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公开(公告)号：US20190111088A1
公开(公告)日：2019-04-18
申请号：US16017064
申请日：2018-06-25
Applicant: Wake Forest University Health Sciences
Inventor： Sean V. Murphy , Aleksander Skardal , Anthony Atala
IPC: A61K35/50 , A61L27/48 , A61L27/36 , C12N5/00 , A61K47/42 , A61L27/52 , A61L27/34 , A61L26/00 , A61L15/40 , A61K47/36
Abstract: The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta. In certain embodiments, the composition comprises amniotic membrane powder or solubilized amniotic membrane (SAM). In some aspects, the composition is cell-free and rich in cytokines, extracellular matrix proteins, and other components that improve tissue regeneration. In one aspect, the composition is a hydrogel scaffold that comprises amniotic membrane. The present invention reduces contraction and improves blood vessel development in regenerating tissue.
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公开(公告)号：US20190022021A1
公开(公告)日：2019-01-24
申请号：US16142480
申请日：2018-09-26
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Benjamin C. Harrison , James J. Yoo , Anthony Atala
IPC: A61K9/70 , A61L27/58 , A61L27/44 , A61L26/00 , A61K31/77 , A61L15/26 , A61L15/18 , A61L15/64 , A61K38/00
Abstract: A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.
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83.发明申请公开(公告)号：US20190015558A1
公开(公告)日：2019-01-17
申请号：US16128273
申请日：2018-09-11
Applicant: Wake Forest University Health Sciences
Inventor： Hyunhee Ahn , Young Min Ju , Anthony Atala , Sang Jin Lee
CPC classification number: A61L27/507 , A61F2/06 , A61F2/062 , A61F2/07 , A61F2210/0076 , A61F2240/001 , A61L27/26 , A61L27/3808 , A61L27/3826 , C12N5/0691 , C12N2533/40 , C12N2533/54 , D01D5/0007 , C08L67/04 , C08L89/06
Abstract: Vascular scaffolds and methods of fabricating the same are disclosed for tissue engineering of vascular constructs. By combining electrospun matrices with cell sheet technologies, vascular constructs with more mature cell layers can be obtained for reconstruction of blood vessels, heart valves and the like. A engineered smooth muscle cell sheet, wrapped around an electrospun vascular scaffold, is able to provide a mature SMC layer that expresses strong cell-to-cell junction markers and contractile proteins. In addition, preconditioning of the cell sheet covered vascular scaffold maintained cell viability and infiltration into the scaffold.
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公开(公告)号：US10016464B2
公开(公告)日：2018-07-10
申请号：US14449867
申请日：2014-08-01
Applicant: Wake Forest University Health Sciences
Inventor： Sean V. Murphy , Aleksander Skardal , Anthony Atala
IPC: A61K35/50 , A61K47/42 , A61L27/52 , A61L27/34 , A61L27/48 , A61L15/40 , A61L26/00 , A61K47/36 , C12N5/00 , A61L27/36
Abstract: The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta. In certain embodiments, the composition comprises amniotic membrane powder or solubilized amniotic membrane (SAM). In some aspects, the composition is cell-free and rich in cytokines, extracellular matrix proteins, and other components that improve tissue regeneration. In one aspect, the composition is a hydrogel scaffold that comprises amniotic membrane. The present invention reduces contraction and improves blood vessel development in regenerating tissue.
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公开(公告)号：US20180140678A1
公开(公告)日：2018-05-24
申请号：US15640063
申请日：2017-06-30
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： James Yoo , Sang Jin Lee , Anthony Atala , Mark Van Dyke
CPC classification number: A61K38/39 , A61K9/0024 , A61K38/4886 , A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/41 , A61L2300/434 , A61L2400/06 , A61L2430/26 , A61K2300/00
Abstract: The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.
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Patent Agency Ranking
公开(公告)号：US09962466B2
公开(公告)日：2018-05-08
申请号：US15159219
申请日：2016-05-19
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Anthony Atala , James Yoo , In Kap Ko
IPC: C12N5/077 , A61L27/36 , A61K35/34 , A61K45/06 , A61K47/34 , A61K47/42 , A61K38/18 , A61L27/18 , A61L27/24 , A61L27/38 , A61L27/54 , C12N5/00 , A61K9/00
CPC classification number: A61L27/3604 , A61K9/0034 , A61K35/34 , A61K38/18 , A61K45/06 , A61K47/34 , A61K47/42 , A61L27/18 , A61L27/24 , A61L27/3683 , A61L27/3687 , A61L27/3834 , A61L27/54 , A61L2300/414 , A61L2400/06 , A61L2430/30 , C12N5/0062 , C12N5/0659 , C12N2513/00 , C12N2533/30 , C12N2533/54 , A61K2300/00 , C08L67/04
Abstract: The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers that are oriented along native muscle. The implanted muscle cells integrate with native vascular and neural network, as confirmed by histology and immunohistochemistry. This invention is particularly advantageous because autologous muscle can be harvested from a donor site, processed and injected into target sites in the operating room. The fragmented muscle fibers can be readily integrated within the host.
