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    Rigid reinforcing exoskeletal sleeve for delivery of flowable biocompatible materials
    1.
    发明授权
    Rigid reinforcing exoskeletal sleeve for delivery of flowable biocompatible materials 有权

    公开(公告)号：US10226569B2

    公开(公告)日：2019-03-12

    申请号：US15137202

    申请日：2016-04-25

    Applicant: Ethicon, Inc.

    Inventor： An-Min Jason Sung ,  Dennis D. Jamiolkowski ,  Guanghui Zhang

    IPC: A61M5/14 ,  A61B17/34 ,  A61M25/02 ,  A61B17/00 ,  A61M5/142

    Abstract: Exoskeletal devices or sleeves that can be used with the delivery tube of an applicator device to help dispense fluids, typically flowable biocompatible materials such as hemostatic agents, adhesives, or sealants, onto specific sites in the human body for a medical reason are disclosed. The exoskeletal devices or sleeves are rigid, pre-shaped, and snappably or slidably affixed to the delivery tube. The exoskeletal devices or sleeves do not come into contact with the flowable biocompatible fluid being dispensed, and they can be placed at any position along the delivery tube to address different application situations. Once the exoskeletal device or sleeve is in place, it can optionally be locked onto the delivery tube to prevent further sliding under stresses when pushed against tissue. Multiple exoskeletal devices or sleeves can also be used to achieve more complicated shapes for hard-to-reach anatomical sites.

    High-glass transition temperature absorbable microspheres
    4.
    发明授权
    High-glass transition temperature absorbable microspheres 有权
    高玻璃化转变温度可吸收微球

    公开(公告)号：US09216142B2

    公开(公告)日：2015-12-22

    申请号：US14062229

    申请日：2013-10-24

    Applicant: Ethicon, Inc.

    Inventor： Dennis D. Jamiolkowski ,  Modesto Erneta ,  Robert DiLuccio

    IPC: A61K9/14 ,  A61L27/58 ,  A61L27/50 ,  A61K8/02 ,  A61K8/85 ,  A61L27/18 ,  A61K9/16

    CPC classification number: A61K8/025 ,  A61K8/85 ,  A61K9/1647 ,  A61K2800/412 ,  A61L27/18 ,  A61L27/50 ,  A61L27/58 ,  Y10T428/2982 ,  C08L67/04

    Abstract: Absorbable microspheres comprising a copolymer formed from greater than 80 to about 99 mole percent D,L-lactideg, L(−)-lactide, D(+)-lactide, or meso-lactide and combinations thereof, and about 1 to less than 20 mole percent of a different second monomer selected from the group consisting of p-dioxanone and trimethylene carbonate and combinations thereof, said microspheres having a particle size ranging from about 5 to 2000 microns. Also described herein are formulations comprising such absorbable microspheres.

    Abstract translation: 包含由大于80-约99摩尔％D，L-丙交酯，L（ - ） - 丙交酯，D（+） - 丙交酯或内消旋丙交酯及其组合形成的共聚物和约1至小于20的可吸收微球 摩尔百分比的选自对二恶烷酮和三亚甲基碳酸酯及其组合的不同的第二单体，所述微球具有约5至2000微米的粒度。 本文还描述了包含这种可吸收微球体的制剂。

    Absorbable bimodal polymeric blend compositions, processing methods, and medical devices
    5.
    发明授权
    Absorbable bimodal polymeric blend compositions, processing methods, and medical devices 有权
    可吸收的双峰聚合物共混组合物，加工方法和医疗装置

    公开(公告)号：US09181427B2

    公开(公告)日：2015-11-10

    申请号：US14533274

    申请日：2014-11-05

    Applicant: Ethicon, Inc.

    Inventor： Dennis D. Jamiolkowski ,  Sasa Andjelic ,  Brian M. Kelly ,  Christopher DeFelice

    IPC: C08G63/91 ,  C08L67/04 ,  A61L31/04 ,  A61L31/14 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  A61B17/064 ,  A61L17/12 ,  C08G63/664 ,  C08G65/32

    CPC classification number: C08L67/04 ,  A61B17/06166 ,  A61B17/064 ,  A61B2017/00004 ,  A61B2017/00831 ,  A61L17/12 ,  A61L27/18 ,  A61L29/06 ,  A61L31/041 ,  A61L31/06 ,  A61L31/148 ,  C08G63/664 ,  C08L2201/06 ,  C08L2203/02 ,  C08L2205/02 ,  C08L2205/025

    Abstract: Novel absorbable polymeric blends having bimodal molecular weight distribution are disclosed. The bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a bimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of unimodal or bimodal molecular weight distribution. Alternately, the bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a unimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of bimodal molecular weight distribution. The novel polymeric bimodal molecular weight blends provide medical devices having improved dimensional stability. Also disclosed are novel absorbable medical devices made from these novel bimodal polymer blends, as well as novel methods of manufacture.

