-
公开(公告)号：US07887691B2
公开(公告)日：2011-02-15
申请号：US10530694
申请日：2003-10-09
申请人： Alexander Giles Davies , Christoph Walti , Anton Peter Jacob Middelberg , Michael Pepper , Rene Wirtz
发明人： Alexander Giles Davies , Christoph Walti , Anton Peter Jacob Middelberg , Michael Pepper , Rene Wirtz
IPC分类号： C25D5/02
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00427 , B01J2219/005 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , C40B60/14 , C12Q2565/607
摘要： The present invention provides a method of forming coatings of at least two different coating molecules on at least two electrodes, the method comprising: (a) providing an array of at least two individually-addressable electrodes, (b) allowing a layer of a masking molecule to adsorb onto all electrodes, (c) inducing electrochemical desorption of the masking molecule from at least one but not all electrodes to expose a first set of exposed electrodes, (d) allowing a first coating molecule to adsorb onto the first set of exposed electrodes, (e) exposing all electrodes to a masking molecule to allow adsorption of the masking molecule onto all electrodes, (f) inducing electrochemical desorption of masking molecule from a second set of electrodes to expose a second set of exposed electrodes, (g) allowing a second coating molecule to adsorb onto the second set of exposed electrodes.
摘要翻译： 本发明提供了一种在至少两个电极上形成至少两种不同涂层分子的涂层的方法，所述方法包括：（a）提供至少两个可单独寻址的电极的阵列，（b）允许掩模层 分子吸附到所有电极上，（c）从至少一个但不是全部电极诱导掩蔽分子的电化学解吸，以暴露出第一组暴露的电极，（d）允许第一涂层分子吸附到第一组曝光 （e）将所有电极暴露于掩蔽分子以允许掩蔽分子吸附到所有电极上，（f）从第二组电极诱导掩蔽分子的电化学解吸，以暴露第二组暴露电极，（g） 允许第二涂层分子吸附到第二组曝光电极上。
-
公开(公告)号：US20150031600A1
公开(公告)日：2015-01-29
申请号：US13994482
申请日：2011-12-14
CPC分类号： C11D3/386 , C07K14/00 , C07K14/001 , C11D3/3719 , C11D3/38
摘要： The present invention relates to designed polypeptide biosurfactants that may be prepared by recombinant technology in commercially useful amounts and purified by simple non-chromatographic methods. The designed polypeptide biosurfactants comprise at least one stimuli-responsive amino acid residue or at least one glutamine or asparagine residue and may be useful in modulating the stability of a foam, alone or in combination with an α-helical peptide. The designed polypeptide biosurfactant may be useful in the formation and collapse of foams in foods, beverages, pharmaceuticals, personal care products, cosmetics, cleaning products, mineral recovery, bioremediation, oil recovery and laundry products. The designed biosurfactants may also be useful in recombinant production and purification of peptides, polypeptides and proteins.
摘要翻译： 本发明涉及可以通过重组技术以商业上有用的量制备并通过简单的非色谱方法纯化的设计的多肽生物表面活性剂。 设计的多肽生物表面活性剂包含至少一种刺激响应性氨基酸残基或至少一种谷氨酰胺或天冬酰胺残基，并且可用于单独或与α-螺旋肽组合调节泡沫的稳定性。 设计的多肽生物表面活性剂可用于食品，饮料，药物，个人护理产品，化妆品，清洁产品，矿物回收，生物修复，油回收和洗衣产品中的泡沫的形成和塌陷。 设计的生物表面活性剂也可用于肽，多肽和蛋白质的重组生产和纯化。
-
公开(公告)号：US09580481B2
公开(公告)日：2017-02-28
申请号：US14237698
申请日：2012-08-13
IPC分类号： C07K14/315 , A61K39/09 , A61K39/145 , A61K39/155 , A61K39/21 , C12N15/62 , A61K9/107 , A61K9/51 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： C07K14/315 , A61K9/1075 , A61K9/5184 , A61K39/09 , A61K39/092 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/21 , A61K2039/523 , A61K2039/5256 , A61K2039/5258 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C12N15/62 , C12N2710/22022 , C12N2710/22043 , C12N2760/16134 , C12N2760/18234 , Y02A50/467
摘要： The present invention provides compositions relating to viral capsomeres which comprise foreign immunogenic sequences for use in pharmaceutical compositions and methods of producing such compositions, and related isolated or purified protein and nucleic acid molecules, vectors, host cells, compositions, and methods of use to augment an immune response, immunize an animal and prophylactically or therapeutically treat a disease, disorder or condition. The viral capsomere may be derived from a polyomavirus and comprise an immunogen of interest at the N-terminus and further at the C-terminus and/or at one or more exposed loops of the capsomere.
