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38 条记录 (耗时 0.037 秒)

    Nasal masks
    3.
    发明申请
    Nasal masks 有权
    鼻罩

    公开(公告)号：US20050028820A1

    公开(公告)日：2005-02-10

    申请号：US10495070

    申请日：2002-10-25

    申请人： Nicholas Smith ,  Alastair McAuley ,  Chris Nightingale ,  Ivan Milivojevic ,  Lewis Gradon

    发明人： Nicholas Smith ,  Alastair McAuley ,  Chris Nightingale ,  Ivan Milivojevic ,  Lewis Gradon

    IPC分类号： A61M16/00 ,  A61M16/06 ,  A61M16/10 ,  A61M16/16 ,  A62B18/02 ,  A62B18/08

    CPC分类号： A61M16/06 ,  A61M16/0069 ,  A61M16/024 ,  A61M16/0633 ,  A61M16/0666 ,  A61M16/0683 ,  A61M16/1095 ,  A61M16/16 ,  A61M2205/0216

    摘要： The present invention is related to patient interfaces, such as nasal masks (2), particularly though not solely for use in providing continuous positive airway pressure therapy or positive pressure ventilation to patients suffering from obstructive sleep apnoea. In a first form the invention is a patient interface that has securement means (601) releasably attaching the interface to headstraps wherein the securement means (601) is slidably engaged with the patient interface. In a second form of the invention the mask headgear is formed of a plurality of straps (701, 702) where at least one of the plurality of straps is slidably engaged with another of the plurality of straps. In a further form the patient interface may be provided with vertically adjustable engaging means (802) that engage the patient interface with the headgear straps.

    摘要翻译： 本发明涉及患者界面，例如鼻罩（2），特别是不仅仅用于向患有阻塞性睡眠呼吸暂停的患者提供持续的气道正压通气或正压通气。 在第一种形式中，本发明是具有固定装置（601）的患者接口，固定装置（601）将接口可释放地附接到头带，其中固定装置（601）可与患者接口滑动接合。 在本发明的第二种形式中，掩模头带由多个带（701,702）形成，其中多个带中的至少一个带可滑动地与多个带中的另一个条带接合。 在另一形式中，患者接口可设置有垂直调节的接合装置（802），其接合患者与头带的接口。

    Breathing assistance apparatus
    4.
    发明申请
    Breathing assistance apparatus 有权
    呼吸辅助器具

    公开(公告)号：US20050056282A1

    公开(公告)日：2005-03-17

    申请号：US10970959

    申请日：2004-10-22

    申请人： Christopher Robertson ,  Nicholas Smith ,  Lewis Gradon

    发明人： Christopher Robertson ,  Nicholas Smith ,  Lewis Gradon

    IPC分类号： A61M16/04 ,  A61M16/06 ,  A61M16/08 ,  A61M16/00

    CPC分类号： A61M16/08 ,  A61M16/0493 ,  A61M16/0495 ,  A61M16/06 ,  A61M16/0825

    摘要： A mouthpiece for oral delivery for oral delivery of CPAP treatment has a vestibular shield for location between the teeth and lips/cheeks of a wearer. The vestibular shield is formed from a very supple material and is dimensioned to extend laterally into the buccal vestibule and vertically to overlap the gums. A gases pathway is provided through the vestibular shield and may include a hard plastic insert through the shield. A connection for connecting the mouthpiece to a breathing circuit is provided which reduces the transfer of forces caused by movement therebetween.

