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公开(公告)号:US10441205B2
公开(公告)日:2019-10-15
申请号:US15191434
申请日:2016-06-23
IPC分类号: A61B5/15 , A61B5/155 , A61B5/145 , A61B5/1486 , A61B5/151 , A61B5/00 , G01N21/03 , A61B5/157 , A61B5/1468 , G01N1/14 , G01N21/77 , G01N27/416
摘要: An arrangement includes a housing, a plurality of sampling and analysis sites contained within the housing, each of the sampling and analysis sites having a skin-penetration member having a first end configured to pierce the skin, and an inner lumen in communication with the first end, an actuator operatively associated with the skin-penetration member, and an analyte quantification member in fluid communication with the inner lumen of the skin-penetration member. Integrated devices including such arrangements are also described.
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公开(公告)号:US09897610B2
公开(公告)日:2018-02-20
申请号:US14557327
申请日:2014-12-01
发明人: Kelley J. Lipman , Michael F. Tomasco , Peter Uy-Vu Ly , Jennifer Y. Blomo , Paul D. Reynolds , John F. Larkin , Robin S. Gaffney , Kimberly J. Tansey , Christopher L. Stewart , Raúl Escutia , Robert W. Bowers
IPC分类号: G01N33/66 , G01N33/96 , A61B5/1495 , B01L3/00 , G01N21/78 , G06F19/00 , A61B5/145 , G01N27/327 , G01N33/487
CPC分类号: G01N33/66 , A61B5/14532 , A61B5/1495 , A61B2560/0223 , A61B2562/08 , B01L3/523 , B01L2200/148 , B01L2300/022 , B01L2300/123 , B01L2400/0481 , B01L2400/0683 , G01N21/78 , G01N27/3273 , G01N27/3274 , G01N33/48785 , G01N33/96 , G01N2201/12707 , G01N2496/80 , G06F19/00 , G16H10/40 , G16H40/63 , Y10T436/10 , Y10T436/107497
摘要: A device includes: a first portion configured to be grasped by the hand of the user, and a second portion defining a reservoir containing a control material, wherein the control material contains a target analyte in a known or predetermined concentration. Methods for verifying the accuracy of an analyte monitoring device include receiving control information from a test cartridge, transporting control material to an analysis site, determining the presence of the control material, analyzing the control material, and providing a pass or fail signal.
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公开(公告)号:US09839384B2
公开(公告)日:2017-12-12
申请号:US14743867
申请日:2015-06-18
IPC分类号: A61B5/151 , A61B5/15 , A61B5/157 , A61B5/155 , A61B5/145 , A61B5/1486 , A61B5/00 , G01N21/03 , A61B5/1468 , G01N1/14 , G01N21/77 , G01N27/416
CPC分类号: A61B5/150984 , A61B5/1411 , A61B5/1427 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150099 , A61B5/150167 , A61B5/150229 , A61B5/150343 , A61B5/150389 , A61B5/150396 , A61B5/150412 , A61B5/150946 , A61B5/150954 , A61B5/150969 , A61B5/151 , A61B5/15111 , A61B5/15113 , A61B5/15117 , A61B5/15121 , A61B5/15123 , A61B5/15146 , A61B5/15148 , A61B5/15151 , A61B5/15161 , A61B5/15163 , A61B5/15186 , A61B5/155 , A61B5/157 , A61B5/681 , A61B5/6824 , A61B5/6828 , A61B2560/0443 , A61B2560/0462 , G01N1/14 , G01N21/0303 , G01N21/77 , G01N27/416
摘要: An arrangement for producing a sample of body fluid from an opening created in a skin surface at a sampling site including a cartridge with a plurality of compartments and a plurality of sampling sites, and a detector assembly. Each sampling site includes a skin-penetration member having a first end configured to pierce the surface of the skin and an inner lumen in communication with the first end, a spring actuator operatively associated with the skin-penetration member, and a needle hub connecting the skin-penetration member and the spring actuator. The needle hub includes a reagent pad and the spring actuator is configured to drive the skin-penetration member to form the wound opening. Each compartment at least partially encloses the skin-penetration member, the spring actuator, and the needle hub of a respective sampling site.
