公开(公告)号：US20130184686A1

公开(公告)日：2013-07-18

申请号：US13822684

申请日：2011-09-15

申请人： Craig Sandford ,  Dean R. Marshall ,  Daniel R. Boggs ,  Alvin Peralla-Faulkner

发明人： Craig Sandford ,  Dean R. Marshall ,  Daniel R. Boggs ,  Alvin Peralla-Faulkner

IPC分类号： A61M25/00

CPC分类号： A61M25/005 ,  A61M25/0009 ,  A61M25/0012 ,  A61M39/08 ,  A61M2025/0059 ,  B29C48/09 ,  B29C48/19 ,  B29C48/20 ,  B29C48/30 ,  B29C48/33 ,  B29L2023/007 ,  B29L2031/7542 ,  B29L2031/7732

摘要： A flexible, kink-resistant medical tube and a method and apparatus for making the same are provided. The tube includes a body having a first end, a second end, an outer surface and an inner surface. The tube includes a lumen defined by the inner surface of the body and extending between the first end and the second end. The tube also includes a helical structure within in the body.

摘要翻译： 提供了一种柔性，耐扭结的医用管及其制造方法和装置。 管包括具有第一端，第二端，外表面和内表面的主体。 该管包括由本体的内表面限定并在第一端和第二端之间延伸的内腔。 管还包括在体内的螺旋结构。

公开(公告)号：US06596230B1

公开(公告)日：2003-07-22

申请号：US09494338

申请日：2000-01-28

申请人： Lecon Woo ,  Daniel R. Boggs ,  Shmuel Sternberg ,  Craig Sandford ,  Atul Khare ,  Julian Breillatt

发明人： Lecon Woo ,  Daniel R. Boggs ,  Shmuel Sternberg ,  Craig Sandford ,  Atul Khare ,  Julian Breillatt

IPC分类号： A61L208

CPC分类号： A61M1/3681 ,  A61L2/0011 ,  A61L2/10 ,  A61M1/0281 ,  A61M2202/0415 ,  A61M2205/053

摘要： A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a “carrying” mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).

摘要翻译： 一种在具有对具有高光密度的流体显示辐射剂量均匀性的连续薄流体流动布置中灭菌治疗性流体中的灭菌辐射的装置和方法。 辐射剂量均匀性部分地通过移动或携带流体的“携带”机构实现，从而消除了通道流速分布，其中通道壁附近的流量具有过度暴露于辐射的风险，这是由于内部的非常大的停留时间 渠道。 该装置包括连接到通过入口（24）的流体流和带室（22）上的出口（26）的相对平坦的带室（22）。 带室（22）具有顶表面（28）和底表面（30）。 辐射透射板（32）邻近带室（22）的顶表面（28）设置并与带室（22）接触。 辐射源（42）邻近于与带室（22）相对的一侧邻近板（32）设置。 具有多个柔性叶片（36）的带（34）邻近带室（22）的底表面（30）设置，使得叶片（36）与带室（22）接触。 皮带由辊机构（38）沿着流体流动的方向驱动。 当流体流过皮带室（22）时，柔性叶片（36）提供刮板状机构，以使流体通过一对叶片（36）限定的离散的分组（40）移动通过皮带室（22） 。 当流体包装移动通过皮带室时，它们暴露于穿过板（32）的灭菌辐射。

公开(公告)号：US06576201B1

公开(公告)日：2003-06-10

申请号：US09493848

申请日：2000-01-28

申请人： Lecon Woo ,  Daniel R. Boggs ,  Shmuel Sternberg ,  Craig Sandford ,  Atul Khare ,  Julian Breillatt

发明人： Lecon Woo ,  Daniel R. Boggs ,  Shmuel Sternberg ,  Craig Sandford ,  Atul Khare ,  Julian Breillatt

IPC分类号： B01J1908

CPC分类号： A61L2/10 ,  A61L2/0011 ,  A61M1/0281 ,  A61M1/3681 ,  A61M2202/0415 ,  A61M2205/053

摘要： A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outlet (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is disposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).

