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    C-5 Substituted uracil nucleosides
    1.
    发明授权
    C-5 Substituted uracil nucleosides 失效
    C-5替代尿嘧啶核苷

    公开(公告)号：US4247544A

    公开(公告)日：1981-01-27

    申请号：US53925

    申请日：1979-07-02

    申请人： Donald E. Bergstrom ,  Jerry L. Ruth

    发明人： Donald E. Bergstrom ,  Jerry L. Ruth

    IPC分类号： C07H19/06 ,  A61K31/70 ,  C07H17/00

    CPC分类号： C07H19/06

    摘要： Compounds of the formula ##STR1## wherein R.sub.o is --CH.dbd.CH--CH.sub.3 or --CH.dbd.CH--CF.sub.3 and R is .beta.-D-ribofuranosyl, .beta.-D-2-deoxyribofuranosyl or .beta.-D-arabinofuranosyl are useful as antiviral agents.

    摘要翻译： 其中Ro为-CH = CH-CH 3或-CH = CH-CF 3且R为β-D-呋喃核糖基，β-D-2-脱氧三呋喃糖基或β-D-阿糖呋喃糖的化合物可用作抗病毒剂 。

    C-5 Substituted cytosine nucleosides
    2.
    发明授权
    C-5 Substituted cytosine nucleosides 失效
    C-5取代的胞嘧啶核苷

    公开(公告)号：US4267171A

    公开(公告)日：1981-05-12

    申请号：US53943

    申请日：1979-07-02

    申请人： Donald E. Bergstrom ,  Jerry L. Ruth

    发明人： Donald E. Bergstrom ,  Jerry L. Ruth

    IPC分类号： C07H19/06 ,  A61K31/70 ,  C07H17/00

    CPC分类号： C07H19/06

    摘要： C-5 Substituted cytosine nucleosides wherein the C-5 substituent is substituted alkyl, alkenyl or substituted alkenyl; and the pharmaceutically acceptable acid addition salts thereof, are useful as antiviral agents. A novel process for the preparation of the subject compounds is also disclosed.

    摘要翻译： C-5取代的胞嘧啶核苷，其中C-5取代基是取代的烷基，烯基或取代的链烯基; 及其药学上可接受的酸加成盐可用作抗病毒剂。 还公开了制备本发明化合物的新方法。

    COFLUORONS AND METHODS OF MAKING AND USING THEM
    4.
    发明申请
    COFLUORONS AND METHODS OF MAKING AND USING THEM 审中-公开
    COFLORONS AND METHODS OF MAKING AND USING THEM

    公开(公告)号：US20140161729A1

    公开(公告)日：2014-06-12

    申请号：US14110019

    申请日：2012-04-09

    申请人： Francis Barany ,  Maneesh Pingle ,  Donald E. Bergstrom ,  Sarah F. Giardina ,  Lee Daniel Arnold

    发明人： Francis Barany ,  Maneesh Pingle ,  Donald E. Bergstrom ,  Sarah F. Giardina ,  Lee Daniel Arnold

    IPC分类号： G01N33/573 ,  C07D405/06 ,  C07D491/107 ,  C07D211/26 ,  C07D263/06 ,  C07F5/02 ,  C07D401/06

    CPC分类号： G01N33/573 ,  C07D211/26 ,  C07D263/06 ,  C07D401/06 ,  C07D405/06 ,  C07D491/107 ,  C07F5/025 ,  C40B30/04 ,  C40B30/06 ,  C40B50/10 ,  C40B50/16

    摘要： The present invention is directed to method of using a collection of monomers capable of forming multimers as a fluorescence reporter in different applications such as ligand detection/screening, disease diagnosis, drug discovery or screening, fluorescent labeling and imaging, or other fluorescent methodologies. Each monomer in the collection includes one or more ligand elements useful for binding to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the ligand elements directly or indirectly through a connector. Association of linker elements of different combinations of monomers, with their ligand elements bound to the target molecule to form a multimer, will generate a unique fluorescent signature different from that produced by those monomers either alone or in association with each other in the absence of the target molecule, when subjected to electromagnetic excitement.

    摘要翻译： 本发明涉及在不同应用如配体检测/筛选，疾病诊断，药物发现或筛选，荧光标记和成像或其它荧光方法中使用能够形成多聚体的单体的集合的方法。 收集物中的每个单体包括一个或多个配体元件，其用于结合具有小于300μM的解离常数的靶分子，以及通过连接器直接或间接连接到配体元件的连接体元件。 不同单体组合的连接体元件与其与靶分子结合以形成多聚体的连接体元件的关联将产生独特的荧光特征，其不同于单独或彼此相关联的单体，不存在 目标分子，当受到电磁兴奋时。

    APPARATUS AND METHOD OF MAKING AN OFFSET NAIL
    6.
    发明申请
    APPARATUS AND METHOD OF MAKING AN OFFSET NAIL 有权
    装备和制造偏心钉的方法

    公开(公告)号：US20100183403A1

    公开(公告)日：2010-07-22

    申请号：US12644890

    申请日：2009-12-22

    申请人： Zafar I. Ali ,  Donald E. Bergstrom ,  William L. Gabriel

    发明人： Zafar I. Ali ,  Donald E. Bergstrom ,  William L. Gabriel

    IPC分类号： F16B15/02 ,  B21G3/00

    CPC分类号： B21G3/12 ,  F16B15/02 ,  Y10S411/923

    摘要： A nail having an offset head is configured with a multi-step support gusset formed integrally between an undersurface of the offset head and a superior portion of a shank. The head of the nail is relatively thin, and the shank is positioned radially off center of the head. A first portion of the gusset defines an angle relative to the shank axis and the second portion of the gusset defines an angle relative to the shank axis different from that of the first portion. The support gusset reinforces the junction of the shank with the head, supports the toe of the head, and distributes the force of a load on the head through a longitudinal axis of the shank, preventing the toe from bending or yielding and prevents the shank from yielding to the stresses of the load applied.

