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    AGP-antibody fusion proteins and related molecules and methods
    4.
    发明授权
    AGP-antibody fusion proteins and related molecules and methods 失效
    AGP抗体融合蛋白及相关分子及方法

    公开(公告)号：US06613746B1

    公开(公告)日：2003-09-02

    申请号：US08472888

    申请日：1995-06-07

    申请人： Brian Seed ,  Gerd Walz

    发明人： Brian Seed ,  Gerd Walz

    IPC分类号： A01N4304

    CPC分类号： C07K16/2854 ,  A61K38/00 ,  C07K14/4703 ,  C07K14/70564 ,  C07K14/70596 ,  C07K16/00 ,  C07K2317/41 ,  C07K2319/00 ,  Y10S435/972

    摘要： Disclosed is a method of inhibiting the binding of a cell bearing a cell adhesion protein to a molecule or cell bearing a carbohydrate determinant specific for the cell adhesion molecule. The method involves contacting the cell adhesion protein-bearing cell with an AGP-antibody bearing the carbohydrate determinant. Also disclosed are AGP-antibody fusion proteins to which are covalently bonded carbohydrate moieties which interfere with the antibody portion's ability to fix complement and bind an Fc receptor. The methods of the invention may be used, for example, in any antibody-based therapy, for example, to reduce inflammation.

    摘要翻译： 公开了抑制携带细胞粘附蛋白的细胞与具有细胞粘附分子特异性的碳水化合物决定簇的分子或细胞的结合的方法。 该方法包括使携带细胞粘附蛋白的细胞与携带碳水化合物决定簇的AGP-抗体接触。 还公开了AGP-抗体融合蛋白，其是共价键合的碳水化合物部分，其干扰抗体部分固定补体并结合Fc受体的能力。 本发明的方法可以用于例如任何基于抗体的治疗中，例如，以减少炎症。

    METHOD FOR DIAGNOSING POLYCYSTIC KIDNEY DISEASE
    6.
    发明申请
    METHOD FOR DIAGNOSING POLYCYSTIC KIDNEY DISEASE 审中-公开
    诊断多囊性疾病的方法

    公开(公告)号：US20110229895A1

    公开(公告)日：2011-09-22

    申请号：US12160696

    申请日：2007-01-17

    申请人： Gerd Walz

    发明人： Gerd Walz

    IPC分类号： C12Q1/68 ,  C07K16/18 ,  G01N33/53

    CPC分类号： G01N33/5091 ,  G01N33/6893 ,  G01N2800/347

    摘要： The present invention relates to the diagnosis of renal disorders, in particular of polycystic kidney disease (PKD). The invention provides methods for diagnosing or monitoring the progression of PKD and test kits useful in those methods.

    摘要翻译： 本发明涉及肾病，特别是多囊肾病（PKD）的诊断。 本发明提供用于诊断或监测PKD进展的方法和用于那些方法的测试试剂盒。

    Unsaturated polyurethanes and their use as dispersants for alkyd resins
    7.
    发明授权
    Unsaturated polyurethanes and their use as dispersants for alkyd resins 失效
    不饱和聚氨酯及其作为醇酸树脂分散剂的用途

    公开(公告)号：US5466772A

    公开(公告)日：1995-11-14

    申请号：US205600

    申请日：1994-03-03

    申请人： Karl-Hans Angelmayer ,  Gerd Walz ,  Joachim Zoeller

    发明人： Karl-Hans Angelmayer ,  Gerd Walz ,  Joachim Zoeller

    IPC分类号： C08G18/67 ,  B01F17/52 ,  C08G18/08 ,  C08G18/28 ,  C08G18/32 ,  C08G18/34 ,  C08G18/48 ,  C08G18/66 ,  C08J3/03 ,  C08L67/00 ,  C08L67/02 ,  C08L75/16 ,  C09D175/14

    CPC分类号： C08J3/03 ,  C08G18/0819 ,  C08G18/2825 ,  C08G18/283 ,  C08G18/284 ,  C08G18/2865 ,  C08G18/4833 ,  C08J2367/08 ,  Y10T428/31645 ,  Y10T428/31649

    摘要： Unsaturated polyurethanes containing from 20 to 80% by weight of polyethylene glycol units, which can be prepared by reactinga) at least one organic polyisocyanate,b) an unsaturated fatty alcohol or its polyalkylene glycol ether, an unsaturated fatty amine or a reaction product of an unsaturated fatty acid and a monoepoxide,c) a compound which contains not only two groups which react with isocyanate groups but also at least one group which is ionic.d) a polyalkylene glycol having a molecular mass of from 750 to 10,000, and if desirede) a compound containing from three to six hydroxyl or amino groups,the ratio of the isocyanate groups in a) to the hydroxyl and amino groups in the remaining components being from 0.7:1 to 1.2:1. These unsaturated polyurethanes are used as dispersants for alkyd resins.

