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1.发明申请Microreactor, method for preparing same, and method for producing a biochemical or biological reaction 有权微反应器，其制备方法以及生物化学或生物反应的生产方法公开(公告)号：US20060051858A1
公开(公告)日：2006-03-09
申请号：US10514066
申请日：2003-05-16
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00889 , B01L3/5027 , B01L2200/12 , B01L2300/0636 , B01L2300/0864 , B01L2400/049 , G01N30/6095
摘要： Microreactor comprising an inlet or feed channel, an inlet or feed zone (1) for a flow of fluid, a reaction zone (2), an outlet zone (3) and an outlet or evacuation channel, said zones (1, 2, 3) and channels (46, 48) being in fluid communication, and at least one compound such as an enzyme capable of producing a biological or biochemical reaction with at least one constituent of said flow of fluid, said compound being attached to the surfaces of said inlet zone (1), reaction zone (2), and outlet zone (3).
摘要翻译： 微反应器包括入口或进料通道，用于流体流动的入口或进料区（1），反应区（2），出口区（3）和出口或抽空通道，所述区（1,2,3） ）和通道（46,48）处于流体连通，以及至少一种化合物，例如能够与所述流体流的至少一种成分产生生物或生物化学反应的酶，所述化合物附着到所述 入口区（1），反应区（2）和出口区（3）。
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2.发明授权Microreactor, process for the preparation thereof, and process for carrying out a biochemical or biological reaction 有权微反应器，其制备方法以及进行生物化学或生物反应的方法公开(公告)号：US08192980B2
公开(公告)日：2012-06-05
申请号：US10514066
申请日：2003-05-16
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00889 , B01L3/5027 , B01L2200/12 , B01L2300/0636 , B01L2300/0864 , B01L2400/049 , G01N30/6095
摘要： A microreactor is shown having an inlet or feed channel, an inlet or feed zone for a flow of fluid, a reaction zone, an outlet zone and an outlet or evacuation channel, the zones and channels being in fluid communication, and at least one compound such as an enzyme capable of producing a biological or biochemical reaction with at least one constituent of the flow of fluid, the compound being attached to the surfaces of the inlet zone, reaction zone, and outlet zone.
摘要翻译： 示出了微反应器具有入口或进料通道，用于流体流动的入口或进料区域，反应区域，出口区域和出口或排出通道，所述区域和通道是流体连通的，以及至少一种化合物 例如能够与流体流动的至少一种成分产生生物或生物化学反应的酶，所述化合物附着到入口区域，反应区域和出口区域的表面。
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公开(公告)号：US20080124252A1
公开(公告)日：2008-05-29
申请号：US11631554
申请日：2005-07-05
申请人： Gilles Marchand , Francoise Vinet , Guillaume Delapierre , Fatima Hassine , Said Gmouh , Michel Vaultier
发明人： Gilles Marchand , Francoise Vinet , Guillaume Delapierre , Fatima Hassine , Said Gmouh , Michel Vaultier
CPC分类号： C07D221/18 , B01F13/0071 , B01F13/0076 , B01J14/00 , B01J19/0093 , B01L3/502792 , B01L2300/0816 , B01L2300/089 , B01L2400/0406 , B01L2400/0415 , B01L2400/0427 , B01L2400/0433 , B01L2400/0442 , B01L2400/0487 , C07C41/14 , C07C227/16 , C12P17/12 , G01N2035/1046
摘要： The present invention relates to a droplet microreactor, i.e. a microreactor consisting of a droplet of a specific liquid, the microreactor being wall-less, wherein the interface of the specific liquid with the ambient environment and with the support on which the droplet is deposited defines the limits of the microreactor. The microreactor is characterized in that it consists of a droplet comprising at least one ionic liquid. The present invention also relates to methods for carrying out chemical or biochemical reactions and/or mixes using said droplet microreactor, and also to a lab-on-chip comprising a microreactor according to the invention.
