-
公开(公告)号：US06203981B1
公开(公告)日：2001-03-20
申请号：US09068172
申请日：1999-02-08
IPC分类号： C12Q168
CPC分类号： G01N33/5438 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00653 , B01J2219/00659 , G01N27/4145
摘要： Adjacent first and second transistors are integrated with a substrate. Each of the first and second transistors has a gate electrode, a source electrode, a drain electrode and a semiconductive channel formed of an organic material, the semiconductive channel electrically coupling the source electrode with the drain electrode. The source electrode of the first transistor is electrically coupled to the source electrode of the second transistor. A molecular receptor is bound directly to a surface of the semiconductive channel of the first transistor. A non-zero offset voltage, which produces equal channel currents in the semiconductive channels of the first and second transistors after a molecule has bound with the molecular receptor without a like binding event proximate to the second transistor, is sensed between the gate electrodes of the first and second transistors.
摘要翻译： 相邻的第一和第二晶体管与衬底集成。 第一和第二晶体管中的每一个具有栅电极，源电极，漏电极和由有机材料形成的半导体沟道，半导体沟道将源电极与漏电极电耦合。 第一晶体管的源电极电耦合到第二晶体管的源电极。 分子受体直接结合到第一晶体管的半导体通道的表面。 在零分子与分子受体结合而没有靠近第二晶体管的相似结合事件之后，在第一和第二晶体管的半导体通道中产生相等的沟道电流的非零偏移电压被感测在 第一和第二晶体管。
-
2.发明授权Method and system for synthesizing oligonucleotides using nucleotide-specific dispensing bars 失效使用核苷酸特异性分配棒合成寡核苷酸的方法和系统
公开(公告)号：US6103467A
公开(公告)日：2000-08-15
申请号：US901102
申请日：1997-07-28
CPC分类号： B01J19/0046 , B01J2219/00306 , B01J2219/00351 , B01J2219/00369 , B01J2219/00376 , B01J2219/00527 , B01J2219/00529 , B01J2219/0054 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/00722 , C40B40/06 , C40B60/14 , C40B70/00 , G01N2035/1037
摘要： A plurality of oligonucleotides are synthesized at a plurality of locations on a substrate using a plurality of dispensing bars. Each of the plurality of dispensing bars has a respective plurality of dispensing heads arranged along a respective axis. Each of the plurality of dispensing bars is operative to selectively deposit a volume of a respective one of a plurality of nucleotide bases in any of a row of locations. A positioning mechanism positions the substrate with respect to the plurality of dispensing bars. A controller controls the plurality of dispensing bars and the positioning mechanism so that, at each of the plurality of locations, a respective sequence of nucleotide bases is deposited to form a respective oligonucleotide.
摘要翻译： 使用多个分配棒在基板上的多个位置处合成多个寡核苷酸。 多个分配棒中的每一个具有沿着相应轴线布置的相应的多个分配头。 多个分配棒中的每一个可操作以选择性地将多个核苷酸碱基中的相应的一个核苷酸碱基的体积任意地沉积在一排位置中。 定位机构使基板相对于多个分配杆定位。 控制器控制多个分配棒和定位机构，使得在多个位置的每一个位置沉积相应的核苷酸碱基序列以形成相应的寡核苷酸。
-
3.发明授权
公开(公告)号：US5671303A
公开(公告)日：1997-09-23
申请号：US634103
申请日：1996-04-17
CPC分类号： G01N21/6454 , G01N21/7703 , G02B6/10
摘要： A target molecule at a binding site is detected using an optical waveguide having a surface proximate to the binding site, and a waveguide detector coupled to the optical waveguide. An incident light beam is applied to the binding site along an axis transverse to the surface of the optical waveguide. The incident light beam impinges an optical indicator associated with the target molecule to form secondary light which is coupled into the optical waveguide. The secondary light is detected by the waveguide detector to thereby detect the target molecule.
