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1.再颁专利Ion beam modification of bioactive ceramics to accelerate biointegration of said ceramics 失效离子束修饰生物活性陶瓷以加速所述陶瓷的生物整合公开(公告)号：USRE37718E1
公开(公告)日：2002-05-28
申请号：US08820813
申请日：1997-04-02
IPC分类号： A61F228
CPC分类号： C23C14/48 , A61F2/30767 , A61F2/3094 , A61F2002/30062 , A61F2210/0004 , A61F2310/00179 , A61F2310/00203 , A61F2310/00293 , A61F2310/00796 , A61L27/32
摘要： The present invention provides for faster and stronger tissue-implant bonding by treating a ceramic implant with an ion beam to modify the surface of the ceramic. The surface modification can give the ceramic improved ion-exchange properties depending upon the particular ceramic and the type of ions used. In a preferred embodiment, a bioactive ceramic orthopaedic, dental, or soft tissue implant is bombarded with a beam of cations. When implanted in the body, the surface modification causes an increase in the release of critical ions, such as calcium or phosphorus, from the surface of the ceramic implant, and thereby accelerates implant-tissue bond formation.
摘要翻译： 本发明通过用离子束处理陶瓷植入物来改变陶瓷的表面来提供更快和更强的组织植入物结合。 根据具体的陶瓷和使用的离子类型，表面改性可以提供陶瓷提高的离子交换性能。 在优选的实施方案中，用阳离子束轰击生物活性陶瓷整形外科，牙科或软组织植入物。 当植入体内时，表面改性导致从陶瓷植入物的表面释放关键离子（例如钙或磷），从而加速植入物组织结合形成。
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2.发明授权Treatments to reduce thrombogeneticity in heart valves made from titanium and its alloys 失效治疗可以降低由钛及其合金制成的心脏瓣膜的血栓形成
公开(公告)号：US5605714A
公开(公告)日：1997-02-25
申请号：US472495
申请日：1995-06-07
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/24 , A61F2/30 , A61F2/46 , A61L27/16 , A61L27/30 , A61L27/50 , A61L33/00 , A61L33/02 , B29C71/00 , C08J7/02 , C23C14/06 , C23C16/02 , C23C16/26 , C23C16/48 , C23C28/00 , B05D3/00 , B01S3/06
CPC分类号： A61F2/30767 , A61F2/468 , A61L27/16 , A61L27/303 , A61L27/50 , A61L33/025 , B29C71/0009 , C08J7/02 , C23C16/0209 , C23C16/0272 , C23C16/26 , C23C16/48 , C23C16/486 , C23C28/044 , C23C28/046 , A61F2/24 , A61F2/3094 , A61F2002/30024 , A61F2240/008 , A61F2250/0021 , A61F2310/00023 , A61F2310/00029 , A61F2310/00059 , A61F2310/00071 , A61F2310/00089 , A61F2310/00101 , A61F2310/00107 , A61F2310/00137 , A61F2310/00149 , A61F2310/0058 , B29C2071/0027 , B29K2023/0683 , Y10S623/922
摘要： The present invention provides a method for coating a titanium based component with diamond-like carbon to reduce the thrombogeneticity of the component. In a preferred embodiment, the titanium based component is a heart valve.According to the present invention, the component is placed in a vacuum chamber and heated to about 600.degree. -650.degree. C. (1112.degree.-1202.degree. F.). Thereafter, silicon is then deposited onto the component, and the component is simultaneously bombarded with a beam of energetic ions to form a metal-silicide bonding layer. The component then is cooled to at least about 100.degree. C. (212.degree. F.), preferably about 80.degree. C. (176.degree. F.), and a diamond-like carbon precursor is condensed onto the metal-silicide bonding layer. The precursor is simultaneously bombarded with a beam of energetic ions to form a coating of diamond-like carbon.
