公开(公告)号：US09775771B2

公开(公告)日：2017-10-03

申请号：US13422263

申请日：2012-03-16

申请人： Guenter Stemple ,  Dieter Gellert ,  Michael Heller

发明人： Guenter Stemple ,  Dieter Gellert ,  Michael Heller

IPC分类号： A61H31/00

CPC分类号： A61H31/006 ,  A61H31/00 ,  A61H31/004 ,  A61H31/005 ,  A61H31/008 ,  A61H2201/0119 ,  A61H2201/0157 ,  A61H2201/0192 ,  A61H2201/1215 ,  A61H2201/149 ,  A61H2201/1619 ,  A61H2201/1664 ,  A61H2201/1685 ,  A61H2201/5007 ,  A61H2201/5043 ,  A61H2201/5064 ,  A61H2201/5069 ,  A61H2201/5097 ,  A61H2203/04 ,  A61H2203/0456 ,  A61H2205/084

摘要： An apparatus for reanimation of a patient that includes a plunger driven by a drive to perform a compressive massage on the patient's body, a position measuring device that measures the respective position of the plunger during its compressive massaging motion, and a holding device for the drive and the plunger.

公开(公告)号：US20120238922A1

公开(公告)日：2012-09-20

申请号：US13422263

申请日：2012-03-16

申请人： Guenter STEMPLE ,  Dieter Gellert ,  Michael Heller

发明人： Guenter STEMPLE ,  Dieter Gellert ,  Michael Heller

IPC分类号： A61H31/00

CPC分类号： A61H31/006 ,  A61H31/00 ,  A61H31/004 ,  A61H31/005 ,  A61H31/008 ,  A61H2201/0119 ,  A61H2201/0157 ,  A61H2201/0192 ,  A61H2201/1215 ,  A61H2201/149 ,  A61H2201/1619 ,  A61H2201/1664 ,  A61H2201/1685 ,  A61H2201/5007 ,  A61H2201/5043 ,  A61H2201/5064 ,  A61H2201/5069 ,  A61H2201/5097 ,  A61H2203/04 ,  A61H2203/0456 ,  A61H2205/084

摘要： An apparatus for reanimation of a patient that includes a plunger driven by a drive to perform a compressive massage on the patient's body, a position measuring device that measures the respective position of the plunger during its compressive massaging motion, and a holding device for the drive and the plunger.

摘要翻译： 一种用于再生患者的装置，包括由驱动器驱动以对患者身体进行压缩按摩的柱塞，位置测量装置，其在压缩按摩运动期间测量柱塞的相应位置，以及用于驱动器的保持装置 和柱塞。

公开(公告)号：US08202689B2

公开(公告)日：2012-06-19

申请号：US11914122

申请日：2006-05-11

申请人： Michael Heller ,  Benjamin Sullivan ,  Dietrich Dehlinger

发明人： Michael Heller ,  Benjamin Sullivan ,  Dietrich Dehlinger

IPC分类号： C12Q1/68

CPC分类号： G01N33/531 ,  B82Y30/00 ,  C12Q1/68 ,  G01N33/48721

摘要： The invention relates to processes and devices for the controlled fabrication of nanostructures from starting components that have high fidelity recognition properties and multiple binding groups. In one embodiment, the invention relates to the formation of nanostructures using controlled sequential addition of nanocomponents at regular intervials via sequential formation of binding pairs or other chemical binding reactions.

摘要翻译： 本发明涉及用于从具有高保真度识别特性和多个结合基团的起始组分控制制造纳米结构的方法和装置。 在一个实施方案中，本发明涉及使用通过连续形成结合对或其它化学结合反应在常规间隔区内以受控顺序添加纳米组分形成纳米结构。

公开(公告)号：US08086524B1

公开(公告)日：2011-12-27

申请号：US11852772

申请日：2007-09-10

申请人： Patrick James Craig ,  Konrad Simeon Feldman ,  Leonard Justin Laufer ,  Michael Heller ,  Paul Sutter ,  Nikolas Alexander Sulkowski

发明人： Patrick James Craig ,  Konrad Simeon Feldman ,  Leonard Justin Laufer ,  Michael Heller ,  Paul Sutter ,  Nikolas Alexander Sulkowski

IPC分类号： G06Q40/00

CPC分类号： G06Q20/10 ,  G06Q40/025

摘要： One embodiment of the present invention relates to a computer implemented method for transaction processing that includes: transacting for a first and a second transactions for at least one of: a purchase; and a cash advance; sending requests for authorization of the first and second transactions; declining, by a primary lender, the requests for authorization; evaluating the declined requests for authorization by a secondary lender; authorizing, by the secondary lender, the declined requests for authorization in the form of authorization approvals; communicating the authorization approvals by the primary lender; posting the transactions to a balance sheet of the secondary lender in the form of amounts due to the primary lender; funding the transactions by the primary lender; summing up one or more debits and one or more credits of the posted transactions of the secondary lender; and settling any amounts due between the primary and secondary lenders.