    摘要翻译： 含有20至80重量％的聚乙二醇单元的不饱和聚氨酯可通过使a）至少一种有机多异氰酸酯，b）不饱和脂肪醇或其聚亚烷基二醇醚，不饱和脂肪胺或不饱和脂肪胺或 不饱和脂肪酸和单环氧化物，c）不仅含有与异氰酸酯基反应的两个基团，而且还含有至少一个离子性基团的化合物。 d）分子量为750至10,000的聚亚烷基二醇，如果需要，e）含有3-6个羟基或氨基的化合物，a）中的异氰酸酯基与剩余的羟基和氨基的比例 组分为0.7:1至1.2:1。 这些不饱和聚氨酯用作醇酸树脂的分散剂。

    Curable copolymers, a process for their preparation and their use
    8.
    发明授权
    Curable copolymers, a process for their preparation and their use 失效
    可固化共聚物，其制备方法及其用途

    公开(公告)号：US4704442A

    公开(公告)日：1987-11-03

    申请号：US826789

    申请日：1986-02-06

    申请人： Christoph Just ,  Dieter Plath ,  Gerd Walz

    发明人： Christoph Just ,  Dieter Plath ,  Gerd Walz

    IPC分类号： C08F222/22 ,  C09D135/00 ,  C08F24/00

    CPC分类号： C08F222/22 ,  C09D135/00

    摘要： Copolymers based on (A) 5-95% by weight of at least one polymerizable carbamoyloxyalkyldicarboxylic acid ester, carrying hydroxyl groups, of the general formula I ##STR1## in which R.sup.1 represents hydrogen or alkyl or hydroxyalkyl having in each case 1 to 30 carbon atoms in the alkyl radical, R.sup.2 represents alkyl or hydroxyalkyl having in each case 1 to 30 carbon atoms in the alkyl radical, or the radical ##STR2## subject to the proviso that R.sup.1 is hydrogen and x is an integer from 2 to 10, R.sup.3 represents linear or branched alkylene having 2 to 5 carbon atoms, R.sup.4 represents hydrogen or methyl and R.sup.5 represents hydroxyalkyl or hydroxyaminoalkyl having in each case 2 to 20 carbon atoms in the alkyl radical, or an alkyl radical of this type which also contains ester groups and/or ether groups, and (B) 5-95% by weight of at least one copolymerizable monomer belonging to the group comprising (a) .alpha.,.beta.-olefinically unsaturated monocarboxylic acid and alkyl and hydroxyalkyl esters thereof having in each case 1 to 18 carbon atoms in the alkyl radical, and amides and nitriles thereof, and also monoalkyl and dialkyl esters of .alpha.,.beta.-olefinically unsaturated dicarboxylic acids having 1 to 18 carbon atoms in the alkyl radical, (b) vinyl-aromatic monomers, (c) vinyl esters of organic monocarboxylic acids having 1 to 18 carbon atoms in the carboxylic acid radical, and (d) glycidyl esters of unsaturated monocarboxylic and/or dicarboxylic acids, the sum of the components (A) and (B) being in all cases 100% by weight, and a process for their preparation.The copolymers are used for the preparation of shaped articles and/or coatings which have excellent properties.

    摘要翻译： 基于（A）5-95重量％的至少一种带有羟基的可聚合的氨基甲酰氧基烷基二羧酸酯，其通式为Ⅰ，其中R1代表氢或烷基或羟基烷基，其中在每种情况下为1-30碳 烷基中的原子，R 2表示在每个情况下在烷基中具有1至30个碳原子的烷基或羟烷基，或者基团，条件是R 1是氢且x是2至10的整数，R 3 表示具有2至5个碳原子的直链或支链亚烷基，R4表示氢或甲基，R5表示在烷基中各自为2至20个碳原子的羟基烷基或羟基氨基烷基，或还含有酯基的这种类型的烷基， /或醚基，和（B）5-95重量％的至少一种可共聚单体，其属于包含（a）α，β-烯属不饱和一元羧酸及其烷基和羟烷基酯的组 在每种情况下，烷基中的1至18个碳原子，以及其酰胺和腈，以及在烷基中具有1至18个碳原子的α，β-烯属不饱和二羧酸的单烷基和二烷基酯，（b）乙烯基 - 芳族单体，（c）在羧酸基团中具有1至18个碳原子的有机单羧酸的乙烯基酯，和（d）不饱和一元羧酸和/或二羧酸的缩水甘油酯，组分（A）和（ B）在所有情况下为100重量％，以及其制备方法。 共聚物用于制备具有优异性能的成型制品和/或涂层。

    Reactive hardenable binder mixture, process for preparing hardened products and use of the mixture for the preparation of coatings
    9.
    发明授权
    Reactive hardenable binder mixture, process for preparing hardened products and use of the mixture for the preparation of coatings 失效
    活性可硬化粘合剂混合物，制备硬化产品的方法和使用该混合物制备涂料