摘要翻译： 本发明提供一种用类金刚石碳涂覆钛基组分以降低组分血栓形成的方法。 在优选的实施方案中，钛基组分是心脏瓣膜。 根据本发明，将组分置于真空室中并加热至约600-650℃（1112-1202°F）。 此后，然后将硅沉积到部件上，并且用一束能量离子同时轰击该部件以形成金属硅化物结合层。 然后将组分冷却至至少约100℃（212°F），优选约80℃（176°F），并将类金刚石碳前体冷凝到金属硅化物结合层上。 同时用一束能量离子轰击前体以形成类金刚石碳。
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3.发明授权Application of diamond-like carbon coatings to cutting surfaces of metal cutting tools 失效金刚石类碳涂层在金属切削刀具切削面上的应用
公开(公告)号：US6087025A
公开(公告)日：2000-07-11
申请号：US946314
申请日：1997-10-07
CPC分类号： C23C16/26 , C23C16/0272 , Y10T428/12549 , Y10T428/12576 , Y10T428/12583 , Y10T428/12625 , Y10T428/2495
摘要： The present invention provides metal working tools with metal working surfaces bearing a coating of diamond-like carbon that is strongly adhered to the surface via the following gradient: metal alloy or cobalt-cemented tungsten carbide base; cobalt or metal-silicide and/or cobalt or metal-germanide; silicon and/or germanium; silicon carbide and/or germanium carbide; and, diamond-like carbon.
摘要翻译： 本发明提供了具有金属加工表面的金属加工工具，其具有类金刚石碳的涂层，其通过以下梯度强烈地附着在表面上：金属合金或钴合金碳化钨基体; 钴或金属硅化物和/或钴或金属锗化物; 硅和/或锗; 碳化硅和/或碳化锗; 和类金刚石碳。
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4.发明授权Treatments to reduce frictional wear between components made of ultra-high molecular weight polyethylene and metal alloys 失效用于减少由超高分子量聚乙烯和金属合金制成的部件之间摩擦磨损的处理
公开(公告)号：US5593719A
公开(公告)日：1997-01-14
申请号：US220234
申请日：1994-03-29
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/24 , A61F2/30 , A61F2/46 , A61L27/16 , A61L27/30 , A61L27/50 , A61L33/02 , B29C71/00 , C08J7/02 , C23C16/02 , C23C16/26 , C23C16/48 , C23C28/00 , B05D3/00 , C23C14/12 , B29C37/00
CPC分类号： C23C28/046 , A61F2/30767 , A61F2/468 , A61L27/16 , A61L27/303 , A61L27/50 , A61L33/025 , B29C71/0009 , C08J7/02 , C23C16/0209 , C23C16/0272 , C23C16/26 , C23C16/48 , C23C16/486 , C23C28/00 , C23C28/044 , A61F2/24 , A61F2/3094 , A61F2002/30024 , A61F2240/008 , A61F2250/0021 , A61F2310/00023 , A61F2310/00029 , A61F2310/00059 , A61F2310/00071 , A61F2310/00089 , A61F2310/00101 , A61F2310/00107 , A61F2310/00137 , A61F2310/00149 , A61F2310/0058 , B29C2071/0027 , B29K2023/0683 , Y10S623/92 , Y10S623/923 , Y10S623/926
摘要： The present invention provides methods for modifying surfaces made from metal alloy and/or UHMWPE, preferably surfaces which are frictionally engaged, e.g., in an orthopaedic implant. The methods of the present invention reduce the coefficient of friction of the metal alloy component, reduce the shearing of fibrils from the UHMWPE component, and reduce sub-surface fatigue in the UHMWPE component. The method involves solvent immersion of the UHMWPE component to remove short chains of polyethylene at or near the surface of the component, and to swell and toughen the subsurface of the component. The method also involves firmly coating the surface of the metal alloy component with an adherent layer of diamond-like carbon ("DLC") by creating a metal-silicide interface at the surface of the metal alloy to permit firmer adhesion of DLC. Although the methods of the present invention are particularly useful in orthopaedic applications, the methods also can be used to treat similar components used in other applications.
