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    OBJECTIVE LENS ARRANGEMENT FOR CONFOCAL ENDOMICROSCOPY
    1.
    发明申请
    OBJECTIVE LENS ARRANGEMENT FOR CONFOCAL ENDOMICROSCOPY 审中-公开
    眼内镜下目标镜片布置

    公开(公告)号：US20140221753A1

    公开(公告)日：2014-08-07

    申请号：US14169467

    申请日：2014-01-31

    申请人： Guillermo J. Tearney ,  Dongkyun Kang ,  Minkyu Kim

    发明人： Guillermo J. Tearney ,  Dongkyun Kang ,  Minkyu Kim

    IPC分类号： A61B1/00

    CPC分类号： A61B1/0019 ,  A61B1/041

    摘要： An apparatus for imaging an anatomical structure(s) can be provided. For example, a housing arrangement can have a shape of a pill and can be to be delivered to the anatomical structure(s). An imaging arrangement can be configured to generate a microscopic image of the anatomical structure(s), wherein the imaging arrangement can include a variable focus lens, and can be provided in the housing arrangement.

    摘要翻译： 可以提供用于对解剖结构进行成像的装置。 例如，壳体布置可以具有药丸的形状并且可以被输送到解剖结构。 成像装置可以被配置为产生解剖结构的微观图像，其中成像装置可以包括可变焦距透镜，并且可以设置在壳体装置中。

    Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample
    2.
    发明授权
    Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample 有权
    用于促进至少一个样品上的分散比例的至少部分重叠的装置和方法

    公开(公告)号：US09254089B2

    公开(公告)日：2016-02-09

    申请号：US13054015

    申请日：2009-07-14

    申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Dongkyun Kang

    发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Dongkyun Kang

    IPC分类号： G01J3/02 ,  A61B5/00 ,  G01N21/47 ,  G02B23/24 ,  G01J3/18

    CPC分类号： A61B1/00172 ,  A61B1/04 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/18 ,  G01N21/4795 ,  G02B23/2423 ,  G02B23/2469

    摘要： Exemplary embodiments of apparatus and method according to the present disclosure are provided. For example, an apparatus for providing electromagnetic radiation to a structure can be provided. The exemplary apparatus can include a first arrangement having at least two wave-guides which can be configured to provide there through at least two respective electromagnetic radiations with at least partially different wavelengths from one another. The exemplary apparatus can also include a dispersive second arrangement structured to receive the electro-magnetic radiations and forward at least two dispersed radiations associated with the respective electro-magnetic radiations to at least one section of the structure. The wave-guide(s) can be structured and/or spatially arranged with respect to the dispersive arrangement to facilitate at least partially overlap of the dispersed radiations on the structure. In addition, another arrangement can be provided which can include at least two further wave-guides which can be configured to receive the electro-magnetic radiations from the dispersive arrangement. Each of the further wave-guides can be structured and/or spatially arranged with respect to the dispersive arrangement to facilitate a receipt of a different one of the such electro-magnetic radiations as a function of wavelengths thereof.

    摘要翻译： 提供了根据本公开的设备和方法的示例性实施例。 例如，可以提供用于向结构提供电磁辐射的装置。 示例性装置可以包括具有至少两个波导的第一装置，所述至少两个波导可被配置成通过至少两个具有彼此具有至少部分不同波长的相应电磁辐射来提供波导。 示例性装置还可以包括分散第二装置，其被构造为接收电磁辐射，并将与各个电磁辐射相关联的至少两个分散的辐射转发到该结构的至少一个部分。 波导可以相对于分散布置被构造和/或空间布置，以促进结构上分散的辐射的至少部分重叠。 此外，可以提供另外的布置，其可以包括至少两个另外的波导，其可被配置为从分散布置接收电磁辐射。 每个其它波导可以相对于色散装置构造和/或空间布置，以便于接收这样的电磁辐射中不同的一个作为其波长的函数。

    APPARATUS AND METHODS FOR COLOR ENDOSCOPY
    3.
    发明申请
    APPARATUS AND METHODS FOR COLOR ENDOSCOPY 有权
    颜色内窥镜的装置和方法

    公开(公告)号：US20110237892A1

    公开(公告)日：2011-09-29

    申请号：US13054015

    申请日：2009-07-14

    申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Dongkyun Kang

    发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Dongkyun Kang

    IPC分类号： A61B1/06

    CPC分类号： A61B1/00172 ,  A61B1/04 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/18 ,  G01N21/4795 ,  G02B23/2423 ,  G02B23/2469

