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公开(公告)号：US20070218452A1
公开(公告)日：2007-09-20
申请号：US10576342
申请日：2004-10-21
CPC分类号： B01L3/5088 , B01J2219/00317 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L2200/0642 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0877 , B01L2300/089 , B01L2400/0487 , C40B40/06 , C40B40/10 , C40B50/08 , C40B60/14 , Y10T436/25
摘要： The present invention relates especially to a process for the localized distribution of drops of a liquid of interest on an active surface. The process comprises the following steps an introduction of liquid of interest into a box containing the said active surface, and an extraction of liquid of interest from the said box, the said active surface and also the other surfaces inside the box being substantially non-wetting with respect to the liquid of interest, with the exception of several uptake areas localized on the said active surface, which are each suitable for taking up a drop of liquid of interest. The uptake areas may surround working areas. The present invention also relates to processes for the electrochemical and optical detection of at least one analyte in a liquid of interest, and to an electropolymerization process.
摘要翻译： 本发明特别涉及一种用于在活性表面上局部分布感兴趣液体的液滴的方法。 该方法包括以下步骤：将感兴趣的液体引入到包含所述活性表面的盒子中，并从所述盒子，所述活性表面以及盒内的其它表面基本上不润湿提取目标液体 相对于感兴趣的液体，除了位于所述活性表面上的几个摄取区域之外，其各自适合于吸收一滴感兴趣的液体。 摄取区域可以围绕工作区域。 本发明还涉及用于对感兴趣的液体中的至少一种分析物进行电化学和光学检测的方法以及电聚合方法。
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2.发明申请Work device comprising bordered work zones, on-chip laboratory and microsystem 审中-公开工作装置包括边界工作区，片上实验室和微系统公开(公告)号：US20070105210A1
公开(公告)日：2007-05-10
申请号：US10577274
申请日：2004-10-21
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00317 , B01J2219/00585 , B01J2219/00596 , B01J2219/0065 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L3/5088 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/089 , B01L2400/0487 , C40B40/06 , C40B40/10 , C40B60/14
摘要： The present invention relates to a work device (1) comprising work zones. It can be used to obtain a matrix of drops on a surface, using a liquid of interest (E). It comprises a work box (Bo) provided with means (o, s) for introducing and extracting the liquid respectively into and from the box; a substrate (S) comprising an active surface that is substantially non-wetting for said liquid of interest contained in said box; distinct work zones (Zt) formed on said active surface and each surrounded by a border (b) formed on said active surface, the borders not touching one another and having no common edge and having a geometry such that when the liquid of interest is extracted from the box, a drop (g) of the liquid of interest remains imprisoned by each border and in contact with the work zone that it surrounds.
摘要翻译： 本发明涉及一种包括工作区的作业装置（1）。 它可用于使用感兴趣的液体（E）获得表面上的液滴基质。 它包括一个设有装置（o，s）的工作箱（Bo），用于分别从盒子中取出和取出液体; 底物（S），其包含对所述盒中包含的所述感兴趣液体基本上不润湿的活性表面; 形成在所述活性表面上并且由形成在所述活性表面上的边界（b）围绕的不同工作区（Zt），所述边界不相互接触并且不具有共同边缘并且具有几何形状，使得当提取所关注的液体时 从盒子里，感兴趣的液体滴（g）仍然被每个边界囚禁，并与其周围的工作区接触。
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3.发明申请Operating Device Comprising A Localized Zone For The Capture Of A Drop A Liquid Of Interest 审中-公开操作装置包含一个本地化区域，用于捕获一滴液体公开(公告)号：US20070207055A1
公开(公告)日：2007-09-06
申请号：US10576345
申请日：2003-10-21
IPC分类号： G01N21/00
CPC分类号： B01L3/502792 , B01J2219/00317 , B01J2219/00527 , B01J2219/00596 , B01J2219/0065 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/502707 , B01L3/50273 , B01L3/5085 , B01L3/5088 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/089 , B01L2400/0487 , C40B40/06 , C40B40/10 , C40B60/14
摘要： The present invention relates to an operating device characterized in that it comprises an active surface that is substantially non-wetting with respect to a liquid of interest; at least one zone for the localized capture of a drop of said liquid formed on said active surface; at least one operating zone arranged with a capture zone in such a way that the operating zone is at least partially covered by the drop of the liquid when said drop is captured by said capture zone; and means for leaving a drop of said liquid on said capture zone. This device makes it possible in particular to form high-density arrays of drops of said liquid on a surface, with the aim in particular of carrying out chemical and/or biochemical reactions and/or of analysing the liquid of interest in each drop. It finds, for example, an application in biological chips.
