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1.发明授权Use of acid scavengers for the synthesis of standard length and long-mer nucleic acid arrays 有权使用酸清除剂合成标准长度和长链核酸阵列公开(公告)号：US08318427B2
公开(公告)日：2012-11-27
申请号：US13238563
申请日：2011-09-21
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00432 , B01J2219/00439 , B01J2219/00441 , B01J2219/00448 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00646 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00693 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B82Y30/00 , C07H21/00 , C07K1/047 , C40B50/14 , Y02P20/55
摘要： Protective groups which may be cleaved with an activatable deprotecting reagents are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for nucleic acids and tBOC for amino acids. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
摘要翻译： 可以用可活化的去保护试剂切割的保护基用于实现多种聚合物的图案阵列的高灵敏度，高分辨率，组合合成。 在本发明的优选实施方案中，可活化的去保护试剂是光酸产生剂，保护基是核酸的DMT和氨基酸的tBOC。 本发明具有广泛的应用，并且对聚合物的固相组合合成特别有用。
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公开(公告)号：US20120196381A1
公开(公告)日：2012-08-02
申请号：US13337024
申请日：2011-12-23
CPC分类号： B82Y25/00 , B82Y20/00 , G01N33/54326 , G01N33/585 , G09F3/00 , G11B5/66 , H01F1/0072
摘要： An encoded microparticle having a spatial code is provided; and a set of encoded microparticles possessing subsets each provided with a distinguishable spatial code, wherein the codes comply with a pre-determined coding scheme. Presented are also methods of using the encoded microparticles in various biological assays, such as various multiplex assays and visualizing them by creating a digital image of the encoded microparticles and determining whether false positives are present. Further are provided methods of manufacture of the encoded microparticles which employ ferromagnetic nanoparticles applied using spin-on-glass techniques.
摘要翻译： 提供具有空间码的编码微粒; 以及一组编码的微粒，其具有各自具有可区分的空间码的子集，其中所述码符合预定编码方案。 还提出了在各种生物测定中使用编码的微粒的方法，例如各种多重测定，并通过产生编码的微粒的数字图像并确定是否存在假阳性来使其可视化。 还提供了使用旋涂玻璃技术应用铁磁性纳米粒子的编码微粒的制造方法。
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3.发明授权Antireflective coatings for high-resolution photolithographic synthesis of DNA array 有权用于高分辨率光刻合成DNA阵列的抗反射涂层公开(公告)号：US08114584B2
公开(公告)日：2012-02-14
申请号：US12832781
申请日：2010-07-08
申请人： Mark O. Trulson , Glenn H. McGall , Bei-Shen Sywe , Lisa T. Kajisa , Dana Truong , Rich P. Rava , Martin J. Goldberg
发明人： Mark O. Trulson , Glenn H. McGall , Bei-Shen Sywe , Lisa T. Kajisa , Dana Truong , Rich P. Rava , Martin J. Goldberg
IPC分类号： C12Q1/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00711 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , G03F7/091 , C12Q2545/101
摘要： The present invention provides an array of polymers and methods of forming arrays of polymers by providing a substrate having a first layer including one or more dielectric coatings on a solid support and a second layer including a plurality of polymers disposed on the first layer. The invention also provides methods for forming an array of polymers on a substrate using light-directed synthesis by providing a substrate having a first layer including one or more dielectric coatings on a solid support, derivatizing the first layer by contacting the first layer with a silanation reagent, and a second layer disposed on said first layer wherein the second layer includes functional groups protected with a photolabile protecting group.