    摘要翻译： 用于口服输送CPAP治疗的口服用具有用于穿戴者的牙齿和嘴唇/脸颊之间的位置的前庭护罩。 前庭护罩由非常柔软的材料形成，并且尺寸设计成横向延伸到颊侧前庭中并且垂直地与牙龈重叠。 通过前庭护罩提供气体通道，并且可以包括穿过护罩的硬塑料插入物。 提供用于将接口连接到呼吸回路的连接，其减少由它们之间的移动引起的力的传递。

    INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE
    6.
    发明申请
    INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE 审中-公开
    用于治疗疾病的组织脱乙酰酶的抑制剂

    公开(公告)号：US20070135438A1

    公开(公告)日：2007-06-14

    申请号：US11608736

    申请日：2006-12-08

    申请人： Joseph Payne ,  Nicholas Smith ,  Shawn Scranton ,  Christian Hassig

    发明人： Joseph Payne ,  Nicholas Smith ,  Shawn Scranton ,  Christian Hassig

    IPC分类号： A61K31/53 ,  A61K31/4965 ,  C07D253/08 ,  A61K31/505

    CPC分类号： C07D213/76 ,  C07D405/12

    摘要： Disclosed herein are carbonyl compounds of having the structural formula: or a pharmaceutically acceptable salt, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

    摘要翻译： 本文公开了具有以下结构式的羰基化合物：或其药学上可接受的盐，酯或前药。公开了用于治疗疾病状态的方法和组合物，包括但不限于癌症，自身免疫疾病，组织损伤，中枢神经系统疾病 使用本发明的化合物，神经变性疾病，纤维化，骨病，聚谷氨酰胺重复病症，贫血，地热病，炎性病症，心血管病症和血管生成在发病机理中发挥作用的病症。 此外，还公开了调节组蛋白脱乙酰酶（HDAC）的活性的方法。

    Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5
    7.
    发明申请
    Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5 审中-公开
    代谢型谷氨酸受体-5的二芳基取代的吡唑调节剂

    公开(公告)号：US20060194807A1

    公开(公告)日：2006-08-31

    申请号：US10551709

    申请日：2004-03-30

    申请人： Nicholas Cosford ,  Brian Eastman ,  Dehua Huang ,  Nicholas Smith ,  Lida Tehrani ,  Essa Hu

    发明人： Nicholas Cosford ,  Brian Eastman ,  Dehua Huang ,  Nicholas Smith ,  Lida Tehrani ,  Essa Hu

    IPC分类号： A61K31/506 ,  A61K31/498 ,  A61K31/4709 ,  A61K31/4439 ,  C07D403/14

    CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04

    摘要： Novel pyrazole compounds such as compounds of the formula (I): (where A, A1, A2, B, R11, W, X, Y and Z are as defined herein) in which the pyrazole is substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, and ii) another heteroaryl or aryl ring, with at least one of the rings being further substituted with another ring, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, panic, and bipolar disorder, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm disorders, obesity, drug addiction, drug abuse, drug withdrawal and other diseases.

    摘要翻译： 新的吡唑化合物，例如式（I）的化合物：其中A，A 1，A 2，B，R 11，W ，X，Y和Z如本文所定义），其中吡唑直接被取代，或通过桥取代，其中i）杂芳基部分含有与杂芳基的连接点相邻的N，和ii）另一个杂芳基或芳基环 ，其中至少一个环被另一个环取代，是用于治疗精神病和情绪障碍的mGluR5调节剂，例如精神分裂症，焦虑症，抑郁症，恐慌症和双相情感障碍，以及在 治疗疼痛，帕金森病，认知功能障碍，癫痫，昼夜节律紊乱，肥胖，药物成瘾，药物滥用，戒毒等疾病。

    Skateboard truck mounting apparatus
    10.
    发明授权
    Skateboard truck mounting apparatus 有权

    公开(公告)号：US12042715B2

    公开(公告)日：2024-07-23

    申请号：US17625401

    申请日：2022-01-06

    申请人： Nicholas Smith

    发明人： Nicholas Smith

    IPC分类号： A63C17/01

    CPC分类号： A63C17/017 ,  A63C2203/42

    摘要： A skateboard truck mounting apparatus is provided. The skateboard truck mounting apparatus includes a rigid body, having a first hole and a second hole, where the holes are configured to interface with the holes on a skateboard deck. Both the first hole and the second hole are equipped with self-locking mechanisms.