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公开(公告)号：US06520197B2
公开(公告)日：2003-02-18
申请号：US09867942
申请日：2001-05-30
申请人： Ajay Deshmukh , Dorian Liepmann
发明人： Ajay Deshmukh , Dorian Liepmann
IPC分类号： F15C104
CPC分类号： B01F13/0072 , B01F5/0403 , B01F13/0093 , B01F15/0201 , B01F15/024 , B01F15/0243 , B01F2005/0031 , B81C1/00611 , B81C2201/0119 , Y10T137/0329 , Y10T137/2185 , Y10T137/2196 , Y10T137/2224
摘要： A micro-electromechanical system and method for continuous laminar fluid mixing. An embodiment of the invention described in the specification includes a mixing channel, a first delivery channel that is connected to the mixing channel, and a second delivery channel that is connected to the mixing channel. A first pump mechanism produces pulses in the first delivery channel. A second pump mechanism produces pulses in the second delivery channel. The first pulsed fluid stream and the second pulsed fluid stream merge in the mixing channel to form a mixed fluid. The pulses in the fluids operate to distort the interface between the fluids to facilitate diffusion between the fluids.
摘要翻译： 一种用于连续层流混合的微机电系统和方法。 在说明书中描述的本发明的实施例包括混合通道，连接到混合通道的第一输送通道和连接到混合通道的第二输送通道。 第一泵机构在第一输送通道中产生脉冲。 第二泵机构在第二输送通道中产生脉冲。 第一脉冲流体流和第二脉冲流体流在混合通道中合并形成混合流体。 流体中的脉冲操作以扭曲流体之间的界面，以促进流体之间的扩散。
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公开(公告)号：US20090069651A1
公开(公告)日：2009-03-12
申请号：US12188918
申请日：2008-08-08
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61B5/14514 , A61B5/14525 , A61B5/14532 , A61B2560/0223 , A61B2562/028
摘要： A method and apparatus for substance monitoring. One application is an easy to handle continuous glucose monitor using a group of hollow out-of-plane silicon microneedles to sample substances in interstitial fluid from the epidermal skin layer. The glucose of the interstitial fluid permeates a dialysis membrane and reaches a sensor. Using MEMS technology, for example, allows well-established batch fabrication at low cost.
摘要翻译： 一种用于物质监测的方法和装置。 一个应用是使用一组中空的平面外的硅微针来容易地处理连续的葡萄糖监测器，以从表皮皮肤层中采集间质液中的物质。 间质液的葡萄糖渗透透析膜并到达传感器。 例如，使用MEMS技术可以以低成本实现良好的批量制造。
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公开(公告)号：US07415299B2
公开(公告)日：2008-08-19
申请号：US10828510
申请日：2004-04-19
IPC分类号： A61B5/05
CPC分类号： A61B5/1486 , A61B5/14514 , A61B5/14525 , A61B5/14532 , A61B2560/0223 , A61B2562/028
摘要： A method and apparatus for substance monitoring. One application is an easy to handle continuous glucose monitor using a group of hollow out-of-plane silicon microneedles to sample substances in interstitial fluid from the epidermal skin layer. The glucose of the interstitial fluid permeates a dialysis membrane and reaches a sensor. Using MEMS technology, for example, allows well-established batch fabrication at low cost.
摘要翻译： 一种用于物质监测的方法和装置。 一个应用是使用一组中空的平面外的硅微针来容易地处理连续的葡萄糖监测器，以从表皮皮肤层中采集间质液中的物质。 间质液的葡萄糖渗透透析膜并到达传感器。 例如，使用MEMS技术可以以低成本实现良好的批量制造。
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公开(公告)号：US20060211933A1
公开(公告)日：2006-09-21
申请号：US10828510
申请日：2004-04-19
CPC分类号： A61B5/1486 , A61B5/14514 , A61B5/14525 , A61B5/14532 , A61B2560/0223 , A61B2562/028
摘要： A method and apparatus for substance monitoring. One application is an easy to handle continuous glucose monitor using a group of hollow out-of-plane silicon microneedles to sample substances in interstitial fluid from the epidermal skin layer. The glucose of the interstitial fluid permeates a dialysis membrane and reaches a sensor. Using MEMS technology, for example, allows well-established batch fabrication at low cost.