摘要翻译： 本发明提供了用于修改由金属合金和/或UHMWPE制成的表面的方法，优选的是例如在矫形植入物中摩擦接合的表面。 本发明的方法降低了金属合金组分的摩擦系数，减少了UHMWPE组分中原纤维的剪切，并降低了UHMWPE组分的表面下疲劳。 该方法涉及UHMWPE组分的溶剂浸渍以除去组分表面处或附近的聚乙烯短链，并且膨胀并增韧组分的表面。 该方法还涉及通过在金属合金的表面产生金属硅化物界面，用金刚石状碳的粘附层（“DLC”）来牢固地涂覆金属合金组分的表面，以允许更牢固地粘附DLC。 尽管本发明的方法在矫形应用中特别有用，但是该方法也可用于治疗其它应用中使用的类似组件。
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5.发明授权Ultra high molecular weight polyethylene components treated to resist shearing and frictional wear 失效超高分子量聚乙烯组分被处理以抵抗剪切和摩擦磨损公开(公告)号：US06171343B2
公开(公告)日：2001-01-09
申请号：US08846673
申请日：1997-04-30
IPC分类号： A61F202
CPC分类号： C23C28/046 , A61F2/24 , A61F2/30 , A61F2/30767 , A61F2/3094 , A61F2/468 , A61F2002/30024 , A61F2240/008 , A61F2250/0021 , A61F2310/00023 , A61F2310/00029 , A61F2310/00059 , A61F2310/00071 , A61F2310/00089 , A61F2310/00101 , A61F2310/00107 , A61F2310/00137 , A61F2310/00149 , A61F2310/0058 , A61L27/16 , A61L27/303 , A61L27/50 , A61L33/025 , B29C71/0009 , B29C2071/0027 , B29K2023/0683 , C08J7/02 , C23C16/0209 , C23C16/0272 , C23C16/26 , C23C16/48 , C23C16/486 , C23C28/00 , C23C28/044 , Y10S623/92 , Y10S623/923 , Y10S623/926 , C08L23/06
摘要： The present invention provides methods for modifying surfaces made from metal alloy and/or UHMWPE, preferably surfaces which are frictionally engaged, e.g., in an orthopaedic implant. The methods of the present invention reduce the coefficient of friction of the metal alloy component, reduce the shearing of fibrils from the UHMWPE component, and reduce sub-surface fatigue in the UHMWPE component. The method involves solvent immersion of the UHMWPE component to remove short chains of polyethylene at or near the surface of the component, and to swell and toughen the subsurface of the component. The method also involves firmly coating the surface of the metal alloy component with an adherent layer of diamond-like carbon (“DLC”) by creating a metal-silicide interface at the surface of the metal alloy to permit firmer adhesion of DLC. Although the methods of the present invention are particularly useful in orthopaedic applications, the methods also can be used to treat similar components used in other applications.
摘要翻译： 本发明提供了用于修改由金属合金和/或UHMWPE制成的表面的方法，优选的是例如在矫形植入物中摩擦接合的表面。 本发明的方法降低了金属合金组分的摩擦系数，减少了UHMWPE组分中原纤维的剪切，并降低了UHMWPE组分的表面下疲劳。 该方法涉及UHMWPE组分的溶剂浸渍以除去组分表面处或附近的聚乙烯短链，并且膨胀并增韧组分的表面。 该方法还涉及通过在金属合金的表面产生金属硅化物界面，用金刚石状碳的粘附层（“DLC”）来牢固地涂覆金属合金组分的表面，以允许更牢固地粘附DLC。 尽管本发明的方法在矫形应用中特别有用，但是该方法也可用于治疗其它应用中使用的类似组件。
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公开(公告)号：US5780119A
公开(公告)日：1998-07-14
申请号：US618568
申请日：1996-03-20
CPC分类号： C23C16/26 , C23C16/029 , C23C16/486
摘要： The present invention provides a method for strongly adhering a diamond-like carbon coating to a metal alloy substrate using ion beam assisted deposition of silicon and/or germanium followed by ion beam assisted deposition of diamond-like carbon.
摘要翻译： 本发明提供了一种使用离子束辅助沉积硅和/或锗然后进行离子束辅助沉积金刚石样碳将金刚石状碳涂层强烈地粘附到金属合金基底上的方法。
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7.发明授权
公开(公告)号：US5731045A
公开(公告)日：1998-03-24
申请号：US592077
申请日：1996-01-26
CPC分类号： C23C30/005 , C22C29/08 , C23C16/0263 , C23C16/0272 , C23C16/26 , C23C26/00 , C23C28/04
摘要： The present invention uses ion beam assisted deposition to adhere a diamond-like carbon coating to a cobalt-cemented tungsten carbide substrate, resulting in the following gradient at the surface of the substrate: substrate/(metal-silicide or metal-germanide)/(silicon or germanium)/(silicon carbide or germanium carbide)/DLC.