摘要翻译： 一种用于在连续流动布置中灭菌治疗流体中的病原体灭活的装置和方法，同时具有辐射剂量均匀性和在装置内的流体的滞留时间分布。 装置（10）包括具有设置在其中的同心圆柱形转子（14）的透射性圆柱形管（12），从而在它们之间提供薄的间隙（16）。 具有流体出口（26）的顶板（18）和具有密封圆柱形管（12）的流体入口（24）的底板（20）。 入口（24）和出口（26）都与薄间隙（16）流体连通。 转子轴（36）轴向设置在圆柱形转子（14）上并与马达（30）连接。 泵提供流过装置（10）的流体。 辐射源通过圆柱形管（12）向流体提供灭菌辐射。 当流体流动时，马达（30）驱动转子（14）以向流体流传递泰勒涡流，流体更接近圆柱形管（12），流体更靠近转子（14）。

公开(公告)号：US20130345674A1

公开(公告)日：2013-12-26

申请号：US14003284

申请日：2012-03-09

申请人： Benjamin E. Kusters ,  Christopher J. Wegener ,  Daniel R. Boggs ,  Kyungyoon Min ,  William H. Cork ,  Daryl R. Calhoun ,  Bryan Blickhan ,  Daniel Lynn

发明人： Benjamin E. Kusters ,  Christopher J. Wegener ,  Daniel R. Boggs ,  Kyungyoon Min ,  William H. Cork ,  Daryl R. Calhoun ,  Bryan Blickhan ,  Daniel Lynn

IPC分类号： A61M1/36 ,  A61M1/38

CPC分类号： A61M1/34 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/265 ,  A61M1/3403 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3687 ,  A61M1/3692 ,  A61M1/38 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/60 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2313/08 ,  B01D2313/20 ,  B01D2315/02 ,  G16H10/40

摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

公开(公告)号：US20110206554A1

公开(公告)日：2011-08-25

申请号：US13100570

申请日：2011-05-04

申请人： Heinz Anderle ,  Peter Matthiessen ,  Hans-Peter Schwarz ,  Peter Turecek ,  Thomas Kreil ,  Daniel R. Boggs

发明人： Heinz Anderle ,  Peter Matthiessen ,  Hans-Peter Schwarz ,  Peter Turecek ,  Thomas Kreil ,  Daniel R. Boggs

IPC分类号： A61L2/10 ,  A61L2/08 ,  B01J19/08 ,  A61L2/24

CPC分类号： A61L2/10 ,  A23L3/26 ,  A23L3/28 ,  A61L2/0011 ,  A61L2/28 ,  G01N21/33 ,  H05B3/0052

摘要： The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivate microorganisms present in a biological fluid, preferably a non-transparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.

摘要翻译： 本发明涉及一种用于确定来自一种或多种光源的有效剂量的单色或多色光以灭活存在于生物流体中，优选非透明流体中的微生物的方法。 此外，提供了在流通反应器中的生物流体中的微生物灭活的方法。 此外，本发明有利地提供具有一个或多个恒温光源的流通反应器。 本发明还提供一种控制从一个或多个光源发射的单色或多色光的光总量的方法，以有效地灭活间歇反应器中存在于生物流体中的微生物。

公开(公告)号：US5314471A

公开(公告)日：1994-05-24

申请号：US861921

申请日：1992-04-01

申请人： James H. Brauker ,  Ronald S. Hill ,  Laura A. Martinson ,  Daniel R. Boggs ,  Robert C. Johnson

发明人： James H. Brauker ,  Ronald S. Hill ,  Laura A. Martinson ,  Daniel R. Boggs ,  Robert C. Johnson

IPC分类号： A61B5/00 ,  A61F2/02 ,  A61F2/06 ,  A61K9/00 ,  A61L27/38 ,  A61L27/56 ,  A61L29/00 ,  A61L29/14 ,  A61J1/00 ,  A61K9/22

CPC分类号： A61K9/0024 ,  A61F2/022 ,  A61L27/38 ,  A61L27/56 ,  A61L29/005 ,  A61L29/146 ,  A61B5/14532

摘要： Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish a boundary between the host and the implanted cells. The boundary has a pore size, an ultimate strength, and a metabolic transit value that assures the survival of the cells during the critical ischemic period and afterward. The boundary allows the fabrication and clinical use of implant assemblies and methodologies that can carry enough cells to be of therapeutic value to the host, yet occupy a relatively small, compact area within the host.