摘要翻译： 本发明涉及一种操作装置，其特征在于其包括相对于感兴趣的液体基本上不润湿的活性表面; 用于局部捕获形成在所述活性表面上的一滴所述液体的至少一个区域; 所述至少一个操作区域布置有捕获区域，使得当所述液滴被所述捕获区域捕获时，所述操作区域至少部分地被所述液滴所覆盖; 以及用于在所述捕获区上留下一滴所述液体的装置。 该装置特别可以在表面上形成所述液体的高密度液滴阵列，其目的是特别是进行化学和/或生物化学反应和/或分析每一滴中感兴趣的液体。 例如，它发现生物芯片中的应用。
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4.发明授权公开(公告)号：US07829271B2
公开(公告)日：2010-11-09
申请号：US10576342
申请日：2004-10-21
IPC分类号： C12Q1/00
CPC分类号： B01L3/5088 , B01J2219/00317 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L2200/0642 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0877 , B01L2300/089 , B01L2400/0487 , C40B40/06 , C40B40/10 , C40B50/08 , C40B60/14 , Y10T436/25
摘要： The present invention relates especially to a process for the localized distribution of drops of a liquid of interest on an active surface. The process comprises the following steps: an introduction of liquid of interest into a box containing the said active surface, and an extraction of liquid of interest from the said box, the said active surface and also the other surfaces inside the box being substantially non-wetting with respect to the liquid of interest, with the exception of several uptake areas localized on the said active surface, which are each suitable for taking up a drop of liquid of interest. The uptake areas may surround working areas. The present invention also relates to processes for the electrochemical and optical detection of at least one analyte in a liquid of interest, and to an electropolymerization process.
摘要翻译： 本发明特别涉及一种用于在活性表面上局部分布感兴趣液体的液滴的方法。 该方法包括以下步骤：将感兴趣的液体引入到包含所述活性表面的盒中，以及从所述盒，所述活性表面以及所述盒内的其它表面基本上不相关的萃取液体， 相对于目标液体润湿，除了位于所述活性表面上的几个吸收区域外，其各自适用于吸收一滴感兴趣的液体。 摄取区域可以围绕工作区域。 本发明还涉及用于对感兴趣的液体中的至少一种分析物进行电化学和光学检测的方法以及电聚合方法。
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公开(公告)号：US08216827B2
公开(公告)日：2012-07-10
申请号：US11815147
申请日：2006-01-31
IPC分类号： C12M1/34
CPC分类号： G01N21/6452 , B01L3/502707 , B01L3/502715 , B01L2200/10 , B01L2300/0636 , B01L2300/0864 , G01N21/76
摘要： The disclosure relates to a biological analysis device including: means for circulating a fluid to be analyzed, comprising a fluidic chamber, optical detection means based on a semiconductor, including a detection front face, a rear face and pads of electrical contacts located on this rear face.
摘要翻译： 本发明涉及一种生物分析装置，包括：用于使待分析流体循环的装置，包括流体室，基于半导体的光学检测装置，包括位于该后部的检测前面，后表面和电触点焊盘 面对。
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6.发明申请公开(公告)号：US20070199901A1
公开(公告)日：2007-08-30
申请号：US10581357
申请日：2004-12-13
IPC分类号： C02F1/48
CPC分类号： G01N33/54326 , B03C1/015 , B03C1/288 , B03C2201/24 , G01N35/0098
摘要： A method for dividing an analyte present in a solution and that is fixed on magnetic particles, and devices to be used in the method and systems for implementing the method. The method includes sedimentation of the magnetic particles together with separation into a plurality of residues. One implementation: forms at least a residue of magnetic particles in a first receptacle; and displaces the at least the residues towards a plurality of second receptacles, preferably by relative translation of a magnetic system. The second receptacle is connected to the first receptacle through a fluid channel.
摘要翻译： 用于分离存在于溶液中并固定在磁性颗粒上的分析物的方法以及用于实施该方法的方法和系统中使用的装置。 该方法包括将磁性颗粒沉淀并分离成多个残余物。 一个实施方案：在第一容器中形成至少一个磁性颗粒残留物; 并且将至少残留物移向多个第二容器，优选通过磁性系统的相对平移。 第二容器通过流体通道连接到第一容器。
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公开(公告)号：US20060023216A1
公开(公告)日：2006-02-02
申请号：US10532167
申请日：2003-10-23
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/6428 , G01N2021/6463
摘要： The invention concerns a device (1) for testing at least one sample by optical detection of luminescence, comprising a site for receiving (3) the sample, said site being arranged in such a way that the sample can receive a luminescence excitation and emit a luminescence light in an optical guiding plane (2) of the device, the device further comprising collection means (7) optically connected to the optical guiding plane (2) to receive the luminescence light. The device further comprises means that make it possible to send back towards the collection means (4) a part of the luminescence light emitted in the optical guiding plane and not directly collected by the collection means.
