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16 条记录 (耗时 0.028 秒)

    Removing surface deposits of concentrated collected particles
    1.
    发明授权
    Removing surface deposits of concentrated collected particles 失效
    去除浓缩的收集颗粒的表面沉积物

    公开(公告)号：US07759123B2

    公开(公告)日：2010-07-20

    申请号：US11385326

    申请日：2006-03-21

    申请人： Charles J. Call ,  Patrick T. Call ,  Vanessa M. Kenning ,  Eric Hanczyc ,  Andrew Kamholz

    发明人： Charles J. Call ,  Patrick T. Call ,  Vanessa M. Kenning ,  Eric Hanczyc ,  Andrew Kamholz

    IPC分类号： G01M3/02

    CPC分类号： B07B7/00 ,  Y10T436/118339 ,  Y10T436/163333 ,  Y10T436/17 ,  Y10T436/173076 ,  Y10T436/25

    摘要： A method and apparatus for removing concentrated spots of collected particulates from an impact collection surface, and transferring those particulates into a container suitable for preparing a liquid sample. A jet of fluid can be utilized to remove and transfer the particulates. If a liquid jet is employed, care is taken to minimize the quantity of liquid to avoid unnecessarily diluting the sample. A mechanical scraper can alternatively be employed to remove and transfer the particulates into the container. The scraper can be rinsed with liquid or vibrated to remove the particulates. Alternatively, the portion of the surface containing a specific spot of particulates can be removed and placed into a container.

    摘要翻译： 一种用于从冲击收集表面去除收集的颗粒的浓缩点并将这些颗粒转移到适于制备液体样品的容器中的方法和装置。 流体喷射可用于去除和转移微粒。 如果使用液体射流，则应注意尽量减少液体量，以避免不必要地稀释样品。 也可以使用机械刮板来移除并将颗粒转移到容器中。 刮刀可以用液体冲洗或振动以除去微粒。 或者，包含特定颗粒点的表面的部分可以被移除并放置在容器中。

    Method for removing surface deposits of concentrated collected particles
    2.
    发明授权
    Method for removing surface deposits of concentrated collected particles 失效
    去除浓缩收集颗粒表面沉积物的方法

    公开(公告)号：US06938777B2

    公开(公告)日：2005-09-06

    申请号：US10366595

    申请日：2003-02-11

    申请人： Charles J. Call ,  Patrick T. Call ,  Vanessa M. Kenning ,  Eric Hanczyc ,  Andrew Kamholz

    发明人： Charles J. Call ,  Patrick T. Call ,  Vanessa M. Kenning ,  Eric Hanczyc ,  Andrew Kamholz

    IPC分类号： B01D45/08 ,  G01N1/22 ,  G01N1/40 ,  B07B7/00 ,  B07B13/00

    CPC分类号： B01D45/08 ,  G01N1/2208 ,  G01N1/2273 ,  G01N1/40

    摘要： A method and apparatus for removing concentrated spots of collected particulates from an impact collection surface, and transferring those particulates into a container suitable for preparing a liquid sample. A jet of fluid can be utilized to remove and transfer the particulates. If a liquid jet is employed, care is taken to minimize the quantity of liquid to avoid unnecessarily diluting the sample. A mechanical scraper can alternatively be employed to remove and transfer the particulates into the container. The scraper can be rinsed with liquid or vibrated to remove the particulates. Alternatively, the portion of the surface containing a specific spot of particulates can be removed and placed into a container.

