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公开(公告)号：US08617905B2
公开(公告)日：2013-12-31
申请号：US13311087
申请日：2011-12-05
申请人： Mark A. Burns , Brian N. Johnson , Michael Chen
发明人： Mark A. Burns , Brian N. Johnson , Michael Chen
IPC分类号： B01L3/00
CPC分类号： F16K99/0061 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00828 , B01J2219/00831 , B01J2219/00837 , B01J2219/00853 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00957 , B01J2219/00961 , B01J2219/0097 , B01L3/502738 , B01L7/52 , B01L2300/0816 , B01L2300/1827 , B01L2400/0487 , B01L2400/0677 , F16K99/0001 , F16K99/0015 , F16K99/0034 , F16K2099/0071 , F16K2099/0074 , F16K2099/0076 , F16K2099/0084 , Y10T436/2575
摘要： The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.
摘要翻译： 使用硅微量元件描述了通过微通道的微滴的运动和混合，包括微滴输送通道，反应区域，电泳模块和辐射探测器。 离散的液滴通过蚀刻通道进行差分加热和推进。 电子元件制造在相同的基板材料上，允许将传感器和控制电路并入同一设备。
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公开(公告)号：US08071056B2
公开(公告)日：2011-12-06
申请号：US11119539
申请日：2005-04-29
申请人： Mark A. Burns , Brian N. Johnson , Michael Chen
发明人： Mark A. Burns , Brian N. Johnson , Michael Chen
IPC分类号： B01L99/00
CPC分类号： B01F13/0071 , B01F5/0085 , B01F5/0403 , B01F13/0072 , B01F13/0084 , B01F13/0093 , B01F15/0232 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00828 , B01J2219/00831 , B01J2219/00837 , B01J2219/00853 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00957 , B01J2219/00961 , B01J2219/0097 , B01L3/50273 , B01L3/502738 , B01L3/502784 , B01L7/52 , B01L2200/0605 , B01L2300/0816 , B01L2300/1827 , B01L2400/0442 , B01L2400/0487 , B01L2400/0677 , B01L2400/0688 , B01L2400/0694 , B82Y30/00 , F15B13/0807 , F15C5/00 , F16K99/0001 , F16K99/0015 , F16K99/0017 , F16K99/0019 , F16K99/0034 , F16K99/0044 , F16K99/0061 , F16K2099/0071 , F16K2099/0074 , F16K2099/0076 , F16K2099/008 , F16K2099/0084 , Y10S366/04 , Y10T137/1812 , Y10T436/2575
摘要： The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.
摘要翻译： 使用硅微量元件描述了通过微通道的微滴的运动和混合，包括微滴输送通道，反应区域，电泳模块和辐射探测器。 离散的液滴通过蚀刻通道进行差分加热和推进。 电子元件制造在相同的基板材料上，允许将传感器和控制电路并入同一设备。
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公开(公告)号：US20100258211A1
公开(公告)日：2010-10-14
申请号：US12731964
申请日：2010-03-25
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/502707 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2200/0689 , B29C65/1406 , B29C65/1412 , B29C65/48 , B29C65/4835 , B29C65/4845 , B29C65/485 , B29C65/4865 , B29C65/56 , B29C66/223 , B29C66/2274 , B29C66/2276 , B29C66/543 , B29C66/71 , B29C66/73161 , B29K2021/00 , B29K2083/00 , B29L2031/756 , B81B1/00 , B81B2201/058 , Y10T137/2224 , Y10T137/5196 , Y10T137/5283 , Y10T137/87885
摘要： A modular microfluidic system comprising a base substrate, a plurality of microfluidic assembly blocks, and an adhesive component is provided. Each individual microfluidic assembly block defines a channel and has a sidewall defining an aperture into the channel. When the plurality of microfluidic assembly blocks are arranged on the base substrate, the aperture into the channel of one microfluidic assembly block aligns with the aperture of another microfluidic assembly block with the channels thereof connected along a plane parallel to the base substrate thereby forming a channel network defined by the plurality of microfluidic assembly blocks. The subject invention also provides a method of assembling a microfluidic device. The method comprising the steps of providing the base substrate, providing the plurality of microfluidic assembly blocks, and arranging the plurality of microfluidic assembly blocks on the base substrate.