摘要翻译： 液滴微反应器本发明涉及液滴微反应器，即由特定液体的液滴组成的微反应器，微反应器是无壁的，其中特定液体与周围环境的界面和其上沉积有液滴的载体界定 微反应器的极限。 微反应器的特征在于其由包含至少一种离子液体的液滴组成。 本发明还涉及使用所述液滴微反应器进行化学或生化反应和/或混合的方法，还涉及包括根据本发明的微反应器的片上实验室。
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4.发明授权Device and methods for coupling/uncoupling a target or an object present in a sample 失效用于耦合/解耦样品中存在的目标或物体的装置和方法公开(公告)号：US08758576B2
公开(公告)日：2014-06-24
申请号：US10555099
申请日：2004-05-17
IPC分类号： C25D17/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00677 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01J2219/00743 , C12Q1/6825 , C40B40/06 , C40B40/10 , G01N33/5438 , C12Q2527/119
摘要： The device of the invention comprises a support having a surface comprising an attachment zone (Z) capable of being functionalized with a probe (A) capable of binding, according to the pH and reversibly, to a target (B) so as to attach it; a working electrode (WE) and a counterelectrode (CE) for this working electrode, arranged on the support in the vicinity of the attachment zone; and means for applying a given electric current or a given potential to said working electrode so as to cause, when said attachment zone and said electrodes are immersed in an aqueous solution, a local variation in pH in the region of said attachment zone.The method for attaching and/or detaching a target or an object according to the invention uses this device, the attachment and/or the detachment being electrochemically controlled with the working electrode.
摘要翻译： 本发明的装置包括具有表面的支撑体，该表面包括能够用能够根据pH并可逆地结合到目标物（B）的探针（A）进行功能化的附着区域（Z），以便附着 ; 用于该工作电极的工作电极（WE）和反电极（CE），布置在安装区附近的支撑件上; 以及用于将给定电流或给定电位施加到所述工作电极的装置，以便当所述附着区域和所述电极浸入水溶液中时，在所述附着区域的区域中导致pH的局部变化。 根据本发明的用于附接和/或拆卸目标或物体的方法使用该装置，附接和/或拆卸由工作电极进行电化学控制。
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5.发明申请Device and methods for coupling/uncoupling a target or an object present in a sample 失效用于耦合/解耦样品中存在的目标或物体的装置和方法公开(公告)号：US20070034511A1
公开(公告)日：2007-02-15
申请号：US10555099
申请日：2004-05-17
IPC分类号： G01N33/487
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00677 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01J2219/00743 , C12Q1/6825 , C40B40/06 , C40B40/10 , G01N33/5438 , C12Q2527/119
摘要： The device of the invention comprises a support having a surface comprising an attachment zone (Z) capable of being functionalized with a probe (A) capable of binding, according to the pH and reversibly, to a target (B) so as to attach it; a working electrode (WE) and a counterelectrode (CE) for this working electrode, arranged on the support in the vicinity of the attachment zone; and means for applying a given electric current or a given potential to said working electrode so as to cause, when said attachment zone and said electrodes are immersed in an aqueous solution, a local variation in pH in the region of said attachment zone. The method for attaching and/or detaching a target or an object according to the invention uses this device, the attachment and/or the detachment being electrochemically controlled with the working electrode.
摘要翻译： 本发明的装置包括具有表面的支撑体，该表面包括能够用能够根据pH并可逆地结合到目标物（B）的探针（A）进行功能化的附着区域（Z），以便附着 ; 用于该工作电极的工作电极（WE）和反电极（CE），布置在安装区附近的支撑件上; 以及用于将给定电流或给定电位施加到所述工作电极的装置，以便当所述附着区域和所述电极浸入水溶液中时，在所述附着区域的区域中导致pH的局部变化。 根据本发明的用于附接和/或拆卸目标或物体的方法使用该装置，附接和/或拆卸由工作电极进行电化学控制。
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公开(公告)号：US08389368B2
公开(公告)日：2013-03-05
申请号：US12727593
申请日：2010-03-19
申请人： Simon Deleonibus , Jean-Marie Basset , Paul Campbell , Thibaut Gutel , Paul-Henri Haumesser , Gilles Marchand , Catherine Santini
发明人： Simon Deleonibus , Jean-Marie Basset , Paul Campbell , Thibaut Gutel , Paul-Henri Haumesser , Gilles Marchand , Catherine Santini
IPC分类号： H01L21/336
CPC分类号： H01L29/66833 , B82Y10/00 , B82Y40/00 , H01L21/28273 , H01L27/11563 , H01L29/42332 , H01L29/513 , H01L29/66545 , H01L29/66825 , H01L29/7881 , Y10S977/773
摘要： A method for producing a memory device with nanoparticles, including steps of: a) forming, in a substrate based on at least one semi-conductor, source and drain regions, and at least one first dielectric on at least one zone of the substrate arranged between the source and drain regions and intended to form a channel of the memory device, b) depositing of at least one ionic liquid that is an organic salt or mixture of organic salts in a liquid state, wherein nanoparticles of at least one electrically conductive material are suspended in the ionic liquid, said ionic liquid covering at least said first dielectric, c) forming a deposition of said nanoparticles at least on said first dielectric, d) removing the ionic liquid remaining on the first dielectric, and e) forming at least one second dielectric and at least one control gate on at least one part of the nanoparticles deposited on the first dielectric.