摘要翻译： 本发明提供了涉及病毒壳聚糖的组合物，其包含用于药物组合物的外源免疫原性序列和生产此类组合物的方法，以及相关的分离或纯化的蛋白质和核酸分子，载体，宿主细胞，组合物和增加使用的方法 免疫应答，免疫动物并预防或治疗治疗疾病，病症或病症。 病毒性胶质瘤可以衍生自多瘤病毒，并且包含感兴趣的免疫原在N末端以及进一步在所述辣椒疫苗的C末端和/或一个或多个暴露的环上。
-
公开(公告)号：US20100273983A1
公开(公告)日：2010-10-28
申请号：US12594821
申请日：2008-04-04
摘要： A method is provided for purifying peptides by selective precipitation of contaminating proteins, such as host cell proteins and cleaved fusion partners. Also provided is a method of cleaving fusion proteins in cell lysates.
摘要翻译： 提供了通过选择性沉淀污染性蛋白质（例如宿主细胞蛋白质和切割的融合配偶体）来纯化肽的方法。 还提供了在细胞裂解物中切割融合蛋白的方法。
-
公开(公告)号：US20100028375A1
公开(公告)日：2010-02-04
申请号：US12444092
申请日：2007-10-04
IPC分类号： A61K39/12 , C07K7/06 , C07K7/08 , C12N15/11 , C12N15/00 , C12N1/21 , C12N5/10 , C07H1/00 , C12P21/02 , A61K38/08
CPC分类号： A61K39/145 , A61K39/12 , A61K39/385 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K2319/735 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2760/16122 , C12N2760/16134 , Y02A50/467
摘要： An isolated protein comprising a VP1 amino acid sequence wherein one or more exposed loops within said VP1 has an insertion of an amino acid sequence from a virus protein other than VP1, and encoding nucleic acid, are provided. Typically, the virus protein other than VP1 is derived from an influenza virus and in particular, avian influenza virus. The isolated protein may have an insertion of amino acid sequence from a single protein or a plurality of proteins. Also provided are expression constructs, VLPs, pharmaceutical compositions, vaccines and methods of treatment that may be useful in the prophylactic and/or therapeutic treatment of any disease of viral origin, and in particular, influenza virus.
摘要翻译： 提供了包含VP1氨基酸序列的分离的蛋白质，其中所述VP1内的一个或多个暴露的环从除了VP1以外的病毒蛋白插入氨基酸序列，并编码核酸。 通常，除VP1以外的病毒蛋白质来自流感病毒，特别是禽流感病毒。 分离的蛋白质可以具有来自单一蛋白质或多种蛋白质的氨基酸序列的插入。 还提供了可用于预防和/或治疗任何病毒来源疾病，特别是流感病毒的表达构建体，VLP，药物组合物，疫苗和治疗方法。
-
公开(公告)号：US20120046444A1
公开(公告)日：2012-02-23
申请号：US13275213
申请日：2011-10-17
CPC分类号： C07K14/00 , B01D17/047 , C07K1/00 , C07K1/107 , C07K7/06 , C07K14/001 , C07K14/47
摘要： Methods of modulating interfacial characteristics in a self-assembled, force-transmitting peptide network at a fluid-fluid interface are disclosed. The methods involve exposing a peptide capable of participating in a self-assembled, force-transmitting peptide network, either before or after it interacts with other peptides to form the peptide network to a stimulus that alters the chemical and/or physical properties of the peptide. Use of such methods in applications such as emulsions and foams are also disclosed.
摘要翻译： 公开了在流体 - 流体界面处调节自组装的力传递肽网络中的界面特性的方法。 所述方法包括将能够参与自组装的力传递肽网络的肽暴露于其与其它肽相互作用之前或之后，以形成肽网络以改变肽的化学和/或物理性质的刺激 。 还公开了在乳液和泡沫等应用中使用这些方法。
-
公开(公告)号：US20100152420A1
公开(公告)日：2010-06-17
申请号：US11817144
申请日：2006-02-24
CPC分类号： C07K14/00 , B01D17/047 , C07K1/00 , C07K1/107 , C07K7/06 , C07K14/001 , C07K14/47
摘要： Methods of modulating interfacial characteristics in a self-assembled, force-transmitting peptide network at a fluid-fluid interface are disclosed. The methods involve exposing a peptide capable of participating in a self-assembled, force-transmitting peptide network, either before or after it interacts with other peptides to form the peptide network to a stimulus that alters the chemical and/or physical properties of the peptide. Use of such methods in applications such as emulsions and foams are also disclosed.