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公开(公告)号:US09782114B2
公开(公告)日:2017-10-10
申请号:US13566886
申请日:2012-08-03
申请人: Paul D. Reynolds , Raul Escutia , John F. Larkin , Charles Hu , Michael F. Tomasco , Daniel R. Bloom , Joseph A. Vivolo , Richard M. Wiard
发明人: Paul D. Reynolds , Raul Escutia , John F. Larkin , Charles Hu , Michael F. Tomasco , Daniel R. Bloom , Joseph A. Vivolo , Richard M. Wiard
IPC分类号: A61B5/1455 , A61B5/157 , A61B5/00 , A61B5/151 , A61B5/145 , G01N15/06 , G01N21/03 , G01N33/487 , G01N21/78 , A61B5/15
CPC分类号: A61B5/157 , A61B5/14507 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/150022 , A61B5/150068 , A61B5/150083 , A61B5/150099 , A61B5/150114 , A61B5/150183 , A61B5/150305 , A61B5/150358 , A61B5/150389 , A61B5/150419 , A61B5/150519 , A61B5/150572 , A61B5/150755 , A61B5/150786 , A61B5/150809 , A61B5/150816 , A61B5/150824 , A61B5/150984 , A61B5/15109 , A61B5/15111 , A61B5/15113 , A61B5/15117 , A61B5/15151 , A61B5/15161 , A61B5/15163 , A61B5/15176 , A61B5/15182 , A61B5/742 , A61B2562/0295 , G01N15/0612 , G01N21/03 , G01N21/78 , G01N33/487
摘要: Described here are meters and methods for sampling, transporting, and/or analyzing a fluid sample. The meters may include a meter housing and a cartridge. In some instances, the meter may include a tower which may engage one or more portions of a cartridge. The meter housing may include an imaging system, which may or may not be included in the tower. The cartridge may include one or more sampling arrangements, which may be configured to collect a fluid sample from a sampling site. A sampling arrangement may include a skin-penetration member, a hub, and a quantification member.
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公开(公告)号:US09603562B2
公开(公告)日:2017-03-28
申请号:US13669366
申请日:2012-11-05
发明人: John Gregory Aceti , Sterling Eduard McBride , Richard Morgan Moroney, III , Christopher Carter Gregory , Peter John Zanzucchi
IPC分类号: A61B5/15 , A61B5/157 , A61B5/145 , A61B5/1455 , A61B5/151 , A61B5/00 , A61M37/00 , G01N33/49 , A61B5/155
CPC分类号: A61B5/150984 , A61B5/1411 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/150022 , A61B5/150076 , A61B5/150213 , A61B5/150389 , A61B5/150503 , A61B5/150526 , A61B5/150755 , A61B5/15087 , A61B5/150969 , A61B5/15109 , A61B5/15119 , A61B5/15123 , A61B5/15146 , A61B5/15153 , A61B5/15163 , A61B5/155 , A61B5/157 , A61B5/681 , A61B5/6833 , A61B2560/0412 , A61B2560/0443 , A61M37/0015 , A61M2037/0023 , A61M2037/0038 , A61M2209/088 , A61M2230/201 , G01N33/491
摘要: The invention relates to analyte monitoring/drug delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The invention can optionally provide for calibration without intervention of the user and can also provide for semi-continuous monitoring for day and night time. The invention can provide up to four, or more, weeks of operation. The invention can provide for a device that is relatively small in size, and therefore unobtrusive. The invention can also provide for device with remote control and interactive electronics. The invention may be also used for the delivery of various pharmaceutical agents.
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公开(公告)号:US08372015B2
公开(公告)日:2013-02-12
申请号:US11510784
申请日:2006-08-28
申请人: Raul Escutia , Jeffrey L. Emery , Craig M. Litherland , Jeffrey M. Jones , Gregory C. Loney , Michael F. Tomasco
发明人: Raul Escutia , Jeffrey L. Emery , Craig M. Litherland , Jeffrey M. Jones , Gregory C. Loney , Michael F. Tomasco
CPC分类号: A61B5/1411 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150358 , A61B5/150389 , A61B5/150503 , A61B5/150748 , A61B5/15109 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15125 , A61B5/15151 , A61B5/15161 , A61B5/157
摘要: An integrated monitoring and body fluid sampling device constructed to permit digital as well as alternate-site body fluid sampling and analysis, the device comprising: a housing; at least one skin-penetration member; and a member constructed for the application of circumferential or vacuum pressure to an appendage; wherein the member is detachably or retractably connected to the housing in a manner such that the integrated monitoring and body fluid sampling device can perform digital or alternate-site body fluid sampling and analysis. Additional arrangements and techniques are also described.