摘要翻译： 植入组件和方法为植入的同种异体移植物，异种移植物和同种移植物提供免疫保护。 组件和方法建立了主体和植入细胞之间的边界。 该边界具有孔隙尺寸，极限强度和代谢转运值，其确保在临界缺血期和之后细胞的存活。 该边界允许植入组件和方法的制造和临床使用，其可以携带足够的细胞以对主体具有治疗价值，但占据主机内相对较小，紧凑的区域。

公开(公告)号：US5232437A

公开(公告)日：1993-08-03

申请号：US496739

申请日：1990-03-21

申请人： Michael J. Lysaght ,  Daniel R. Boggs ,  Philip L. Ritger ,  Robert R. Stromberg ,  Leonard I. Friedman

发明人： Michael J. Lysaght ,  Daniel R. Boggs ,  Philip L. Ritger ,  Robert R. Stromberg ,  Leonard I. Friedman

IPC分类号： A61M1/30 ,  A61M1/36 ,  A61M5/148

CPC分类号： A61M5/1483 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M5/148 ,  A61M1/3643 ,  A61M2205/8225

摘要： Methods and systems for collection of blood components, such as plasma, from donors are provided. One method includes the steps of collecting a unit of whole blood from a donor; forcing the collected blood unit through a plasma separator; accumulating the plasma in a container; and returning concentrated cells to the donor. One system includes a disposable blood collection set and a reusable fixture into which the collection set can be mounted. The fixture is operated by a self-contained energy source, requiring no exterior electrical connection or other external source of energy.

摘要翻译： 提供了从供体收集血液成分（如血浆）的方法和系统。 一种方法包括从供体收集全血的单元的步骤; 通过等离子体分离器迫使收集的血液单元; 将等离子体积聚在容器中; 并将浓缩的细胞返回给供体。 一个系统包括一次性血液收集装置和可重复使用的固定装置，收集装置可安装在其上。 夹具由独立的能源操作，不需要外部电气连接或其他外部能源。

公开(公告)号：US4410026A

公开(公告)日：1983-10-18

申请号：US282894

申请日：1981-07-13

申请人： Daniel R. Boggs ,  Carl Aronson

发明人： Daniel R. Boggs ,  Carl Aronson

IPC分类号： A61J1/00 ,  A61J1/05 ,  B65D33/38 ,  B65D30/24

CPC分类号： A61J1/10 ,  Y10T137/1632

摘要： A port block assembly for interconnecting a fluid container with a fluid conduit includes a body which has a port and which is attachable to the container with the port in flow communication with the container interior. The assembly also includes a rigid, tubular insert which is engageable within the body port and to which the fluid conduit can be attached. A secure and rugged interconnection between the container and the conduit results. When the container and conduit are fabricated from dissimilar materials, the body of the assembly is fabricated from the same materal as the container, and the associated insert is fabricated from the same material as the conduit and adapted for an interference or friction fit within the body port. The same secure and rugged interconnection between the container and conduit is achieved, despite the presence of dissimilar materials.

