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公开(公告)号：US06203981B1
公开(公告)日：2001-03-20
申请号：US09068172
申请日：1999-02-08
IPC分类号： C12Q168
CPC分类号： G01N33/5438 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00653 , B01J2219/00659 , G01N27/4145
摘要： Adjacent first and second transistors are integrated with a substrate. Each of the first and second transistors has a gate electrode, a source electrode, a drain electrode and a semiconductive channel formed of an organic material, the semiconductive channel electrically coupling the source electrode with the drain electrode. The source electrode of the first transistor is electrically coupled to the source electrode of the second transistor. A molecular receptor is bound directly to a surface of the semiconductive channel of the first transistor. A non-zero offset voltage, which produces equal channel currents in the semiconductive channels of the first and second transistors after a molecule has bound with the molecular receptor without a like binding event proximate to the second transistor, is sensed between the gate electrodes of the first and second transistors.
摘要翻译： 相邻的第一和第二晶体管与衬底集成。 第一和第二晶体管中的每一个具有栅电极，源电极，漏电极和由有机材料形成的半导体沟道，半导体沟道将源电极与漏电极电耦合。 第一晶体管的源电极电耦合到第二晶体管的源电极。 分子受体直接结合到第一晶体管的半导体通道的表面。 在零分子与分子受体结合而没有靠近第二晶体管的相似结合事件之后，在第一和第二晶体管的半导体通道中产生相等的沟道电流的非零偏移电压被感测在 第一和第二晶体管。
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2.发明授权Method and system for synthesizing oligonucleotides using nucleotide-specific dispensing bars 失效使用核苷酸特异性分配棒合成寡核苷酸的方法和系统
公开(公告)号：US6103467A
公开(公告)日：2000-08-15
申请号：US901102
申请日：1997-07-28
CPC分类号： B01J19/0046 , B01J2219/00306 , B01J2219/00351 , B01J2219/00369 , B01J2219/00376 , B01J2219/00527 , B01J2219/00529 , B01J2219/0054 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/00722 , C40B40/06 , C40B60/14 , C40B70/00 , G01N2035/1037
摘要： A plurality of oligonucleotides are synthesized at a plurality of locations on a substrate using a plurality of dispensing bars. Each of the plurality of dispensing bars has a respective plurality of dispensing heads arranged along a respective axis. Each of the plurality of dispensing bars is operative to selectively deposit a volume of a respective one of a plurality of nucleotide bases in any of a row of locations. A positioning mechanism positions the substrate with respect to the plurality of dispensing bars. A controller controls the plurality of dispensing bars and the positioning mechanism so that, at each of the plurality of locations, a respective sequence of nucleotide bases is deposited to form a respective oligonucleotide.
摘要翻译： 使用多个分配棒在基板上的多个位置处合成多个寡核苷酸。 多个分配棒中的每一个具有沿着相应轴线布置的相应的多个分配头。 多个分配棒中的每一个可操作以选择性地将多个核苷酸碱基中的相应的一个核苷酸碱基的体积任意地沉积在一排位置中。 定位机构使基板相对于多个分配杆定位。 控制器控制多个分配棒和定位机构，使得在多个位置的每一个位置沉积相应的核苷酸碱基序列以形成相应的寡核苷酸。
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3.发明授权
公开(公告)号：US5671303A
公开(公告)日：1997-09-23
申请号：US634103
申请日：1996-04-17
CPC分类号： G01N21/6454 , G01N21/7703 , G02B6/10
摘要： A target molecule at a binding site is detected using an optical waveguide having a surface proximate to the binding site, and a waveguide detector coupled to the optical waveguide. An incident light beam is applied to the binding site along an axis transverse to the surface of the optical waveguide. The incident light beam impinges an optical indicator associated with the target molecule to form secondary light which is coupled into the optical waveguide. The secondary light is detected by the waveguide detector to thereby detect the target molecule.