摘要翻译： 一种制备具有纳米颗粒的存储器件的方法，包括以下步骤：a）在基板中基于至少一个半导体源极和漏极区域形成基底，并且至少一个第一电介质在衬底的至少一个区域上被布置 在源极和漏极区之间并且旨在形成存储器件的通道，b）沉积至少一种离子液体，其是液态的有机盐或有机盐的混合物，其中至少一种导电材料的纳米颗粒 悬浮在离子液体中，所述离子液体至少覆盖所述第一电介质，c）至少在所述第一电介质上形成所述纳米颗粒的沉积，d）去除残留在第一电介质上的离子液体，和e）至少形成 在沉积在第一电介质上的纳米颗粒的至少一部分上的一个第二电介质和至少一个控制栅极。
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7.发明申请METHOD FOR DETECTING ANALYTE IN A BODILY FLUID, AND DRESSING FOR IMPLEMENTING SUCH A METHOD 有权用于检测体液中分析物的方法和用于实施这种方法的连接公开(公告)号：US20120283529A1
公开(公告)日：2012-11-08
申请号：US13520078
申请日：2010-12-29
申请人： Gilles Marchand , Pierre Marcoux
发明人： Gilles Marchand , Pierre Marcoux
IPC分类号： A61B5/1455
CPC分类号： G01N33/5088 , A61B5/00 , A61F13/0213 , A61F13/0226 , A61F13/0273 , A61F2013/00429 , A61F2013/00846 , A61F2013/00965 , A61L15/56
摘要： A method for detecting an analyte in a bodily fluid includes placing the detector in contact with at least one metabolite resulting from the metabolism or degradation of the analyte. The contact between the detector and the metabolite produces an optically detectable signal. The detection method includes the detection of the metabolite only in gas form, said metabolite in gas form coming from the evaporation of at least a part of said metabolite. The detection is also carried out without contact between the bodily fluid and the detector. A dressing for implementing the detection method is also described.
摘要翻译： 用于检测体液中的分析物的方法包括使检测器与由分析物的代谢或降解导致的至少一种代谢物接触。 检测器和代谢物之间的接触产生可光学检测的信号。 检测方法包括仅以气体形式检测代谢物，所述代谢物以气体形式来自至少一部分所述代谢物的蒸发。 检测也可以在体液和检测器之间没有接触的情况下进行。 还描述了用于实现检测方法的敷料。
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公开(公告)号：US20070218452A1
公开(公告)日：2007-09-20
申请号：US10576342
申请日：2004-10-21
CPC分类号： B01L3/5088 , B01J2219/00317 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L2200/0642 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0877 , B01L2300/089 , B01L2400/0487 , C40B40/06 , C40B40/10 , C40B50/08 , C40B60/14 , Y10T436/25
摘要： The present invention relates especially to a process for the localized distribution of drops of a liquid of interest on an active surface. The process comprises the following steps an introduction of liquid of interest into a box containing the said active surface, and an extraction of liquid of interest from the said box, the said active surface and also the other surfaces inside the box being substantially non-wetting with respect to the liquid of interest, with the exception of several uptake areas localized on the said active surface, which are each suitable for taking up a drop of liquid of interest. The uptake areas may surround working areas. The present invention also relates to processes for the electrochemical and optical detection of at least one analyte in a liquid of interest, and to an electropolymerization process.