    摘要翻译： 具有偏移头的钉构造为具有整体形成在偏移头的下表面和柄部的上部之间的多级支撑角撑板。 钉子的头部相对较薄，并且柄部位于头部的中心的径向偏心处。 角撑板的第一部分限定了相对于柄轴线的角度，并且角撑板的第二部分相对于与第一部分的轴线不同的柄轴线限定了一个角度。 支撑角撑板加强了柄与头部的连接处，支撑头部的脚趾，并通过柄的纵向轴线将负载的力分布在头部上，防止脚趾弯曲或屈曲，并防止柄部 屈服于施加的载荷的应力。

    DEBRIS-FREE PLASTIC COLLATING STRIP FOR NAILS
    7.
    发明申请
    DEBRIS-FREE PLASTIC COLLATING STRIP FOR NAILS 有权
    用于钉子的无破碎塑料收缩条

    公开(公告)号：US20070264103A1

    公开(公告)日：2007-11-15

    申请号：US11734684

    申请日：2007-04-12

    申请人： Lawrence S. Shelton ,  Paul J. Storiz ,  Michael Starozhitsky ,  Algis P. Suopys ,  Donald E. Bergstrom ,  Isaac H. Heskel ,  Anthony M. Versino

    发明人： Lawrence S. Shelton ,  Paul J. Storiz ,  Michael Starozhitsky ,  Algis P. Suopys ,  Donald E. Bergstrom ,  Isaac H. Heskel ,  Anthony M. Versino

    IPC分类号： F16B15/08

    CPC分类号： F16B15/08

    摘要： A fastener assembly for use in an associated fastener driving tool for driving a fastener from the assembly, in sequential order, into an associated substrate, includes a row of fasteners arranged substantially parallel to each other, each fastener having a shank and defining an axis and a collation system formed from a plastic material that is molded onto and adhered to the fasteners. The plastic material defines a collar portion at least substantially encircling the fastener shank and a connecting portion extending between and connecting adjacent collar portions. When the fastener is driven from the driving tool, the collar portion remains adhered to the fastener such that the collar portion penetrates the substrate with the fastener, and the connecting portion includes a preferentially weakened region to influence separation of the connecting portion from the collar at a desired location.

    摘要翻译： 用于在相关联的紧固件驱动工具中使用的紧固件组件，用于将紧固件从组件按顺序驱动到相关联的基底中，包括一排基本上彼此平行布置的紧固件，每个紧固件具有柄并限定轴线， 由塑料材料形成的对照系统，该塑料材料被模制并粘附到紧固件上。 塑料材料限定至少基本上环绕紧固件柄的套环部分和在相邻套环部分之间延伸并连接相邻套环部分的连接部分。 当紧固件从驱动工具驱动时，套环部分保持粘附到紧固件上，使得套环部分用紧固件穿透衬底，并且连接部分包括优先弱化区域，以影响连接部分与套环的分离 一个理想的位置。

    Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
    9.
    发明授权
    Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process 有权
    耦合聚合酶链反应 - 限制性内切酶消化 - 连接酶检测反应过程

    公开(公告)号：US07014994B1

    公开(公告)日：2006-03-21

    申请号：US09528014

    申请日：2000-03-17

    申请人： Francis Barany ,  Joseph P. Day ,  Robert P. Hammer ,  Donald E. Bergstrom

    发明人： Francis Barany ,  Joseph P. Day ,  Robert P. Hammer ,  Donald E. Bergstrom

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

    CPC分类号： C12Q1/683 ,  C12Q1/6816 ,  C12Q1/6853 ,  C12Q2531/137 ,  C12Q2563/179 ,  C12Q2565/125 ,  C12Q2565/501 ,  C12Q2537/149 ,  C12Q2535/125 ,  C12Q2525/155

    摘要： The present invention provides a method for identifying one or more low abundance sequences differing by one or more single-base changes, insertions, or deletions, from a high abundance sequence in a plurality of target nucleotide sequences. The high abundance wild-type sequence is selectively removed using high fidelity polymerase chain reaction analog conversion, facilitated by optimal buffer conditions, to create a restriction endonuclease site in the high abundance wild-type gene, but not in the low abundance mutant gene. This allows for digestion of the high abundance DNA. Subsequently the low abundant mutant DNA is amplified and detected by the ligase detection reaction assay. The present invention also relates to a kit for carrying out this procedure.

    摘要翻译： 本发明提供了一种用于从多个靶核苷酸序列中的高丰度序列鉴定一个或多个不同于一个或多个单碱基变化，插入或缺失的低丰度序列的方法。 使用高保真聚合酶链反应模拟转化，通过最佳缓冲条件促进高丰度野生型序列，在高丰度野生型基因中产生限制性内切核酸酶位点而不是在低丰度突变基因中产生限制性内切核酸酶位点。 这样可以消化高丰度DNA。 随后，通过连接酶检测反应测定扩增和检测低丰度突变体DNA。 本发明还涉及用于实施该方法的试剂盒。