摘要翻译： 本发明涉及一种用于通过光学检测发光来测试至少一个样品的装置（1），其包括用于接收（3）样品的部位，所述部位以使得样品能够接收发光激发并发射 所述装置的光导平面（2）中的发光，所述装置还包括光学连接到所述光引导平面（2）以接收所述发光的收集装置（7）。 该装置还包括使得可以向收集装置（4）发送在光导平面中发射的并且不被收集装置直接收集的发光的一部分的装置。
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8.发明授权公开(公告)号：US08215338B2
公开(公告)日：2012-07-10
申请号：US12223059
申请日：2007-02-15
申请人： Cyril Delattre , Raymond Charles , Patrick Pouteau
发明人： Cyril Delattre , Raymond Charles , Patrick Pouteau
IPC分类号： A61M5/168
CPC分类号： B01J19/0093 , B01J2219/00286 , B01J2219/00353 , B01J2219/00418 , B01J2219/00585 , B01J2219/0059 , B01J2219/00689 , B01J2219/00698 , B01J2219/00702 , B01J2219/0072 , B01J2219/0074 , B01J2219/00853 , B01J2219/0086 , B01J2219/00862 , B01J2219/00867 , B01J2219/00869 , B01J2219/00891 , B01J2219/0095 , B01J2219/00959 , B01J2219/00963 , B01J2219/00986 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2300/0816 , B01L2300/0864 , B01L2300/161 , B01L2400/0487 , B01L2400/0688 , Y10T137/0396 , Y10T137/2224 , Y10T137/87306 , Y10T137/87499
摘要： The method for controlling the progression of a fluid, from upstream to downstream, in a microfluidic component comprising for example a plurality of microchannels each comprising a plurality of successive reaction or detection zones and a plurality of passive valves, controls the progression of the fluid in the microchannels by controlling the increase of a pressure difference between upstream and downstream of the component. The method controls the pressure difference increase discontinuously in the form of enabling pulses so as in particular to synchronize passing of the corresponding passive valves of the microchannels. The pressure difference is advantageously adjusted to a zero value between two successive enabling pulses.
摘要翻译： 用于控制微流体组件中的流体从上游到下游的方法，所述微流体组分包括例如多个微通道，每个微通道包括多个连续的反应或检测区域以及多个被动阀门，控制流体在 通过控制组件的上游和下游之间的压力差的增加来实现微通道。 该方法以可启动脉冲的形式不连续地控制压力差增加，特别是使微通道的相应的被动阀的通过同步。 压力差有利地在两个连续使能脉冲之间调整为零值。
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9.发明申请公开(公告)号：US20080314454A1
公开(公告)日：2008-12-25
申请号：US12223059
申请日：2007-02-15
申请人： Cyril Delattre , Raymond Charles , Patrick Pouteau
发明人： Cyril Delattre , Raymond Charles , Patrick Pouteau
IPC分类号： G05D7/00
CPC分类号： B01J19/0093 , B01J2219/00286 , B01J2219/00353 , B01J2219/00418 , B01J2219/00585 , B01J2219/0059 , B01J2219/00689 , B01J2219/00698 , B01J2219/00702 , B01J2219/0072 , B01J2219/0074 , B01J2219/00853 , B01J2219/0086 , B01J2219/00862 , B01J2219/00867 , B01J2219/00869 , B01J2219/00891 , B01J2219/0095 , B01J2219/00959 , B01J2219/00963 , B01J2219/00986 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2300/0816 , B01L2300/0864 , B01L2300/161 , B01L2400/0487 , B01L2400/0688 , Y10T137/0396 , Y10T137/2224 , Y10T137/87306 , Y10T137/87499
摘要： The method for controlling the progression of a fluid, from upstream to downstream, in a microfluidic component comprising for example a plurality of microchannels each comprising a plurality of successive reaction or detection zones and a plurality of passive valves, controls the progression of the fluid in the microchannels by controlling the increase of a pressure difference between upstream and downstream of the component. The method controls the pressure difference increase discontinuously in the form of enabling pulses so as in particular to synchronize passing of the corresponding passive valves of the microchannels. The pressure difference is advantageously adjusted to a zero value between two successive enabling pulses.
摘要翻译： 用于控制微流体组件中的流体从上游到下游的方法，所述微流体组分包括例如多个微通道，每个微通道包括多个连续的反应或检测区域以及多个被动阀门，控制流体在 通过控制组件的上游和下游之间的压力差的增加来实现微通道。 该方法以可启动脉冲的形式不连续地控制压力差增加，特别是使微通道的相应的被动阀的通过同步。 压力差有利地在两个连续使能脉冲之间调整为零值。
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10.发明授权公开(公告)号：US08673153B2
公开(公告)日：2014-03-18
申请号：US10581357
申请日：2004-12-13
IPC分类号： B03C1/02
CPC分类号： G01N33/54326 , B03C1/015 , B03C1/288 , B03C2201/24 , G01N35/0098
摘要： A method for dividing an analyte present in a solution and that is fixed on magnetic particles, and devices to be used in the method and systems for implementing the method. The method includes sedimentation of the magnetic particles together with separation into a plurality of residues. One implementation: forms at least a residue of magnetic particles in a first receptacle; and displaces the at least the residues towards a plurality of second receptacles, preferably by relative translation of a magnetic system. The second receptacle is connected to the first receptacle through a fluid channel.
摘要翻译： 用于分离存在于溶液中并固定在磁性颗粒上的分析物的方法以及用于实施该方法的方法和系统中使用的装置。 该方法包括将磁性颗粒沉淀并分离成多个残余物。 一个实施方案：在第一容器中形成至少一个磁性颗粒残留物; 并且将至少残留物移向多个第二容器，优选通过磁性系统的相对平移。 第二容器通过流体通道连接到第一容器。
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