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1.发明授权公开(公告)号：US07829271B2
公开(公告)日：2010-11-09
申请号：US10576342
申请日：2004-10-21
IPC分类号： C12Q1/00
CPC分类号： B01L3/5088 , B01J2219/00317 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L2200/0642 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0877 , B01L2300/089 , B01L2400/0487 , C40B40/06 , C40B40/10 , C40B50/08 , C40B60/14 , Y10T436/25
摘要： The present invention relates especially to a process for the localized distribution of drops of a liquid of interest on an active surface. The process comprises the following steps: an introduction of liquid of interest into a box containing the said active surface, and an extraction of liquid of interest from the said box, the said active surface and also the other surfaces inside the box being substantially non-wetting with respect to the liquid of interest, with the exception of several uptake areas localized on the said active surface, which are each suitable for taking up a drop of liquid of interest. The uptake areas may surround working areas. The present invention also relates to processes for the electrochemical and optical detection of at least one analyte in a liquid of interest, and to an electropolymerization process.
摘要翻译： 本发明特别涉及一种用于在活性表面上局部分布感兴趣液体的液滴的方法。 该方法包括以下步骤：将感兴趣的液体引入到包含所述活性表面的盒中，以及从所述盒，所述活性表面以及所述盒内的其它表面基本上不相关的萃取液体， 相对于目标液体润湿，除了位于所述活性表面上的几个吸收区域外，其各自适用于吸收一滴感兴趣的液体。 摄取区域可以围绕工作区域。 本发明还涉及用于对感兴趣的液体中的至少一种分析物进行电化学和光学检测的方法以及电聚合方法。
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2.发明申请Operating Device Comprising A Localized Zone For The Capture Of A Drop A Liquid Of Interest 审中-公开操作装置包含一个本地化区域，用于捕获一滴液体公开(公告)号：US20070207055A1
公开(公告)日：2007-09-06
申请号：US10576345
申请日：2003-10-21
IPC分类号： G01N21/00
CPC分类号： B01L3/502792 , B01J2219/00317 , B01J2219/00527 , B01J2219/00596 , B01J2219/0065 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/502707 , B01L3/50273 , B01L3/5085 , B01L3/5088 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/089 , B01L2400/0487 , C40B40/06 , C40B40/10 , C40B60/14
摘要： The present invention relates to an operating device characterized in that it comprises an active surface that is substantially non-wetting with respect to a liquid of interest; at least one zone for the localized capture of a drop of said liquid formed on said active surface; at least one operating zone arranged with a capture zone in such a way that the operating zone is at least partially covered by the drop of the liquid when said drop is captured by said capture zone; and means for leaving a drop of said liquid on said capture zone. This device makes it possible in particular to form high-density arrays of drops of said liquid on a surface, with the aim in particular of carrying out chemical and/or biochemical reactions and/or of analysing the liquid of interest in each drop. It finds, for example, an application in biological chips.
摘要翻译： 本发明涉及一种操作装置，其特征在于其包括相对于感兴趣的液体基本上不润湿的活性表面; 用于局部捕获形成在所述活性表面上的一滴所述液体的至少一个区域; 所述至少一个操作区域布置有捕获区域，使得当所述液滴被所述捕获区域捕获时，所述操作区域至少部分地被所述液滴所覆盖; 以及用于在所述捕获区上留下一滴所述液体的装置。 该装置特别可以在表面上形成所述液体的高密度液滴阵列，其目的是特别是进行化学和/或生物化学反应和/或分析每一滴中感兴趣的液体。 例如，它发现生物芯片中的应用。
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公开(公告)号：US20070218452A1
公开(公告)日：2007-09-20
申请号：US10576342
申请日：2004-10-21
CPC分类号： B01L3/5088 , B01J2219/00317 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L2200/0642 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0877 , B01L2300/089 , B01L2400/0487 , C40B40/06 , C40B40/10 , C40B50/08 , C40B60/14 , Y10T436/25
摘要： The present invention relates especially to a process for the localized distribution of drops of a liquid of interest on an active surface. The process comprises the following steps an introduction of liquid of interest into a box containing the said active surface, and an extraction of liquid of interest from the said box, the said active surface and also the other surfaces inside the box being substantially non-wetting with respect to the liquid of interest, with the exception of several uptake areas localized on the said active surface, which are each suitable for taking up a drop of liquid of interest. The uptake areas may surround working areas. The present invention also relates to processes for the electrochemical and optical detection of at least one analyte in a liquid of interest, and to an electropolymerization process.