摘要翻译： 本发明提供了一种聚合物阵列和通过提供一种具有第一层的衬底来形成聚合物阵列的方法，所述第一层包括在固体载体上的一个或多个电介质涂层和包含设置在第一层上的多个聚合物的第二层。 本发明还提供了使用光导合成法在基底上形成聚合物阵列的方法，该方法是通过提供具有第一层的基底，该第一层包含固体支持物上的一个或多个电介质涂层，通过使第一层与硅烷化接触来衍生第一层 试剂和设置在所述第一层上的第二层，其中所述第二层包括用光不稳定保护基团保护的官能团。
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公开(公告)号：US08067578B2
公开(公告)日：2011-11-29
申请号：US12634475
申请日：2009-12-09
申请人： Martin J Goldberg , Martin Diggelman , Earl A. Hubbell , Glenn H. McGall , Nam Quoc Ngo , MacDonald Morris , Melvin Yamamoto , Jennifer Tan , Richard P. Rava
发明人： Martin J Goldberg , Martin Diggelman , Earl A. Hubbell , Glenn H. McGall , Nam Quoc Ngo , MacDonald Morris , Melvin Yamamoto , Jennifer Tan , Richard P. Rava
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , C07B2200/11 , C07H21/00 , C40B40/06 , C40B40/10 , C40B60/14 , Y02P20/55 , Y10S436/809
摘要： The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays.
摘要翻译： 本发明提供了用于大规模制备聚合物序列阵列的新方法，其中每个阵列包括具有已知单体序列的多个不同的位置不同的聚合物序列。 本发明的方法将高通量处理步骤与高分辨率光刻技术结合在聚合物阵列的制造中。
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5.发明申请USE OF ACID SCAVENGERS FOR THE SYNTHESIS OF STANDARD LENGTH AND LONG-MER POLYER ARRAYS 有权酸性螯合剂在标准长度和长聚合物阵列合成中的应用公开(公告)号：US20110124526A1
公开(公告)日：2011-05-26
申请号：US13011030
申请日：2011-01-21
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00432 , B01J2219/00439 , B01J2219/00441 , B01J2219/00448 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00646 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00693 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B82Y30/00 , C07H21/00 , C07K1/047 , C40B50/14 , Y02P20/55
摘要： Protective groups which may be cleaved with an activatable deprotecting reagents are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for nucleic acids and tBOC for amino acids. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
摘要翻译： 可以用可活化的去保护试剂切割的保护基用于实现多种聚合物的图案阵列的高灵敏度，高分辨率，组合合成。 在本发明的优选实施方案中，可活化的去保护试剂是光酸产生剂，保护基是核酸的DMT和氨基酸的tBOC。 本发明具有广泛的应用，并且对聚合物的固相组合合成特别有用。
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6.发明申请USE OF ACID SCAVENGERS FOR THE SYNTHESIS OF STANDARD LENGTH AND LONG-MER POLYMER ARRAYS 有权用于合成标准长度和长聚合物阵列的酸性螯合剂的使用公开(公告)号：US20110015098A1
公开(公告)日：2011-01-20
申请号：US12838279
申请日：2010-07-16
IPC分类号： C40B50/18
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00432 , B01J2219/00439 , B01J2219/00441 , B01J2219/00448 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00646 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00693 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B82Y30/00 , C07H21/00 , C07K1/047 , C40B50/14 , Y02P20/55
摘要： Protective groups which may be cleaved with an activatable deprotecting reagents are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for nucleic acids and tBOC for amino acids. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
摘要翻译： 可以用可活化的去保护试剂切割的保护基用于实现多种聚合物的图案阵列的高灵敏度，高分辨率，组合合成。 在本发明的优选实施方案中，可活化的去保护试剂是光酸产生剂，保护基是核酸的DMT和氨基酸的tBOC。 本发明具有广泛的应用，并且对聚合物的固相组合合成特别有用。
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7.发明授权Use of acid scavengers for the synthesis of standard length and long-mer nucleic acid arrays 有权使用酸清除剂合成标准长度和长链核酸阵列公开(公告)号：US07862996B2
公开(公告)日：2011-01-04
申请号：US11617431
申请日：2006-12-28
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00432 , B01J2219/00439 , B01J2219/00441 , B01J2219/00448 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00646 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00693 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B82Y30/00 , C07H21/00 , C07K1/047 , C40B50/14 , Y02P20/55
摘要： Protective groups which may be cleaved with an activatable deprotecting reagent are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for nucleic acids and tBOC for amino acids. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
摘要翻译： 可以用可活化的脱保护试剂切割的保护基团用于实现多种聚合物的图案阵列的高灵敏度，高分辨率，组合合成。 在本发明的优选实施方案中，可活化的去保护试剂是光酸产生剂，保护基是核酸的DMT和氨基酸的tBOC。 本发明具有广泛的应用，并且对聚合物的固相组合合成特别有用。
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公开(公告)号：US06667394B2
公开(公告)日：2003-12-23
申请号：US09841405
申请日：2001-04-24
申请人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler
发明人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler
IPC分类号： C07H2100
CPC分类号： G03F7/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00382 , B01J2219/00385 , B01J2219/00427 , B01J2219/00432 , B01J2219/00454 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B41M3/00 , B82Y30/00 , C07B2200/11 , C07H21/00 , C07K1/047 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among other materials. The method and apparatus also relies upon standard DMT based chemistry, and a vapor phase deprotection agent such as solid TCA and the like.
