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1.发明授权Method and system for synthesizing oligonucleotides using nucleotide-specific dispensing bars 失效使用核苷酸特异性分配棒合成寡核苷酸的方法和系统
公开(公告)号：US6103467A
公开(公告)日：2000-08-15
申请号：US901102
申请日：1997-07-28
CPC分类号： B01J19/0046 , B01J2219/00306 , B01J2219/00351 , B01J2219/00369 , B01J2219/00376 , B01J2219/00527 , B01J2219/00529 , B01J2219/0054 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/00722 , C40B40/06 , C40B60/14 , C40B70/00 , G01N2035/1037
摘要： A plurality of oligonucleotides are synthesized at a plurality of locations on a substrate using a plurality of dispensing bars. Each of the plurality of dispensing bars has a respective plurality of dispensing heads arranged along a respective axis. Each of the plurality of dispensing bars is operative to selectively deposit a volume of a respective one of a plurality of nucleotide bases in any of a row of locations. A positioning mechanism positions the substrate with respect to the plurality of dispensing bars. A controller controls the plurality of dispensing bars and the positioning mechanism so that, at each of the plurality of locations, a respective sequence of nucleotide bases is deposited to form a respective oligonucleotide.
摘要翻译： 使用多个分配棒在基板上的多个位置处合成多个寡核苷酸。 多个分配棒中的每一个具有沿着相应轴线布置的相应的多个分配头。 多个分配棒中的每一个可操作以选择性地将多个核苷酸碱基中的相应的一个核苷酸碱基的体积任意地沉积在一排位置中。 定位机构使基板相对于多个分配杆定位。 控制器控制多个分配棒和定位机构，使得在多个位置的每一个位置沉积相应的核苷酸碱基序列以形成相应的寡核苷酸。
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2.发明授权
公开(公告)号：US5671303A
公开(公告)日：1997-09-23
申请号：US634103
申请日：1996-04-17
CPC分类号： G01N21/6454 , G01N21/7703 , G02B6/10
摘要： A target molecule at a binding site is detected using an optical waveguide having a surface proximate to the binding site, and a waveguide detector coupled to the optical waveguide. An incident light beam is applied to the binding site along an axis transverse to the surface of the optical waveguide. The incident light beam impinges an optical indicator associated with the target molecule to form secondary light which is coupled into the optical waveguide. The secondary light is detected by the waveguide detector to thereby detect the target molecule.
摘要翻译： 使用具有接近结合位点的表面的光波导和耦合到光波导的波导检测器来检测结合位点处的靶分子。 沿着横向于光波导表面的轴将入射光束施加到结合位点。 入射光束照射与靶分子相关联的光学指示器，以形成耦合到光波导中的次级光。 二次光被波导检测器检测，从而检测目标分子。
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3.发明授权
公开(公告)号：US5841914A
公开(公告)日：1998-11-24
申请号：US861927
申请日：1997-05-22
CPC分类号： G01N21/6454 , G01N21/7703 , G02B6/10
摘要： A target molecule at a binding site is detected using an optical waveguide having a surface proximate to the binding site, and a waveguide detector coupled to the optical waveguide. An incident light beam is applied to the binding site along an axis transverse to the surface of the optical waveguide. The incident light beam impinges an optical indicator associated with the target molecule to form secondary light which is coupled into the optical waveguide. The secondary light is detected by the waveguide detector to thereby detect the target molecule.