摘要翻译： 用于将流体容器与流体导管互连的端口块组件包括具有端口并且可附接到容器的主体，其中端口与容器内部流动连通。 组件还包括刚性的管状插入件，其可接合在主体端口内并且流体导管可附接到该插入件。 容器和管道之间的牢固连接牢固结合。 当容器和​​导管由不相似的材料制成时，组件的主体由与容器相同的侧面制成，并且相关的插入件由与导管相同的材料制成，并适于在体内进行干涉或摩擦配合 港口。 尽管存在不同的材料，但实现了容器和导管之间相同的牢固和坚固的互连。

公开(公告)号：US4325417A

公开(公告)日：1982-04-20

申请号：US27575

申请日：1979-04-06

申请人： Daniel R. Boggs ,  Peter C. Kwong ,  Dean G. Laurin

发明人： Daniel R. Boggs ,  Peter C. Kwong ,  Dean G. Laurin

IPC分类号： A61L2/08 ,  A61M39/14 ,  B29C35/08 ,  B29C65/00 ,  B29C65/02 ,  B29C65/14 ,  B29C65/58 ,  F16L37/26 ,  F16L55/10 ,  B65B3/04

CPC分类号： B29C65/58 ,  A61L2/08 ,  A61M39/143 ,  B29C65/1435 ,  B29C65/148 ,  B29C65/7473 ,  B29C66/137 ,  B29C66/5221 ,  B29C66/5223 ,  B29C66/52298 ,  B29C66/534 ,  B29C66/54 ,  B29C66/73362 ,  B29C66/73776 ,  B29C66/73921 ,  B29C66/857 ,  F16L37/26 ,  F16L55/10 ,  A61M2039/1027 ,  B29C2035/0822 ,  B29C2793/0045 ,  B29C65/1406 ,  B29C65/1409 ,  B29C65/1412 ,  B29C65/16 ,  B29C66/71 ,  B29C66/73366 ,  B29K2023/00 ,  B29K2027/12 ,  B29K2067/006 ,  B29K2069/00 ,  B29K2077/00 ,  B29K2995/0025 ,  B29K2995/0027 ,  B29L2031/753 ,  Y10S604/905

摘要： A connector member for a fluid flow path is provided which comprises a transparent housing enclosing an opaque barrier membrane or wall portion blocking flow through the flow path. The barrier membrane is adapted to be openable by exposure to radiant energy from the exterior through the transparent housing. In accordance with this invention, the barrier membrane is made of a predominantly crystalline plastic material, and, accordingly, exhibits a relatively sharp melting point for improved opening characteristics upon exposure to the radiant energy.

摘要翻译： 提供了一种用于流体流动路径的连接器构件，其包括封闭不透明阻挡膜的透明壳体或阻挡流过所述流动路径的壁的壁部分。 阻挡膜适于通过从外部通过透明壳体暴露于辐射能而可打开。 根据本发明，阻挡膜由主要为结晶的塑料材料制成，因此，在暴露于辐射能时，显示出相当尖的熔点以改善开口特性。

公开(公告)号：US09408961B2

公开(公告)日：2016-08-09

申请号：US14003281

申请日：2012-03-09

申请人： Christopher J. Wegener ,  Kyungyoon Min ,  Laurent Forcioli ,  Mark J. Brierton ,  Daniel R. Boggs

发明人： Christopher J. Wegener ,  Kyungyoon Min ,  Laurent Forcioli ,  Mark J. Brierton ,  Daniel R. Boggs

IPC分类号： A61M1/34 ,  A61M1/02 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  A61M1/38 ,  A61M1/26 ,  A61M1/36

CPC分类号： A61M1/34 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/265 ,  A61M1/3403 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3687 ,  A61M1/3692 ,  A61M1/38 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/60 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2313/08 ,  B01D2313/20 ,  B01D2315/02 ,  G16H10/40

摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

摘要翻译： 公开了膜分离装置以及在血液处理程序中采用该装置的系统和方法。 在一个实施例中，提供了一种纺丝膜分离器，其中在膜和壳体之间的间隙中产生至少两个区域或区域，使得两个区域之间的流体的混合被与膜相关联的径向肋 这减小了膜和壳体之间的间隙以限定两个流体区域，脊部分离两个区域中的流体以最小化两者之间的混合。 公开了自动化系统和方法，用于将先前收集的全血的单元分离成诸如浓红细胞和血浆的组分，用于在单次通过中从供体直接收集红细胞和血浆，以及用于细胞洗涤。 还公开了数据管理系统和方法以及启动方法。