摘要翻译： 公开了在流体 - 流体界面处调节自组装的力传递肽网络中的界面特性的方法。 所述方法包括将能够参与自组装的力传递肽网络的肽暴露于其与其它肽相互作用之前或之后，以形成肽网络以改变肽的化学和/或物理性质的刺激 。 还公开了在乳液和泡沫等应用中使用这些方法。
-
公开(公告)号：US20140302076A1
公开(公告)日：2014-10-09
申请号：US14237698
申请日：2012-08-13
IPC分类号： C07K14/005 , C07K14/315
CPC分类号： C07K14/315 , A61K9/1075 , A61K9/5184 , A61K39/09 , A61K39/092 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/21 , A61K2039/523 , A61K2039/5256 , A61K2039/5258 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C12N15/62 , C12N2710/22022 , C12N2710/22043 , C12N2760/16134 , C12N2760/18234 , Y02A50/467
摘要： The present invention provides compositions relating to viral capsomeres which comprise foreign immunogenic sequences for use in pharmaceutical compositions and methods of producing such compositions, and related isolated or purified protein and nucleic acid molecules, vectors, host cells, compositions, and methods of use to augment an immune response, immunise an animal and prophylactically or therapeutically treat a disease, disorder or condition. The viral capsomere may be derived from a polyomavirus and comprise an immunogen of interest at the N-terminus and further at the C-terminus and/or at one or more exposed loops of the capsomere.
摘要翻译： 本发明提供了涉及病毒壳聚糖的组合物，其包含用于药物组合物的外源免疫原性序列和生产此类组合物的方法，以及相关的分离或纯化的蛋白质和核酸分子，载体，宿主细胞，组合物和增加使用的方法 免疫应答，免疫动物并预防或治疗治疗疾病，病症或病症。 病毒性胶质瘤可以衍生自多瘤病毒，并且包含感兴趣的免疫原在N末端以及进一步在所述辣椒疫苗的C末端和/或一个或多个暴露的环上。
-
公开(公告)号：US08512711B2
公开(公告)日：2013-08-20
申请号：US12444092
申请日：2007-10-04
IPC分类号： A61K39/12 , A61K39/145 , A61K39/295 , C12Q1/70
CPC分类号： A61K39/145 , A61K39/12 , A61K39/385 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K2319/735 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2760/16122 , C12N2760/16134 , Y02A50/467
摘要： An isolated protein comprising a VP1 amino acid sequence wherein one or more exposed loops within said VP1 has an insertion of an amino acid sequence from a virus protein other than VP1, and encoding nucleic acid, are provided. Typically, the virus protein other than VP1 is derived from an influenza virus and in particular, avian influenza virus. The isolated protein may have an insertion of amino acid sequence from a single protein or a plurality of proteins. Also provided are expression constructs, VLPs, pharmaceutical compositions, vaccines and methods of treatment that may be useful in the prophylactic and/or therapeutic treatment of any disease of viral origin, and in particular, influenza virus.
摘要翻译： 提供了包含VP1氨基酸序列的分离的蛋白质，其中所述VP1内的一个或多个暴露的环从除了VP1以外的病毒蛋白插入氨基酸序列，并编码核酸。 通常，除VP1以外的病毒蛋白质来自流感病毒，特别是禽流感病毒。 分离的蛋白质可以具有来自单一蛋白质或多种蛋白质的氨基酸序列的插入。 还提供了可用于预防和/或治疗任何病毒来源疾病，特别是流感病毒的表达构建体，VLP，药物组合物，疫苗和治疗方法。
-
公开(公告)号：US08039582B2
公开(公告)日：2011-10-18
申请号：US11817144
申请日：2006-02-24
CPC分类号： C07K14/00 , B01D17/047 , C07K1/00 , C07K1/107 , C07K7/06 , C07K14/001 , C07K14/47
摘要： Methods of modulating interfacial characteristics in a self-assembled, force-transmitting peptide network at a fluid-fluid interface are disclosed. The methods involve exposing a peptide capable of participating in a self-assembled, force-transmitting peptide network, either before or after it interacts with other peptides to form the peptide network to a stimulus that alters the chemical and/or physical properties of the peptide. Use of such methods in applications such as emulsions and foams are also disclosed.
摘要翻译： 公开了在流体 - 流体界面处调节自组装的力传递肽网络中的界面特性的方法。 所述方法包括将能够参与自组装的力传递肽网络的肽暴露于其与其它肽相互作用之前或之后，以形成肽网络以改变肽的化学和/或物理性质的刺激 。 还公开了在乳液和泡沫等应用中使用这些方法。
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.033 秒)