摘要翻译： 提供了包括基底基板，多个微流体组装块和粘合剂部件的模块化微流体系统。 每个单独的微流体组装块限定通道并且具有限定通道的孔的侧壁。 当多个微流体组装块被布置在基底衬底上时，一个微流体组装块的通道中的孔与另一个微流体组装块的孔对准，其通道沿着平行于基底衬底的平面连接，从而形成通道 网络由多个微流体组装块限定。 本发明还提供了组装微流体装置的方法。 该方法包括以下步骤：提供基底，提供多个微流体组装块，以及将多个微流体组装块布置在基底基底上。
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公开(公告)号：US06379929B1
公开(公告)日：2002-04-30
申请号：US08974738
申请日：1997-11-19
IPC分类号： C12P1934
CPC分类号： B82Y30/00 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00853 , B01J2219/00871 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00912 , B01J2219/00952 , B01J2219/00961 , B01J2219/00986 , B01J2219/00995 , B01L3/5027 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L7/52 , B01L7/54 , B01L2200/0605 , B01L2200/10 , B01L2200/12 , B01L2300/0861 , B01L2300/0887 , B01L2300/163 , B01L2300/165 , B01L2300/1805 , B01L2400/0406 , B01L2400/0442 , B01L2400/0448 , B01L2400/0677 , B01L2400/0688 , C12Q1/6844
摘要： Disclosed are methods and compositions for isothermal amplification of nucleic acids in a microfabricated substrate. Methods and compositions for the analysis of isothermally amplified nucleic acids in a microfabricated substrate are disclosed as well. The microfabricated substrates and isothermal amplification and detection methods provided are envisioned for use in various diagnostic methods, particularly those connected with diseases characterized by altered gene sequences or gene expression.
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公开(公告)号：US06949385B1
公开(公告)日：2005-09-27
申请号：US09517680
申请日：2000-03-02
申请人： Mark A. Burns , Brian N. Johnson , Michael Chen
发明人： Mark A. Burns , Brian N. Johnson , Michael Chen
IPC分类号： B81B3/00 , B01F5/04 , B01F13/00 , B01J19/00 , B01L3/00 , B01L7/00 , B81C1/00 , C12M1/34 , C12Q1/68 , F15B13/00 , F15B13/08 , F15C5/00 , F16K31/02 , F16K31/64 , F16K99/00 , G01N37/00 , H01L27/14 , B01L11/00
CPC分类号： B01F13/0071 , B01F5/0085 , B01F5/0403 , B01F13/0072 , B01F13/0084 , B01F13/0093 , B01F15/0232 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00828 , B01J2219/00831 , B01J2219/00837 , B01J2219/00853 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00957 , B01J2219/00961 , B01J2219/0097 , B01L3/50273 , B01L3/502738 , B01L3/502784 , B01L7/52 , B01L2200/0605 , B01L2300/0816 , B01L2300/1827 , B01L2400/0442 , B01L2400/0487 , B01L2400/0677 , B01L2400/0688 , B01L2400/0694 , B82Y30/00 , F15B13/0807 , F15C5/00 , F16K99/0001 , F16K99/0015 , F16K99/0017 , F16K99/0019 , F16K99/0034 , F16K99/0044 , F16K99/0061 , F16K2099/0071 , F16K2099/0074 , F16K2099/0076 , F16K2099/008 , F16K2099/0084 , Y10S366/04 , Y10T137/1812 , Y10T436/2575
摘要： The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.