摘要翻译： 使用具有接近结合位点的表面的光波导和耦合到光波导的波导检测器来检测结合位点处的靶分子。 沿着横向于光波导表面的轴将入射光束施加到结合位点。 入射光束照射与靶分子相关联的光学指示器，以形成耦合到光波导中的次级光。 二次光被波导检测器检测，从而检测目标分子。
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4.发明授权
公开(公告)号：US5841914A
公开(公告)日：1998-11-24
申请号：US861927
申请日：1997-05-22
CPC分类号： G01N21/6454 , G01N21/7703 , G02B6/10
摘要： A target molecule at a binding site is detected using an optical waveguide having a surface proximate to the binding site, and a waveguide detector coupled to the optical waveguide. An incident light beam is applied to the binding site along an axis transverse to the surface of the optical waveguide. The incident light beam impinges an optical indicator associated with the target molecule to form secondary light which is coupled into the optical waveguide. The secondary light is detected by the waveguide detector to thereby detect the target molecule.
摘要翻译： 使用具有接近结合位点的表面的光波导和耦合到光波导的波导检测器来检测结合位点处的靶分子。 沿着横向于光波导表面的轴将入射光束施加到结合位点。 入射光束照射与靶分子相关联的光学指示器，以形成耦合到光波导中的次级光。 二次光被波导检测器检测，从而检测目标分子。
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公开(公告)号：US5945832A
公开(公告)日：1999-08-31
申请号：US24147
申请日：1998-02-17
CPC分类号： G01N27/07
摘要： A method of measuring electrical characteristics of a molecule including providing a first metal contact having a major surface, an insulating layer overlying the major surface of the first metal contact and a second metal contact overlying the insulating layer so as to have an edge spaced a molecular distance from the major surface of the first metal contact. A conductive organic molecule including a metal binding group is coupled between the metal contacts.
摘要翻译： 一种测量分子的电特性的方法，包括提供具有主表面的第一金属触点，覆盖在第一金属触点的主表面上的绝缘层和覆盖绝缘层的第二金属触点，以便具有间隔开分子的边缘 距离第一金属触点的主表面。 包含金属结合基团的导电有机分子被连接在金属触点之间。
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6.发明授权
公开(公告)号：US5733509A
公开(公告)日：1998-03-31
申请号：US634082
申请日：1996-04-17
CPC分类号： B01J19/0046 , B01J2219/00306 , B01J2219/00351 , B01J2219/00369 , B01J2219/00376 , B01J2219/00527 , B01J2219/00529 , B01J2219/0054 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/00722 , C40B40/06 , C40B60/14 , C40B70/00 , G01N2035/1037
摘要： A plurality of oligonucleotides are synthesized at a plurality of locations on a substrate using a plurality of dispensing bars. Each of the plurality of dispensing bars has a respective plurality of dispensing heads arranged along a respective axis. Each of the plurality of dispensing bars is operative to selectively deposit a volume of a respective one of a plurality of nucleotide bases in any of a row of locations. A positioning mechanism positions the substrate with respect to the plurality of dispensing bars. A controller controls the plurality of dispensing bars and the positioning mechanism so that, at each of the plurality of locations, a respective sequence of nucleotide bases is deposited to form a respective oligonucleotide.
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7.发明授权White light generating organic electroluminescent device and method of fabrication 失效白光产生有机电致发光器件及其制造方法
公开(公告)号：US6133692A
公开(公告)日：2000-10-17
申请号：US93080
申请日：1998-06-08
申请人： Ji-Hai Xu , Thomas B. Harvey, III
发明人： Ji-Hai Xu , Thomas B. Harvey, III
CPC分类号： H01L51/5036 , H01L51/5265
摘要： A white light generating organic electroluminescent device including an organic light emitting diode emitting a broad spectrum light including a component of each primary color. A multi-mode microcavity structure is positioned to cooperate with the diode defining an optical length of the microcavity structure to enhance the broad spectrum light and obtain multiple resonant peaks, one at each primary color. A plurality of filters are positioned to receive and adjust the multiple resonant peaks to provide substantially balanced multiple resonant peaks.