    摘要翻译： 一种用于从冲击收集表面去除收集的颗粒的浓缩点并将这些颗粒转移到适于制备液体样品的容器中的方法和装置。 流体喷射可用于去除和转移微粒。 如果使用液体射流，则应注意尽量减少液体量，以避免不必要地稀释样品。 也可以使用机械刮板来移除并将颗粒转移到容器中。 刮刀可以用液体冲洗或振动以除去微粒。 或者，包含特定颗粒点的表面的部分可以被移除并放置在容器中。

    Method for surface deposition of concentrated airborne particles
    3.
    发明授权
    Method for surface deposition of concentrated airborne particles 失效
    浓缩空气中颗粒的表面沉积方法

    公开(公告)号：US06695146B2

    公开(公告)日：2004-02-24

    申请号：US09955481

    申请日：2001-09-17

    申请人： Charles J. Call ,  Patrick T. Call ,  Vanessa M. Kenning ,  Andrew Kamholz

    发明人： Charles J. Call ,  Patrick T. Call ,  Vanessa M. Kenning ,  Andrew Kamholz

    IPC分类号： B07B700

    CPC分类号： G01N1/4077 ,  B01D21/2455 ,  B01D45/08 ,  G01N1/2208 ,  G01N1/2273 ,  G01N1/34 ,  G01N1/40 ,  G01N15/0255 ,  G01N35/00009 ,  G01N2001/022 ,  G01N2015/0026 ,  G01N2015/0046 ,  G01N2015/0088 ,  G01N2015/0288

    摘要： The present invention employs a virtual impactor to separate a flow of fluid into a major flow and a minor flow, such that the minor flow contains a higher concentration of particulates of a desired size. The minor flow is directed toward an archival surface, causing the particulates to impact against and be deposited on the archival surface. Over time, the archival surface and the virtual impactor are moved relative to one another such that particulates collected at different times are deposited as spaced-apart spots on different portions of the archival surface. The particulates are stored on the archival surface until analysis of the particulates is required. The archival surface can be coated with a material that enhances the deposition and retention of the particulates and can further be coated with materials that sustain the life of biological organism particulates deposited on the archival surface.

    摘要翻译： 本发明使用虚拟冲击器将流体流分离成主流和小流，使得次流含有较高浓度的所需尺寸的颗粒。 微小的流动指向档案表面，导致微粒冲击并沉积在档案表面上。 随着时间的推移，归档表面和虚拟冲击器相对于彼此移动，使得在不同时间收集的微粒被沉积成在档案表面的不同部分上的间隔开的斑点。 颗粒存储在档案表面上，直到需要分析颗粒物。 归档表面可以涂覆有增强颗粒的沉积和保留的材料，并且可以进一步涂覆保持沉积在档案表面上的生物体微生物的寿命的材料。

    Robust system for screening enclosed spaces for biological agents
    5.
    发明申请
    Robust system for screening enclosed spaces for biological agents 审中-公开
    用于生物制剂封闭空间的屏蔽系统

    公开(公告)号：US20060257287A1

    公开(公告)日：2006-11-16

    申请号：US11058442

    申请日：2005-02-15

    申请人： Charles Call ,  Andrew Kamholz ,  Eric Hanczyc

    发明人： Charles Call ,  Andrew Kamholz ,  Eric Hanczyc

    IPC分类号： G01N33/00 ,  G01N7/00 ,  G01N31/00 ,  B32B27/04 ,  B32B27/12 ,  B32B5/02 ,  G01N21/00 ,  G01N27/00

    CPC分类号： G01N1/2211 ,  B01D45/04 ,  G01N1/2208 ,  G01N15/0255 ,  G01N2001/025 ,  G01N2015/0088

    摘要： Items of mail are rapidly processed in a mail sampling system to determine if the mail is contaminated with a chemical or biological agent. The mail sampling system maintains a negative pressure in a containment chamber and includes a triggering sampler that makes a threshold determination regarding possible contamination, and a detecting sampler that obtains a sample for more detailed analysis in response to a signal from the triggering sampler. A sample of particulates collected from an item of mail is either removed for analysis or analyzed in the system to identify a contaminating agent. Optionally, the system includes an archiving sampler, which archives samples for subsequent processing and analysis, and a decontamination system, which is activated to decontaminate the mail if needed.