摘要翻译： 本发明使用离子束辅助沉积法将类金刚石碳涂层粘附到钴硬质合金基体上，导致在基底表面上的以下梯度：基底/（金属硅化物或金属锗化物）/（ 硅或锗）/（碳化硅或碳化锗）/ DLC。
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8.发明授权Medical implants made of metal alloys bearing cohesive diamond like carbon coatings 失效医用植入物由金属合金制成，内含聚碳酸酯金刚石涂层
公开(公告)号：US5725573A
公开(公告)日：1998-03-10
申请号：US630141
申请日：1996-04-10
IPC分类号： A61F2/00 , A61F2/24 , A61F2/46 , A61L33/02 , C23C16/02 , C23C16/26 , C23C16/48 , B05D3/00 , B32B9/00 , C23C14/00
CPC分类号： C23C16/0209 , A61F2/468 , A61L33/025 , C23C16/0272 , C23C16/26 , C23C16/48 , A61F2/24 , A61F2310/00023 , A61F2310/0058
摘要： The present invention provides a method for coating a metal alloy component of a medical implant, particularly a component of a heart valve made of a titanium base alloy, with a strongly adhered coating of diamond-like carbon. The method uses ion beam assisted deposition to form a gradient at the surface of the titanium alloy comprising metal alloy/metal-silicide/(silicon or germanium)/silicon- or germanium-carbide/DLC.
摘要翻译： 本发明提供一种用于涂覆医用植入物的金属合金组分的方法，特别是由钛基合金制成的心脏瓣膜的组分，其具有类似金刚石的碳的强粘附涂层。 该方法使用离子束辅助沉积在包含金属合金/金属硅化物/（硅或锗）/硅或碳化锗/ DLC的钛合金的表面上形成梯度。
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9.发明授权
公开(公告)号：US5496374A
公开(公告)日：1996-03-05
申请号：US285994
申请日：1994-08-04
CPC分类号： C23C14/48 , A61F2/30767 , A61L27/32 , A61F2/3094 , A61F2002/30062 , A61F2210/0004 , A61F2310/00179 , A61F2310/00203 , A61F2310/00293 , A61F2310/00796
摘要： The present invention provides for faster and stronger tissue-implant bonding by treating a ceramic implant with an ion beam to modify the surface of the ceramic. The surface modification can give the ceramic improved ion-exchange properties depending upon the particular ceramic and the type of ions used. In a preferred embodiment, a bioactive ceramic orthopaedic, dental, or soft tissue implant is bombarded with a beam of cations. When implanted in the body, the surface modification causes an increase in the release of critical ions, such as calcium or phosphorus, from the surface of the ceramic implant, and thereby accelerates implant-tissue bond formation.
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公开(公告)号：US5358935A
公开(公告)日：1994-10-25
申请号：US978768
申请日：1992-11-19
IPC分类号： A61K38/00 , A61L27/22 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/50 , C07K14/47 , A61F2/02 , A61K37/12 , C07K3/02
CPC分类号： C07K14/4741 , A61L27/227 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/50 , A61K38/00 , Y10S514/937 , Y10S530/842 , Y10S623/901
摘要： The present invention is a new nonantigenic keratinous protein material that may be used as a number of purposes, including correction of soft tissue deficiencies and the creation of biomedical implants and implant coatings. The present invention also includes processes for using the nonantigenic keratinous protein material for soft tissue augmentation, creating implants, and the coating of biocompatible implants. The nonantigenic keratinous protein material can be formed by obtaining nonantigenic keratinous protein and processing it to a powder form. If hair from the recipient or a compatible doner is used, it is bleached and rinsed, then dried and chopped into about 0.25 inch pieces. The keratinous protein is then homogenized in a solvent to a particular size generally in the range of about 0.1 to about 500 .mu.m. The particles are then ultrasonicated in a solvent. Afterwards, the solvent is evaporated, and the powdered protein is sterilized and suspended in a sterile bioinert solvent to create a protein colloid at a solids concentrations suitable for injection.
摘要翻译： 本发明是一种新的非抗原性角质蛋白材料，其可用作许多目的，包括矫正软组织缺陷以及生物医学植入物和植入物涂层的产生。 本发明还包括使用非抗原角质蛋白材料用于软组织增加，产生植入物和生物相容性植入物的包衣的方法。 非抗原角化蛋白质材料可以通过获得非抗原角化蛋白质并将其加工成粉末形式来形成。 如果使用来自接收者的头发或使用相容的发丝器，则将其漂白并漂洗，然后干燥并切碎成约0.25英寸的片。 然后将角质蛋白质在溶剂中均化至一般在约0.1至约500μm范围内的特定尺寸。 然后将颗粒在溶剂中超声波处理。 然后蒸发溶剂，将粉状蛋白质灭菌并悬浮于无菌生物惰性溶剂中以产生适于注射的固体浓度的蛋白质胶体。
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