摘要翻译： 使用硅微量元件描述了通过微通道的微滴的运动和混合，包括微滴输送通道，反应区域，电泳模块和辐射探测器。 离散的液滴通过蚀刻通道进行差分加热和推进。 电子元件制造在相同的基板材料上，允许将传感器和控制电路并入同一设备。
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公开(公告)号：US08573259B2
公开(公告)日：2013-11-05
申请号：US12731964
申请日：2010-03-25
IPC分类号： F15C1/06
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01L3/502707 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2200/0689 , B29C65/1406 , B29C65/1412 , B29C65/48 , B29C65/4835 , B29C65/4845 , B29C65/485 , B29C65/4865 , B29C65/56 , B29C66/223 , B29C66/2274 , B29C66/2276 , B29C66/543 , B29C66/71 , B29C66/73161 , B29K2021/00 , B29K2083/00 , B29L2031/756 , B81B1/00 , B81B2201/058 , Y10T137/2224 , Y10T137/5196 , Y10T137/5283 , Y10T137/87885
摘要： A modular microfluidic system comprising a base substrate, a plurality of microfluidic assembly blocks, and an adhesive component is provided. Each individual microfluidic assembly block defines a channel and has a sidewall defining an aperture into the channel. When the plurality of microfluidic assembly blocks are arranged on the base substrate, the aperture into the channel of one microfluidic assembly block aligns with the aperture of another microfluidic assembly block with the channels thereof connected along a plane parallel to the base substrate thereby forming a channel network defined by the plurality of microfluidic assembly blocks. The subject invention also provides a method of assembling a microfluidic device. The method comprising the steps of providing the base substrate, providing the plurality of microfluidic assembly blocks, and arranging the plurality of microfluidic assembly blocks on the base substrate.
摘要翻译： 提供了包括基底基板，多个微流体组装块和粘合剂部件的模块化微流体系统。 每个单独的微流体组装块限定通道并且具有限定通道的孔的侧壁。 当多个微流体组装块被布置在基底衬底上时，一个微流体组装块的通道中的孔与另一个微流体组装块的孔对准，其通道沿着平行于基底衬底的平面连接，从而形成通道 网络由多个微流体组装块限定。 本发明还提供了组装微流体装置的方法。 该方法包括以下步骤：提供基底，提供多个微流体组装块，以及将多个微流体组装块布置在基底基底上。
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公开(公告)号：US06271021B1
公开(公告)日：2001-08-07
申请号：US09271963
申请日：1999-03-18
申请人： Mark A. Burns , Carlos H. Mastrangelo , Timothy S. Sammarco , Francis P. Man , James R. Webster , Brian N. Johnson , Bradley Foerster , Darren Jones
发明人： Mark A. Burns , Carlos H. Mastrangelo , Timothy S. Sammarco , Francis P. Man , James R. Webster , Brian N. Johnson , Bradley Foerster , Darren Jones
IPC分类号： C12M134
CPC分类号： B01F13/0072 , B01F5/0085 , B01F5/0403 , B01F13/0071 , B01F13/0084 , B01F13/0093 , B01F15/0232 , F15B13/0807 , F15C5/00 , F16K99/0001 , F16K99/0017 , F16K99/0019 , F16K99/0028 , F16K99/0036 , F16K99/0044 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G05D23/1917 , Y10T436/143333
摘要： The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.