    摘要翻译： 在邮件采样系统中快速处理邮件，以确定邮件是否被化学或生物制剂污染。 邮件采样系统在容纳室中保持负压，并且包括对可能的污染进行阈值确定的触发采样器，以及响应于来自触发采样器的信号而获得更详细分析的样本的检测采样器。 从邮件项目中收集的颗粒物样本被去除，以便在系统中进行分析或分析，以识别污染物质。 可选地，系统包括归档采样器，其归档用于后续处理和分析的样本，以及净化系统，其被激活以在需要时去除消息。

    Removing surface deposits of concentrated collected particles
    6.
    发明申请
    Removing surface deposits of concentrated collected particles 失效
    去除浓缩的收集颗粒的表面沉积物

    公开(公告)号：US20070048186A1

    公开(公告)日：2007-03-01

    申请号：US11385326

    申请日：2006-03-21

    申请人： Charles Call ,  Patrick Call ,  Vanessa Kenning ,  Eric Hanczyc ,  Andrew Kamholz

    发明人： Charles Call ,  Patrick Call ,  Vanessa Kenning ,  Eric Hanczyc ,  Andrew Kamholz

    IPC分类号： G01N33/48

    CPC分类号： B07B7/00 ,  Y10T436/118339 ,  Y10T436/163333 ,  Y10T436/17 ,  Y10T436/173076 ,  Y10T436/25

    摘要： A method and apparatus for removing concentrated spots of collected particulates from an impact collection surface, and transferring those particulates into a container suitable for preparing a liquid sample. A jet of fluid can be utilized to remove and transfer the particulates. If a liquid jet is employed, care is taken to minimize the quantity of liquid to avoid unnecessarily diluting the sample. A mechanical scraper can alternatively be employed to remove and transfer the particulates into the container. The scraper can be rinsed with liquid or vibrated to remove the particulates. Alternatively, the portion of the surface containing a specific spot of particulates can be removed and placed into a container.

    摘要翻译： 一种用于从冲击收集表面去除收集的颗粒的浓缩点并将这些颗粒转移到适于制备液体样品的容器中的方法和装置。 流体喷射可用于去除和转移微粒。 如果使用液体射流，则应注意尽量减少液体量，以避免不必要地稀释样品。 也可以使用机械刮板来移除并将颗粒转移到容器中。 刮刀可以用液体冲洗或振动以除去微粒。 或者，包含特定颗粒点的表面的部分可以被移除并放置在容器中。

    Microscale diffusion immunoassay
    7.
    发明授权
    Microscale diffusion immunoassay 有权
    微尺度扩散免疫测定

    公开(公告)号：US07271007B2

    公开(公告)日：2007-09-18

    申请号：US10368511

    申请日：2003-02-18

    申请人： Bernhard H Weigl ,  Paul Yager ,  Andrew Kamholz ,  Anson Hatch

    发明人： Bernhard H Weigl ,  Paul Yager ,  Andrew Kamholz ,  Anson Hatch

    IPC分类号： G01N35/08 ,  G01N21/00 ,  G01N1/10 ,  G01N33/53 ,  G01N33/533

    CPC分类号： B01F5/0403 ,  B01F13/0059 ,  B01F13/0093 ,  B01J19/0093 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0487 ,  G01N15/10 ,  G01N15/14 ,  G01N30/0005 ,  G01N30/38 ,  G01N30/6095 ,  G01N30/74 ,  G01N33/558 ,  G01N35/085 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/25375 ,  Y10T436/2575

    摘要： Methods and apparatuses are provided for determining presence and concentration of analytes by exploiting molecular binding reactions and differential diffusion rates. Analyte particles and binding particles are allowed to diffuse toward each other, and slowing of the diffusion front is detected when they meet. From the position of the diffusion front, presence and concentration of analyte particles can be determined. One embodiment provides a competitive immunoassay in a microfluidic format. This diffusion immunoassay (DIA) relies on measuring the concentration of labeled antigen along one dimension of a microchannel after allowing it to diffuse for a short time into a region containing specific antibodies. A simple microfluidic device, the T-Sensor, was used to implement a DIA to measure the concentration of phenytoin, a small drug molecule. Concentrations of analyte over the range of 50 to 1600 nM can be measured in less than a minute. The assay is homogeneous, rapid, requires only microliter volumes of reagents and sample, and is applicable to a wide range of analytes, including therapeutic drugs, molecular biological markers, and environmental contaminants. Methods for separating particles of similar size in a diffusion separator are also provided.