摘要翻译： 使用具有接近结合位点的表面的光波导和耦合到光波导的波导检测器来检测结合位点处的靶分子。 沿着横向于光波导表面的轴将入射光束施加到结合位点。 入射光束照射与靶分子相关联的光学指示器，以形成耦合到光波导中的次级光。 二次光被波导检测器检测，从而检测目标分子。
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4.发明授权
公开(公告)号：US5733509A
公开(公告)日：1998-03-31
申请号：US634082
申请日：1996-04-17
CPC分类号： B01J19/0046 , B01J2219/00306 , B01J2219/00351 , B01J2219/00369 , B01J2219/00376 , B01J2219/00527 , B01J2219/00529 , B01J2219/0054 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/00722 , C40B40/06 , C40B60/14 , C40B70/00 , G01N2035/1037
摘要： A plurality of oligonucleotides are synthesized at a plurality of locations on a substrate using a plurality of dispensing bars. Each of the plurality of dispensing bars has a respective plurality of dispensing heads arranged along a respective axis. Each of the plurality of dispensing bars is operative to selectively deposit a volume of a respective one of a plurality of nucleotide bases in any of a row of locations. A positioning mechanism positions the substrate with respect to the plurality of dispensing bars. A controller controls the plurality of dispensing bars and the positioning mechanism so that, at each of the plurality of locations, a respective sequence of nucleotide bases is deposited to form a respective oligonucleotide.
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公开(公告)号：US06203981B1
公开(公告)日：2001-03-20
申请号：US09068172
申请日：1999-02-08
IPC分类号： C12Q168
CPC分类号： G01N33/5438 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00653 , B01J2219/00659 , G01N27/4145
摘要： Adjacent first and second transistors are integrated with a substrate. Each of the first and second transistors has a gate electrode, a source electrode, a drain electrode and a semiconductive channel formed of an organic material, the semiconductive channel electrically coupling the source electrode with the drain electrode. The source electrode of the first transistor is electrically coupled to the source electrode of the second transistor. A molecular receptor is bound directly to a surface of the semiconductive channel of the first transistor. A non-zero offset voltage, which produces equal channel currents in the semiconductive channels of the first and second transistors after a molecule has bound with the molecular receptor without a like binding event proximate to the second transistor, is sensed between the gate electrodes of the first and second transistors.
摘要翻译： 相邻的第一和第二晶体管与衬底集成。 第一和第二晶体管中的每一个具有栅电极，源电极，漏电极和由有机材料形成的半导体沟道，半导体沟道将源电极与漏电极电耦合。 第一晶体管的源电极电耦合到第二晶体管的源电极。 分子受体直接结合到第一晶体管的半导体通道的表面。 在零分子与分子受体结合而没有靠近第二晶体管的相似结合事件之后，在第一和第二晶体管的半导体通道中产生相等的沟道电流的非零偏移电压被感测在 第一和第二晶体管。
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公开(公告)号：US5945832A
公开(公告)日：1999-08-31
申请号：US24147
申请日：1998-02-17
CPC分类号： G01N27/07
摘要： A method of measuring electrical characteristics of a molecule including providing a first metal contact having a major surface, an insulating layer overlying the major surface of the first metal contact and a second metal contact overlying the insulating layer so as to have an edge spaced a molecular distance from the major surface of the first metal contact. A conductive organic molecule including a metal binding group is coupled between the metal contacts.
摘要翻译： 一种测量分子的电特性的方法，包括提供具有主表面的第一金属触点，覆盖在第一金属触点的主表面上的绝缘层和覆盖绝缘层的第二金属触点，以便具有间隔开分子的边缘 距离第一金属触点的主表面。 包含金属结合基团的导电有机分子被连接在金属触点之间。
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公开(公告)号：US5629533A
公开(公告)日：1997-05-13
申请号：US384095
申请日：1995-02-06
IPC分类号： G01N21/77 , H01L31/173 , H01L51/50 , H01L27/15 , H01L33/00
CPC分类号： G01N21/77 , H01L31/173 , H01L51/5012 , G01N2201/0628
摘要： An optical sensor (10,30) uses a polymer light emitting diode (12, 31, 41, 51) to emit light detected by a polymer photodetector (13, 36, 46, 56). The polymer light emitting diode (12, 31, 41, 51) containing an indicator that reacts with an analyte and alters the light emitted by the polymer light emitting diode (12, 31, 41, 51). The change is detected by the polymer photodector (13, 36, 46, 56) and is used to detect the presence of the analyte.