    公开(公告)号：US4411955A

    公开(公告)日：1983-10-25

    申请号：US316806

    申请日：1981-11-02

    申请人： Josef Mondt ,  Gerd Walz ,  Thaddaus Wirth

    发明人： Josef Mondt ,  Gerd Walz ,  Thaddaus Wirth

    IPC分类号： C08G59/00 ,  C08G59/14 ,  C08G59/24 ,  C08G59/34 ,  C08G59/42 ,  C08G59/48 ,  C08G59/68 ,  C08L33/00 ,  C08L33/02 ,  C08L63/00 ,  C08L67/00 ,  C09D163/00 ,  C09J163/00 ,  B32B27/28

    CPC分类号： C08G59/027 ,  C08G59/145 ,  C08G59/24 ,  C08G59/42 ,  C08G59/4246 ,  C08G59/685 ,  C09D163/00 ,  Y10T428/31511

    摘要： A reactive hardenable binder composition based on(A) at least one aliphatic, cycloaliphatic or aliphatic-cycloaliphatic polyepoxide wherein at least 2 epoxidized cycloaliphatic radicals are bound via an aliphatic bridge,(B) at least one polycarboxylic acid unit of formula ##STR1## having an acid number between 30 and 400 whereinR.sup.1 is a radical of an at least oligomer product selected from the group consisting of polyesters and polymers having initially free OH-groups,R.sup.2 is a radical of a dicarboxylic carbocyclic acid having a COOH-group in ortho-position to its ester bond and(C) a catalyst component of the formula ##STR2## wherein R.sup.3 is a radical of a homo- or copolymer or combination of both of an unsaturated carboxylic acid with a statistically distributed number of COOH side groups or the radical of a polyester having initially free COOH-groups andMe is one equivalent of an alkaline or an alkaline earth metal, thus being present in its salt form, a process for the preparation of hardened products from said composition and a coated article having a coating based on said composition.

    摘要翻译： 一种基于（A）至少一种脂肪族，脂环族或脂族 - 脂环族聚环氧化物的反应性可硬化粘合剂组合物，其中至少2个环氧化脂环族基团通过脂族桥键合，（B）至少一种式（IMAGE）的多元羧酸单元 I），其酸值在30和400之间，其中R1是选自具有起始游离OH-基团的聚酯和聚合物的至少低聚物产物的基团，R 2是具有COOH- （C）催化剂组分，其中R 3是具有统计分布数的不饱和羧酸的均聚物或共聚物或两者的组合的基团 的COOH侧基或具有起始游离COOH基团的聚酯的基团，Me为1当量碱金属或碱土金属，因此以其盐形式存在，制备方法 所述组合物的硬化产物的定量和具有基于所述组合物的涂层的涂覆制品。

    Thermosetting compositions
    10.
    发明授权
    Thermosetting compositions 失效
    热固性组合物

    公开(公告)号：US4208488A

    公开(公告)日：1980-06-17

    申请号：US877868

    申请日：1978-02-15

    申请人： Kurt Kraft ,  Gerd Walz ,  Thaddaus Wirth

    发明人： Kurt Kraft ,  Gerd Walz ,  Thaddaus Wirth

    IPC分类号： C09D5/08 ,  C08G59/00 ,  C08G59/42 ,  C08L1/00 ,  C08L23/00 ,  C08L27/00 ,  C08L33/00 ,  C08L33/02 ,  C08L67/00 ,  C08L67/08 ,  C08L101/00 ,  C09D163/00 ,  C09D167/00 ,  C09J133/04 ,  C09J163/00 ,  C09J167/00 ,  C08L63/00

    CPC分类号： C09D167/00 ,  C08K5/04 ,  C09J167/00

    摘要： A thermosetting coating or adhesive composition based on (A) at least one component selected from the group consisting of oligomeric and polymeric compounds containing at least one of the functional groups hydroxyl and epoxy groups, and (B) a polycarboxylic acid mixture comprising trimellitic acid and a major amount of at least one compound of one of the formulae ##STR1## wherein R, R' and R'", being the same or different, each represents a di- to hexavalent hydrocarbon radical having a total of from 1 to 12 carbon atoms, said radical containing from zero to 2 olefinic double bonds, said radical without double bonds being interrupted by up to 3 ether bridges:x and y which may be the same or different, each represents an integer of from 2 to 6;t an integer of from 1 to 5; andz and u, which may be the same or different, each represents zero or an integer of from 1 to 5 and a process for coating a substrate with said composition.

    摘要翻译： 一种基于（A）选自包含至少一个官能团羟基和环氧基团的低聚物和聚合物的至少一种成分的组合物的热固性涂料或粘合剂组合物，和（B）包含偏苯三酸和 主要量的至少一种下式之一的化合物：其中R，R'和R“'相同，其中R，R'和R”'相同 或不同的，每个表示总共具有1至12个碳原子的二价至六价烃基，所述基团含有0至2个烯属双键，所述无双键的基团被多达3个醚桥隔开：x和 y可以相同或不同，各自表示2〜6的整数; t为1〜5的整数; 和可以相同或不同的z和u各自表示0或1〜5的整数，以及用所述组合物涂布基材的方法。