    Abstract translation: 公开了具有双峰分子量分布的新型可吸收聚合物共混物。 双峰共混物具有第一组分，其是聚丙交酯聚合物或具有双峰分子量分布的丙交酯和乙交酯的共聚物，以及作为单峰或双峰分子量分布的聚（对二恶烷酮）聚合物的第二组分。 或者，双峰共混物具有第一组分，其是具有单峰分子量分布的聚丙交酯聚合物或丙交酯和乙交酯的共聚物，以及作为双峰分子量分布的聚（对二恶烷酮）聚合物的第二组分。 新型聚合双峰分子量共混物提供具有改进的尺寸稳定性的医疗装置。 还公开了由这些新型双峰聚合物共混物制成的新型可吸收医疗装置，以及新颖的制造方法。

    Absorbable Polymeric Blend Compositions with Precisely Controllable Absorption Rates, Processing Methods, and Dimensionally Stable Medical Devices Therefrom
    7.
    发明申请
    Absorbable Polymeric Blend Compositions with Precisely Controllable Absorption Rates, Processing Methods, and Dimensionally Stable Medical Devices Therefrom 审中-公开
    可吸收的具有精确控制吸收率的聚合物混合组合物，加工方法和尺寸稳定的医疗器械

    公开(公告)号：US20150148496A1

    公开(公告)日：2015-05-28

    申请号：US14548536

    申请日：2014-11-20

    Applicant: Ethicon, Inc.

    Inventor： Dennis D. Jamiolkowski ,  Daniel Steiger ,  Brian M. Kelly ,  Christopher DeFelice ,  Sasa Andjelic ,  Modesto Erneta

    IPC: A61L31/04 ,  A61L31/14

    CPC classification number: A61L31/041 ,  A61B17/06166 ,  A61B17/064 ,  A61B2017/00004 ,  A61L17/105 ,  A61L27/26 ,  A61L27/58 ,  A61L31/148 ,  C08L67/04 ,  C08L2205/03 ,  C08L2666/18

    Abstract: Novel absorbable polymeric blends are disclosed. The blends have a first absorbable polymer type that is a polylactide polymer or a copolymer of lactide and glycolide and a second absorbable polymer type that is poly(p-dioxanone), wherein the first absorbable polymer type or the second absorbable polymer type or the first absorbable polymer type and the second absorbable polymer type additionally comprise a first polymeric component and a second polymeric component. The first polymeric component has a higher weight average molecular weight than the second polymeric component and at least one of said components is at least partially end-capped by a carboxylic acid. The novel polymeric blends are useful for manufacturing medical devices having dimensional stability, having engineered degradation and breaking strength retention in vivo. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.

    Abstract translation: 公开了新颖的可吸收聚合物共混物。 共混物具有第一可吸收聚合物类型，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，以及聚（对二恶烷酮）的第二可吸收聚合物类型，其中第一可吸收聚合物类型或第二可吸收聚合物类型或第一可吸收聚合物类型 可吸收聚合物类型和第二可吸收聚合物类型另外包含第一聚合物组分和第二聚合物组分。 第一聚合物组分具有比第二聚合物组分更高的重均分子量，并且至少一种所述组分至少部分地被羧酸封端。 新型聚合物共混物可用于制造具有尺寸稳定性，具有工程化降解和体内断裂强度保持性的医疗装置。 还公开了由这些新型聚合物共混物制成的新型可吸收医疗器件以及新颖的制造方法。

    APPLICATOR SYSTEMS FOR SURGICAL FASTENERS
    8.
    发明申请
    APPLICATOR SYSTEMS FOR SURGICAL FASTENERS 审中-公开
    手术紧固器的应用系统

    公开(公告)号：US20140276968A1

    公开(公告)日：2014-09-18

    申请号：US14177894

    申请日：2014-02-11

    Applicant: Ethicon, Inc.

    Inventor： Anthony Miksza ,  Robert Nering ,  Mark D. Kenyon ,  Omar J. Vakharia ,  Dennis D. Jamiolkowski

    IPC: A61B17/10 ,  A61F2/00

    Abstract: An applicator system for surgical fasteners includes an insertion tool having a shaft with a proximal end, a distal end, and an insertion fork connected to the distal end of the shaft, and at least one cartridge containing a plurality of surgical fasteners used for securing an implant to tissue. The surgical fasteners are removed one at a time from the cartridge by engaging one of the surgical fasteners with the insertion fork and removing the engaged surgical fastener from the cartridge. The insertion fork with the loaded surgical fastener is manually inserted through an implant and into tissue for securing the implant to the tissue.

    Abstract translation: 一种用于外科手术紧固件的涂抹器系统，包括一个插入工具，该插入工具具有一个轴，该轴具有近端，远端和连接到该轴的远端的插入叉，以及至少一个容纳多个用于固定 植入组织。 通过将外科紧固件中的一个与插入叉接合并且将所接合的手术紧固件从药筒中移除，从而一次从药筒移除手术紧固件。 具有加载的手术紧固件的插入叉通过植入物手动地插入组织中，以将植入物固定到组织。

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