摘要翻译： 一种用于物质监测的方法和装置。 一个应用是使用一组中空的平面外的硅微针来容易地处理连续的葡萄糖监测器，以从表皮皮肤层中采集间质液中的物质。 间质液的葡萄糖渗透透析膜并到达传感器。 例如，使用MEMS技术可以以低成本实现良好的批量制造。
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公开(公告)号：US06976527B2
公开(公告)日：2005-12-20
申请号：US10198626
申请日：2002-07-16
IPC分类号： F28D15/04 , H01L23/427 , F28D15/00
CPC分类号： B82Y30/00 , F28D15/043 , H01L23/427 , H01L2924/0002 , H01L2924/00
摘要： A microcapillary pumped loop (CPL) for chip level temperature control includes two mating substrates which define an evaporator, a condenser, and a reservoir for a liquid. A first substrate includes a vapor line which couples vapor from the evaporator to the condenser, and a liquid line which couples liquid from the condenser back to the evaporator. A wicking structure for the evaporator is formed by etching in the second substrate. The wicking structure couples the evaporator to the reservoir and to the liquid line. The condenser includes a plurality of grooves formed in the second substrate which couples liquid from the condenser to the liquid line.
摘要翻译： 用于芯片级温度控制的微毛细管泵回路（CPL）包括限定蒸发器，冷凝器和用于液体的储存器的两个配合基板。 第一衬底包括将蒸气从蒸发器耦合到冷凝器的蒸汽管线，以及将液体从冷凝器连接回蒸发器的液体管线。 用于蒸发器的芯吸结构通过在第二衬底中的蚀刻形成。 芯吸结构将蒸发器连接到储存器和液体管线。 冷凝器包括形成在第二基板中的多个槽，其将液体从冷凝器连接到液体管线。
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6.发明授权Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby 有权在半导体衬底内形成垂直的中空针的方法，以及由此形成的针公开(公告)号：US06406638B1
公开(公告)日：2002-06-18
申请号：US09478913
申请日：2000-01-06
申请人： Boris Stoeber , Dorian Liepmann
发明人： Boris Stoeber , Dorian Liepmann
IPC分类号： H01L21302
摘要： A method of forming a needle includes the step of anisotropically etching a channel into the back side of a semiconductor substrate. The front side of the semiconductor substrate is then isotropically etched to form a vertical axial surface surrounding the channel. The resultant needle has an elongated body formed of a semiconductor material. The elongated body includes an axial surface positioned between a first end and a second end. The axial surface defines a channel between the first end and the second end. In one embodiment, the first end has a sloping tip with a single circumferential termination point.
摘要翻译： 形成针的方法包括将通道各向异性地蚀刻到半导体衬底的背面中的步骤。 然后对半导体衬底的前侧进行各向同性蚀刻以形成围绕通道的垂直轴向表面。 所得针具有由半导体材料形成的细长体。 细长主体包括位于第一端和第二端之间的轴向表面。 轴向表面限定了在第一端和第二端之间的通道。 在一个实施例中，第一端具有具有单个圆周终止点的倾斜尖端。
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公开(公告)号：US20090306454A1
公开(公告)日：2009-12-10
申请号：US12083586
申请日：2006-05-03
申请人： Kimberly P. Cockerham , Harvey A. Fishman , Anthony Liu , Alissa M. Fitzgeral , Dorian Liepmann , Benjamin W. Chul , Michael F. Marmor , Wentai Liu , Juan G. Santiago
发明人： Kimberly P. Cockerham , Harvey A. Fishman , Anthony Liu , Alissa M. Fitzgeral , Dorian Liepmann , Benjamin W. Chul , Michael F. Marmor , Wentai Liu , Juan G. Santiago
CPC分类号： A61N1/36067 , A61M5/14276 , A61M2205/0244 , A61M2210/0612 , A61N1/0543 , A61N1/36017 , A61N1/36046 , A61N1/37205 , A61N1/37288 , A61N1/375 , A61N1/3787
摘要： Devices, systems and methods are provided for directly stimulating tissues, particularly muscle tissues, to modulate muscle contractions (i.e. provide reanimation of the muscle or to suppress undesired muscle contractions). Reanimation of muscles may be desired when damage to the brain, nervous system or neuromuscular junctions have occurred, causing a muscle tissue to lack sufficient motor control. Suppression of muscle contractions may be desired in situations of pathologically hyperactive muscles, such as in conditions of muscle spasm (e.g. blepharospasm and hemifacial spasm) or muscle dystonia. Direct stimulation is achieved by delivering a chemical agent directly to the muscle tissue, particularly the motor end plate, bypassing the nerves and neuromuscular junctions which may be damaged or diseased. Implanted hybrid chemical and electromagnetic stimulation devices can modulate muscle contraction in response to signals from a controller.