摘要翻译： 一种产生白光的有机电致发光器件，包括发射包含每种原色成分的广谱光的有机发光二极管。 多模微腔结构被定位成与限定微腔结构的光学长度的二极管配合，以增强广谱光并获得多个谐振峰，每个原色一个。 定位多个滤波器以接收和调整多个谐振峰值以提供基本平衡的多个谐振峰值。
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8.发明授权Organic light emitting diodes with molecular alignment and method of fabrication 失效具有分子取向和制造方法的有机发光二极管
公开(公告)号：US5677545A
公开(公告)日：1997-10-14
申请号：US304449
申请日：1994-09-12
申请人： Song Q. Shi , Franky So , Thomas B. Harvey, III
发明人： Song Q. Shi , Franky So , Thomas B. Harvey, III
CPC分类号： H01L51/5012 , B82Y10/00 , B82Y30/00 , H01L51/0035 , H01L51/0038 , Y10S428/917
摘要： An organic LED including a conductive layer with a planar surface and a layer of semiconductive polymer molecules having anchoring groups at each end, uniformly oriented perpendicularly on the planar surface, by deposition and self-assembly technique. A coupling layer positioned on the organic layer and a second organic layer uniformly oriented on the coupling layer, by deposition and self-assembly technique, parallel to the first semiconductive polymer molecules. Additional coupling layers and organic layers are alternately positioned on the second organic layer and on each other to form an LED of desired dimensions and a second conductive layer is deposited on the final layer.
摘要翻译： 通过沉积和自组装技术，包括具有平坦表面的导电层和在每一端具有锚定基团的半导体聚合物分子层的有机LED，通过沉积和自组装技术垂直于平面表面均匀取向。 通过沉积和自组装技术，平行于第一半导体聚合物分子定位在有机层上的耦合层和均匀地定向在耦合层上的第二有机层。 另外的耦合层和有机层交替地定位在第二有机层上并且彼此上形成所需尺寸的LED，并且第二导电层沉积在最终层上。
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公开(公告)号：US4666249A
公开(公告)日：1987-05-19
申请号：US765891
申请日：1985-08-14
申请人： Robert E. Bauman , S. Kumar Chandrasekaran , Shaow B. Lin , Lyle M. Bowman , Thomas B. Harvey, III
发明人： Robert E. Bauman , S. Kumar Chandrasekaran , Shaow B. Lin , Lyle M. Bowman , Thomas B. Harvey, III
摘要： A contact lens for correction of astigmatism is formed from a single polymeric or copolymeric material. The lens has a central optical zone of greater rigidity than a surrounding non-optical zone. The rigidity of the central optical zone is sufficient for it to retain an astigmatism-correcting shape when worn on an eye, while the surrounding non-optical zone conforms to the shape of the eye.
摘要翻译： 用于矫正散光的隐形眼镜由单一聚合物或共聚物材料形成。 透镜具有比周围的非光学区域更大的刚性的中心光学区域。 中心光学区域的刚度足以使其佩戴在眼睛上时保持像散矫正形状，而周围的非光学区域符合眼睛的形状。
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公开(公告)号：US5771562A
公开(公告)日：1998-06-30
申请号：US433909
申请日：1995-05-02
申请人： Thomas B. Harvey, III , Franky So
发明人： Thomas B. Harvey, III , Franky So
IPC分类号： H05B33/04 , H01L33/00 , H01L51/05 , H01L51/40 , H01L51/50 , H01L51/52 , H05B33/12 , H01S4/00
CPC分类号： H01L51/5253 , H01L51/5243 , Y10T29/49002
摘要： A method of passivating organic devices positioned on a supporting substrate including the steps of overcoating the organic device with a low temperature deposited film of dielectric material, and sealingly engaging an inorganic layer over the dielectric material so as to substantially hermetically seal the organic device. In a typical embodiment, the dielectric layer is SiO.sub.2 and the inorganic layer is a metal can.
摘要翻译： 一种钝化位于支撑衬底上的有机器件的方法，包括以下步骤：用介电材料的低温沉积膜对有机器件进行涂覆，并将绝缘材料上的无机层密封地接合，从而基本上气密地密封有机器件。 在典型的实施例中，电介质层是SiO 2，无机层是金属罐。
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