摘要翻译： 使用具有接近结合位点的表面的光波导和耦合到光波导的波导检测器来检测结合位点处的靶分子。 沿着横向于光波导表面的轴将入射光束施加到结合位点。 入射光束照射与靶分子相关联的光学指示器，以形成耦合到光波导中的次级光。 二次光被波导检测器检测，从而检测目标分子。
-
4.发明授权
公开(公告)号：US5841914A
公开(公告)日：1998-11-24
申请号：US861927
申请日：1997-05-22
CPC分类号： G01N21/6454 , G01N21/7703 , G02B6/10
摘要： A target molecule at a binding site is detected using an optical waveguide having a surface proximate to the binding site, and a waveguide detector coupled to the optical waveguide. An incident light beam is applied to the binding site along an axis transverse to the surface of the optical waveguide. The incident light beam impinges an optical indicator associated with the target molecule to form secondary light which is coupled into the optical waveguide. The secondary light is detected by the waveguide detector to thereby detect the target molecule.
摘要翻译： 使用具有接近结合位点的表面的光波导和耦合到光波导的波导检测器来检测结合位点处的靶分子。 沿着横向于光波导表面的轴将入射光束施加到结合位点。 入射光束照射与靶分子相关联的光学指示器，以形成耦合到光波导中的次级光。 二次光被波导检测器检测，从而检测目标分子。
-
公开(公告)号：US5945832A
公开(公告)日：1999-08-31
申请号：US24147
申请日：1998-02-17
CPC分类号： G01N27/07
摘要： A method of measuring electrical characteristics of a molecule including providing a first metal contact having a major surface, an insulating layer overlying the major surface of the first metal contact and a second metal contact overlying the insulating layer so as to have an edge spaced a molecular distance from the major surface of the first metal contact. A conductive organic molecule including a metal binding group is coupled between the metal contacts.
摘要翻译： 一种测量分子的电特性的方法，包括提供具有主表面的第一金属触点，覆盖在第一金属触点的主表面上的绝缘层和覆盖绝缘层的第二金属触点，以便具有间隔开分子的边缘 距离第一金属触点的主表面。 包含金属结合基团的导电有机分子被连接在金属触点之间。
-
6.发明授权
公开(公告)号：US5733509A
公开(公告)日：1998-03-31
申请号：US634082
申请日：1996-04-17
CPC分类号： B01J19/0046 , B01J2219/00306 , B01J2219/00351 , B01J2219/00369 , B01J2219/00376 , B01J2219/00527 , B01J2219/00529 , B01J2219/0054 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/00722 , C40B40/06 , C40B60/14 , C40B70/00 , G01N2035/1037
摘要： A plurality of oligonucleotides are synthesized at a plurality of locations on a substrate using a plurality of dispensing bars. Each of the plurality of dispensing bars has a respective plurality of dispensing heads arranged along a respective axis. Each of the plurality of dispensing bars is operative to selectively deposit a volume of a respective one of a plurality of nucleotide bases in any of a row of locations. A positioning mechanism positions the substrate with respect to the plurality of dispensing bars. A controller controls the plurality of dispensing bars and the positioning mechanism so that, at each of the plurality of locations, a respective sequence of nucleotide bases is deposited to form a respective oligonucleotide.
-
公开(公告)号：US20180052106A1
公开(公告)日：2018-02-22
申请号：US15239032
申请日：2016-08-17
申请人： Kerry Gunning , Donald Ackley , Chan-Long Shieh
发明人： Kerry Gunning , Donald Ackley , Chan-Long Shieh
IPC分类号： G01N21/64 , C12Q1/68 , G01N27/414
CPC分类号： G01N21/6428 , C12Q1/6869 , G01N27/4145 , G01N2021/6439 , G01N2201/062 , C12Q2563/107 , C12Q2565/607
摘要： Apparatus for fluorescent and ion sensing of DNA nucleotide incorporation events including DNA nucleotide incorporation structure designed to have sequencing primers bonded to a surface for the incorporation of DNA nucleotides thereon. At least some of the DNA nucleotides having a fluorescent label. A photodiode positioned adjacent the incorporation structure and an illumination device positioned adjacent the DNA nucleotide incorporation structure to illuminate DNA nucleotides incorporated onto the sequencing primers. The illumination device exciting the fluorescent labels when incorporation occurs and the photodiode positioned to sense the excited fluorescent labels. Ion sensing apparatus positioned adjacent the DNA nucleotide incorporation structure including a metal oxide thin film transistor with a gate electrically coupled to receive an electrical signal indicative of ion emissions produced by the DNA nucleotide incorporated onto DNA target fragments or sequencing primers.