摘要翻译： 本发明特别涉及一种用于在活性表面上局部分布感兴趣液体的液滴的方法。 该方法包括以下步骤：将感兴趣的液体引入到包含所述活性表面的盒子中，并从所述盒子，所述活性表面以及盒内的其它表面基本上不润湿提取目标液体 相对于感兴趣的液体，除了位于所述活性表面上的几个摄取区域之外，其各自适合于吸收一滴感兴趣的液体。 摄取区域可以围绕工作区域。 本发明还涉及用于对感兴趣的液体中的至少一种分析物进行电化学和光学检测的方法以及电聚合方法。
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4.发明申请Work device comprising bordered work zones, on-chip laboratory and microsystem 审中-公开工作装置包括边界工作区，片上实验室和微系统公开(公告)号：US20070105210A1
公开(公告)日：2007-05-10
申请号：US10577274
申请日：2004-10-21
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00317 , B01J2219/00585 , B01J2219/00596 , B01J2219/0065 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L3/5088 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/089 , B01L2400/0487 , C40B40/06 , C40B40/10 , C40B60/14
摘要： The present invention relates to a work device (1) comprising work zones. It can be used to obtain a matrix of drops on a surface, using a liquid of interest (E). It comprises a work box (Bo) provided with means (o, s) for introducing and extracting the liquid respectively into and from the box; a substrate (S) comprising an active surface that is substantially non-wetting for said liquid of interest contained in said box; distinct work zones (Zt) formed on said active surface and each surrounded by a border (b) formed on said active surface, the borders not touching one another and having no common edge and having a geometry such that when the liquid of interest is extracted from the box, a drop (g) of the liquid of interest remains imprisoned by each border and in contact with the work zone that it surrounds.
摘要翻译： 本发明涉及一种包括工作区的作业装置（1）。 它可用于使用感兴趣的液体（E）获得表面上的液滴基质。 它包括一个设有装置（o，s）的工作箱（Bo），用于分别从盒子中取出和取出液体; 底物（S），其包含对所述盒中包含的所述感兴趣液体基本上不润湿的活性表面; 形成在所述活性表面上并且由形成在所述活性表面上的边界（b）围绕的不同工作区（Zt），所述边界不相互接触并且不具有共同边缘并且具有几何形状，使得当提取所关注的液体时 从盒子里，感兴趣的液体滴（g）仍然被每个边界囚禁，并与其周围的工作区接触。
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公开(公告)号：US08389368B2
公开(公告)日：2013-03-05
申请号：US12727593
申请日：2010-03-19
申请人： Simon Deleonibus , Jean-Marie Basset , Paul Campbell , Thibaut Gutel , Paul-Henri Haumesser , Gilles Marchand , Catherine Santini
发明人： Simon Deleonibus , Jean-Marie Basset , Paul Campbell , Thibaut Gutel , Paul-Henri Haumesser , Gilles Marchand , Catherine Santini
IPC分类号： H01L21/336
CPC分类号： H01L29/66833 , B82Y10/00 , B82Y40/00 , H01L21/28273 , H01L27/11563 , H01L29/42332 , H01L29/513 , H01L29/66545 , H01L29/66825 , H01L29/7881 , Y10S977/773
摘要： A method for producing a memory device with nanoparticles, including steps of: a) forming, in a substrate based on at least one semi-conductor, source and drain regions, and at least one first dielectric on at least one zone of the substrate arranged between the source and drain regions and intended to form a channel of the memory device, b) depositing of at least one ionic liquid that is an organic salt or mixture of organic salts in a liquid state, wherein nanoparticles of at least one electrically conductive material are suspended in the ionic liquid, said ionic liquid covering at least said first dielectric, c) forming a deposition of said nanoparticles at least on said first dielectric, d) removing the ionic liquid remaining on the first dielectric, and e) forming at least one second dielectric and at least one control gate on at least one part of the nanoparticles deposited on the first dielectric.
