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公开(公告)号：US20160109466A1
公开(公告)日：2016-04-21
申请号：US14927505
申请日：2015-10-30
IPC分类号： G01N33/76
CPC分类号： G01N33/76 , B01L3/50273 , B01L3/502738 , B01L2200/04 , B01L2200/0605 , B01L2200/0647 , B01L2200/0689 , B01L2200/141 , B01L2200/16 , B01L2300/0636 , B01L2300/0672 , B01L2300/0681 , B01L2300/0867 , B01L2300/161 , B01L2300/163 , B01L2400/043 , B01L2400/0481 , B01L2400/0688 , C07K16/26 , G01N33/5302 , G01N33/543 , G01N33/74 , G01N2333/59
摘要： The invention relates to antibody characteristics used to design a whole blood Point of Care Thyroid Stimulating Hormone (TSH) immunoassay using an ELISA sandwich assay lacking one or more wash steps between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
摘要翻译： 本发明涉及使用在抗原捕获，检测抗体添加和底物引入步骤之间缺少一个或多个洗涤步骤的ELISA夹心测定来设计全血点护甲甲状腺刺激激素（TSH）免疫测定的抗体特征。 本发明与生物相似的干扰交叉反应物质如卵泡刺激激素（FSH），促黄体激素（LH）和绒毛膜促性腺激素（CG）表现出低交叉反应性。
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公开(公告)号：US08389042B2
公开(公告)日：2013-03-05
申请号：US13478260
申请日：2012-05-23
IPC分类号： B05D3/00
CPC分类号： C12Q1/003 , B05C5/0291 , B05C9/12 , B05C11/1034 , C12Q1/00 , C12Q1/005 , C12Q1/006 , C12Q1/26 , C12Q1/28 , C12Q1/42 , C12Q1/58
摘要： The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.
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公开(公告)号：US20120282602A1
公开(公告)日：2012-11-08
申请号：US13462632
申请日：2012-05-02
CPC分类号： G01N33/5302 , B01L3/502715 , G01N27/26 , G01N27/3273 , G01N33/54306 , G01N2035/00158
摘要： Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to devices, systems, and kits for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications.
摘要翻译： 本文提供了与生物样品测试有关的技术，特别是但不排他地涉及用于以一次性一次性格式对样品进行多个同时实时测定的装置，系统和试剂盒。 例如，该技术涉及一种用于例如用于点护理诊断的装置，包括在事故现场，急诊室，手术中，重症监护病房以及非医疗应用中的使用。
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公开(公告)号：US20100291666A1
公开(公告)日：2010-11-18
申请号：US12308307
申请日：2005-12-21
申请人： Gordon Bruce Collier , John Allister Wood , Jason Andrew MacLeod , William Charles Dicke , Attila Csaba Nemeth , Cary James Miller
发明人： Gordon Bruce Collier , John Allister Wood , Jason Andrew MacLeod , William Charles Dicke , Attila Csaba Nemeth , Cary James Miller
IPC分类号： C12M1/34
CPC分类号： C12Q1/6853 , B01L3/502715 , B01L3/502761 , B01L3/502769 , B01L7/52 , B01L2200/027 , B01L2200/0647 , B01L2200/10 , B01L2300/0816 , B01L2400/0421 , B01L2400/0487 , C12N15/1013 , C12Q1/6844 , C12Q1/686
摘要： The present invention relates to automated devices and methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. The invention is particularly suited for use in point-of-care medical diagnostic testing.
摘要翻译： 本发明涉及用于从细胞中提取核酸的自动化装置和方法，扩增核酸片段和检测核酸，所有这些都以便利和便携的方式。 本发明特别适用于护理点医疗诊断测试。
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公开(公告)号：US20100255120A1
公开(公告)日：2010-10-07
申请号：US11961498
申请日：2007-12-20
CPC分类号： C12Q1/005 , C12N11/08 , C12Y305/01005
摘要： The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.
摘要翻译： 本发明涉及酶固定组合物，其包含：在基本上均匀的含水混合物中的一种或多种酶，湿润剂，丙烯酸类单体，水溶性有机光引发剂和水溶性丙烯酸类交联剂。 本发明还涉及用于形成包含这种组合物的传感器的方法，并且通过将这样的组合物分配到基底上来设置在传感器阵列上形成固定化层的阵列。
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公开(公告)号：US08703445B2
公开(公告)日：2014-04-22
申请号：US11611677
申请日：2006-12-15
CPC分类号： B01L7/52 , B01L3/50273 , B01L3/502738 , B01L3/5029 , B01L2200/027 , B01L2200/10 , B01L2200/147 , B01L2200/16 , B01L2300/041 , B01L2300/0636 , B01L2300/0645 , B01L2300/0867 , B01L2300/1827 , B01L2300/1844 , B01L2400/0421 , B01L2400/0481
摘要： The present invention relates to automated devices and methods for the amplification of segments of nucleic acid in a convenient and portable manner. A single-use nucleic acid amplification device for producing an amplicon includes a housing and an amplification chamber. The chamber includes an ingress with a first reversible seal, an egress with a second reversible seal, a sealable sample entry orifice, and a first wall forming a portion of the chamber. The first wall includes a thermally conductive material and includes an interior surface and an exterior surface. The exterior surface includes a heating circuit and a temperature sensor. The sample entry orifice permits a sample of nucleic acid to enter the amplification chamber. The ingress is connected to a first conduit along with a pneumatic pump and a fluid pouch. The egress is connected to a second conduit permitting egress of the amplicon from the amplification chamber.