-
公开(公告)号：US09911857B2
公开(公告)日：2018-03-06
申请号：US12915712
申请日：2010-10-29
申请人： Chan-Long Shieh , Fatt Foong , Gang Yu
发明人： Chan-Long Shieh , Fatt Foong , Gang Yu
IPC分类号： H01L29/786
CPC分类号： H01L29/7869 , H01L29/78696
摘要： A metal oxide semiconductor device including an active layer of metal oxide, a layer of gate dielectric, and a layer of low trap density material. The layer of low trap density material is sandwiched between the active layer of metal oxide and the layer of gate dielectric. The layer of low trap density material has a major surface parallel and in contact with a major surface of the active layer of metal oxide to form a low trap density interface with the active layer of metal oxide. A second layer of low trap density material can optionally be placed in contact with the opposed major surface of the active layer of metal oxide so that a low trap density interface is formed with both surfaces of the active layer of metal oxide.
-
公开(公告)号：US09773824B2
公开(公告)日：2017-09-26
申请号：US15087716
申请日：2016-03-31
申请人： Chan-Long Shieh , Gang Yu
发明人： Chan-Long Shieh , Gang Yu
IPC分类号： H01L27/146 , H01L27/12 , H01L33/00 , H01L33/44 , H01L33/46 , H01L33/62 , H01L33/64 , H01L27/15
CPC分类号： H01L27/14609 , H01L27/1225 , H01L27/1248 , H01L27/1262 , H01L27/14603 , H01L27/1463 , H01L27/14663 , H01L27/14692 , H01L27/156 , H01L33/0075 , H01L33/44 , H01L33/46 , H01L33/62 , H01L33/642 , H01L2933/0025 , H01L2933/0033 , H01L2933/0066 , H01L2933/0075
摘要： A method of fabricating a pixelated imager and structure including a substrate with a bottom contact layer and active element blanket layers deposited on the bottom contact layer. The blanket layers are separated into an array of active elements with trenches isolating adjacent active elements in the array. A dielectric passivation/planarization layer is positioned over the array of active elements. An array of active element readout circuits overlies the passivation/planarization layer above the trenches with one active element readout circuit coupled to each active element of the array of active elements. Each active element and coupled active element readout circuit defines a pixel and the array of active elements and the coupled array of active element readout circuits defines a pixelated imager, and the readout circuit coupled to each active element includes at least one TFT with an active channel comprising a metal-oxide semiconductor material.
-
10.发明授权公开(公告)号：US09614102B2
公开(公告)日：2017-04-04
申请号：US15080231
申请日：2016-03-24
申请人： Chan-Long Shieh , Gang Yu , Fatt Foong
发明人： Chan-Long Shieh , Gang Yu , Fatt Foong
IPC分类号： H01L29/786 , H01L27/12 , H01L29/66 , H01L21/70 , H01L21/02
CPC分类号： H01L29/78696 , H01L21/02554 , H01L21/02565 , H01L21/707 , H01L27/1225 , H01L27/124 , H01L27/1288 , H01L29/66969 , H01L29/78606 , H01L29/7869
摘要： A method of fabricating MO TFTs includes positioning opaque gate metal on a transparent substrate to define a gate area. Depositing gate dielectric material overlying the gate metal and a surrounding area, and depositing metal oxide semiconductor material thereon. Depositing etch stop material on the semiconductor material. Positioning photoresist defining an isolation area in the semiconductor material, the etch stop material and the photoresist being selectively removable. Exposing the photoresist from the rear surface of the substrate and removing exposed portions to leave the etch stop material uncovered except for a portion overlying and aligned with the gate metal. Etching uncovered portions of the semiconductor material to isolate the TFT. Using the photoresist, selectively etching the etch stop layer to leave a portion overlying and aligned with the gate metal and defining a channel area in the semiconductor material. Depositing and patterning conductive material to form source and drain areas.
-
-
-
-
-
-
-
-
-
搜索结果
166 条记录 (耗时 0.021 秒)