    摘要： Exemplary embodiments of apparatus and method according to the present disclosure are provided. For example, an apparatus for providing electromagnetic radiation to a structure can be provided. The exemplary apparatus can include a first arrangement having at least two wave-guides which can be configured to provide there through at least two respective electro-magnetic radiations with at least partially different wavelengths from one another. The exemplary apparatus can also include a dispersive second arrangement structured to receive the electro-magnetic radiations and forward at least two dispersed radiations associated with the respective electro-magnetic radiations to at least one section of the structure. The wave-guide(s) can be structured and/or spatially arranged with respect to the dispersive arrangement to facilitate at least partially overlap of the dispersed radiations on the structure. In addition, another arrangement can be provided which can include at least two further wave-guides which can be configured to receive the electro-magnetic radiations from the dispersive arrangement. Each of the further wave-guides can be structured and/or spatially arranged with respect to the dispersive arrangement to facilitate a receipt of a different one of the such electro-magnetic radiations as a function of wavelengths thereof.

    摘要翻译： 提供了根据本公开的设备和方法的示例性实施例。 例如，可以提供用于向结构提供电磁辐射的装置。 示例性装置可以包括具有至少两个波导的第一装置，所述至少两个波导可以被配置成通过至少两个彼此具有至少部分不同波长的相应的电磁辐射来提供它们。 示例性装置还可以包括分散第二装置，其被构造为接收电磁辐射，并将与各个电磁辐射相关联的至少两个分散的辐射转发到该结构的至少一个部分。 波导可以相对于分散布置被构造和/或空间布置，以促进结构上分散的辐射的至少部分重叠。 此外，可以提供另外的布置，其可以包括至少两个另外的波导，其可被配置为从分散布置接收电磁辐射。 每个其它波导可以相对于色散装置构造和/或空间布置，以便于接收这样的电磁辐射中不同的一个作为其波长的函数。

    ENDOSCOPIC BIOPSY APPARATUS, SYSTEM AND METHOD
    4.
    发明申请
    ENDOSCOPIC BIOPSY APPARATUS, SYSTEM AND METHOD 有权
    内窥镜生物仪器，系统和方法

    公开(公告)号：US20100210937A1

    公开(公告)日：2010-08-19

    申请号：US12690686

    申请日：2010-01-20

    申请人： Guillermo J. Tearney ,  Brett E. Bouma ,  Dongkyun Kang ,  Melissa J. Suter

    发明人： Guillermo J. Tearney ,  Brett E. Bouma ,  Dongkyun Kang ,  Melissa J. Suter

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0066 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0086

    摘要： Exemplary embodiments of apparatus, method and system for determining a position on or in a biological tissue can be provided. For example, using such exemplary embodiment, it is possible to control the focus of an optical imaging probe. In another exemplary embodiment, it is possible to implement a marking apparatus together with or into an optical imaging probe. According to one exemplary embodiment, it is possible (using one or more arrangements) to receive information associated with at least one image of at least one portion of the biological tissue obtained using an optical imaging technique. Further, it is possible to, based on the information, cause a visible change on or in at least location of the portion(s) using at least one electro-magnetic radiation.

    摘要翻译： 可以提供用于确定生物组织上或生物组织中的位置的装置，方法和系统的示例性实施例。 例如，使用这样的示例性实施例，可以控制光学成像探针的焦点。 在另一个示例性实施例中，可以与光学成像探头一起实现标记设备， 根据一个示例性实施例，可以（使用一个或多个布置）接收与使用光学成像技术获得的生物组织的至少一部分的至少一个图像相关联的信息。 此外，可以基于该信息，使用至少一个电磁辐射在该部分的至少位置上或至少位置处引起可见的变化。

    METHOD, APPARATUS AND COMPUTER ACCESSIBLE MEDIUM FOR PROVIDING SIGNAL AND CONTRAST ENHANCEMENT(S) IN OPTICAL IMAGING METHODS
    6.
    发明申请
    METHOD, APPARATUS AND COMPUTER ACCESSIBLE MEDIUM FOR PROVIDING SIGNAL AND CONTRAST ENHANCEMENT(S) IN OPTICAL IMAGING METHODS 审中-公开
    光学成像方法中提供信号和对比度增强的方法，装置和计算机可访问介质

    公开(公告)号：US20140194736A1

    公开(公告)日：2014-07-10

    申请号：US14147403

    申请日：2014-01-03

    申请人： Guillermo J. Tearney ,  Tao Wu ,  Dongkyun Kang ,  Melissa J. Suter

    发明人： Guillermo J. Tearney ,  Tao Wu ,  Dongkyun Kang ,  Melissa J. Suter

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0059 ,  A61B1/041 ,  A61B1/043 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6852 ,  A61B5/6861

    摘要： A system for facilitating imaging of an anatomical structure(s) can be provided, and can include, for example, a substance which can induce a change in the anatomical structure(s) when applied to the anatomical structure(s), and an imaging arrangement which can be configured to generate an image of the anatomical structure(s) based on the change of the anatomical structure(s) when the substance is applied. The imaging arrangement can include an apparatus which can be configured to (i) illuminate the anatomical structure(s) with a first electro-magnetic radiation(s), and (ii) receive a second electro-magnetic radiation from the anatomical structure(s) that can be based on the first electro-magnetic radiation. The change can affect a characteristic(s) of the second electro-magnetic radiation.

