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    Cyclic polyamine compounds for cancer therapy
    8.
    发明申请
    Cyclic polyamine compounds for cancer therapy 审中-公开
    循环多胺化合物用于癌症治疗

    公开(公告)号：US20050130949A1

    公开(公告)日：2005-06-16

    申请号：US11046344

    申请日：2005-01-27

    申请人： Benjamin Frydman ,  Manfred Hesse ,  Armin Guggisberg ,  Kasim Popaj ,  Konstantin Drandarov ,  Hirak Basu ,  Subhra Bhattacharya ,  Yu Wang

    发明人： Benjamin Frydman ,  Manfred Hesse ,  Armin Guggisberg ,  Kasim Popaj ,  Konstantin Drandarov ,  Hirak Basu ,  Subhra Bhattacharya ,  Yu Wang

    IPC分类号： C07D255/02 ,  C07D257/02 ,  C07D245/02 ,  A61K31/506

    CPC分类号： C07D255/02 ,  C07D257/02

    摘要： Novel cyclic polyamine compounds of the form where A1, each A2 (if present), and A3 are independently selected from C1-C8 alkyl, where each Y is independently selected from H or C1-C4 alkyl, where M is selected from C1-C4 alkyl, where k is 0, 2, or 3, and where R is selected from C1-C32 alkyl, as well as all stereoisomers and salts thereof, are disclosed. Additional compounds where k is 1 and A2 is independently selected from C1-C3 alkyl or C5-C8 alkyl are also disclosed. Cyclic polyamines, where the amide group is reduced to a secondary amino group, and various derivatives of these compounds, are also described. Synthetic methods for the compounds are described. The compounds are useful for treating diseases caused by uncontrolled proliferation of cells, such as cancer, especially prostate cancer, and for inducing intracellular ATP hydrolysis for treatment of other disorders.

    摘要翻译： 其中A 1 A 1，每个A 2（如果存在）和A 3 N 3的形式的新型环状多胺化合物独立地选自C SUB 其中每个Y独立地选自H或C 1 -C 4烷基，其中M（C 1 -C 4）烷基，其中每个Y独立地选自H或C 1 -C 4烷基，其中M 选自C 1 -C 4烷基，其中k是0,1,2或3，并且其中R选自C 1 -C 4 - C 32烷基，以及其全部立体异构体和盐。 其中k为1且A 2 H 2的其它化合物独立地选自C 1 -C 3烷基或C 5 - -C 8烷基也被公开。 还描述了其中酰胺基还原为仲氨基的环状多胺，以及这些化合物的各种衍生物。 描述了化合物的合成方法。 该化合物可用于治疗由不受控制的细胞增殖（例如癌症，特别是前列腺癌）引起的疾病，并用于诱导细胞内ATP水解以治疗其他疾病。