Process for providing a frozen fish product
    3.
    发明授权
    Process for providing a frozen fish product 失效
    提供冷冻鱼制品的方法

    公开(公告)号:US6007864A

    公开(公告)日:1999-12-28

    申请号:US15562

    申请日:1998-01-29

    IPC分类号: A23B4/06 A23L3/015 A23L1/325

    CPC分类号: A23L3/0155 A23B4/06

    摘要: A process for obtaining a frozen fish product comprises: treating frozen or non-frozen fish, which comprises molecules of myosin and molecules of actin, each molecule of myosin having a head region (6) and a tail region (8), such that the conformation of the head region of the molecule of myosin changes irreversibly and the conformation of the molecule of actin does not change completely and irreversibly; and storing the fish under freezing conditions. Suitable treatments for affecting the conformational change include application of pressure. The treated fish product has an increased resistance to frozen deterioration of texture.

    摘要翻译: 一种用于获得冷冻鱼产品的方法包括:处理包含肌球蛋白和肌动蛋白分子的冷冻或非冷冻鱼,每个肌球蛋白分子具有头部区域(6)和尾部区域(8),使得 肌球蛋白分子的头部区域的构象不可逆地变化,肌动蛋白分子的构象不会完全和不可逆地变化; 并将鱼储存在冷冻条件下。 用于影响构象变化的合适处理包括施加压力。 经处理的鱼制品对纹理的冷冻变质具有增加的抗性。

    Analysis based on flow restriction
    7.
    发明授权
    Analysis based on flow restriction 失效
    基于流量限制的分析

    公开(公告)号:US5486335A

    公开(公告)日:1996-01-23

    申请号:US427493

    申请日:1995-04-24

    摘要: Disclosed are devices and methods for detecting the presence of a preselected analyte in a fluid sample. The invention provides a device comprising a solid substrate, typically on the order of a few millimeters thick and approximately a 0.2 to 2.0 centimeters square, microfabricated to define a sample inlet port and a mesoscale flow system. A sample is passed through the mesoscale flow system, and the restriction or blockage of flow through the flow system is detected as a positive indication of the presence of the analyte. The mesoscale flow system includes in one embodiment a primary sample flow channel extending from the inlet port, and a fractal region, in fluid communication with the flow channel, comprising bifurcations leading to plural secondary flow channels. The device may be adapted for operation in conjunction with a pump, for example, to induce flow of a sample through the flow system. A detector may also be provided for detecting analyte induced changes in flow properties in the mesoscale flow system. The devices of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, such as viruses.

    摘要翻译: 公开了用于检测流体样品中预选分析物的存在的装置和方法。 本发明提供了一种包括固体基底的装置,通常为几毫米厚和大约0.2至2.0厘米2平方英寸的微米级,以限定样品入口和中尺度流动系统。 样品通过中尺度流动系统,并且检测到通过流动系统的流动的限制或阻塞作为分析物存在的肯定指示。 中等尺度流动系统在一个实施例中包括从入口端口延伸的主要样品流动通道和与流动通道流体连通的分形区域,其包括通向多个二次流动通道的分叉。 该装置可以适于与泵一起操作,例如,以诱导样品流过流动系统。 还可以提供检测器用于检测中尺度流系统中分析物引起的流动特性变化。 本发明的装置可以用于广泛的应用,包括细胞或大分子如病毒的检测。

    Fluid handling in mesoscale analytical devices
    8.
    发明授权
    Fluid handling in mesoscale analytical devices 失效
    中尺度分析装置中的流体处理

    公开(公告)号:US5304487A

    公开(公告)日:1994-04-19

    申请号:US877536

    申请日:1992-05-01

    摘要: Devices are provided for analyzing a fluid cell containing sample. The devices comprise a solid substrate, microfabricated to define at least one sample inlet port and a mesoscale flow system. The mesoscale flow system includes a sample flow channel, extending from the inlet port, and a cell handling region for treating cells disposed in fluid communication with the flow channel. The devices may further include a structure inducing flow of cells in the sample through the flow system. In one embodiment, the cell-handling region may comprise a cell lysis structure to enable the lysis of cells in the sample, prior to, e.g., the detection of an intracellular component in the cell sample. In another embodiment, the cell handling region may comprise a cell capture region, comprising binding sites which reversibly bind to a specific population of cells in the cell sample, to permit the isolation of the specific cell population from the sample. The devices can be utilized in a wide range of automated sensitive and rapid tests for the analysis of a fluid cell containing sample.

    摘要翻译: 提供了用于分析含有流体池的样品的装置。 这些装置包括固体基底,微细加工以限定至少一个样品入口和中尺度流动系统。 中尺度流动系统包括从入口延伸的样品流动通道和用于处理与流动通道流体连通地设置的细胞的细胞处理区域。 装置还可以包括通过流动系统诱导样品中的细胞流的结构。 在一个实施方案中,细胞处理区域可以包括细胞裂解结构,以在样品中的细胞裂解之前,例如检测细胞样品中的细胞内组分。 在另一个实施方案中,细胞处理区域可以包含细胞捕获区域,其包含可逆结合细胞样品中的特定细胞群的结合位点,以允许从样品中分离特定细胞群体。 该装置可用于广泛的自动敏感和快速测试,用于分析含有流体细胞的样品。