摘要翻译： 一种制备具有纳米颗粒的存储器件的方法，包括以下步骤：a）在基板中基于至少一个半导体源极和漏极区域形成基底，并且至少一个第一电介质在衬底的至少一个区域上被布置 在源极和漏极区之间并且旨在形成存储器件的通道，b）沉积至少一种离子液体，其是液态的有机盐或有机盐的混合物，其中至少一种导电材料的纳米颗粒 悬浮在离子液体中，所述离子液体至少覆盖所述第一电介质，c）至少在所述第一电介质上形成所述纳米颗粒的沉积，d）去除残留在第一电介质上的离子液体，和e）至少形成 在沉积在第一电介质上的纳米颗粒的至少一部分上的一个第二电介质和至少一个控制栅极。
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6.发明申请METHOD FOR DETECTING ANALYTE IN A BODILY FLUID, AND DRESSING FOR IMPLEMENTING SUCH A METHOD 有权用于检测体液中分析物的方法和用于实施这种方法的连接公开(公告)号：US20120283529A1
公开(公告)日：2012-11-08
申请号：US13520078
申请日：2010-12-29
申请人： Gilles Marchand , Pierre Marcoux
发明人： Gilles Marchand , Pierre Marcoux
IPC分类号： A61B5/1455
CPC分类号： G01N33/5088 , A61B5/00 , A61F13/0213 , A61F13/0226 , A61F13/0273 , A61F2013/00429 , A61F2013/00846 , A61F2013/00965 , A61L15/56
摘要： A method for detecting an analyte in a bodily fluid includes placing the detector in contact with at least one metabolite resulting from the metabolism or degradation of the analyte. The contact between the detector and the metabolite produces an optically detectable signal. The detection method includes the detection of the metabolite only in gas form, said metabolite in gas form coming from the evaporation of at least a part of said metabolite. The detection is also carried out without contact between the bodily fluid and the detector. A dressing for implementing the detection method is also described.
摘要翻译： 用于检测体液中的分析物的方法包括使检测器与由分析物的代谢或降解导致的至少一种代谢物接触。 检测器和代谢物之间的接触产生可光学检测的信号。 检测方法包括仅以气体形式检测代谢物，所述代谢物以气体形式来自至少一部分所述代谢物的蒸发。 检测也可以在体液和检测器之间没有接触的情况下进行。 还描述了用于实现检测方法的敷料。
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7.发明授权Method for detecting analyte in a bodily fluid, and dressing for implementing such a method 有权用于检测体液中的分析物的方法，以及用于实施这种方法的敷料公开(公告)号：US09551701B2
公开(公告)日：2017-01-24
申请号：US13520078
申请日：2010-12-29
申请人： Gilles Marchand , Pierre Marcoux
发明人： Gilles Marchand , Pierre Marcoux
CPC分类号： G01N33/5088 , A61B5/00 , A61F13/0213 , A61F13/0226 , A61F13/0273 , A61F2013/00429 , A61F2013/00846 , A61F2013/00965 , A61L15/56
摘要： A method for detecting an analyte in a bodily fluid includes placing the detector in contact with at least one metabolite resulting from the metabolism or degradation of the analyte. The contact between the detector and the metabolite produces an optically detectable signal. The detection method includes the detection of the metabolite only in gas form, said metabolite in gas form coming from the evaporation of at least a part of said metabolite. The detection is also carried out without contact between the bodily fluid and the detector. A dressing for implementing the detection method is also described.