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9.发明授权Printing molecular library arrays using deprotection agents solely in the vapor phase 失效使用去保护剂仅在气相中印刷分子库阵列
公开(公告)号：US5599695A
公开(公告)日：1997-02-04
申请号：US395604
申请日：1995-02-27
申请人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler
发明人： R. Fabian Pease , Glenn McGall , Martin J. Goldberg , Richard P. Rava , Stephen P. A. Fodor , Virginia Goss , Lubert Stryer , James L. Winkler
IPC分类号： B01J19/00 , B41M3/00 , C07H21/00 , C40B40/06 , C40B50/14 , C40B60/14 , G03F7/00 , C12P19/34 , C07H21/02 , C07K5/00 , G01N33/543
CPC分类号： C07H21/00 , B01J19/0046 , G03F7/00 , B01J2219/00378 , B01J2219/00382 , B01J2219/00385 , B01J2219/00427 , B01J2219/00454 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00722 , B41M3/00 , C40B40/06 , C40B50/14 , C40B60/14
摘要： A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among other materials. The method and apparatus also relies upon standard DMT based chemistry, and a vapor phase deprotection agent such as solid TCA and the like.
摘要翻译： 一种用于选择性地将印刷材料施加到基底上以在基底的选定区域合成寡核苷酸阵列的方法和装置。 印刷材料包括阻挡材料，单体序列，核苷，去保护剂，载体材料等。 该方法和装置还依赖于基于标准的基于DMT的化学，以及气相脱保护剂如固体TCA等。
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10.发明授权Covalent compound having a radical-cationic moiety covalently linked to a radical anionicmoiety 失效共价化合物具有与自由基阴离子性共价连接的自由基 - 阳离子部分
公开(公告)号：US5563273A
公开(公告)日：1996-10-08
申请号：US193921
申请日：1994-02-09
申请人： Stephen L. Buchwalter , Martin J. Goldberg , Revathi Iyengar , Terrence R. O'Toole , Alfred Viehbeck
发明人： Stephen L. Buchwalter , Martin J. Goldberg , Revathi Iyengar , Terrence R. O'Toole , Alfred Viehbeck
IPC分类号： G02F1/15 , C09K9/00 , C09K9/02 , G09F9/30 , G09G3/38 , H01B1/12 , C07D213/22 , C07D487/02
摘要： An electrochemical color change cell incorporating as a color changing agent intramolecular charge transfer salt or an intermolecular charge transfer salt. The intermolecular charge transfer salts and the intramolecular charge transfer salts have a plurality of oxidation states and a wide variation in color change. The intermolecular and intramolecular charge transfer salts preferably contain a violene moiety and a moiety having a carbonyl group conjugated to an aromatic moiety. The intramolecular charge transfer salts have a stable covalent radical-anion/radical-cation configuration. The intermolecular charge transfer salts have a stable ionic radical-anion/radical-cation configuration.
摘要翻译： 一种结合作为变色剂分子内电荷转移盐或分子内电荷转移盐的电化学变色细胞。 分子间电荷转移盐和分子内电荷转移盐具有多种氧化态和颜色变化的广泛变化。 分子间和分子内电荷转移盐优选含有突出部分和具有与芳族部分结合的羰基的部分。 分子内电荷转移盐具有稳定的共价自由基 - 阴离子/自由基 - 阳离子配置。 分子间电荷转移盐具有稳定的离子自由基 - 阴离子/自由基 - 阳离子配置。
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