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公开(公告)号：US20100041645A1
公开(公告)日：2010-02-18
申请号：US12521817
申请日：2008-01-02
申请人： Georg Dahmann , Eugene Richard Hickey , Xiang Li , Wang Mao , Daniel R. Marshall , Tina M. Morwick , Robert Sibley , Roger John Snow , Ronald J. Sorcek , Frank Wu , Erick Richard Roush Young
发明人： Georg Dahmann , Eugene Richard Hickey , Xiang Li , Wang Mao , Daniel R. Marshall , Tina M. Morwick , Robert Sibley , Roger John Snow , Ronald J. Sorcek , Frank Wu , Erick Richard Roush Young
IPC分类号： A61K31/472 , C07D217/22 , C07D413/08 , C07D417/08 , A61K31/5377 , A61K31/541 , A61P11/00 , A61P35/00 , A61P25/00
CPC分类号： C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/42 , C07C323/62 , C07C2602/08 , C07D209/44 , C07D211/26 , C07D211/34 , C07D217/02 , C07D217/04 , C07D223/16 , C07D231/12 , C07D249/08 , C07D277/46 , C07D277/60 , C07D285/135 , C07D295/088 , C07D295/135 , C07D307/68 , C07D417/04 , C07D471/04 , C07D498/04 , C07D513/04
摘要： Substituted amide and urea derivatives useful as inhibitors of Rho kinase are described, which inhibitors can be useful in the treatment of various disorders such as cardiovascular diseases, cancer, neurological diseases, renal diseases, bronchial asthma, erectile dysfunction and glaucoma.
摘要翻译： 描述了可用作Rho激酶抑制剂的取代的酰胺和脲衍生物，该抑制剂可用于治疗各种疾病如心血管疾病，癌症，神经疾病，肾脏疾病，支气管哮喘，勃起功能障碍和青光眼。
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公开(公告)号：US08093266B2
公开(公告)日：2012-01-10
申请号：US12521817
申请日：2008-01-02
申请人： Georg Dahmann , Eugene Richard Hickey , Xiang Li , Wang Mao , Daniel R. Marshall , Tina M. Morwick , Robert Sibley , Roger John Snow , Ronald J. Sorcek , Frank Wu , Erick Richard Roush Young
发明人： Georg Dahmann , Eugene Richard Hickey , Xiang Li , Wang Mao , Daniel R. Marshall , Tina M. Morwick , Robert Sibley , Roger John Snow , Ronald J. Sorcek , Frank Wu , Erick Richard Roush Young
IPC分类号： A61K31/472 , A61K31/4365 , A61K31/17 , C07D217/22 , C07D211/34 , C07C233/64 , C07C275/28
CPC分类号： C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/42 , C07C323/62 , C07C2602/08 , C07D209/44 , C07D211/26 , C07D211/34 , C07D217/02 , C07D217/04 , C07D223/16 , C07D231/12 , C07D249/08 , C07D277/46 , C07D277/60 , C07D285/135 , C07D295/088 , C07D295/135 , C07D307/68 , C07D417/04 , C07D471/04 , C07D498/04 , C07D513/04
摘要： Substituted amide and urea derivatives useful as inhibitors of Rho kinase are described, which inhibitors can be useful in the treatment of various disorders such as cardiovascular diseases, cancer, neurological diseases, renal diseases, bronchial asthma, erectile dysfunction and glaucoma.
摘要翻译： 描述了可用作Rho激酶抑制剂的取代的酰胺和脲衍生物，该抑制剂可用于治疗各种疾病如心血管疾病，癌症，神经疾病，肾脏疾病，支气管哮喘，勃起功能障碍和青光眼。
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公开(公告)号：US09403830B2
公开(公告)日：2016-08-02
申请号：US13942988
申请日：2013-07-16
申请人： Asitha Abeywardane , Steven Richard Brunette , Michael Jason Burke , Thomas Martin Kirrane, Jr. , Chuk Chui Man , Daniel Richard Marshall , Anil Kumar Padyana , Hossein Razavi , Robert Sibley , Lana Louise Smith Keenan , Roger John Snow , Ronald John Sorcek , Hidenori Takahashi , Steven John Taylor , Michael Robert Turner , Erick Richard Roush Young , Qiang Zhang , Yunlong Zhang , Renee M. Zindell
发明人： Asitha Abeywardane , Steven Richard Brunette , Michael Jason Burke , Thomas Martin Kirrane, Jr. , Chuk Chui Man , Daniel Richard Marshall , Anil Kumar Padyana , Hossein Razavi , Robert Sibley , Lana Louise Smith Keenan , Roger John Snow , Ronald John Sorcek , Hidenori Takahashi , Steven John Taylor , Michael Robert Turner , Erick Richard Roush Young , Qiang Zhang , Yunlong Zhang , Renee M. Zindell
IPC分类号： C07D487/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D401/12 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K31/551 , C07D405/12 , C07D497/08 , C07D498/04
CPC分类号： C07D487/04 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K31/551 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , C07D497/08 , C07D498/04
摘要： The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中A1，A2，L1和B如本文所定义。 式（I）化合物可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关病症。 本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。
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公开(公告)号：US20120165322A1
公开(公告)日：2012-06-28
申请号：US13171696
申请日：2011-06-29
申请人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
发明人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
IPC分类号： A61K31/472 , A61K31/4725 , C07D471/04 , C07D487/04 , A61K31/4985 , C07D417/14 , C07D417/12 , A61K31/5415 , A61K31/541 , C07D413/12 , C07D413/14 , C07D401/12 , A61K31/506 , C07D405/12 , A61K31/5377 , A61K31/538 , A61K31/497 , A61K31/4439 , C07D513/04 , A61K31/428 , A61P9/12 , A61P9/10 , A61P9/00 , A61P25/00 , A61P15/10 , A61P13/12 , A61P11/06 , A61P27/06 , A61P35/00 , A61P25/28 , A61P29/00 , A61P17/06 , A61P1/00 , A61K31/437 , C07D217/02
CPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1和R 2如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08697911B2
公开(公告)日：2014-04-15
申请号：US13171696
申请日：2011-06-29
申请人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
发明人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
IPC分类号： A01N37/18 , A61K31/165 , C07C239/00 , C07C279/16 , C07D473/00 , C07D417/00 , C07C45/78 , C07C271/06 , C07D271/12 , C07D413/00 , C07D271/00 , C07D285/02 , C07D285/04 , C07D498/00 , C07D513/00 , C07D277/82 , C07D263/60 , C07D249/04 , C07D249/08 , C07D233/02 , C07D231/00
CPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1和R 2如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08450317B2
公开(公告)日：2013-05-28
申请号：US12768268
申请日：2010-04-27
申请人： Jennifer A. Kowalski , Daniel Richard Marshall , Anthony S. Prokopowicz, III , Sabine Schlyer , Robert Sibley , Ronald John Sorcek , Di Wu , Frank Wu , Erick Richard Roush Young
发明人： Jennifer A. Kowalski , Daniel Richard Marshall , Anthony S. Prokopowicz, III , Sabine Schlyer , Robert Sibley , Ronald John Sorcek , Di Wu , Frank Wu , Erick Richard Roush Young
IPC分类号： C07D239/34 , C07D239/42 , A61K31/506
CPC分类号： C07D471/04 , C07D209/48 , C07D213/26 , C07D213/56 , C07D213/65 , C07D213/74 , C07D217/00 , C07D231/10 , C07D233/90 , C07D235/04 , C07D239/34 , C07D239/42 , C07D277/30 , C07D295/185 , C07D307/68 , C07D317/68 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D491/08
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R5, A, B, D and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1至R 5，A，B，D和X如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US09079880B2
公开(公告)日：2015-07-14
申请号：US13171701
申请日：2011-06-29
申请人： John David Ginn , Daniel Richard Marshall , Robert Sibley , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
发明人： John David Ginn , Daniel Richard Marshall , Robert Sibley , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
IPC分类号： C07D513/04 , A61K31/381 , C07D401/12 , C07D207/09 , C07D217/22 , C07D277/60 , C07D417/12 , C07D417/14
CPC分类号： C07D401/12 , C07D207/09 , C07D217/22 , C07D277/60 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1和X如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08946203B2
公开(公告)日：2015-02-03
申请号：US13785034
申请日：2013-03-05
申请人： Asitha Abeywardane , Steven Richard Brunette , Michael J. Burke , Suresh R. Kapadia , Thomas Martin Kirrane , Matthew Russell Netherton , Hossein Razavi , Sonia Rodriguez , Anjan Saha , Robert Sibley , Lana Louise Smith-Keenan , Hidenori Takahashi , Michael Robert Turner , Jiang-Ping Wu , Erick Richard Roush Young , Qiang Zhang , Qing Zhang , Renee M. Zindell
发明人： Asitha Abeywardane , Steven Richard Brunette , Michael J. Burke , Suresh R. Kapadia , Thomas Martin Kirrane , Matthew Russell Netherton , Hossein Razavi , Sonia Rodriguez , Anjan Saha , Robert Sibley , Lana Louise Smith-Keenan , Hidenori Takahashi , Michael Robert Turner , Jiang-Ping Wu , Erick Richard Roush Young , Qiang Zhang , Qing Zhang , Renee M. Zindell
IPC分类号： C07D519/00 , C07D491/04 , C07D487/08 , A61K31/357 , C07D491/052 , C07D405/10 , C07D295/096 , C07D295/155 , C07D513/04 , C07D405/14 , C07D319/20 , C07D405/12 , C07D487/10 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04
CPC分类号： C07D491/052 , A61K31/357 , C07D295/096 , C07D295/155 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
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公开(公告)号：US09000154B2
公开(公告)日：2015-04-07
申请号：US13274610
申请日：2011-10-17
申请人： Thomas Martin Kirrane , Daniel Richard Marshall , Robert Sibley , Roger John Snow , Fariba Soleymanzadeh , Ronald John Sorcek
发明人： Thomas Martin Kirrane , Daniel Richard Marshall , Robert Sibley , Roger John Snow , Fariba Soleymanzadeh , Ronald John Sorcek
IPC分类号： C07D417/14 , A61K31/5355 , C07D417/12 , C07D277/60
CPC分类号： C07D417/12 , C07D277/60 , C07D417/14
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 3和X如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US10450314B2
公开(公告)日：2019-10-22
申请号：US15763690
申请日：2016-09-28
申请人： Boehringer Ingelheim International GmbH , Steven Richard Brunette , Johanna Csengery , Robert Owen Hughes , Xiang Li , Robert Sibley , Michael Robert Turner , Zhaoming Xiong
发明人： Steven Richard Brunette , Johanna Csengery , Robert Owen Hughes , Xiang Li , Robert Sibley , Michael Robert Turner , Zhaoming Xiong
IPC分类号： C07D475/00 , A61K31/519 , C07D475/10
摘要： The present invention encompasses compounds of formula (I) wherein the variables are defined herein which are suitable for the modulation of RORγ and the treatment of diseases related to the modulation of RORγ. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.
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