摘要翻译： 用于检测体液中的分析物的方法包括使检测器与由分析物的代谢或降解导致的至少一种代谢物接触。 检测器和代谢物之间的接触产生可光学检测的信号。 检测方法包括仅以气体形式检测代谢物，所述代谢物以气体形式来自至少一部分所述代谢物的蒸发。 检测也可以在体液和检测器之间没有接触的情况下进行。 还描述了用于实现检测方法的敷料。
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公开(公告)号：US20140046076A1
公开(公告)日：2014-02-13
申请号：US14003195
申请日：2012-03-02
申请人： Gilles Marchand , Antoine Hoang , Olivier Zaouak , Carole Sauer
发明人： Gilles Marchand , Antoine Hoang , Olivier Zaouak , Carole Sauer
IPC分类号： B05D1/00
CPC分类号： B05D1/00 , B01J20/286 , B01J20/3204 , B01J20/3208 , B01J20/3217 , B01J20/3248 , B01J20/3257 , B05D1/185 , B05D2201/02 , B05D2202/00 , B05D2203/30 , B05D2350/10 , B82Y30/00 , B82Y40/00
摘要： The present invention relates to a process that is useful for surface functionalization of a substrate comprising at least one hydroxyl function, in which one or more point regions of said surface are brought into contact with an ionic liquid matrix containing at least one reactive molecule, as it is known, that carries at least one reactive function, under conditions that are suitable for the creation of a covalent bond between said reactive function of the molecule and a hydroxyl function of said surface.
摘要翻译： 本发明涉及一种可用于包含至少一个羟基官能团的基材的表面官能化的方法，其中所述表面的一个或多个点区域与含有至少一个反应性分子的离子液体基质接触，作为 在适于在所述分子的反应性功能和所述表面的羟基官能团之间产生共价键的条件下，已知其具有至少一个反应性官能团。
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9.发明授权Microreactor, process for the preparation thereof, and process for carrying out a biochemical or biological reaction 有权微反应器，其制备方法以及进行生物化学或生物反应的方法公开(公告)号：US08192980B2
公开(公告)日：2012-06-05
申请号：US10514066
申请日：2003-05-16
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00889 , B01L3/5027 , B01L2200/12 , B01L2300/0636 , B01L2300/0864 , B01L2400/049 , G01N30/6095
摘要： A microreactor is shown having an inlet or feed channel, an inlet or feed zone for a flow of fluid, a reaction zone, an outlet zone and an outlet or evacuation channel, the zones and channels being in fluid communication, and at least one compound such as an enzyme capable of producing a biological or biochemical reaction with at least one constituent of the flow of fluid, the compound being attached to the surfaces of the inlet zone, reaction zone, and outlet zone.
摘要翻译： 示出了微反应器具有入口或进料通道，用于流体流动的入口或进料区域，反应区域，出口区域和出口或排出通道，所述区域和通道是流体连通的，以及至少一种化合物 例如能够与流体流动的至少一种成分产生生物或生物化学反应的酶，所述化合物附着到入口区域，反应区域和出口区域的表面。
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10.发明申请Microreactor, method for preparing same, and method for producing a biochemical or biological reaction 有权微反应器，其制备方法以及生物化学或生物反应的生产方法公开(公告)号：US20060051858A1
公开(公告)日：2006-03-09
申请号：US10514066
申请日：2003-05-16
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00889 , B01L3/5027 , B01L2200/12 , B01L2300/0636 , B01L2300/0864 , B01L2400/049 , G01N30/6095
摘要： Microreactor comprising an inlet or feed channel, an inlet or feed zone (1) for a flow of fluid, a reaction zone (2), an outlet zone (3) and an outlet or evacuation channel, said zones (1, 2, 3) and channels (46, 48) being in fluid communication, and at least one compound such as an enzyme capable of producing a biological or biochemical reaction with at least one constituent of said flow of fluid, said compound being attached to the surfaces of said inlet zone (1), reaction zone (2), and outlet zone (3).
摘要翻译： 微反应器包括入口或进料通道，用于流体流动的入口或进料区（1），反应区（2），出口区（3）和出口或抽空通道，所述区（1,2,3） ）和通道（46,48）处于流体连通，以及至少一种化合物，例如能够与所述流体流的至少一种成分产生生物或生物化学反应的酶，所述化合物附着到所述 入口区（1），反应区（2）和出口区（3）。
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