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公开(公告)号：US20170107370A1
公开(公告)日：2017-04-20
申请号：US15394297
申请日：2016-12-29
IPC分类号： C08L33/02 , C08G18/83 , C08G18/48 , A61F2/30 , C08F220/14 , C08G77/38 , C08F220/06 , C08G18/44 , C08F236/06
CPC分类号： C08L33/02 , A61F2/30 , A61F2/30988 , A61F2/3099 , A61F2/32 , A61F2/3804 , A61F2/3859 , A61F2/3872 , A61F2/3877 , A61F2/4081 , A61F2/4202 , A61F2/4225 , A61F2/4241 , A61F2/4261 , A61F2/442 , A61F2002/30998 , A61F2002/4205 , A61F2002/4238 , A61F2002/4256 , A61F2310/00011 , A61F2310/00179 , C08F220/06 , C08F220/14 , C08F236/06 , C08G18/44 , C08G18/4854 , C08G18/7671 , C08G18/831 , C08G18/837 , C08G77/38 , C08G2270/00 , C08L75/04 , C08L75/06 , C08L75/16 , C08L2205/04
摘要： Orthopedic implants having a bone interface member and a water swellable IPN or semi-IPN with a stiffness, hydration, and/or compositional gradient from one side to the other and physically attached to the bone interface member. The invention also includes an orthopedic implant system including an implant that may conform to a bone surface and a joint capsule. The invention also includes orthopedic implants with water swellable IPN or semi-IPNs including a hydrophobic thermoset or thermoplastic polymer first network and an ionic polymer second network, joint capsules, labral components, and bone interface members. The invention also includes a method of inserting an orthopedic implant having a metal portion and a flexible polymer portion into a joint, including inserting the implant in a joint in a first shape and changing the implant from a first shape to a second shape to conform to a shape of a bone.
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公开(公告)号：US20170035975A1
公开(公告)日：2017-02-09
申请号：US15331603
申请日：2016-10-21
CPC分类号： A61M37/00 , A61F9/0008 , A61M5/158 , A61M2037/0007
摘要： This invention relates to a device and method for the vacuum-assisted delivery of drugs through an intact surface membrane of an organ.
摘要翻译： 本发明涉及通过器官的完整表面膜真空辅助递送药物的装置和方法。
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3.发明授权公开(公告)号：US08883915B2
公开(公告)日：2014-11-11
申请号：US13219348
申请日：2011-08-26
IPC分类号： C08G18/42 , C08G18/08 , C08L75/00 , A61K9/16 , C08L31/02 , D06M15/263 , C08L75/04 , A61K6/09 , C08G18/83 , C08L75/06 , C08L75/16 , C08L33/12 , C08L33/02
CPC分类号： C10M107/44 , A61K6/09 , C08G18/831 , C08G2270/00 , C08L33/02 , C08L33/12 , C08L75/04 , C08L75/06 , C08L75/16 , Y10T428/31551 , C08L2666/04 , C08L2666/20
摘要： A composition of matter comprising a hydrophobic or hydrophilic (or both) interpenetrating polymer network containing a non-ionic/ionic polymer and a hydrophobic thermoset or thermoplastic polymer, articles made from such composition and methods of preparing such articles. The invention also includes a process for preparing a hydrophobic/hydrophilic IPN or semi-IPN from a hydrophobic thermoset or thermoplastic polymer including the steps of placing an non-ionizable/ionizable monomer solution in contact with a hydrophobic thermoset or thermoplastic polymer; diffusing the monomer solution into the hydrophobic thermoset or thermoplastic polymer; and polymerizing the monomers to form a penetrating polymer inside the hydrophobic thermoset or thermoplastic polymer, thereby forming the IPN or semi-IPN.
