述光纤平行的平面（ 13）。 磁体（11）附着在光纤（13）上，使得电线圈（12）可以在磁铁（11）上产生一个力。 磁体（11）在刚好在电线圈（12）之前或之后的位置处附接到光纤（13），磁体（11）的宽度使得磁体（11）在电线圈（12）上方延伸 ）。
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公开(公告)号：US20100094385A1
公开(公告)日：2010-04-15
申请号：US12440071
申请日：2007-09-20
IPC分类号： A61F7/00
CPC分类号： A61N5/06 , A61B2017/00084 , A61N2005/0636 , A61N2005/0645 , A61N2005/0652
摘要： An infrared radiant heating system for raising or maintaining a uniform core temperature of the body of a patient during surgery, substantially without affecting the temperature of the area surrounding the patient's body, comprising: infrared radiant heating means which in use is located in an unobtrusive position near the patient to provide radiant heat to the entire body or one or more parts of the body of the patient; and control means in communication with the heating means for controlling the intensity level and distribution of intensity of the radiant heat on the patient's body such that in use the skin temperature of the patient's body is raised or maintained within a predetermined range resulting in the uniform core body temperature, substantially without affecting the temperature of the area surrounding the patient's body.
摘要翻译： 一种红外辐射加热系统，用于在手术过程中提高或保持患者身体的均匀核心温度，基本上不影响患者身体周围区域的温度，包括：使用中的红外辐射加热装置位于不引人注目的位置 靠近患者以向患者的身体的整个身体或身体的一个或多个部分提供辐射热; 以及与加热装置通信的控制装置，用于控制患者身体上的辐射强度的强度水平和分布，使得在使用中，患者身体的皮肤温度升高或维持在预定范围内，从而产生均匀的芯 体温，基本上不影响患者身体周围区域的温度。
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90.发明申请SYSTEM, DEVICE, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR IN VIVO IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE 审中-公开系统，装置，方法，计算机可读介质，以及用于在解剖结构中进行组织成像的用途公开(公告)号：US20100056916A1
公开(公告)日：2010-03-04
申请号：US12515023
申请日：2007-11-16
申请人： Levinus Peter Bakker , Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark , Rene Van Den Ham , Bernardus Hendrikus Wilhelmus Hendriks , Ralf Hoffmann , Nijs Cornelis Van Der Vaart , Marjolein Van Der Voort
发明人： Levinus Peter Bakker , Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark , Rene Van Den Ham , Bernardus Hendrikus Wilhelmus Hendriks , Ralf Hoffmann , Nijs Cornelis Van Der Vaart , Marjolein Van Der Voort
CPC分类号： A61B5/0095 , A61B5/0035 , A61B5/0084 , A61B5/0086 , A61B8/12 , A61B8/4416
摘要： A system is provided that may be used for locating and diagnosing lesions in the human body in vivo. In some embodiments, once the exact position of a lesion is found, a biopsy may be taken from the lesion using e.g. ultra sound techniques for guidance of the biopsy needle. Use of the system drastically reduces the negative biopsy samples compared to currently used “blind sampling” techniques. This reduces patient discomfort and minimizes infections as the number of biopsy samples is reduced. A method and computer-readable medium is also provided.
摘要翻译： 提供了可用于在体内定位和诊断人体损伤的系统。 在一些实施例中，一旦发现病变的确切位置，可以使用例如病变从病变中取出活组织检查。 超声技术用于指导活检针。 与目前使用的“盲采”技术相比，使用该系统大大减少了活检样本的阴性。 随着活检样本的数量减少，这减少了患者的不适，并使感染最小化。 还提供了一种方法和计算机可读介质。
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