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    Method of influencing the inflection angle of railway vehicle wagons, and railway vehicle for carrying out this method
    1.
    发明授权
    Method of influencing the inflection angle of railway vehicle wagons, and railway vehicle for carrying out this method 失效
    影响铁路车辆车辆拐点的方法，铁路车辆执行该方法

    公开(公告)号：US06161064A

    公开(公告)日：2000-12-12

    申请号：US117638

    申请日：1998-12-01

    Applicant: Andreas Strasser ,  Ulrich Hachmann

    Inventor： Andreas Strasser ,  Ulrich Hachmann

    IPC: B61F5/42 ,  B61D3/10 ,  B61F5/38 ,  B61F5/44

    CPC classification number: B61D3/10 ,  B61F5/386 ,  B61F5/44

    Abstract: A multiple-unit railway vehicle having three car bodies where the respective neighboring car bodies are each connected in a pivoting manner to one another by means of a single coupling, and each car body sits only on one two-axle truck. In the vicinity of the respective center pivot and possibly also on the trucks, there are actuator elements that are used to influence the articulation angle between the longitudinal axes of the car bodies. To control the articulation angle so that when the train is traveling over a curved segment of track, the car bodies assume a position in relation to one another that corresponds at least to a significant extent to the static rest position of the railway vehicle on the corresponding section of track, the profile and curvature of the track are determined during travel for the segment of the track that currently lies between the first and last trucks, and from that measurement, the set point position is determined, and by means of the actuator system measurements are taken to counteract at least an overshooting or undershooting of the set point value.

    Abstract translation: PCT No.PCT / EP97 / 06249 371 1998年12月1日第 102（e）日期1998年12月1日PCT 1997年11月11日PCT PCT。 公开号WO98 / 24676 日期1998年6月11日具有三个汽车车体的多单元铁路车辆，其中各个相邻的车体通过单个联轴节彼此以枢转的方式相互连接，并且每个车身仅位于一个双轴卡车 。 在相应的中心枢轴附近以及在卡车附近，存在用于影响车体的纵向轴线之间的铰接角度的致动器元件。 为了控制关节角度，使得当火车行驶在轨道的弯曲部分上时，车体相对于彼此呈现至少相当大程度上对应于相应的铁路车辆的静止静止位置的位置 轨道的截面，轨迹的轮廓和曲率在目前位于第一和最后一个卡车之间的轨道段的行驶期间确定，并且从该测量中确定设定点位置，并且借助于致动器系统 进行测量以至少抵消设定点值的过冲或下冲。

    Machine tool and method for operating a machine tool
    6.
    发明授权
    Machine tool and method for operating a machine tool 失效
    用于操作机床的机床和方法

    公开(公告)号：US07636516B2

    公开(公告)日：2009-12-22

    申请号：US11814394

    申请日：2006-09-11

    Applicant: Karl Frauhammer ,  Gerhard Meixner ,  Martin Rittner ,  Heinz Schnerring ,  Andreas Strasser

    Inventor： Karl Frauhammer ,  Gerhard Meixner ,  Martin Rittner ,  Heinz Schnerring ,  Andreas Strasser

    IPC: H02P5/00

    CPC classification number: B25F5/00 ,  B25D16/006 ,  Y10S388/937

    Abstract: The invention relates to a machine tool comprising an electric motor (2) which serves to drive a tool and which has an adjustable, electric brush arrangement (3), and comprising a mode selector switch (6) having various switch positions. Provision is made for an adjusting device (8) to displace the brush arrangement (3) as a function of the switch position of the mode selector switch (6). Furthermore, the invention relates to a corresponding method.

    Abstract translation: 本发明涉及一种包括电动机（2）的机床，其用于驱动工具并具有可调整的电刷装置（3），并且包括具有各种开关位置的模式选择器开关（6）。 根据模式选择器开关（6）的开关位置，调整装置（8）用于移动刷子装置（3）。 此外，本发明涉及一种相应的方法。

    Bcl-2-modifying factor (bmf) sequences and their use in modulating apoptosis
    9.
    发明申请
    Bcl-2-modifying factor (bmf) sequences and their use in modulating apoptosis 失效
    Bcl-2修饰因子（bmf）序列及其在凋亡调控中的应用

    公开(公告)号：US20050064593A1

    公开(公告)日：2005-03-24

    申请号：US10479307

    申请日：2002-05-30

    Applicant: Andreas Strasser ,  Hamsa Puthalakath ,  Andreas Villunger ,  Leigh Coultas ,  Jennifer Beaumont ,  Lorraine O'reilly ,  David Huang

    Inventor： Andreas Strasser ,  Hamsa Puthalakath ,  Andreas Villunger ,  Leigh Coultas ,  Jennifer Beaumont ,  Lorraine O'reilly ,  David Huang

    IPC: A01K67/027 ,  A61K38/00 ,  A61K45/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07K14/47 ,  C07K16/18 ,  C12N5/10 ,  C12N15/09 ,  C12N15/11 ,  C12N15/12 ,  C12P21/08 ,  G01N33/53 ,  A61K48/00 ,  C07H21/04

    CPC classification number: C07K14/4747 ,  A01K2217/05 ,  A61K38/00

    Abstract: The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bmf”, and to genetic sequences encoding same and to regulatory sequences such as a promoter sequence directing expression of Bmf. Bmf comprises a BH3 domain which facilitates interaction to pro-survival Bcl-2 family members thereby triggering apoptosis. Bmf is regarded, therefore, as a BH3-only molecule. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry. The present invention further contemplates genetically modified animals in which one or both alleles of Bmf are mutated or partially or wholly deleted alone or in combination with a mutation in one or both alleles of another Bcl-2-type molecule such as but not limited to Bim. The genetically modified animals are useful inter alia in screening for agents which ameliorate the symptoms of diseases caused by defects in apoptosis or which specifically promote apoptosis of target cells.

    Abstract translation: 本发明一般涉及能够特别调节哺乳动物细胞凋亡和编码其的遗传序列的新型分子。 更具体地，本发明涉及Bcl-2家族蛋白质的新成员，本文称为“Bmf”，以及编码它们的遗传序列以及调节序列，例如引导Bmf表达的启动子序列。 Bmf包含BH3结构域，其促进与生存Bcl-2家族成员的相互作用，从而引发细胞凋亡。 因此，Bmf被认为是仅BH3分子。 本发明的分子可用于例如治疗，诊断，抗体产生以及作为能够调节生理细胞死亡或生存和/或调节细胞周期进入的治疗剂的筛选工具。 本发明进一步考虑了遗传修饰的动物，其中Bmf的一个或两个等位基因单独突变或部分或全部缺失，或与另一个Bcl-2型分子的一个或两个等位基因中的突变组合，例如但不限于Bim 。 遗传修饰的动物尤其可用于筛选改善由凋亡缺陷引起的疾病症状或特异性促进靶细胞凋亡的药剂。

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