摘要翻译： 包含含有非离子/离子聚合物和疏水性热固性或热塑性聚合物的疏水或亲水（或两者）互穿聚合物网络的物质组合物，由这样的组合物制成的制品以及制备这种制品的方法。 本发明还包括从疏水性热固性或热塑性聚合物制备疏水/亲水IPN或半IPN的方法，包括以下步骤：将不可离子化/可离子化的单体溶液与疏水性热固性或热塑性聚合物接触; 将单体溶液扩散到疏水性热固性聚合物或热塑性聚合物中; 并聚合单体以在疏水性热固性聚合物或热塑性聚合物内形成穿透性聚合物，从而形成IPN或半IPN。
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公开(公告)号：US20140172098A1
公开(公告)日：2014-06-19
申请号：US14188257
申请日：2014-02-24
申请人： David MYUNG , Lampros KOURTIS , Laura HARTMANN , Curtis W. FRANK , Stuart B. GOODMAN , Dennis R. CARTER
发明人： David MYUNG , Lampros KOURTIS , Laura HARTMANN , Curtis W. FRANK , Stuart B. GOODMAN , Dennis R. CARTER
IPC分类号： A61F2/30
CPC分类号： A61F2/30756 , A61F2/34 , A61F2/36 , A61F2/3603 , A61F2/3872 , A61F2/4202 , A61F2/4225 , A61F2/4241 , A61F2/4405 , A61F2002/30075 , A61F2002/30448 , A61F2002/30754 , A61F2002/3619 , A61F2210/0061 , A61F2220/005 , A61F2310/00293 , A61L27/18 , A61L27/34 , A61L27/3843 , A61L27/50 , A61L27/52 , A61L2430/24
摘要： An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.
摘要翻译： 提供了一种具有互穿聚合物网络（IPN）水凝胶的关节成形术装置，其通过溶胀变形硬化并且适于通过符合骨几何形状在关节中保持就位。 应变硬化IPN水凝胶基于两个不同的网络：（1）通过其端基聚合化学交联的预先形成的亲水非离子遥爪大分子单体的非硅氧烷网络，和（2）非硅氧烷网络 的可离子化单体。 第二个网络在第一个网络的存在下被聚合和化学交联，并与第一个网络形成了物理交叉链路。 在IPN中，第二个网络中的化学交联程度小于第一个网络中的化学交联度。 使用盐水溶液（中性pH）来电离和膨胀第二网络。 第二个网络的肿胀受到第一个网络的限制，导致IPN内有效的物理交叉链路的增加。
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5.发明申请公开(公告)号：US20130131741A1
公开(公告)日：2013-05-23
申请号：US13683731
申请日：2012-11-21
IPC分类号： A61F2/46
CPC分类号： A61F2/4603 , A61B17/1664 , A61B17/1666 , A61B17/1764 , A61F2/0095 , A61F2/30756 , A61F2/34 , A61F2/36 , A61F2/38 , A61F2/40 , A61F2/4618 , A61F2/4657 , A61F2/4675 , A61F2002/30014 , A61F2002/30069 , A61F2002/3009 , A61F2002/30594 , A61F2002/30757 , A61F2002/30878 , A61F2002/30971 , A61F2002/3412 , A61F2002/4627 , A61F2002/4628 , A61F2002/4629 , A61F2002/4631 , A61F2002/465 , A61F2002/4685 , A61F2002/4696
摘要： Methods, devices, and systems for delivering and attaching flexible implants to a bone or joint surface. An implant container includes a first component for surrounding and enclosing an implant and a second component adapted for maintaining, supporting, and conforming the shape of the implant. The implant container designed to have at least one component attachable to the implant and to a delivery instrument or tool. The implant container component having a material allowing transmission of light through a thickness of the container and a thickness of an attached implant to cure an adhesive placed between the implant and a bone surface. Additionally, embodiments described provide delivery instruments and tools for attaching implants and implants within containers to a joint or bone surface.
摘要翻译： 用于将柔性植入物递送和附接到骨骼或关节表面的方法，装置和系统。 植入物容器包括用于包围和封闭植入物的第一部件和适于维持，支撑和使其适应植入物形状的第二部件。 植入物容器被设计成具有至少一个可附接到植入物和递送仪器或工具的部件。 植入物容器部件具有允许光穿过容器的厚度的材料和附着的植入物的厚度，以固化放置在植入物和骨表面之间的粘合剂。 另外，所描述的实施例提供了用于将容器内的植入物和植入物附接到关节或骨表面的递送仪器和工具。
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6.发明申请公开(公告)号：US20130103157A1
公开(公告)日：2013-04-25
申请号：US13573788
申请日：2012-10-03
申请人： Lampros Kourtis , David Myung , Daniel Chang , Bing Yu , Timothy Sun , Michael J. Jaasma , Vernon Hartdegen
发明人： Lampros Kourtis , David Myung , Daniel Chang , Bing Yu , Timothy Sun , Michael J. Jaasma , Vernon Hartdegen
IPC分类号： C09J133/14 , A61F2/30 , A61M5/19 , A61K47/32 , B65D85/00
CPC分类号： C08G18/6229 , A61B17/56 , A61F2/30 , A61K47/32 , A61L24/001 , A61L24/0015 , A61L24/043 , A61L24/06 , A61L2300/406 , A61L2430/24 , A61M5/19 , B65D85/70 , C08G18/3206 , C08G18/4854 , C08G18/6511 , C08G18/6705 , C08G18/728 , C08G81/024 , C08L33/08 , C08L33/12 , C09J4/06 , C09J133/14 , C09J135/02 , F01D5/082 , F01D11/001 , F01D11/025 , F05D2240/57 , F05D2260/14 , C08F2220/343 , C08F220/14
摘要： Methods, compositions, and kits for adhering polymers and other materials to another material, and in particular to bone or bone-like structures or surfaces. A composition of matter includes a urethane dimethacrylate-methyl methacrylate copolymer with a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate. The method includes placing an orthopedic joint implant having an attachment surface in a joint space, applying a first non-urethane-containing precursor, a second urethane-containing precursor, and a initiator to the attachment surface; contacting the first and second precursors and the initiator with the joint surface; and copolymerizing the first and second precursors and forming an adhesive copolymer and attaching the implant to the joint.