摘要翻译： 提供装置，系统和方法用于直接刺激组织，特别是肌肉组织，以调节肌肉收缩（即，提供肌肉的再生或抑制不需要的肌肉收缩）。 当发生对脑，神经系统或神经肌肉接头的损伤时，可能需要恢复肌肉，导致肌肉组织缺乏足够的运动控制。 在病理性活动过度肌肉的情况下，例如肌肉痉挛（例如睑痉挛和半面肌痉挛）或肌肉肌张力障碍的情况下，可能需要抑制肌肉收缩。 直接刺激通过将化学药剂直接递送到肌肉组织，特别是马达端板，绕过可能被损坏或患病的神经和神经肌肉接头来实现。 植入式混合化学和电磁刺激装置可以响应于来自控制器的信号来调节肌肉收缩。
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8.发明申请Method for forming hollow out-of-plane microneedles and devices formed hereby 审中-公开用于形成中空的平面外微针的方法和由此形成的装置公开(公告)号：US20060025717A1
公开(公告)日：2006-02-02
申请号：US11117641
申请日：2005-04-27
IPC分类号： A61M31/00
CPC分类号： B81C1/00111 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , B81B2201/055
摘要： A method and apparatus for forming microneedles and other microstructures using hardenable materials and useful for substance monitoring and/or drug delivery.
摘要翻译： 一种用于使用可硬化材料形成微针和其它微结构并用于物质监测和/或药物递送的方法和装置。
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公开(公告)号：US6065864A
公开(公告)日：2000-05-23
申请号：US999597
申请日：1998-01-23
申请人： John Evans , Dorian Liepmann , Albert P. Pisano
发明人： John Evans , Dorian Liepmann , Albert P. Pisano
CPC分类号： B01F5/0403 , B01F13/0064 , B01F13/0094 , B01F5/10 , B01F2005/0028 , Y10S366/01 , Y10S366/03
摘要： A microelectromechanical system mixes a fluid using predominantly planar laminar flow. The microelectromechanical system includes a mixing chamber and a set of valves to establish the planar laminar flow in the mixing chamber. In one embodiment, bubble-controlled pumps are operated with bubble-controlled valves to establish the predominantly planar laminar flow in the mixing chamber. The bubble-controlled pumps and valves may be used to establish a pulsed double-dipole flow field in the mixing chamber.
摘要翻译： 微机电系统使用主要为平面的层流混合流体。 微机电系统包括混合室和一组阀门，以在混合室中建立平面层流。 在一个实施例中，气泡控制的泵用气泡控制的阀操作以在混合室中建立主要平面的层流。 气泡控制的泵和阀可用于在混合室中建立脉冲双偶极流场。
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公开(公告)号：US20180071730A1
公开(公告)日：2018-03-15
申请号：US15634097
申请日：2017-06-27
申请人： Keith Joseph Breinlinger , Eric D. Hobbs , Dorian Liepmann , Joshua Tanner Nevill , Mark P. White , Maria Jimena Loureiro
发明人： Keith Joseph Breinlinger , Eric D. Hobbs , Dorian Liepmann , Joshua Tanner Nevill , Mark P. White , Maria Jimena Loureiro
CPC分类号： B01L3/5027 , B01L2200/0647 , B01L2200/0684 , B01L2300/0864 , B01L2300/0883 , B01L2400/086 , C12M23/16 , Y10T436/2575
摘要： Some configurations of a microfluidic apparatus can comprise a fluidic circuit of interconnected fluidic structures into which a plurality of different media can be introduced or extracted. A variety of operations can be performed with the different media including isolating with a second medium one or more of the fluidic structures that is filled partially or fully with a first medium. Discrete volumes of a medium can be moved through the isolating second medium to deliver materials or micro-objects to or remove micro-objects or materials from a fluidic structure that is otherwise isolated by the second medium. Some configurations of a microfluidic apparatuses can isolate microfluidic structures in a microfluidic apparatus using flow rates or blocking structures, and some configurations can manage bubbles in fluidic structures.
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