摘要翻译： 本发明特别涉及一种用于在活性表面上局部分布感兴趣液体的液滴的方法。 该方法包括以下步骤：将感兴趣的液体引入到包含所述活性表面的盒子中，并从所述盒子，所述活性表面以及盒内的其它表面基本上不润湿提取目标液体 相对于感兴趣的液体，除了位于所述活性表面上的几个摄取区域之外，其各自适合于吸收一滴感兴趣的液体。 摄取区域可以围绕工作区域。 本发明还涉及用于对感兴趣的液体中的至少一种分析物进行电化学和光学检测的方法以及电聚合方法。
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9.发明申请Work device comprising bordered work zones, on-chip laboratory and microsystem 审中-公开工作装置包括边界工作区，片上实验室和微系统公开(公告)号：US20070105210A1
公开(公告)日：2007-05-10
申请号：US10577274
申请日：2004-10-21
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00317 , B01J2219/00585 , B01J2219/00596 , B01J2219/0065 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L3/5088 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/089 , B01L2400/0487 , C40B40/06 , C40B40/10 , C40B60/14
摘要： The present invention relates to a work device (1) comprising work zones. It can be used to obtain a matrix of drops on a surface, using a liquid of interest (E). It comprises a work box (Bo) provided with means (o, s) for introducing and extracting the liquid respectively into and from the box; a substrate (S) comprising an active surface that is substantially non-wetting for said liquid of interest contained in said box; distinct work zones (Zt) formed on said active surface and each surrounded by a border (b) formed on said active surface, the borders not touching one another and having no common edge and having a geometry such that when the liquid of interest is extracted from the box, a drop (g) of the liquid of interest remains imprisoned by each border and in contact with the work zone that it surrounds.
摘要翻译： 本发明涉及一种包括工作区的作业装置（1）。 它可用于使用感兴趣的液体（E）获得表面上的液滴基质。 它包括一个设有装置（o，s）的工作箱（Bo），用于分别从盒子中取出和取出液体; 底物（S），其包含对所述盒中包含的所述感兴趣液体基本上不润湿的活性表面; 形成在所述活性表面上并且由形成在所述活性表面上的边界（b）围绕的不同工作区（Zt），所述边界不相互接触并且不具有共同边缘并且具有几何形状，使得当提取所关注的液体时 从盒子里，感兴趣的液体滴（g）仍然被每个边界囚禁，并与其周围的工作区接触。
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10.发明授权Method for detecting analyte in a bodily fluid, and dressing for implementing such a method 有权用于检测体液中的分析物的方法，以及用于实施这种方法的敷料公开(公告)号：US09551701B2
公开(公告)日：2017-01-24
申请号：US13520078
申请日：2010-12-29
申请人： Gilles Marchand , Pierre Marcoux
发明人： Gilles Marchand , Pierre Marcoux
CPC分类号： G01N33/5088 , A61B5/00 , A61F13/0213 , A61F13/0226 , A61F13/0273 , A61F2013/00429 , A61F2013/00846 , A61F2013/00965 , A61L15/56
摘要： A method for detecting an analyte in a bodily fluid includes placing the detector in contact with at least one metabolite resulting from the metabolism or degradation of the analyte. The contact between the detector and the metabolite produces an optically detectable signal. The detection method includes the detection of the metabolite only in gas form, said metabolite in gas form coming from the evaporation of at least a part of said metabolite. The detection is also carried out without contact between the bodily fluid and the detector. A dressing for implementing the detection method is also described.
摘要翻译： 用于检测体液中的分析物的方法包括使检测器与由分析物的代谢或降解导致的至少一种代谢物接触。 检测器和代谢物之间的接触产生可光学检测的信号。 检测方法包括仅以气体形式检测代谢物，所述代谢物以气体形式来自至少一部分所述代谢物的蒸发。 检测也可以在体液和检测器之间没有接触的情况下进行。 还描述了用于实现检测方法的敷料。
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