摘要翻译： 使用硅微量元件描述了通过微通道的微滴的运动和混合，包括微滴输送通道，反应区域，电泳模块和辐射探测器。 离散的液滴通过蚀刻通道进行差分加热和推进。 电子元件制造在相同的基板材料上，允许将传感器和控制电路并入同一设备。
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公开(公告)号：US6057149A
公开(公告)日：2000-05-02
申请号：US529293
申请日：1995-09-15
申请人： Mark A. Burns , Carlos H. Mastrangelo , Timothy S. Sammarco , Francis P. Man , James R. Webster , Brian N. Johnson , Bradley Foerster , Darren Jones , Yakeitha Fields , Adam Kaiser , David T. Burke
发明人： Mark A. Burns , Carlos H. Mastrangelo , Timothy S. Sammarco , Francis P. Man , James R. Webster , Brian N. Johnson , Bradley Foerster , Darren Jones , Yakeitha Fields , Adam Kaiser , David T. Burke
IPC分类号： B01F5/04 , B01F13/00 , F15B13/00 , F15B13/08 , F15C5/00 , F16K99/00 , C12M1/00 , C12Q1/68 , G01N33/00 , G05D23/00
CPC分类号： B01F13/0072 , B01F13/0071 , B01F13/0093 , B01F15/0232 , B01F5/0085 , B01F5/0403 , F15B13/0807 , F15C5/00 , F16K99/0001 , F16K99/0017 , F16K99/0019 , F16K99/0028 , F16K99/0036 , F16K99/0044 , B01F13/0084 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , Y10T436/143333
摘要： The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.
摘要翻译： 使用硅微量元件描述了通过微通道的微滴的运动和混合，包括微滴输送通道，反应区域，电泳模块和辐射探测器。 离散的液滴通过蚀刻通道进行差分加热和推进。 电子元件制造在相同的基板材料上，允许将传感器和控制电路并入同一器件。
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公开(公告)号：US20120077231A1
公开(公告)日：2012-03-29
申请号：US13311087
申请日：2011-12-05
申请人： Mark A. Burns , Brian N. Johnson , Michael Chen
发明人： Mark A. Burns , Brian N. Johnson , Michael Chen
IPC分类号： C12P19/34
CPC分类号： F16K99/0061 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00828 , B01J2219/00831 , B01J2219/00837 , B01J2219/00853 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00957 , B01J2219/00961 , B01J2219/0097 , B01L3/502738 , B01L7/52 , B01L2300/0816 , B01L2300/1827 , B01L2400/0487 , B01L2400/0677 , F16K99/0001 , F16K99/0015 , F16K99/0034 , F16K2099/0071 , F16K2099/0074 , F16K2099/0076 , F16K2099/0084 , Y10T436/2575
摘要： The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.
摘要翻译： 使用硅微量元件描述了通过微通道的微滴的运动和混合，包括微滴输送通道，反应区域，电泳模块和辐射探测器。 离散的液滴通过蚀刻通道进行差分加热和推进。 电子元件制造在相同的基板材料上，允许将传感器和控制电路并入同一设备。
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公开(公告)号：US07066453B2
公开(公告)日：2006-06-27
申请号：US09751493
申请日：2000-12-28
申请人： Mark A. Burns , Carlos H. Mastrangelo , Timothy S. Sammarco , Francis P. Man , James R. Webster , Brian N. Johnson , Bradley Foerster , Darren Jones , Yakeitha Fields , Adam Kaiser , David T. Burke
发明人： Mark A. Burns , Carlos H. Mastrangelo , Timothy S. Sammarco , Francis P. Man , James R. Webster , Brian N. Johnson , Bradley Foerster , Darren Jones , Yakeitha Fields , Adam Kaiser , David T. Burke
CPC分类号： B01F13/0072 , B01F5/0085 , B01F5/0403 , B01F13/0071 , B01F13/0084 , B01F13/0093 , B01F15/0232 , F15B13/0807 , F15C5/00 , F16K99/0001 , F16K99/0017 , F16K99/0019 , F16K99/0028 , F16K99/0036 , F16K99/0044 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G05D23/1917 , Y10T436/143333
摘要： The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.
摘要翻译： 使用硅微量元件描述了通过微通道的微滴的运动和混合，包括微滴输送通道，反应区域，电泳模块和辐射探测器。 离散的液滴通过蚀刻通道进行差分加热和推进。 电子元件制造在相同的基板材料上，允许将传感器和控制电路并入同一设备。
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