    摘要翻译： 可以提供用于促进解剖结构成像的系统，并且可以包括例如当应用于解剖结构时可以引起解剖结构变化的物质，以及成像 布置，其可以被配置为基于当施加物质时解剖结构的变化来生成解剖结构的图像。 成像装置可以包括可以被配置为（i）用第一电磁辐射照射解剖结构的装置，以及（ii）从解剖结构（s）接收第二电磁辐射 ）可以基于第一次电磁辐射。 该变化可影响第二电磁辐射的特性。

    Devices and methods for imaging particular cells including eosinophils
    7.
    发明申请
    Devices and methods for imaging particular cells including eosinophils 审中-公开
    用于成像特定细胞（包括嗜酸性粒细胞）的装置和方法

    公开(公告)号：US20110137178A1

    公开(公告)日：2011-06-09

    申请号：US12899524

    申请日：2010-10-06

    申请人： Guillermo J. Tearney ,  Brett E. Bouma ,  Dongkyun Kang ,  Hongki Yoo

    发明人： Guillermo J. Tearney ,  Brett E. Bouma ,  Dongkyun Kang ,  Hongki Yoo

    IPC分类号： A61B6/00

    CPC分类号： A61B5/411 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/037 ,  A61B5/4233 ,  A61B5/68 ,  A61B5/6852 ,  A61B5/6853 ,  G02B21/0064 ,  G02B21/0076

    摘要： An exemplary embodiment of apparatus and method according to the present disclosure can be provided. For example, using at least one first arrangement, it is possible to direct at least one first electro-magnetic radiation to at least one portion of tissue within a body. Using at least one second arrangement, it is possible to receive at least one second electro-magnetic radiation provided from the portion, which is based on the first electro-magnetic radiation. Further, using at least one third arrangement, it is possible to differentiate at least one particular cell which is eosinophil, mast cell, basophil, monocyte and/or nutrophil from other cells in the portion based on the second electro-magnetic radiation.

    摘要翻译： 可以提供根据本公开的装置和方法的示例性实施例。 例如，使用至少一个第一布置，可以将至少一个第一电磁辐射引导到身体内的组织的至少一部分。 使用至少一个第二布置，可以接收从基于第一电磁辐射的部分提供的至少一个第二电磁辐射。 此外，使用至少三分之一布置，可以基于第二电磁辐射将部分中的至少一种特定的嗜酸性粒细胞，肥大细胞，嗜碱性粒细胞，单核细胞和/或营养细胞与其他细胞区分开。

    APPARATUS AND METHOD FOR OBTAINING AND PROVIDING IMAGING INFORMATION ASSOCIATED WITH AT LEAST ONE PORTION OF A SAMPLE, AND EFFECTING SUCH PORTION(S)
    10.
    发明申请
    APPARATUS AND METHOD FOR OBTAINING AND PROVIDING IMAGING INFORMATION ASSOCIATED WITH AT LEAST ONE PORTION OF A SAMPLE, AND EFFECTING SUCH PORTION(S) 有权
    用于获取和提供与至少一个样品部分相关的成像信息的装置和方法，以及影响这些部分

    公开(公告)号：US20130066215A1

    公开(公告)日：2013-03-14

    申请号：US13614459

    申请日：2012-09-13

    申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin

    发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin

    IPC分类号： A61B1/07

    CPC分类号： A61B1/07 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B18/22 ,  A61B2017/00061

    摘要： Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) second different wavelengths of at least one second electro-magnetic radiation within a second wavelength range can be provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion.

    摘要翻译： 可以提供示例性装置和过程用于与样品的至少一部分相关联的成像信息。 例如，（i）可在提供在样品部分上的第一波长范围内提供至少一个第一电磁辐射的第一不同波长，以便确定该部分的至少一个第一横向位置，和（ii ）可以在该部分上提供在第二波长范围内的至少一个第二电磁辐射的第二不同波长，以便确定该部分的至少一个第二横向位置。 第一和第二范围可以在该部分上部分重叠。 此外，可以获得从样品返回的至少一个第三电磁辐射电磁辐射与从基准返回的至少一个第四电磁辐射之间的相对相位，以确定该部分的相对深度位置。