    摘要翻译： 提供了通过开发分子结合反应和差异扩散速率来确定分析物的存在和浓度的方法和装置。 允许分析物颗粒和结合颗粒彼此扩散，并且当它们相遇时检测到扩散前沿的减慢。 从扩散前沿的位置可以确定分析物颗粒的存在和浓度。 一个实施方案提供了以微流体形式的竞争性免疫测定。 这种扩散免疫测定（DIA）依赖于在允许其在短时间内扩散到含有特异性抗体的区域之后测量沿着微通道的一个维度的标记抗原的浓度。 使用简单的微流体装置T-Sensor来实施DIA来测量苯妥英（一种小药物分子）的浓度。 可以在不到一分钟的时间内测量分析物在50至1600nM范围内的浓度。 该测定是均匀的，快速的，仅需要微量体积的试剂和样品，并且适用于广泛的分析物，包括治疗药物，分子生物标志物和环境污染物。 还提供了在扩散分离器中分离类似尺寸的颗粒的方法。

    Magnetically actuated fluid handling devices for microfluidic applications
    9.
    发明授权
    Magnetically actuated fluid handling devices for microfluidic applications 有权
    用于微流体应用的磁致动流体处理装置

    公开(公告)号：US06415821B2

    公开(公告)日：2002-07-09

    申请号：US09739074

    申请日：2000-12-15

    申请人： Andrew Kamholz ,  Anson Hatch ,  Karl Bohringer ,  Paul Yager

    发明人： Andrew Kamholz ,  Anson Hatch ,  Karl Bohringer ,  Paul Yager

    IPC分类号： F15C104

    CPC分类号： F04F99/00 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/088 ,  B01L2400/043 ,  B01L2400/0694 ,  F04B17/044 ,  F04B43/046 ,  F16K13/10 ,  F16K31/08 ,  F16K99/0019 ,  F16K99/0046 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T137/0318 ,  Y10T137/2191 ,  Y10T137/4643

    摘要： Magnetically actuated fluid handling devices using magnetic fluid to move one or more fluids (gases or liquids or both) through microsized flow channels are provided. Fluid handling devices include micropumps and microvalves. Magnetically actuated slugs of magnetic fluid are moved within microchannels of a microfluidic device to facilitate valving and/or pumping of fluids and no separate pump is required. The magnets used to control fluid movement can be either individual magnets moved along the flow channels or one or more arrays of magnets whose elements can be individually controlled to hold or move a magnetic slug. Fluid handling devices include those having an array of electromagnets positioned along a flow channel which are turned on and off in a predetermined pattern to move magnetic fluid slugs in desired paths in the flow channel. The fluid handling devices of the present invention can handle gases and liquids simultaneously and thus can be made to be self-priming. These devices are more resistant to fluctuations in fluid input than other types of micropumps which need to be tuned to pump either liquid or gas. In a particular embodiment, a micropump having a loop channel containing a stationary magnetic slug and one or more moving slugs is provided.

    摘要翻译： 提供使用磁性流体通过微型流动通道移动一种或多种流体（气体或液体或两者）的磁致动流体处理装置。 流体处理装置包括微型泵和微型阀。 磁性流体的磁力驱动在微流体装置的微通道内移动以便于流体的阀门和/或泵送，并且不需要单独的泵。 用于控制流体运动的磁体可以是沿着流动通道移动的单个磁体或者一个或多个磁体阵列，其元件可以被单独控制以保持或移动磁性块。 流体处理装置包括具有沿着流动通道定位的电磁体阵列的装置，其以预定模式被打开和关闭，以在流动通道中的所需路径中移动磁性流体段塞。 本发明的流体处理装置可以同时处理气体和液体，因此可以进行自吸。 这些装置比其他类型的需要调节以泵送液体或气体的微型泵更能抵抗流体输入的波动。 在特定实施例中，提供了一种具有包含固定磁段和一个或多个移动段的环通道的微型泵。