摘要翻译： 本发明的一个实施例涉及一种用于交易处理的计算机实现方法，其包括：对于以下中的至少一个交易第一和第二交易：购买; 和现金预支; 发送第一次和第二次交易授权请求; 由主要贷款人拒绝授权请求; 评估二级贷方拒绝的授权请求; 由二级贷方授权以授权批准的形式拒绝授权; 传达主要贷方的授权许可; 以次级贷款人的款项的形式将交易发布到次级贷方的资产负债表; 为主要贷方提供交易资金; 总结一次或多次借方和一次或多次次级贷方的贴现交易; 并处理小学和中学贷款人之间的任何欠款。

公开(公告)号：US20050176029A1

公开(公告)日：2005-08-11

申请号：US10970756

申请日：2004-10-20

申请人： Michael Heller ,  Benjamin Sullivan ,  Sanja Zlatanovic ,  Sadik Esener ,  Dietrich Dehlinger

发明人： Michael Heller ,  Benjamin Sullivan ,  Sanja Zlatanovic ,  Sadik Esener ,  Dietrich Dehlinger

IPC分类号： C12Q1/68 ,  G01N20060101 ,  G01N33/00 ,  G01N33/53 ,  G01N33/543 ,  H01L21/00

CPC分类号： G01N33/54346 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y15/00 ,  B82Y30/00

摘要： The present invention relates to nanoscale transduction systems that produce reversible signals to facilitate detection. In one respect, the invention relates to the analysis of molecular binding events using higher order signaling nanoscale constructs, or “nanomachines”, that allow nanostructures to be individually detectable, even in the midst of high background noise. Such systems are particularly useful for improving the performance of rare target detection methods, as well as being generally useful in any field in which sensitivity, discrimination and confidence in detection are important.

摘要翻译： 本发明涉及产生可逆信号以促进检测的纳米尺度转导系统。 在一个方面，本发明涉及使用更高级信号的纳米尺度构建体或“纳米机器”的分子结合事件的分析，即使在高背景噪声中也允许纳米结构单独检测。 这种系统对于改善稀有目标检测方法的性能特别有用，并且在敏感性，鉴别和检测置信度重要的任何领域中通常是有用的。

公开(公告)号：US20050173247A1

公开(公告)日：2005-08-11

申请号：US10980821

申请日：2004-11-04

申请人： Shila Jalali ,  Karla Ewalt ,  Paul Swanson ,  Brian Dwyer ,  Michael Heller ,  John Havens ,  Eugene Tu

发明人： Shila Jalali ,  Karla Ewalt ,  Paul Swanson ,  Brian Dwyer ,  Michael Heller ,  John Havens ,  Eugene Tu

IPC分类号： C12Q1/37 ,  C12Q1/42 ,  C12Q1/48 ,  G01N27/447 ,  G01N33/561 ,  G01N27/453

CPC分类号： G01N33/561 ,  C12Q1/37 ,  C12Q1/42 ,  C12Q1/48 ,  G01N27/44717 ,  G01N27/44782

摘要： The present invention relates generally to microtiter plate format devices and methods for separating molecules having different net charges. The devices and methods of the invention are particularly suited for use in high-throughput screening to monitor enzymatic reactions which result in a product having an altered net charge. For example, the systems and methods disclosed herein may be used to detect the activity of phosphatases, proteases and kinases on various peptidic substrates under various conditions.

摘要翻译： 本发明一般涉及用于分离具有不同净电荷的分子的微量滴定板格式装置和方法。 本发明的装置和方法特别适用于高通量筛选以监测酶反应，这导致产品具有改变的净电荷。 例如，本文公开的系统和方法可以用于在各种条件下检测各种肽基底上的磷酸酶，蛋白酶和激酶的活性。

公开(公告)号：US08507218B2

公开(公告)日：2013-08-13

申请号：US12866732

申请日：2009-02-09

申请人： Michael Heller ,  Geert W. Schmid-Schoenbein ,  Roy B. Lefkowitz ,  Benjamin Sullivan

发明人： Michael Heller ,  Geert W. Schmid-Schoenbein ,  Roy B. Lefkowitz ,  Benjamin Sullivan

IPC分类号： C12Q1/37

CPC分类号： G01N33/54386 ,  C07K5/1008 ,  C07K7/06 ,  C07K7/08 ,  C12Q1/34 ,  C12Q1/37 ,  G01N33/53 ,  G01N33/573

摘要： Provided herein are methods useful in detecting degradative enzymes in bodily fluid samples.