摘要翻译： 光学传感器（10,30）使用聚合物发光二极管（12,31,41,51）发射由聚合物光电探测器（13,36,46,56）检测到的光。 所述聚合物发光二极管（12,31,41,51）包含与分析物反应并改变由所述聚合物发光二极管（12,31,41,51）发射的光的指示剂。 该变化由聚合物光敏剂（13,36,46,56）检测，并用于检测分析物的存在。
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公开(公告)号：US6013446A
公开(公告)日：2000-01-11
申请号：US951319
申请日：1997-10-16
CPC分类号： G03F7/0002 , B01J19/0046 , B01J4/02 , B82Y10/00 , B82Y40/00 , C12Q1/6837 , G01N33/5302 , B01J2219/00317 , B01J2219/00367 , B01J2219/00369 , B01J2219/00382 , B01J2219/00385 , B01J2219/00387 , B01J2219/00495 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , B01J2219/00662 , C40B60/14
摘要： An apparatus for placing at least one biological reagent at a plurality of locations on a substrate includes a stamp member onto which the at least one biological reagent is applied. The stamp member defines a plurality of transfer elements patterned to correspond to the plurality of locations. The stamp member contacts the substrate to transfer the at least one biological reagent from the plurality of transfer elements to the plurality of locations. The transfer elements can be defined by reservoirs or projected portions of the stamp member.
摘要翻译： 用于在基板上的多个位置放置至少一种生物试剂的装置包括在其上施加至少一种生物试剂的印模部件。 印模构件限定了图案化以对应于多个位置的多个传送元件。 印模构件接触基底以将至少一种生物试剂从多个转印元件转移到多个位置。 转印元件可以由印模部件的储存器或突出部分限定。
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公开(公告)号：US5731152A
公开(公告)日：1998-03-24
申请号：US648635
申请日：1996-05-13
CPC分类号： G03F7/0002 , B01J19/0046 , B01J4/02 , B82Y10/00 , B82Y40/00 , C12Q1/6837 , G01N33/5302 , B01J2219/00317 , B01J2219/00367 , B01J2219/00369 , B01J2219/00382 , B01J2219/00385 , B01J2219/00387 , B01J2219/00495 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , B01J2219/00662 , C40B60/14
摘要： An apparatus for placing at least one biological reagent at a plurality of locations on a substrate includes a stamp member onto which the at least one biological reagent is applied. The stamp member defines a plurality of transfer elements patterned to correspond to the plurality of locations. The stamp member contacts the substrate to transfer the at least one biological reagent from the plurality of transfer elements to the plurality of locations. The transfer elements can be defined by reservoirs or projected portions of the stamp member. A method of using said apparatus is also disclosed.
摘要翻译： 用于在基板上的多个位置放置至少一种生物试剂的装置包括在其上施加至少一种生物试剂的印模部件。 印模构件限定了图案化以对应于多个位置的多个传送元件。 印模构件接触基底以将至少一种生物试剂从多个转印元件转移到多个位置。 转印元件可以由印模部件的储存器或突出部分限定。 还公开了使用所述装置的方法。
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10.发明授权White light generating organic electroluminescent device and method of fabrication 失效白光产生有机电致发光器件及其制造方法
公开(公告)号：US6133692A
公开(公告)日：2000-10-17
申请号：US93080
申请日：1998-06-08
申请人： Ji-Hai Xu , Thomas B. Harvey, III
发明人： Ji-Hai Xu , Thomas B. Harvey, III
CPC分类号： H01L51/5036 , H01L51/5265
摘要： A white light generating organic electroluminescent device including an organic light emitting diode emitting a broad spectrum light including a component of each primary color. A multi-mode microcavity structure is positioned to cooperate with the diode defining an optical length of the microcavity structure to enhance the broad spectrum light and obtain multiple resonant peaks, one at each primary color. A plurality of filters are positioned to receive and adjust the multiple resonant peaks to provide substantially balanced multiple resonant peaks.
摘要翻译： 一种产生白光的有机电致发光器件，包括发射包含每种原色成分的广谱光的有机发光二极管。 多模微腔结构被定位成与限定微腔结构的光学长度的二极管配合，以增强广谱光并获得多个谐振峰，每个原色一个。 定位多个滤波器以接收和调整多个谐振峰值以提供基本平衡的多个谐振峰值。
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