摘要翻译: 一种综合监测和体液采样装置,其被构造成允许数字和备用体液采样和分析,所述装置包括:壳体; 至少一个皮肤穿透部件; 以及为了向附属物施加周向或真空压力而构造的构件; 其中所述构件以使得所述综合监测和体液采样装置可以执行数字或替代站点体液采样和分析的方式可拆卸地或可缩回地连接到所述壳体。 还描述了附加的布置和技术。
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公开(公告)号:US20100010374A1
公开(公告)日:2010-01-14
申请号:US12457085
申请日:2009-06-01
申请人: Rául Escutia , Craig M. Litherland , Jeffrey L. Emery , Jeffrey M. Jones , Michael F. Tomasco , Kelley J. Lipman
发明人: Rául Escutia , Craig M. Litherland , Jeffrey L. Emery , Jeffrey M. Jones , Michael F. Tomasco , Kelley J. Lipman
IPC分类号: A61B5/00
CPC分类号: A61B5/150832 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150091 , A61B5/150099 , A61B5/150183 , A61B5/150229 , A61B5/150259 , A61B5/150267 , A61B5/150274 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150748 , A61B5/150809 , A61B5/150816 , A61B5/150824 , A61B5/150954 , A61B5/150984 , A61B5/15107 , A61B5/15109 , A61B5/15117 , A61B5/15151 , A61B5/15161 , A61B5/157 , A61M5/422
摘要: An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site includes: a housing, the housing comprising a first opening; a skin interface member disposed in the first opening, the skin interface member comprising an inner member having a second opening, and an outer member at least partially surrounding the inner member and attached to the first opening; and at least one skin-penetration member configured and arranged to project within the second opening. Arrangements having alternatively constructed skin interface members are also described.
摘要翻译: 用于从采样部位的皮肤表面产生的伤口开口产生体液样本的装置包括:壳体,壳体包括第一开口; 设置在所述第一开口中的皮肤界面构件,所述皮肤界面构件包括具有第二开口的内部构件和至少部分地围绕所述内部构件并附接到所述第一开口的外部构件; 以及至少一个皮肤穿透构件,其被构造和布置成在所述第二开口内突出。 还描述了替代地构造的皮肤界面构件的布置。
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公开(公告)号:US07585278B2
公开(公告)日:2009-09-08
申请号:US10722074
申请日:2003-11-24
申请人: John Gregory Aceti , Zvi Gerald Lowey , Richard Morgan Moroney , Christopher Carter Gregory , Peter John Zanzucchi
发明人: John Gregory Aceti , Zvi Gerald Lowey , Richard Morgan Moroney , Christopher Carter Gregory , Peter John Zanzucchi
IPC分类号: A61B5/00
CPC分类号: A61B5/157 , A61B5/14532 , A61B5/1455 , A61B5/1486 , A61B5/150022 , A61B5/150229 , A61B5/150389 , A61B5/150473 , A61B5/150511 , A61B5/150755 , A61B5/15117 , A61B5/15123 , A61B5/15146 , A61B5/15153 , A61B5/15163 , G06F19/00
摘要: Provided is an analyte monitoring device having a housing, the device comprising: a plurality of needles, each having a tip, a retracted position, a position wherein the tip is extended from the housing a distance adapted to pierce skin; an electrically or spring powered needle pushing apparatus movable to separately engage each of the needles to move each from the retracted position to the extended position; an energy source located within the housing; a plurality of analysis sites comprising an analysis preparation, each adapted to receive liquid from the needles to wet the analysis preparation; one or more light sources adapted to direct light at the analysis sites; one or more light detectors adapted to receive light from the analysis sites; and a processor.
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公开(公告)号:US20210307662A1
公开(公告)日:2021-10-07
申请号:US17099697
申请日:2020-11-16
IPC分类号: A61B5/15 , A61B5/151 , A61B5/155 , A61B5/145 , A61B5/1486 , A61B5/00 , G01N21/03 , A61B5/157 , A61B5/1468 , G01N1/14 , G01N21/77 , G01N27/416
摘要: An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site includes at least one skin-penetration member having a first end configured to pierce the surface of the skin, and a inner lumen in communication with the first end; at least one actuator operatively associated with the at least one skin-penetration member; and at least one catalyst device configured to cause perfusion of body fluid at the sampling site; wherein the at least one actuator is configured to locate the at least one skin-penetration member so as to obstruct the wound opening while transporting body fluid through the inner lumen. Associated methods are also described.
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公开(公告)号:US11051734B2
公开(公告)日:2021-07-06
申请号:US15697311
申请日:2017-09-06
发明人: Raul Escutia , Daniel R. Bloom , Charles Hu , Paul D. Reynolds , Joseph A. Vivolo , Michael F. Tomasco
IPC分类号: A61B5/1455 , A61B5/157 , G01N15/06 , G01N21/03 , G01N33/487 , G01N21/78 , A61B5/15 , A61B5/151 , A61B5/145 , A61B5/00 , G01N21/00
摘要: Described here are meters and methods for sampling, transporting, and/or analyzing a fluid sample. The meters may include a meter housing and a cartridge. In some instances, the meter may include a tower which may engage one or more portions of a cartridge. The meter housing may include an imaging system, which may or may not be included in the tower. The cartridge may include one or more sampling arrangements, which may be configured to collect a fluid sample from a sampling site. A sampling arrangement may include a skin-penetration member, a hub, and a quantification member.
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