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公开(公告)号：US20170368743A1
公开(公告)日：2017-12-28
申请号：US15672885
申请日：2017-08-09
Applicant: Wake Forest University Health Sciences
Inventor： Hyun-Wook Kang , Sang Jin Lee , Anthony Atala , James J. Yoo
IPC: B29C64/112 , A61L27/26 , A61L27/38 , B29C64/393 , A61L27/52 , A61L27/20 , A61L27/22 , B33Y80/00 , B33Y70/00 , B33Y30/00 , A61K35/12 , B29K105/00 , B29L31/00 , C12M3/00 , B33Y10/00 , C12M1/26 , C12M1/00
CPC classification number: B29C64/112 , A61K35/12 , A61L27/20 , A61L27/222 , A61L27/225 , A61L27/26 , A61L27/38 , A61L27/52 , B29C64/124 , B29C64/386 , B29C64/393 , B29K2105/0005 , B29K2267/04 , B29L2031/7532 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B33Y80/00 , C12M21/08 , C12M23/50 , C12M33/00 , C08L5/08
Abstract: A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.
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公开(公告)号：US20170333177A1
公开(公告)日：2017-11-23
申请号：US15667986
申请日：2017-08-03
Applicant: Wake Forest University Health Sciences
Inventor： James Yoo , Joel D. Stitzel, JR. , Anthony Atala , George Christ
CPC classification number: A61F2/08 , A61F2002/0894 , A61L27/3604 , A61L27/367 , A61L27/3683 , A61L27/3691 , A61L27/3826 , A61L27/3895 , A61L2430/30 , A61L2430/34 , C12M21/08 , C12M35/04 , C12N5/0658 , C12N2527/00 , C12N2539/00
Abstract: A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically stretching and relaxing the support at least twice along a first axis during a first time period; and then (c) optionally but preferably maintaining the support in a substantially static position during a second time period; and then (d) repeating steps (b) and (c) for a number of times sufficient to enhance the functionality of the tissue formed on the support and/or produce organized skeletal muscle tissue on the solid support from the precursor muscle cells.
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公开(公告)号：US09764516B2
公开(公告)日：2017-09-19
申请号：US14476359
申请日：2014-09-03
Applicant: Wake Forest University Health Sciences
Inventor： Hyun-Wook Kang , Sang Jin Lee , Anthony Atala , James J. Yoo
IPC: C12N5/00 , C12N5/02 , A61F13/00 , B29C67/00 , A61L27/20 , A61L27/22 , A61L27/38 , A61L27/52 , A61L27/26 , A61K35/12 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B33Y80/00 , B29K105/00 , B29L31/00 , C12M3/00 , C12M1/00 , C12M1/26
CPC classification number: B29C64/112 , A61K35/12 , A61L27/20 , A61L27/222 , A61L27/225 , A61L27/26 , A61L27/38 , A61L27/52 , B29C64/124 , B29C64/386 , B29C64/393 , B29K2105/0005 , B29K2267/04 , B29L2031/7532 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B33Y80/00 , C12M21/08 , C12M23/50 , C12M33/00 , C08L5/08
Abstract: A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.
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公开(公告)号：US09763986B2
公开(公告)日：2017-09-19
申请号：US15014536
申请日：2016-02-03
Applicant: Wake Forest University Health Sciences
Inventor： Emmanuel Opara , James J. Yoo , Justin M. Saul , Sittadjody Sivanandane , Anthony Atala
IPC: C12N5/07 , C12N5/00 , C12N5/02 , C12N5/071 , A61K35/54 , A61K31/565 , A61K31/57 , A61K9/16 , A61K9/50
CPC classification number: A61K35/54 , A61K9/167 , A61K9/5036 , A61K9/5073 , A61K31/565 , A61K31/57 , A61K2300/00
Abstract: A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the granulosa cells and the theca cells are contained in separate microcapsules in the composition; in some embodiments, the granulosa cells and the theca cells are contained together in the same microcapsules in the composition The composition is can be used for estrogen, and optionally also progesterone, delivery, and hence is preferably free or essentially free of oocytes. Methods of using the same and pharmaceutical formulations containing the same are also described.
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