摘要翻译： 本发明涉及以方便和便携的方式扩增核酸片段的自动化装置和方法。 用于产生扩增子的一次性核酸扩增装置包括壳体和扩增室。 腔室包括具有第一可逆密封件的入口，具有第二可逆密封件的出口，可密封的样品入口孔口和形成腔室的一部分的第一壁。 第一壁包括导热材料并且包括内表面和外表面。 外表面包括加热电路和温度传感器。 样品入口孔允许核酸样品进入扩增室。 入口连同气动泵和流体袋一起连接到第一导管。 出口连接到允许扩增器从放大室排出的第二导管。
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7.发明申请TSH IMMUNOASSAYS EMPLOYING SCAVENGING REAGENTS FOR CROSS-REACTING ENDOCRINE GLYCOPROTEIN HORMONE ANALOGUES 有权TSH免疫组织使用SCAVENGING试剂进行交联反应内皮素GLYCOPROTEIN HORMONE ANALOGUES公开(公告)号：US20120301906A1
公开(公告)日：2012-11-29
申请号：US13306712
申请日：2011-11-29
CPC分类号： G01N33/74 , G01N33/53 , G01N33/54326 , G01N33/76 , G01N2333/59 , Y10S436/825
摘要： The invention relates to Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay that employs scavenging or sacrificial beads for reducing interference caused by cross-reacting endocrine glycoprotein hormone analogues such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
摘要翻译： 本发明涉及使用ELISA夹心测定法的甲状腺刺激激素（TSH）免疫测定法，其使用清除或牺牲珠来减少由交叉反应的内分泌糖蛋白激素类似物如卵泡刺激激素（FSH），促黄体激素（LH）和绒毛膜 促性腺激素（CG）。
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公开(公告)号：US08241697B2
公开(公告)日：2012-08-14
申请号：US11961550
申请日：2007-12-20
IPC分类号： B05D3/00
CPC分类号： C12Q1/003 , B05C5/0291 , B05C9/12 , B05C11/1034 , C12Q1/00 , C12Q1/005 , C12Q1/006 , C12Q1/26 , C12Q1/28 , C12Q1/42 , C12Q1/58
摘要： The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.
摘要翻译： 本发明涉及酶固定组合物，其包含：在基本上均匀的含水混合物中的一种或多种酶，湿润剂，丙烯酸类单体，水溶性有机光引发剂和水溶性丙烯酸类交联剂。 本发明还涉及用于形成包含这种组合物的传感器的方法，并且通过将这样的组合物分配到基底上来设置在传感器阵列上形成固定化层的阵列。
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9.发明授权Methods of performing nucleic acid amplification assays using modified primers 有权使用修饰的引物进行核酸扩增测定的方法公开(公告)号：US08048633B2
公开(公告)日：2011-11-01
申请号：US12826450
申请日：2010-06-29
申请人： Gordon Bruce Collier , John Allister Wood , Jason Andrew MacLeod , William Charles Dicke , Attila Csaba Nemeth , Cary James Miller
发明人： Gordon Bruce Collier , John Allister Wood , Jason Andrew MacLeod , William Charles Dicke , Attila Csaba Nemeth , Cary James Miller
CPC分类号： C12Q1/6853 , B01L3/502715 , B01L3/502761 , B01L3/502769 , B01L7/52 , B01L2200/027 , B01L2200/0647 , B01L2200/10 , B01L2300/0816 , B01L2400/0421 , B01L2400/0487 , C12N15/1013 , C12Q1/6844 , C12Q1/686
摘要： The invention relates to a method for the extraction of nucleic acid from cells, the amplification of segments of nucleic acid using modified primers, and the detection of nucleic acids.
摘要翻译： 本发明涉及一种从细胞中提取核酸的方法，使用修饰的引物扩增核酸片段，并检测核酸。
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公开(公告)号：US08017340B2
公开(公告)日：2011-09-13
申请号：US12846609
申请日：2010-07-29
申请人： Gordon Bruce Collier , John Allister Wood , Jason Andrew MacLeod , William Charles Dicke , Attila Csaba Nemeth , Cary James Miller
发明人： Gordon Bruce Collier , John Allister Wood , Jason Andrew MacLeod , William Charles Dicke , Attila Csaba Nemeth , Cary James Miller
CPC分类号： C12Q1/6853 , B01L3/502715 , B01L3/502761 , B01L3/502769 , B01L7/52 , B01L2200/027 , B01L2200/0647 , B01L2200/10 , B01L2300/0816 , B01L2400/0421 , B01L2400/0487 , C12N15/1013 , C12Q1/6844 , C12Q1/686
摘要： The present invention relates to methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. In one embodiment, a sample comprising cells containing nucleic acid is exposed to an aqueous mixture comprising a lytic reagent and one or more beads capable of binding the nucleic acid released from said cells to form a nucleic acid-bead complex. The nucleic acid-bead complex is passed through an immiscible liquid layer to separate the nucleic acid from the aqueous mixture. The one or more beads are magnetic, and the nucleic acid-bead complex is passed through and separated from the immiscible liquid layer with an applied magnetic field. The invention is particularly suited for use in point-of-care medical diagnostics testing.
摘要翻译： 本发明涉及从细胞中提取核酸的方法，扩增核酸片段和检测核酸，所有这些都以方便和便携的方式。 在一个实施方案中，将包含含有核酸的细胞的样品暴露于包含裂解试剂和能够结合从所述细胞释放的核酸形成核酸珠复合物的一种或多种珠粒的含水混合物。 核酸 - 珠复合物通过不混溶的液体层以从核酸与水性混合物分离。 一个或多个珠粒是磁性的，核酸 - 珠子复合物通过施加的磁场通过并与不混溶的液体层分离。 本发明特别适用于护理点医疗诊断测试。
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