摘要翻译： 本文提供了可用于检测体液样品中降解酶的方法。

公开(公告)号：US20090221443A1

公开(公告)日：2009-09-03

申请号：US11914122

申请日：2006-05-11

申请人： Michael Heller ,  Benjamin Sullivan ,  Dietrich Dehlinger

发明人： Michael Heller ,  Benjamin Sullivan ,  Dietrich Dehlinger

IPC分类号： C40B60/14 ,  C40B50/14 ,  C40B40/00 ,  C40B40/18 ,  C40B40/14 ,  C40B40/06

CPC分类号： G01N33/531 ,  B82Y30/00 ,  C12Q1/68 ,  G01N33/48721

摘要： The invention relates to processes and devices for the controlled fabrication of nanostructures from starting components that have high fidelity recognition properties and multiple binding groups. In one embodiment, the invention relates to the formation of nanostructures using controlled sequential addition of nanocomponents at regular intervials via sequential formation of binding pairs or other chemical binding reactions.

摘要翻译： 本发明涉及从具有高保真度识别特性和多个结合基团的起始组分控制制造纳米结构的方法和装置。 在一个实施方案中，本发明涉及使用通过连续形成结合对或其它化学结合反应在常规间隔区内以受控顺序添加纳米组分形成纳米结构。

公开(公告)号：US20070042386A1

公开(公告)日：2007-02-22

申请号：US11170514

申请日：2005-06-28

申请人： Michael Heller

发明人： Michael Heller

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： G11C13/0019 ,  B01J2219/00536 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/00659 ,  B82Y10/00 ,  C12Q1/6818 ,  C12Q1/686 ,  G06N3/123 ,  G11B7/244 ,  G11B2007/24624 ,  G11C13/0014 ,  G11C13/04 ,  H01L24/95 ,  H01L25/50 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01011 ,  H01L2924/01012 ,  H01L2924/01013 ,  H01L2924/01019 ,  H01L2924/0102 ,  H01L2924/01023 ,  H01L2924/01025 ,  H01L2924/01032 ,  H01L2924/01033 ,  H01L2924/01039 ,  H01L2924/01043 ,  H01L2924/01044 ,  H01L2924/01054 ,  H01L2924/0106 ,  H01L2924/01074 ,  H01L2924/01075 ,  H01L2924/01076 ,  H01L2924/01077 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/12042 ,  H01L2924/12043 ,  H01L2924/14 ,  Y10S435/80 ,  Y10S436/80 ,  Y10T436/13 ,  C12Q2531/113 ,  C12Q2565/101 ,  C12Q2563/107 ,  H01L2924/00

摘要： The present invention contemplates monitoring the amplification of nucleic acid using chromophore-containing polynucleotides having at least two donor chromophores operatively linked to the polynucleotide by linker arms, such that the chromophores are positioned by linkage along the length of the polynucleotide at a donor-donor transfer distance, and at least one fluorescing acceptor chromophore operatively linked to the polynucleotide by a linker arm, such that the fluorescing acceptor chromophore is positioned by linkage at a donor-acceptor transfer distance from at least one of the donor chromophores, to form a photonic structure for collecting photonic energy and transferring the energy to an acceptor chromophore, and methods using the photonic structures.

摘要翻译： 本发明考虑使用含有至少两个供体生色团的含发色团的多核苷酸监测核酸的扩增，所述多核苷酸通过连接臂与多核苷酸可操作地连接，使得通过在供体 - 供体转移下沿着多核苷酸的长度连接定位发色团 距离以及通过连接臂与多核苷酸可操作地连接的至少一个荧光受体发色团，使得荧光受体发色团通过以至少一个供体生色团的供体 - 受体转移距离连接而定位，以形成光子结构 用于收集光能并将能量转移到受体发色团，以及使用光子结构的方法。

公开(公告)号：US20050191447A1

公开(公告)日：2005-09-01

申请号：US10789039

申请日：2004-02-27

申请人： Kevin Kidnie ,  Michael Heller ,  M. Ali

发明人： Kevin Kidnie ,  Michael Heller ,  M. Ali

IPC分类号： B41M5/00 ,  B41M5/382 ,  B41M5/42 ,  B41M5/52 ,  B41M5/40

CPC分类号： B41M5/42 ,  B41M5/38257 ,  B41M5/52

摘要： The present invention concerns a multi-layer thermal imaging receptor having superior transferability and image color stability for color proofing applications where the images are generated by a laser thermal process. The present invention includes a first support coated by at least, in order, a heat sensitive releasable transfer layer coated, an interfacial bonding layer and an image receiving layer of the present invention adapted to adhere to a second support when heated. The interfacial bonding layer is adapted to enhance adhesion between the heat sensitive releasable transfer layer and the image receiving layer. The present invention further provides a method of making a multi-layer thermal imaging receptor and a method of imaging using the receptor.

摘要翻译： 本发明涉及对通过激光热处理产生图像的彩色打样应用具有优异的转印性和图像颜色稳定性的多层热成像受体。 本发明包括至少按顺序涂覆的热敏可释放转印层的第一载体，本发明的界面粘合层和图像接收层适于在加热时粘附到第二载体上。 界面结合层适于增强热敏可释放转印层和图像接收层之间的粘附。 本发明还提供一种制备多层热成像受体的方法和使用该受体成像的方法。