公开(公告)号：US20050076396A1

公开(公告)日：2005-04-07

申请号：US10651564

申请日：2003-08-29

申请人： Adam Katz ,  Ramon Llull ,  J. Futrell ,  Marc Hedrick ,  Prosper Benhaim ,  Hermann Lorenz ,  Min Zhu ,  Patricia Zuk ,  Peter Ashjian

发明人： Adam Katz ,  Ramon Llull ,  J. Futrell ,  Marc Hedrick ,  Prosper Benhaim ,  Hermann Lorenz ,  Min Zhu ,  Patricia Zuk ,  Peter Ashjian

IPC分类号： A61K35/12 ,  A61K48/00 ,  C12N5/00 ,  C12N5/074 ,  C12N5/077 ,  C12N5/0775 ,  C12N5/0789 ,  A01K67/00 ,  C12N5/08

CPC分类号： C12N5/0653 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N5/0607 ,  C12N5/0647 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0658 ,  C12N5/0667 ,  C12N9/1276 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/15 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2510/00 ,  C12N2533/90 ,  C12Y207/07049

摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

公开(公告)号：US20050153442A1

公开(公告)日：2005-07-14

申请号：US10845315

申请日：2004-05-12

申请人： Adam Katz ,  Ramon Llull ,  J. Futrell ,  Marc Hedrick ,  Prosper Benhaim ,  Hermann Lorenz ,  Min Zhu ,  Patricia Zuk ,  Peter Ashjian

发明人： Adam Katz ,  Ramon Llull ,  J. Futrell ,  Marc Hedrick ,  Prosper Benhaim ,  Hermann Lorenz ,  Min Zhu ,  Patricia Zuk ,  Peter Ashjian

IPC分类号： A61K35/12 ,  A61K48/00 ,  A61L27/22 ,  A61L27/38 ,  C12N5/00 ,  C12N5/074 ,  C12N5/077 ,  C12N5/0775 ,  C12N5/0789 ,  C12N15/85 ,  C12N5/08

CPC分类号： A61L27/3612 ,  A61K35/12 ,  A61K48/00 ,  A61L27/225 ,  A61L27/3654 ,  A61L27/38 ,  C12N5/0068 ,  C12N5/0607 ,  C12N5/0647 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0658 ,  C12N5/0667 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/15 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2502/1305 ,  C12N2510/00 ,  C12N2533/90

摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

摘要翻译： 本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。 一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。 另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。 另一方面，本发明提供了一种基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。 晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

公开(公告)号：US20050282275A1

公开(公告)日：2005-12-22

申请号：US11211114

申请日：2005-08-24

申请人： Adam Katz ,  Ramon Llull ,  J. Futrell ,  Marc Hedrick ,  Prosper Benhaim ,  Hermann Lorenz ,  Min Zhu

发明人： Adam Katz ,  Ramon Llull ,  J. Futrell ,  Marc Hedrick ,  Prosper Benhaim ,  Hermann Lorenz ,  Min Zhu

IPC分类号： C12N5/071 ,  A61K35/12 ,  A61K48/00 ,  C12N5/00 ,  C12N5/077 ,  C12N5/0775 ,  C12N5/0789 ,  C12N5/10 ,  C12N15/63 ,  C12N5/08

CPC分类号： C12N5/0658 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N5/0647 ,  C12N5/0652 ,  C12N5/0653 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0667 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2502/1305 ,  C12N2506/1384 ,  C12N2510/00 ,  C12N2533/90

摘要： The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The invention also provides a method of isolating stem cells from adipose tissues. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

摘要翻译： 本发明提供脂肪来源的干细胞和晶格。 一方面，本发明提供了一种基本上不含脂肪细胞和结缔组织干细胞的红细胞和克隆群的脂衍生的干细胞。 本发明还提供了从脂肪组织分离干细胞的方法。 细胞可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。 此外，细胞可以扩增和培养以产生激素，并提供条件培养基以支持其他细胞群体的生长和扩增。 另一方面，本发明提供了一种基本上不含细胞的脂衍生晶格，其包括来自脂肪组织的细胞外基质材料。 晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

公开(公告)号：US20050153441A1

公开(公告)日：2005-07-14

申请号：US10740315

申请日：2003-12-17

申请人： Marc Hedrick ,  Adam Katz ,  Ramon Llull ,  J. Futrell ,  Prosper Benhaim ,  Hermann Lorenz ,  Min Zhu

发明人： Marc Hedrick ,  Adam Katz ,  Ramon Llull ,  J. Futrell ,  Prosper Benhaim ,  Hermann Lorenz ,  Min Zhu

IPC分类号： C12N15/09 ,  A61K35/12 ,  A61K48/00 ,  A61L27/00 ,  C12M3/08 ,  C12N5/00 ,  C12N5/074 ,  C12N5/077 ,  C12N5/0775 ,  C12N5/0789 ,  C12N5/10 ,  C12N5/08

CPC分类号： C12N5/0667 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/15 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2510/00 ,  C12N2533/90

摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

公开(公告)号：US20190008993A1

公开(公告)日：2019-01-10

申请号：US15867295

申请日：2018-01-10

申请人： George Rodeheaver ,  Adam Katz

发明人： George Rodeheaver ,  Adam Katz

IPC分类号： A61L15/44 ,  A61F13/00 ,  A61F13/02 ,  A61K31/765 ,  A61K33/38 ,  A61L26/00 ,  A61K47/18 ,  A61K31/505 ,  A61K31/555 ,  A61K31/77 ,  A61K9/00 ,  A01N43/54 ,  A01N59/16 ,  A61K31/4178 ,  A61K31/635 ,  A61L15/48 ,  A61L15/46 ,  A61K47/10 ,  A01N25/00 ,  A01N25/30 ,  A01N31/02

摘要： Compositions containing a surface active agent and a sub-lethal amount of an antimicrobial agent and methods for using such compositions are provided herein.

公开(公告)号：US20090202615A1

公开(公告)日：2009-08-13

申请号：US12033692

申请日：2008-02-19

申请人： George Rodeheaver ,  Adam Katz

发明人： George Rodeheaver ,  Adam Katz

IPC分类号： A61K9/70 ,  A61K35/64 ,  A61K31/555 ,  A61P31/00

CPC分类号： A61L15/44 ,  A01N43/54 ,  A01N59/16 ,  A61F13/00063 ,  A61F13/0269 ,  A61F2013/00638 ,  A61K9/0014 ,  A61K31/4178 ,  A61K31/505 ,  A61K31/555 ,  A61K31/635 ,  A61K31/765 ,  A61K31/77 ,  A61K33/38 ,  A61K47/10 ,  A61K47/18 ,  A61L15/46 ,  A61L15/48 ,  A61L26/0019 ,  A61L26/0066 ,  A61L2300/104 ,  A61L2300/204 ,  A61L2300/216 ,  A61L2300/404 ,  A61L2300/406 ,  A01N2300/00 ,  A01N25/00 ,  A01N25/30 ,  A01N31/02

摘要： Compositions containing a surface active agent and a sub-lethal amount of an antimicrobial agent and methods for using such compositions are provided herein.

摘要翻译： 本文提供了含有表面活性剂和亚致死量的抗微生物剂的组合物和使用这些组合物的方法。