摘要翻译： 用于将聚合物和其它材料粘附到另一种材料，特别是骨或骨样结构或表面上的方法，组合物和试剂盒。 物质组合物包括具有多个基于氨基甲酸酯二甲基丙烯酸酯的多个第一聚合物区域的氨基甲酸酯二甲基丙烯酸酯 - 甲基丙烯酸甲酯共聚物和基于甲基丙烯酸甲酯的多个第二聚合物区域。 该方法包括将具有附接表面的整形外科关节植入物放置在关节空间中，将第一非氨基甲酸酯的前体，第二含氨基甲酸酯的前体和引发剂施加到所述附着表面; 使第一和第二前体和引发剂与接合表面接触; 并共聚第一和第二前体并形成粘合剂共聚物并将植入物附着到接头上。
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公开(公告)号：US20120209396A1
公开(公告)日：2012-08-16
申请号：US13347647
申请日：2012-01-10
CPC分类号： C08L33/02 , A61F2/30 , A61F2/30988 , A61F2/3099 , A61F2/32 , A61F2/3804 , A61F2/3859 , A61F2/3872 , A61F2/3877 , A61F2/4081 , A61F2/4202 , A61F2/4225 , A61F2/4241 , A61F2/4261 , A61F2/442 , A61F2002/30998 , A61F2002/4205 , A61F2002/4238 , A61F2002/4256 , A61F2310/00011 , A61F2310/00179 , C08F220/06 , C08F220/14 , C08F236/06 , C08G18/44 , C08G18/4854 , C08G18/7671 , C08G18/831 , C08G18/837 , C08G77/38 , C08G2270/00 , C08L75/04 , C08L75/06 , C08L75/16 , C08L2205/04
摘要： Orthopedic implants having a bone interface member and a water swellable IPN or semi-IPN with a stiffness, hydration, and/or compositional gradient from one side to the other and physically attached to the bone interface member. The invention also includes an orthopedic implant system including an implant that may conform to a bone surface and a joint capsule. The invention also includes orthopedic implants with water swellable IPN or semi-IPNs including a hydrophobic thermoset or thermoplastic polymer first network and an ionic polymer second network, joint capsules, labral components, and bone interface members. The invention also includes a method of inserting an orthopedic implant having a metal portion and a flexible polymer portion into a joint, including inserting the implant in a joint in a first shape and changing the implant from a first shape to a second shape to conform to a shape of a bone.
摘要翻译： 矫形植入物具有骨界面构件和具有从一侧到另一侧的刚度，水合和/或组成梯度的水膨胀性IPN或半IPN，并且物理附接到骨界面构件。 本发明还包括矫形植入物系统，其包括可以符合骨表面和关节囊的植入物。 本发明还包括具有水溶胀性IPN或半IPN的矫形植入物，其包括疏水性热固性或热塑性聚合物第一网络和离子聚合物第二网络，关节囊，唇部组分和骨界面构件。 本发明还包括将具有金属部分和柔性聚合物部分的整形外科植入体插入到关节中的方法，包括将植入物插入第一形状的关节中并将植入物从第一形状改变为第二形状以符合 骨的形状。
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公开(公告)号：US20110182968A1
公开(公告)日：2011-07-28
申请号：US12928818
申请日：2010-12-20
申请人： David Myung , Christopher N. Ta , Curtis W. Frank , Won-Gun Koh , Jaan Noolandi , Laura Hartmann
发明人： David Myung , Christopher N. Ta , Curtis W. Frank , Won-Gun Koh , Jaan Noolandi , Laura Hartmann
IPC分类号： A61K9/00 , A61K35/12 , A61K38/02 , A61K38/16 , A61K31/197 , A61K31/70 , A61K31/7052 , A61K39/395 , A61K38/18 , A61P27/02
CPC分类号： A61F2/142 , A61L27/26 , A61L27/3804 , A61L27/3869 , A61L27/52 , A61L27/54 , A61L2300/214 , A61L2300/23 , A61L2300/252 , A61L2300/414 , A61L2430/16 , C12N5/0621 , C12N2533/30 , C12N2533/50 , C12N2533/54 , C12N2535/10 , C08L33/08 , C08L71/02
摘要： The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylamide, PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.
摘要翻译： 本发明提供具有高葡萄糖和透氧性，强度，含水量和抗蛋白质吸附性的材料。 这些材料包括涂覆有生物分子的互穿聚合物网络（IPN）水凝胶。 IPN水凝胶包括两个互穿聚合物网络。 第一个聚合物网络是基于亲水的遥爪大分子单体。 第二聚合物网络基于亲水性单体。 在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。 在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酰胺，PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水单体是丙烯酸类单体。 任何生物分子可以连接到IPN水凝胶，但优选是支持角膜衍生细胞生长的生物分子。 该材料设计用作角膜假体。
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公开(公告)号：US20110152868A1
公开(公告)日：2011-06-23
申请号：US12973829
申请日：2010-12-20
申请人： Lampros Kourtis , David Myung , Michael J. Jaasma
发明人： Lampros Kourtis , David Myung , Michael J. Jaasma
CPC分类号： A61B17/1725 , A61B17/025 , A61B17/1617 , A61B17/1637 , A61B17/1659 , A61B17/1662 , A61B17/1666 , A61B17/1668 , A61B17/1697 , A61B17/742 , A61B2017/0275 , A61B2090/033
摘要： Described herein are methods and devices useful for reaming and shaping the surfaces of a joint in a mammalian body. The reaming and shaping devices and methods are particularly useful in preparation of a joint for a minimally invasive joint replacement or resurfacing, though they may he used as part of any appropriate arthroplasty procedure.
摘要翻译： 本文描述了可用于铰链和成形哺乳动物体内关节表面的方法和装置。 扩孔和成型装置和方法在准备微创关节置换或表面置换的关节时特别有用，尽管它们可以用作任何适当关节成形术的一部分。
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10.发明申请Hydrophilic Interpenetrating Polymer Networks Derived From Hydrophobic Polymers 审中-公开来自疏水聚合物的亲水互穿聚合物网络公开(公告)号：US20100010114A1
公开(公告)日：2010-01-14
申请号：US12499041
申请日：2009-07-07
申请人： David Myung , Michael J. Jaasma , Lampros Kourtis
发明人： David Myung , Michael J. Jaasma , Lampros Kourtis
CPC分类号： A61L27/26 , A61F2/02 , A61F2/28 , A61F2/30756 , C08F220/06 , C08F222/1006 , C08F283/006 , C08F283/02 , C08F283/06 , C08F297/04 , C08G18/831 , C08G2270/00 , C08L33/02 , C08L75/04 , C08L75/06 , C08L75/16 , C08L2205/04 , C08L2666/04 , C08L2666/20
摘要： A composition of matter comprising a water-swellable IPN or semi-IPN including a hydrophobic thermoset or thermoplastic polymer and an ionic polymer, articles made from such composition and methods of using such articles. The invention also includes a process for producing a water-swellable IPN or semi-IPN from a hydrophobic thermoset or thermoplastic polymer including the steps of placing an ionizable monomer solution in contact with a solid form of the hydrophobic thermoset or thermoplastic polymer; diffusing the ionizable monomer solution into the hydrophobic thermoset or thermoplastic polymer; and polymerizing the ionizable monomers to form a ionic polymer inside the hydrophobic thermoset or thermoplastic polymer, thereby forming the IPN or semi-IPN.
摘要翻译： 包含水溶胀性IPN或半IPN的物质组合物包括疏水性热固性或热塑性聚合物和离子型聚合物，由该组合物制成的制品以及使用该制品的方法。 本发明还包括从疏水热固性或热塑性聚合物生产水溶胀性IPN或半IPN的方法，包括以下步骤：将可电离的单体溶液与固体形式的疏水性热固性或热塑性聚合物接触; 将可电离单体溶液扩散到疏水性热固性或热塑性聚合物中; 并使可离子化单体聚合以在疏水性热固性聚合物或热塑性聚合物内形成离子聚合物，由此形成IPN或半IPN。
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